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Nanotechnology for Oral Drug Delivery: From Concept to Applications discusses the current challenges of oral drug delivery, broadly revising the different physicochemical barriers faced by nanotechnolgy-based oral drug delivery systems, and highlighting the challenges of improving intestinal permeability and drug absorption. Oral delivery is the most widely used form of drug administration due to ease of ingestion, cost effectiveness, and versatility, by allowing for the accommodation of different types of drugs, having the highest patient compliance. In this book, a comprehensive overview of the most promising and up-to-date engineered and surface functionalized drug carrier systems, as well as opportunities for the development of novel and robust delivery platforms for oral drug administration are discussed. The relevance of controlling the physicochemical properties of the developed particle formulations, from size and shape to drug release profile are broadly reviewed. Advances in both in vitro and in vivo scenarios are discussed, focusing on the possibilities to study the biological-material interface. The industrial perspective on the production of nanotechnology-based oral drug delivery systems is also covered. Nanotechnology for Oral Drug Delivery: From Concept to Applications is essential reading for researchers, professors, advanced students and industry professionals working in the development, manufacturing and/or commercialization of nanotechnology-based systems for oral drug delivery, targeted drug delivery, controlled drug release, materials science and biomaterials, in vitro and in vivo testing of potential oral drug delivery technologies.
- Highlights the relevance of oral drug delivery in the clinical setting
- Covers the most recent advances in the field of nanotechnology for oral drug delivery
- Provides the scientific community with data that can facilitate and guide their research
Pharmaceutical Scientists; Researchers and Advanced Students in drug delivery, biomaterials and nanotechnology.
Part I: Biological aspects and properties of nanomaterials for oral drug delivery
1. Oral drug delivery: overview
2. Organization of the intestinal mucosa and barriers to oral drug delivery
3. Nanomaterials for oral drug administration
4. Mucoadhesive and mucus-penetrating polymers for drug delivery
5. Size, shape and surface charge considerations of orally delivered nanomedicines
6. Modified drug release: current strategies and novel technologies for oral drug delivery
7. Delivery platforms for oral drug administration
8. (Trans)Buccal drug delivery
Part II: Advanced technologies for oral delivery applications
9. Spray drying for the formulation of oral drug delivery systems
10. Microdevices to successfully deliver orally administered drugs
11. Batch and microfluidic reactors in the synthesis of enteric drug carriers
12. 3D printing in oral drug delivery
Part III: Methods for the evaluation of oral drug delivery systems
13. 3D intestinal models towards a more realistic permeability screening
14. In vitro relevant information for the assessment of nanoparticles for oral drug administration
15. In vivo testing of orally delivered nanoparticles
Part IV: Pharmaceutical industry perspective
16. Industrial perspectives and future of oral drug delivery
- No. of pages:
- © Academic Press 2020
- 27th July 2020
- Academic Press
- Paperback ISBN:
- eBook ISBN:
João Pedro Martins graduated in Biomedical Engineering at the Faculty of Engineering of the University of Porto (FEUP) in collaboration with the Institute of Biomedical Engineering (INEB), Porto, Portugal. Currently, he is a fourth-year PhD student at the Faculty of Pharmacy of the University of Helsinki, Finland. In the framework of his PhD, J.P. Martins is developing advanced drug delivery systems with the aim of making oral administration of nanomedicines carrying anti-diabetic drugs a reality. So far, he has authored/co-authored 12 scientific publications (original and review articles), 2 book chapters, and 1 conference proceedings, and has given 8 oral communications and 13 poster presentations in scientific meetings. J.P. Martins has more than 150 citations (Google Scholar 190; h-index = 8), and has also served as a reviewer for 7 international peer-reviewed scientific journals.
Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Finland
Hélder A. Santos is a Professor in Pharmaceutical Nanotechnology, Principal Investigator/Group Leader, Director of the Doctoral Program in Drug Research, and Head of the Nanomedicines and Biomedical Engineering Group at the Faculty of Pharmacy, University of Helsinki (Finland). Prof. Santos' research is focused on nanobiomaterials, including nanoporous silica/silicon materials and polymeric-based nanoparticles for controlled drug delivery, diagnostics and therapy. The research interests include the development of nanoparticles/nanomedicines for biomedical and healthcare applications. His current work makes the bridge between engineering, pharmaceutical and medical research. His main research focus is in the use of biodegradable and biocompatible nanoporous silicon nanomaterials, polymers, the application of microfluidics technology for nanoparticle production for simultaneous controlled drug delivery, diagnostic and treatment of cancer, diabetes, and cardiovascular diseases, and further translation of these technologies into the clinic. Prof. Santos is the author/co-author of more than 280 publications, including reviews, journal editorials, book chapters and 4 patents (> 8100 citations, h-index = 54), and more than 250 conference proceedings/abstracts.
Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Finland and Helsinki Institute of Life Science, University of Helsinki, Finland
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