Nathan and Oski's Hematology and Oncology of Infancy and Childhood, 2-Volume Set - 8th Edition - ISBN: 9781455754144, 9780323291774

Nathan and Oski's Hematology and Oncology of Infancy and Childhood, 2-Volume Set

8th Edition

Authors: Stuart Orkin David Nathan David Ginsburg A. Thomas Look David Fisher Samuel Lux
eBook ISBN: 9780323291774
eBook ISBN: 9780323294676
Hardcover ISBN: 9781455754144
Imprint: Saunders
Published Date: 5th December 2014
Page Count: 2752

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 Written by the leading names in pediatric oncology and hematology, Nathan and Oski’s Hematology and Oncology of Infancy and Childhood offers you the essential tools you need to overcome the unique challenges and complexities of childhood cancers and hematologic disorders. Meticulously updated, this exciting full-color, two-volume set brings together the pathophysiology of disease with detailed clinical guidance to provide you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children.

Key Features

  • Form a definitive diagnosis and create the best treatment plans possible with comprehensive coverage of all pediatric cancers, including less-common tumors, as well as all hematologic disorders, including newly recognized ones.
  • Develop a thorough, understanding of the underlying science of diseases through summaries of relevant pathophysiology balanced with clear, practical clinical guidance. Nathan and Oski’s is the only comprehensive product on the market that relates pathophysiology in such depth to hematologic and oncologic diseases affecting children.
  • Quickly and effortlessly access the key information you need with the help of a consistent organization from chapter to chapter and from volume to volume.

Table of Contents

Section I Neonatal Hematology

1. Anatomy and Physiology of Hematopoiesis

2. The Neonatal Erythrocyte and Its Disorders

3. Immune Hemolytic Disease

4. Neonatal Jaundice and Disorders of Bilirubin Metabolism

5. Hemostasis in the Newborn and Infant

Section II Bone Marrow Failure

6. Acquired Aplastic Anemia and Pure Red Cell Aplasia

7. Inherited Bone Marrow Failure Syndromes

8. Principles of Bone Marrow and Stem Cell Transplantation

Section III Disorders of Erythrocyte Production

9. Diagnostic Approach to the Anemic Patient

10. Megaloblastic Anemia

11. Disorders of Iron and Copper Metabolism, Sideroblastic Anemias and Lead Toxicity

12. Porphyrias

Section IV Hemolytic Anemias

13. Autoimmune Hemolytic Anemia

14. Paroxysmal Nocturnal Hemoglobinuria

15. Red Cell Membrane

16. Disorders of the Red Cell Membrane

17. Pyruvate Kinase Deficiency and Disorders of Glycolysis

18. Glucose-6-Phosphate Dehydrogenase Deficiency

19. Normal and Abnormal Hemoglobins

Section V Disorders of Hemoglobin

20. Sickle Cell Disease

21. Thalassemias

Section VI Phagocyte System

22. Phagocyte System and Disorders of Granulopoiesis and Granulocyte Function

Section VII Immune System

23. Immune Response

24. Primary Immunodeficiency Diseases

Section VIII Storage Diseases

25. Lysosomal Storage Diseases

Section IX Hemostasis

26. Platelets and the Vessel Wall

27. Blood Coagulation

28. Molecular Basis of Fibrinolysis

29. Approach to the Child with a Suspected Bleeding Disorder

30. Inherited Platelet Disorders

31. Hemophilia and von Willebrand Disease

32. Rare Hereditary Coagulation Factor Abnormalities

33. Inherited Disorders of Thrombosis and Fibrinolysis

34. Acquired Platelet Defects

35. Acquired Disorders of Hemostasis

Section X Supportive Therapy

36. Transfusion Medicine

Section XI Hematologic Manifestations of Systemic Diseases

37. Hematological Manifestations of Systemic Diseases

38. Hematology Manifestations of Systemic Diseases in Children of the Developing World

Section XII Biology of Cancer

39. Origins and Evolution of Pediatric Cancer

40. Epidemiology of Leukemia in Childhood

41. Informatics

42. Genetic Predisposition to Cancer

43. Genetic and Epigenetics of Childhood Cancers

44. Targeted Therapies in Oncology

45. Cytogenetic and Molecular Pathology of Pediatric Cancer 

Section XIII Pediatric Cancer Therapeutics

46. Cancer Chemotherapy for Pediatric Patients

47. Immunotherapy of Cancer

48. Pediatric Radiation Oncology

48. Pediatric Surgical Oncology 

Section XIV Hematologic Malignancy

50. Acute Lymphoblastic Leukemia 

51. Pediatric Myeloid Leukemia, Myelodysplasia, and Myeloproliferative Disease

52. Infant Leukemias

53. Pediatric Lymphoma

Section XV Solid Tumors

54. Neuroblastoma

55. Pediatric Renal Tumors

56. Retinoblastoma

57. Tumors of the Brain and Spinal Cord 

58. Hepatoblastoma and Other Liver Tumors in Children

59. Rhabdomyosarcoma

60. Nonrhabdomyosarcoma Soft Tissue Sarcomas and Other Soft Tissue Tumors 

61. Ewing Sarcoma

62. Osteosarcoma

63. Pediatric Germ Cell Tumors

64. Histiocytoses

65. Rare Tumors of Childhood

66. Imaging in the Evaluation and Management of Childhood Cancer

Section XVI Supportive Care

67. Infectious Disease in the Pediatric Cancer Patient 

68. Oncologic Emergencies

69. Nursing Care of Patients with Childhood Cancer 

70. Palliative Care in Pediatric Oncology

71. Symptom Management in Children with Cancer

72. Childhood Cancer Survivorship

73. Psychosocial Care of the Child and Family

74. Ethical Considerations in Pediatric Oncology Clinical Trials 

Appendices: Reference Values in Infancy and Childhood


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About the Author

Stuart Orkin

Affiliations and Expertise

David G Nathan Professor of Pediatrics, Harvard Medical School; Chair, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston Children's Hospital; Investigator, Howard Hughes Medical Institute, Boston, Massachusetts

David Nathan

Affiliations and Expertise

President Emeritus, Dana-Farber Cancer Institute, Physician-in-Chief Emeritus, Boston Children's Hospital; Stranahan Distinguished Professor of Pediatrics and Professor of Medicine, Harvard Medical School, Boston, Massachusetts

David Ginsburg

Affiliations and Expertise

James V Neel Distinguished University Professor, Departments of Internal Medicine, Pediatrics, and Communicable Diseases, and Human Genetics, Investigator, Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, Michigan

A. Thomas Look

Affiliations and Expertise

Professor of Pediatrics, Harvard Medical School; Vice Chair for Research, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston Children's Hospital, Boston, Massachusetts

David Fisher

Affiliations and Expertise

Chief, Department of Dermatology, Director, Cutaneous Biology Research Center, Massachusetts General Hospital; Director, Melanoma Program, Massachusetts General Hospital Cancer Center, Boston, Massachusetts

Samuel Lux

Affiliations and Expertise

Robert A Stranahan Professor of Pediatrics, Harvard Medical School; Chief Emeritus, Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts