Nanotechnology Applications for Cancer Chemotherapy

Nanotechnology Applications for Cancer Chemotherapy

1st Edition - September 30, 2020

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  • Authors: Sanyog Jain, Kaisar Raza, Ashish Kumar Agrawal, Ankur Vaidya
  • eBook ISBN: 9780128178478
  • Paperback ISBN: 9780128178461

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Description

Applications of Nanotechnology in Cancer Chemotherapy offers a complete and concise summary of nanotechnological interventions for cancer management. It highlights the basics of oncology, the cancer microenvironment, targets for active drug delivery, the underlying mechanisms and molecular pathways to enhance the drug delivery to the cancer site. The book discusses the principles of basic and innovative nanocarrier-based therapeutic approaches to modulate the progression of the disease. In addition, this book also explores the evolving targeting approaches specific to the cancer site and type. The scope of the book is not limited to targeted drug delivery for various cancers, but also explores the advancements in cancer imaging and diagnostics employing the nanotechnological tools. Emphasis has been given on the important evaluation techniques like in-vitro cell culture and in-vivo animal models to assess the performance of cancer nanomedicines. The book includes clinical study reports of various drug moieties explored using variety of nanoconstructs in myriad cancer conditions with the input of global market and pharmacoeconomics.

Key Features

  • Discusses how organic and inorganic nanoplatforms are being used in cancer treatment
  • Shows how nanotechnology is being used to create new and more accurate diagnostic tools
  • Surveys the current generation of cancer nanomedicines, assessing their advantages and challenges

Readership

Academics and R&D industry researchers in the fields of materials science and biomedical research

Table of Contents

  • 1. Basic pathology and etiology of tumor and its microenvironment
    2. EPR effect and its implication in passive targeting of nanocarrier to the tumor
    3. pH sensitive carriers as delivery to tumor
    4. Temperature sensitive carrier temperature directed tumor cell eradication
    5. Magnetically responsive delivery into tumor environment
    6. Ligands used for tumor targeting
    7. Therapy targeting angiogenic potential of tumor
    8. Immunotherapy of cancer
    9. Chemical linkers: Potential approach to target tumor
    10. Cell penetrating peptide in cancer targeting
    11. Inorganic nanoparticles: A new avenue in improving diagnostic
    12. Development of photodynamic cancer therapy
    13. Therapeutic based on small interfering RNAs (siRNA)
    14. Aptamer conjugates: A new avenue
    15. Application of cancer stem cells in improving therapeutics
    16. Targeting breast cancer
    17. Lung cancer: improving efficacy and reducing side effects
    18. Colorectal cancer: and its targeting
    19. Hepatic cancer targeting
    20. Solid tumor: Addressing the problems associated
    21. Pancreatic cancer: Removing extracellular matrix barrier in delivery
    22. Targeting to the CNS: Approach for brain tumor
    23. Metastatic cancer: How one can address the therapeutic challenge
    24. Prostate cancer: Delivery aspect and prospect
    25. Leukemia: trends in treatment and how close we have achieved eradication
    26. Tumor imaging and its application in tumor targeted drug delivery
    27. 2D and 3D cell culture: Getting close to mimicking tumor microenvironment in vitro
    28. In vivo animal model for cancer: What have we learnt from chemical induced and xenograft models
    29. Nanosystem: regulatory aspects, clinical development and market potential

Product details

  • No. of pages: 702
  • Language: English
  • Copyright: © Elsevier 2020
  • Published: September 30, 2020
  • Imprint: Elsevier
  • eBook ISBN: 9780128178478
  • Paperback ISBN: 9780128178461

About the Authors

Sanyog Jain

Sanyog Jain is an Associate Professor of Pharmaceutics at the Centre for Pharmaceutical Nanotechnology, National Institute of Pharmaceutical Education and Research (NIPER), India. His research focuses in the areas of nanomedicine and advanced drug delivery. His laboratory has been actively engaged with the design and evaluation of myriad of nanostructured drug delivery vehicles, a few of which are already at advanced stage of development.

Affiliations and Expertise

Associate Professor of Pharmaceutics at the Centre for Pharmaceutical Nanotechnology, National Institute of Pharmaceutical Education and Research (NIPER), India

Kaisar Raza

Kaisar Raza is an Assistant Professor at the Department of Pharmacy, Central University of Rajasthan, Ajmer, India. His research focuses on the development of nanoscale systems for the improvement of cancer chemotherapy, brain delivery, dermal and transdermal assimilation and oral bioavailability of many of drugs Apart from routine nanotechnological interventions, his expertise lies in pharmacokinetics and quality-by-design.

Affiliations and Expertise

Assistant Professor at the Department of Pharmacy, Central University of Rajasthan, Ajmer, India

Ashish Kumar Agrawal

Ashish Kumar Agrawal is Assistant Professor, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (Banaras Hindu University), India. His research interests include targeted and controlled drug delivery by using nanotechnology based approaches, development of vesicular and particulate nanocarriers for various biomedical applications, and protein and peptide delivery through alternative routes.

Affiliations and Expertise

Assistant Professor, Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology (Banaras Hindu University), India

Ankur Vaidya

Ankur Vaidya is an Assistant Professor at Pharmacy College Saifai, in the Uttar Pradesh University of Medical Sciences (UPUMS), Saifai, Etawah India. His research focuses on the use of nanomaterials and nanotechnology-based drug delivery products.

Affiliations and Expertise

Assistant Professor, Pharmacy College Saifai, in the Uttar Pradesh University of Medical Sciences (UPUMS), Saifai, Etawah India

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