Natural and Induced Cell-Mediated Cytotoxicity

Effector and Regulatory Mechanisms

1st Edition - January 1, 1979
Editors: Gert Riethmüller, Peter Wernet, Gustavo Cudkowicz
Language: English
eBook ISBN:
9 7 8 - 1 - 4 8 3 2 - 6 9 8 2 - 5

Natural and Induced Cell-Mediated Cytotoxicity: Effector and Regulatory Mechanisms contains the proceedings of the Erwin Riesch Symposium organized on the occasion of the Fifth… Read more

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Natural and Induced Cell-Mediated Cytotoxicity: Effector and Regulatory Mechanisms contains the proceedings of the Erwin Riesch Symposium organized on the occasion of the Fifth Centennial of the University of Tübingen in Germany on October 20-23, 1977. The symposium provided a forum for reviewing the progress that has been made in understanding the effector and regulatory mechanisms underlying natural and induced cell-mediated cytotoxicity. Topics covered range from the immunobiology of natural killer cells to the role of macrophages as regulator, accessory, and effector cells in cytotoxicity. Comprised of 27 chapters, this book begins by analyzing the characteristics of natural cytotoxic cells in mice, followed by a discussion on the generation in vivo of mouse natural cytotoxic cells and the role of cytotoxic T cells in the local defense against solid tumors. Subsequent chapters focus on the natural cytotoxicity of human lymphocytes; opposing effects of interferon on natural killer and target cells; susceptibility of cloned melanoma to natural cytotoxicity; and cell-mediated immunity against avian virus-induced tumor cells. The book also examines alternative routes of entry for cell surface antigens into the immune system before concluding with a chapter that considers interferon induction by Corynebacterium parvum. This monograph should be of value to students, researchers, and practitioners in the fields of biology and immunology.

ConfereesPrefaceAcknowledgmentsImmunobiology of Natural Killer Cells: Mechanisms and Regulation in the Murine System Characteristics of Natural Cytotoxic Cells in Mice Generation in Vivo of Mouse Natural Cytotoxic Cells Are Cytotoxic T Cells Relevant in the Local Defense Against Solid Tumors?Immunobiology of Natural Killer Cells: Nature of Effector Cells in the Human System Natural Cytotoxicity of Human Lymphocytes. Immunoglobulin Dependent and Independent Systems Characterization of Effector Cells in Human Natural Cytotoxicity Effector Cells of Natural Cytotoxicity Against Human Melanoma Cells Relation of Effector Mechanisms to Target Cell OriginMechanisms, Target Cells, and Regulation of Natural Killer Cell Activity in Man Models for Mechanisms of Natural Cytotoxicity Opposing Effects of Interferon on Natural Killer and Target Cells Specificity of Natural Cytotoxic Cells Determined by Antibody Manipulations of Natural Cytotoxicity in Tumor Patients via BCG Susceptibility of Cloned Melanoma to Natural CytotoxicityInduced Cell-Mediated Cytotoxicity: Targets, Mechanisms, and Concepts Antigen Recognition by Cytotoxic T Lymphocytes Generation of TNP-Specific H-2-Restricted Murine Cytotoxic Cells as a Function of TNP-Cell Surface Presentation Secondary Sendai-Specific T Effector Cells: Requirements for Restimulation, Target Cell Recognition, and Lysis Cytotoxic T Lymphocytes Induced by H-2 Negative Stimulator Cells Cell-Mediated Immunity Against Avian Virus-Induced Tumor Cells Alternative Routes of Entry for Cell Surface Antigens into the Immune SystemInduced Cell-Mediated Cytotoxicity: Reactivity Against Modified Self in Man Cell-Mediated Cytotoxicity Against TNP-Modified Human Leukocytes HLA Restriction of Cytotoxicity Against Influenza-Infected Human Cells Self-Restricted Cytotoxicity Against Acute Myeloid Leukemia CellsMacrophages as Regulator, Accessory, and Effector Cells in Cytotoxicity Regulatory Role of Macrophages in Normal and Neoplastic Hemopoiesis Serum Hematopoietic Inhibitors and Tumor Necrosis Factor Role of Adherent Cells in the Induction of Cytotoxic T Lymphocytes: Promotion, Suppression, and Antigen Presentation Cytotoxicity of Bone Marrow Macrophages for Normal and Malignant Targets Interferon Induction by Corynebacterium parvumConclusions and Overview Recapitulation and Assessment of the Conference Discussions