Nanotechnology-based Targeted Drug Delivery Systems for Brain Tumors - 1st Edition - ISBN: 9780128122181

Nanotechnology-based Targeted Drug Delivery Systems for Brain Tumors

1st Edition

Editors: Prashant Kesharwani Umesh Gupta
Paperback ISBN: 9780128122181
Imprint: Academic Press
Published Date: 1st June 2018
Page Count: 344
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Description

Brain tumors remain among the most lethal forms of cancer, despite their relatively low frequency as compared with other forms. Most drug delivery systems are effective outside the brain, but fail to treat brain tumors in clinical trials because the blood brain barrier (BBB) inhibits the permeation of most drugs. The need for innovative technologies and nanodrug delivery systems to improve the targeting and delivery of diagnostic agents and therapeutics to brain tumors is urgent, and Nanotechnology-based Targeted Drug Delivery Systems for Brain Tumors addresses this need. An introductory chapter on brain anatomy and brain tumors is followed by a discussion of the progress and challenges in delivering drugs across the BBB. Several chapters are devoted to the latest technologies and advances in nanotechnology and include practical solutions on how to design more effective nanocarriers for drug and gene delivery. This is a valuable resource that prepares readers to develop novel drug delivery systems for the treatment of brain tumors that take advantage of and further promote the latest nanomedical technologies.

Key Features

  • Addresses the progress and challenges inherent in delivering drugs across the blood brain barrier and offers strategies to maximize effectiveness
  • Draws upon the experience and expertise of international scientists working in the fields of drug delivery and nanomedicine
  • Considers the future possibilities of nanotechnology for delivering nanocarriers that better diagnose and treat brain tumors

Readership

Pharmaceutical industry scientists, graduate students and academic researchers in pharmaceutical science and materials science working in drug delivery and nanotechnology, clinical researchers including neuroscientists and cancer researchers

Table of Contents

  1. Introduction: An Overview of the Anatomy and Physiology of the Brain
    2. Angiogenesis in brain tumors
    3. Physiology of the Blood Brain Barrier (BBB) and mechanisms of Transport across the BBB
    4. Active Targeting Systems (Ligands) / Receptor overexpressed on brain
    5. Nanotechnology in Brain Targeting
    6. Polymeric nanoparticles based drug delivery for brain tumors
    7. Solid lipid nanoparticles (SLN)based drug delivery for brain tumors
    8. Liposomes based drug delivery for brain tumors
    9. Dendrimers based drug delivery for brain tumors
    10. Micelles based drug delivery for brain tumors
    11. Nanoemulsions based drug delivery for brain tumors
    12. Nanogel based drug delivery for brain tumors
    13. Beyond the blood–brain barrier — facing new challenges
    14. Towards development of neuro-diagnostic nano-imaging platform
    15. Future prospects of nanoparticles on brain targeted drug delivery

Details

No. of pages:
344
Language:
English
Copyright:
© Academic Press 2018
Published:
Imprint:
Academic Press
Paperback ISBN:
9780128122181

About the Editor

Prashant Kesharwani

Dr. Prashant Kesharwani is currently working as Ramanujan Fellow at Central Drug Research Institute (CDRI), Lucknow. He received his doctoral degree in Pharmaceutical Sciences from the Dr H.S. Gour University (Sagar, India) with Prof N.K Jain’s group. He is a recipient of several internationally acclaimed awards viz “Ramanujan Fellowship, DST, India-2017”, “Excellence Research Award-2014”, “Young Innovator Award (Gold medal)-2012”, “International Travel Award/Grant from DST (New Delhi), and INSA (CCSTDS, Chennai)-2012”. He has received ICMR Senior Research Fellowship (in PhD) and AICTE Junior Research Fellowship (in M. Pharm.). After his doctorate, he worked as postdoctoral fellows in the Wayne State University, Detroit (Michigan, USA). Dr. Kesharwani subsequently joined the School of Pharmacy, International Medical University (Malaysia) as lecturer in Pharmaceutical Technology. An overarching goal of his current research is the development of nano-engineered drug delivery systems for cancer through with prime focus on dendrimer and polymeric nanomicelles mediated drug delivery systems. Dr. Kesharwani is a co-author on more than 90 publications in high impact factor international journals and 2 international books with total citations of more than 2000 (h index of 22 as per Google Scholar).

Affiliations and Expertise

Pharmaceutics Division, CSIR-Central Drug Research Institute (CDRI), Uttar Pradesh, India

Umesh Gupta

Dr. Umesh Gupta, currently working as Assistant Professor at Department of Pharmacy, Central University of Rajasthan, India, did his bachelor's, master's and doctorate degree in Pharmaceutical Sciences from Dr. H. S. Gour University, India under the mentorship of Prof. NK Jain. He has recently been awarded for “DAAD Research Stays for Academics and Scientists” at Leibniz-institut fur Polymerforschung Dresden, Germany. He has the past experience of Research Scientist at Ranbaxy Research Laboratories, India and Post-Doctoral Research Associate at South Dakota State University, USA. HE is also recipient of Young Scientist Award by Department of Science and Technology, Government of India as well as Ranbaxy Science Scholar Award 2008 by Ranbaxy Research Laboratories, India. He has been awarded more than 3-4 times the overseas travel award by different funding agencies of Indian government to share and present his research at international platform in countries like Germany, USA and Singapore etc. He has more than ten years of research and academic experience. The area of research is mainly focused on dendrimer mediated drug delivery, solubilization and targeting. His laboratory equally focuses on effective brain delivery through nanotechnological carriers such as polymeric micelles, nanoparticles and dendrimers. He has more than 48 publications and seven book chapters to his credit with total citations of more than 2300 (h index of 23 as per Google Scholar).

Affiliations and Expertise

School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Ajmer-305817, India