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Nanotechnology in Diagnosis, Treatment and Prophylaxis of Infectious Diseases - 1st Edition - ISBN: 9780128013175, 9780128014714

Nanotechnology in Diagnosis, Treatment and Prophylaxis of Infectious Diseases

1st Edition

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Editors: Mahendra Rai Kateryna Kon
Paperback ISBN: 9780128013175
eBook ISBN: 9780128014714
Imprint: Academic Press
Published Date: 15th March 2015
Page Count: 344
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Nanotechnology in Diagnosis, Treatment and Prophylaxis of Infectious Diseases delivers comprehensive coverage of the application of nanotechnology to pressing problems in infectious disease.

This text equips readers with cutting-edge knowledge of promising developments and future prospects in nanotechnology, paying special attention to microbes that are now resistant to conventional antibiotics, a concerning problem in modern medicine.

Readers will find a thorough discussion of this new approach to infectious disease treatment, including the reasons nanotechnology presents a promising avenue for the diagnosis, treatment, and prophylaxis of infectious diseases.

Key Features

  • Provides a comprehensive overview of the use of nanotechnology in the treatment and diagnosis of infectious diseases
  • Covers all common types of infective agents, including bacteria, viruses, fungi, and protozoa, along with their vectors, ticks, mosquitoes, flies, etc.
  • Delivers commentary from an international researcher base, providing insights across differing economic statuses
  • Includes a foundation of basic nanotechnological concepts to aid in designing new strategies to combat several pathogenic diseases and cancer
  • Illustrates the high antimicrobial potential of nanoparticles, ultimately demonstrating how they are a promising alternative class that can be successfully used in fighting a myriad of infections


Researchers, scientists, graduate and postgraduate students in biology: microbiology, bacteriology, biotechnology, mycology, virology, infectious diseases, surgery, dermatology, and pharmacology

Table of Contents

  • List of Contributors
  • Preface
  • Chapter 1. Gold and Silver Nanoparticles for Diagnostics of Infection
    • 1.1 Nanotechnology and Infection
    • 1.2 Gold and Silver NPs for Molecular Diagnostics
    • 1.3 Nanodiagnostics for Nucleic Acids
    • 1.4 Aptamers and Antibodies
    • 1.5 iPCR and Other Methods
    • 1.6 Conclusion
    • Acknowledgments
    • References
  • Chapter 2. Antimicrobial Models in Nanotechnology: From the Selection to Application in the Control and Treatment of Infectious Diseases
    • 2.1 Introduction
    • 2.2 Antimicrobial Susceptibility Testing Methods of NMs
    • 2.3 Nanotoxicology
    • 2.4 In Vitro Pharmacokinetics/Pharmacodynamic Models
    • 2.5 Conclusions
    • Acknowledgment
    • References
  • Chapter 3. Silver Nanoparticles for the Control of Vector-Borne Infections
    • 3.1 Introduction
    • 3.2 Louse-Borne Infections and Activity of AgNPs Against Lice
    • 3.3 Mosquito-Borne Infections and Activity of AgNPs Against Mosquitoes
    • 3.4 Tick-Borne Infections and Activity of AgNPs Against Ticks
    • 3.5 Flies, Their Role in Transmission and Spread of Infections, and Activity of AgNPs Against Flies
    • 3.6 Conclusions and Future Prospects
    • References
  • Chapter 4. Magnetite Nanostructures: Trends in Anti-Infectious Therapy
    • 4.1 Introduction
    • 4.2 Nanoparticles with Biomedical Applications
    • 4.3 Conclusions
    • Acknowledgments
    • References
  • Chapter 5. Photodynamic Therapy of Infectious Disease Mediated by Functionalized Fullerenes
    • 5.1 Introduction
    • 5.2 Antibiotic Resistance and the Need for PDT
    • 5.3 PDT Mechanism of Action
    • 5.4 Applications
    • 5.5 The Ideal PS
    • 5.6 PDT Using Fullerenes
    • 5.7 In Vitro Studies
    • 5.8 In Vivo Studies
    • 5.9 Conclusions
    • Acknowledgments
    • References
  • Chapter 6. Nonconventional Routes to Silver Nanoantimicrobials: Technological Issues, Bioactivity, and Applications
    • 6.1 Introduction
    • 6.2 Ion Beam Sputtering Deposition of AgNP-Based Coatings
    • 6.3 Photo-Assisted Deposition of AgNP-Based Coatings
    • 6.4 Electrochemical Methods for Nanomaterial Synthesis
    • 6.5 Overview of the Most Widely Accepted Bioactivity Mechanisms
    • 6.6 Overview of the Most Promising Applications
    • 6.7 Conclusions and Future Perspectives
    • References
  • Chapter 7. Application of Nanomaterials in Prevention of Bone and Joint Infections
    • 7.1 Introduction
    • 7.2 Orthopedic Implants and Infections
    • 7.3 Local Delivery of Antimicrobials
    • 7.4 Antimicrobial Implant Coatings
    • 7.5 Implant Coating with Nano-Silver
    • 7.6 Conclusion and Future Perspectives
    • Acknowledgments
    • References
  • Chapter 8. The Potential of Metal Nanoparticles for Inhibition of Bacterial Biofilms
    • 8.1 Introduction
    • 8.2 Diseases Caused by Bacterial Biofilms
    • 8.3 Biofilm Resistance to Conventional Antibiotics and New Alternative Strategies to Combat Bacterial Biofilms
    • 8.4 Antibiofilm Activity of Metal NPs
    • 8.5 Conclusions
    • References
  • Chapter 9. Tackling the Problem of Tuberculosis by Nanotechnology: Disease Diagnosis and Drug Delivery
    • 9.1 Introduction
    • 9.2 The Present Scenario of Antibiotics Used Against TB
    • 9.3 Nanotechnology as a Novel Approach in Drug Discovery
    • 9.4 Nano-Based DNA Vaccines for TB
    • 9.5 Role of Nanobiosensors in Diagnostics of TB
    • 9.6 Conclusion and Future Perspectives
    • References
  • Chapter 10. Influence of Physicochemical Properties of Nanomaterials on Their Antibacterial Applications
    • 10.1 Introduction
    • 10.2 Physicochemical Properties of Nanomaterials and Their Influence on Antibacterial Performance
    • 10.3 Conclusions
    • References
  • Chapter 11. Nanocarriers Against Bacterial Biofilms: Current Status and Future Perspectives
    • 11.1 Introduction
    • 11.2 Biofilms—Health and Economic Burdens
    • 11.3 Biofilms—Definition, Composition, and Development
    • 11.4 Challenges in Antimicrobial Treatment of Biofilms
    • 11.5 Current Approaches for Efficient Anti-Infective Therapy
    • 11.6 Biofilm Targeting
    • 11.7 Experimental Evaluation of Nanocarrier–Biofilm Interaction
    • 11.8 Pharmaceutical Application of Nanoantimicrobials
    • 11.9 Clinical Studies and Marketed Products
    • 11.10 Conclusion and Future Perspectives
    • References
  • Chapter 12. Nanomaterials for Antibacterial Textiles
    • 12.1 Introduction
    • 12.2 Textile Fibers
    • 12.3 Preparatory Processes
    • 12.4 Coloration Processes
    • 12.5 Environmental Concerns
    • 12.6 Antibacterial Function Finish
    • 12.7 Antibacterial Textiles Using Nanomaterials
    • 12.8 Potential Implications
    • 12.9 Evaluation of Antibacterial Efficacy
    • 12.10 Future Scope
    • Acknowledgment
    • References
  • Chapter 13. Complexes of Metal-Based Nanoparticles with Chitosan Suppressing the Risk of Staphylococcus aureus and Escherichia coli Infections
    • 13.1 Introduction
    • 13.2 Synthesis of Metal Nanoparticles, Characterization, and Modification
    • 13.3 Interaction of Metal Nanoparticles with Cell Components Affecting Cellular Processes
    • 13.4 Biochemical Mechanism of Toxicity to Prokaryotic Cells
    • 13.5 Oxidative Stress and Formation of ROS by Metal Nanoparticles
    • 13.6 Antibacterial Effect of Metal Nanoparticles in Complex with Chitosan
    • 13.7 Effect of Metal Nanoparticles in Specific Examples
    • 13.8 Conclusion
    • Acknowledgment
    • References
  • Chapter 14. Nanotechnology—Is There Any Hope for Treatment of HIV Infections or Is It Simply Impossible?
    • 14.1 Introduction
    • 14.2 Current Antiretroviral Chemotherapy
    • 14.3 Nanotechnology in HIV Chemotherapy—Why?
    • 14.4 Nanoparticle Research
    • 14.5 Industry Approach and Commercialization Success
    • 14.6 Conclusion and Perspectives
    • References
  • Chapter 15. Nanotherapeutic Approach to Targeting HIV-1 in the CNS: Role of Tight Junction Permeability and Blood–Brain Barrier Integrity
    • 15.1 Introduction
    • 15.2 HIV-1 Reservoir in the Brain
    • 15.3 Characteristics of Nanoparticles That Enhance Their Applicability to Biomedical Application
    • 15.4 Nanotechnology-Based HIV Therapeutics
    • 15.5 The Blood–Brain Barrier
    • 15.6 In Vitro Model of the Human BBB
    • 15.7 Role of TJ Protein in BBB Preservation
    • 15.8 Key TJ Proteins—JAM-2, ZO-1, Claudin-5, and Occludin
    • 15.9 Mechanisms of TJ Modulation
    • 15.10 Effect of Nanoparticles on TJ Proteins in BMVEC Cultures
    • 15.11 Conclusion
    • References
  • Chapter 16. A Novel Fungicidal Action of Silver Nanoparticles: Apoptosis Induction
    • 16.1 Introduction
    • 16.2 ROS Accumulation
    • 16.3 Phosphatidyl Serine Exposure
    • 16.4 Mitochondrial Dysfunction
    • 16.5 Caspase Activation
    • 16.6 DNA Fragmentation and Chromosome Condensation
    • 16.7 Cell-Cycle Arrest
    • 16.8 Synergistic Effect of Silver Nanoparticles
    • 16.9 Conclusion and Future Prospects
    • References
  • Chapter 17. Silver Nanoparticles to Fight Candida Coinfection in the Oral Cavity
    • 17.1 Introduction
    • 17.2 Silver Nanoparticles Against Candida Biofilms
    • 17.3 Conclusions and Future Perspectives
    • References
  • Chapter 18. Nanomedical Therapeutic and Prophylaxis Strategies Against Intracellular Protozoa in the Americas
    • 18.1 Introduction
    • 18.2 Leishmaniasis
    • 18.3 Chagas Disease
    • 18.4 Conclusions
    • References
  • Index


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© Academic Press 2015
15th March 2015
Academic Press
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About the Editors

Mahendra Rai

Mahendra Rai

Dr Mahendra Rai: Professor and Head of the Department of Biotechnology at Amravati University in Maharashtra, India. He has published 210 research papers, more than 100 popular articles in Indian and foreign journals and 30 books from reputed publishers like Elsevier, Springer, CRC, Taylor and Francis and Scientific Publisher. He is a member of several scientific societies and has been a national Scholar for five years. He has received several prestigious awards, including the father T.A. Mathias award (1989) from the All India Association for Christian Higher Education, and the Medini award (1999) from the Department of Environment and Forest, Government of India. He also received SERC visiting fellowship by Department of Science and Technology (1996), INSA visiting fellowship by Indian National Science Academy (1998) and TWAS-UNESCO Associateship (2002), Italy. Dr. Rai serves as a referee for 20 international journals and is a member of editorial board of ten national and international journals. He has approximately three decades of teaching and research experience. The main focus of his research is plant and nanobased bioactives against human pathogenic microbes.

Affiliations and Expertise

Professor and Head, Department of Biotechnology, SGB Amravati University, Amravati, Maharashtra, India

Kateryna Kon

Kateryna Kon

Dr. Kateryna Kon, MD, PhD, currently works at the Department of Microbiology, Virology and Immunology at Kharkiv National Medical University, Kharkiv, Ukraine as an Associate Professor. Dr. Kon received the Best Young Scientist of Kharkiv Award in 2007. She has ten years of teaching and fifteen years of research experience. She is an editorial board member of six international peer-reviewed journals.

Dr. Kon's scientific contributions include more than 100 publications, 6 books and 18 scientific articles. The main focus of Dr. Kon’s research is antibiotic resistance in bacteria, coping with microbial resistance by plant essential oils and nanoparticles, microbiology of surgical and gynaecological infections, application of different statistical methods to analysis of biomedical data.

Affiliations and Expertise

Associate Professor, Department of Microbiology, Virology and Immunology, Kharkiv National Medical University, Kharkiv, Ukraine

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