Nanostructures for Novel Therapy - 1st Edition - ISBN: 9780323461429, 9780323461481

Nanostructures for Novel Therapy

1st Edition

Synthesis, Characterization and Applications

Editors: Denisa Ficai Alexandru Grumezescu
eBook ISBN: 9780323461481
Hardcover ISBN: 9780323461429
Imprint: Elsevier
Published Date: 6th March 2017
Page Count: 906
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Table of Contents

Chapter 1: Novel approaches for preparation of nanoparticles

  • Abstract
  • 1. Introduction
  • 2. Synthetic Methods for Preparation of Metal Nanoparticles
  • 3. Application of Metal Nanoparticles in Theranostics
  • 4. Conclusions
  • Acknowledgments

Chapter 2: Applications of nanoscale drugs carriers in the treatment of chronic diseases

  • Abstract
  • 1. Introduction in Drug Delivery and Targeting
  • 2. Applications of Nanotechnology in Drug Delivery and Targeting
  • 3. Conclusions

Chapter 3: Functionalization of nanoparticles in specific targeting and mechanism release

  • Abstract
  • 1. Introduction
  • 2. Controlled-Release Mechanisms
  • 3. Project of Nanoparticles
  • 4. Nanoparticles Targeting
  • 5. Conclusions

Chapter 4: Fabrication and characterization of natural/synthesized, micro-, and nanostructured materials for biomedical applications

  • Abstract
  • 1. Introduction
  • 2. Pearl Shell
  • 3. Microstructure Analysis of Nacre by Transmission Electron Microscopy
  • 4. Micro-/Nanoparticles
  • 5. Surface Modification of Nanoparticles
  • 6. 2D Periodic Structure by Thermal Imprinting Process
  • 7. Functionalities for Biomedical Applications
  • 8. Summary and Future Directions

Chapter 5: Multifunctional nanostructured biopolymeric materials for therapeutic applications

  • Abstract
  • 1. Introduction
  • 2. Biopolymers
  • 3. Multifunctional Nanostructured Materials
  • 4. Therapeutic Applications
  • 5. Conclusions and Perspectives

Chapter 6: Polymeric pharmaceutical nanoparticles developed by electrospray

  • Abstract
  • 1. Introduction
  • 2. Polymeric Particles and Atomizers
  • 3. Electrospray
  • 4. Therapeutic Nanoparticles Loaded by Electrospray
  • 5. Conclusions

Chapter 7: Nanoformulation and administration of PUFA-rich systems for applications in modern healthcare

  • Abstract
  • 1. Introduction
  • 2. Lipid Nanoparticles: Types and Fabrication Technology
  • 3. Understanding the Physiological System for Therapy: The Significance of Lipid Nanotechnology at Tissue and Cellular Level
  • 4. Therapeutic Lipid Nanostructures
  • 5. Risk and Hazard Assessment
  • 6. Challenges and Scope
  • 7. Conclusions
  • Acknowledgments

Chapter 8: Electrospinning and surface modification methods for functionalized cell scaffolds

  • Abstract
  • 1. Electrospinning for Tissue Engineering
  • 2. Fundamentals of the Electrospinning Process
  • 3. Tuning the Morphology of Electrospun Scaffolds and its Effects on Cell Behavior
  • 4. Surface Modification Methods of Electrospun Nanofibers
  • 5. Conclusions

Chapter 9: Short peptide self-assembled nanostructures for therapeutics innovative delivery

  • Abstract
  • 1. Introduction
  • 2. Preparation and Characterization of Self-Assembling Short Peptides
  • 3. Drug-Delivery Applications
  • 4. Self-Assembly to Achieve a Therapeutic Effect
  • 5. Conclusions and Future Outlook
  • Abbreviations

Chapter 10: Peptoids: tomorrow’s therapeutics

  • Abstract
  • 1. Introduction
  • 2. Peptoid Synthesis
  • 3. Peptoid Structures
  • 4. Applications of Peptoids
  • 5. Conclusions

Chapter 11: Electrospinning of collagen nanofiber scaffolds for tissue repair and regeneration

  • Abstract
  • 1. Introduction
  • 2. Tissue Engineering
  • 3. Scaffold
  • 4. Nanofibers
  • 5. Electrospinning
  • 6. Applications of Electrospun Collagen

Chapter 12: Nanostructured therapeutic systems with bioadhesive and thermoresponsive properties

  • Abstract
  • 1. Introduction
  • 2. Bioadhesive Systems
  • 3. Stimuli-Responsive Polymers
  • 4. Hydrogels
  • 5. Mucoadhesive Thermoresponsive Systems
  • 6. Characterization of Mucoadhesive Thermoresponsive Systems
  • 7. Conclusions

Chapter 13: Design considerations in the development of wound healing bionanomaterials

  • Abstract
  • 1. Introduction
  • 2. Skin: Properties, Growth, and Regeneration
  • 3. Bionanomaterials
  • 4. Nanostructures
  • 5. Nanofabrication
  • 6. Conclusions

Chapter 14: Role of nanostructure molecules in enhancing the bioavailability of oral drugs

  • Abstract
  • 1. Nanotechnology: Some Basic Concepts
  • 2. Nanostructure Molecules or Nanoparticles
  • 3. Absorption of Oral Drugs in the Gastrointenstinal Tract
  • 4. Nanoscience and Nanotechnology: From Basic Science to Applications

Chapter 15: Improvement steps of plastic surgery to tissue engineering by nanotechnology

  • Abstract
  • 1. Introduction
  • 2. Development of Nanotechnology Into Nanomedicine
  • 3. Nanomaterials Used in Medical Therapeutics
  • 4. Nanotechnology in Diagnostics
  • 5. Nanotechnology and Drug Delivery
  • 6. Use of Nanotechnology in Tissue Engineering
  • 7. Conclusions

Chapter 16: Dendrimers and dendronized materials as nanocarriers

  • Abstract
  • 1. Introduction
  • 2. Synthetic Approach
  • 3. Physico-Chemical Properties of Dendritic Molecules useful for Nanocarriers
  • 4. Drug–Dendritic Polymer Interactions
  • 5. Types of Targeting by Nanodelivery System
  • 6. Routes of Administration of Dendritic Molecules
  • 7. Successful Examples of Dendritic Molecules as Nanocarriers
  • 8. Conclusions
  • Acknowledgments

Chapter 17: Gold nanostructures: preparation, properties, application in SERS, and biophotonics

  • Abstract
  • 1. Introduction
  • 2. Experimental
  • 3. Theoretical
  • 4. Methods for Preparation of Gold Nanoparticles and Nanostructures. Application in SERS
  • 5. Application of Au Nanostructures in Biophotonics
  • 6. Conclusions
  • Acknowledgments

Chapter 18: Quantum dots for bioimaging and therapeutic applications

  • Abstract
  • 1. Introduction
  • 2. QDs for Bioimaging Applications
  • 3. QDs for Therapy
  • 4. Conclusions

Chapter 19: Lipid-based synthetic gene carriers

  • Abstract
  • 1. Introduction
  • 2. Equilibrium Lipoplex Structure on the Nanoscale
  • 3. The Kinetics of Lipoplex Formation
  • 4. Discussion
  • 5. Conclusions
  • Conflict of Interests

Chapter 20: Using microsensors to promote the development of innovative therapeutic nanostructures

  • Abstract
  • 1. Introduction
  • 2. Nano-Objects Definition and Properties
  • 3. Integrated Analyte Handling
  • 4. Measurements Techniques
  • 5. Conclusions

Chapter 21: The effect of nanostructured surfaces on stem cell fate

  • Abstract
  • 1. Introduction
  • 2. Nanostructured Surfaces
  • 3. Stem Cells within the Human Body and Their Use in Regenerative Medicine
  • 4. Interactions of Nanostructured Surfaces and Stem Cells
  • 5. Future Perspective
  • Acknowledgments

Chapter 22: Applications of aptamers for the diagnosis and therapy of different diseases

  • Abstract
  • 1. Introduction
  • 2. Selection of Aptamers
  • 3. Aptamers as Therapeutics
  • 4. Challenges of Aptamers
  • 5. Nanotechnology and Aptamers
  • 6. Conclusions

Chapter 23: Recent progress in therapeutic diagnosis using photonic crystal nanostructures

  • Abstract
  • 1. Introduction to Photonic Crystal Nanostructures
  • 2. Origin of Photonic Bandgap
  • 3. Photonic Crystal Slabs
  • 4. Materials and Fabrication Methods
  • 5. Introduction to Biosensors
  • 6. PC Laser Biosensors and Lab-on-Chip Devices
  • 7. Conclusions

Chapter 24: Novel carriers and approaches: insight for psoriasis management

  • Abstract
  • 1. Introduction
  • 2. Types of Psoriasis
  • 3. Pathogenesis of Psoriasis
  • 4. Function of Cytokines
  • 5. Treatment Approaches for Psoriasis
  • 6. Novel Colloidal Carriers for Psoriasis Treatment
  • 7. Lipid-Based Particulate Carriers
  • 8. Emulsion-Based Carriers
  • 9. Conclusions

Chapter 25: Use of nanostructures based on noble metals in nanobiomedicine

  • Abstract
  • 1. Introduction
  • 2. Optical Properties of Metal Nanostructures
  • 3. Applications in Biological Systems and Biomedicine
  • 4. Summary

Chapter 26: Innovative nonviral vectors for small-interfering RNA delivery and therapy

  • Abstract
  • 1. Introduction
  • 2. Obstacles to In Vivo siRNA Delivery: The Biological Barriers and the Immunological Response
  • 3. Chemical Modifications of siRNA
  • 4. siRNA Delivery Systems: Focus on Liposomes and Lipoplexes
  • 5. Clinical Trials
  • 6. Conclusions

Chapter 27: siRNA-based nucleoceuticals for tissue regeneration

  • Abstract
  • 1. Introduction
  • 2. Heart Regeneration
  • 3. Kidney Regeneration
  • 4. Liver Regeneration
  • 5. Ocular Regeneration
  • 6. Peritoneal Fibrosis Regeneration
  • 7. Cartilage Regeneration
  • 8. Skin Regeneration
  • 9. Bone Regeneration
  • 10. Nerve Regeneration
  • 11. Conclusions

Chapter 28: Bone tissue regenerative medicine via bioactive nanomaterials

  • Abstract
  • 1. Introduction
  • 2. Synthetic Approaches for Bone Tissue Replacement
  • 3. Nanomaterials as key Enablers of Bone Regeneration
  • 4. Risks and Obstacles of Nanomaterials Applications
  • 5. Perspectives and Outlooks
  • Acknowledgments

Chapter 29: Toxicity of nanostructures—a general approach

  • Abstract
  • 1. Introduction
  • 2. Metallic Nanostructures
  • 3. Nonmetallic Nanostructures
  • 4. Conclusions

Chapter 30: Role of Excipients in formulation development and biocompatibility of lipid nanoparticles (SLNs/NLCs)

  • Abstract
  • 1. Introduction
  • 2. Role of Excipients in SLNs and NLCs
  • 3. Conclusions
  • Acknowledgment

Description

Nanostructures for Novel Therapy: Synthesis, Characterization and Applications focuses on the fabrication and characterization of therapeutic nanostructures, in particular, synthesis, design, and in vitro and in vivo therapeutic evaluation. The chapters provide a cogent overview of recent therapeutic applications of nanostructured materials that includes applications of nanostructured materials for wound healing in plastic surgery and stem cell therapy.

The book explores the promise for more effective therapy through the use of nanostructured materials, while also assessing the challenges their use might pose from both an economic and medicinal point of view. This innovative look at how nanostructured materials are used in therapeutics will be of great benefit to researchers, providing a greater understanding of the different ways nanomaterials could improve medical treatment, along with a discussion of the obstacles that need to be overcome in order to guarantee widespread availability.

Key Features

  • Outlines how the characteristics of nanostructures made from different materials gives particular properties that can be successfully used in therapeutics
  • Compares the properties of different nanostructures, allowing medicinal chemists and engineers to select which are most appropriate for their needs
  • Highlights new uses of nanostructures within the therapeutic field, enabling the discovery of new, more effective drugs

Readership

Biomaterials scientists, materials scientists, biomedical engineers, medicinal chemists and postgraduate students specializing in the areas of nanomedicine, bionanomaterials and nanotechnology applications in healthcare


Details

No. of pages:
906
Language:
English
Copyright:
© Elsevier 2017
Published:
Imprint:
Elsevier
eBook ISBN:
9780323461481
Hardcover ISBN:
9780323461429

About the Editors

Denisa Ficai Editor

Denisa Ficai is Associate Professor of Inorganic Chemistry, Faculty of Applied Chemistry and Materials Sciences at the University Politehnica, Bucharest. Her research interests are currently focused on nanomaterials (especially ferrites, oxides, phosphates) and composite materials (especially hybrid composite materials comprising 0D, 1D and 2D reinforcing agents) most of these materials being designed for medical and health industrial applications. She has published over 50 papers in international scientific journals that have been cited more than 200 times. She has presented at more than 40 conferences and holds 6 patents. She is a co-author of three books on chemistry and also authored four book chapters.

Affiliations and Expertise

Associate Professor of Inorganic Chemistry, Faculty of Applied Chemistry and Materials Sciences, University Politehnica, Bucharest

Alexandru Grumezescu Editor

Dr. Grumezescu is Assistant Professor at the Department of Science and Engineering of Oxide Materials and Nanomaterials, in the Faculty of Applied Chemistry and Materials Science, with a second affiliation to the Faculty of Medical Engineering, at the Politehnica University of Bucharest in Romania. He is an experienced and oft-published researcher and editor in the field of nano and biomaterials, and he is the Editor-in-Chief of three journals: Biointerface Research in Applied Chemistry, Letters and Applied NanoBioScience, and Biomaterials and Tissue Engineering Bulletin. He also serves as editor or guest editor for several notable journals. Dr. Grumezescu has published 150 peer-reviewed papers, 20 book chapters, 6 co-authored books and 11 edited books.

Affiliations and Expertise

Assistant Professor, Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science and Faculty of Medical Engineering, Politehnica University of Bucharest, Romania