Nanoinformatics: Principles and Practice

1st Edition


  • Mark Hoover
  • Frederick Klaessig
  • Stacey Harper
  • Juli Klemm
  • Nathan Baker
  • Victor Maojo
  • Nanoinformatics: Principles and Practice

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    There is a growing consensus that technically sound knowledge management and informatics tools must be developed and applied to provide a strong basis for the rational design of nanomaterials and products, prioritization of research, and assessment of risk across the nanoproduct lifecycle. For scientists in the field of nanotechnology, this book provides a guide to the principles and practice of informatics approaches, explains the benefits of good informatics practice in nanotechnology research, and summarizes resources currently available. For students and practitioners alike, this book introduces the special informatics needs in the growing field of nanotechnology.

    Edited by experts in the field, four of whom made substantial contributions to the development of the Nanoinformatics 2020 Roadmap from the NSF (USA National Science Foundation), this is the first book-length study of the field of Nanoinformatics. In addition to informing current practitioners in both nanotechnology and informatics about current principles and practice, this book is designed to contribute to the accelerating rate and quality of nanotechnology discovery and applications.

    Nanoinformatics presents some particular challenges. As a multidisciplinary field, nanotechnology has to bridge the terminology in use across disparate fields such as materials science, chemistry and drug design. In medical applications, both terminology and practice varies around the globe. In addition, at the nanoscale familiar distinctions such as the differentiation between a drug and a device become less clear. Similarly, applying the concept of positive controls to materials with a particle/chemical duality is not a straightforward extension of traditional biological test protocols. The authors of this book engage with these differences, and propose a methodical approach to nanoinformatics as essential for the rapid and efficient development of nanotechnology.

    Key Features

    • Aids the efficient design of nanomaterials and products, prioritization of research, and assessment of risk across the nanoproduct lifecycle
    • Provides the key to safe and effective nanotechnology research and applications across different academic disciplines and geographies
    • Written by leading experts, several of whom have played a major role in drawing up the Nanoinformatics 2020 Roadmap from the NSF (USA National Science Foundation)


    Scientists, engineers and R&D staff in fields including biomedicine, nanotechnology regulation, environmental health and safety, occupational health and safety, computational nanotechnology and informatics, toxicology, industrial process design, patents and intellectual property, and legal requirements of nanotechnology

    Table of Contents

    PART I Introduction to Nanotechnology and Informatics

    Chapter 1 Objectives for Establishing a Nanoinformatics Program (review of types of applications)

    Chapter 2 Nanotechnology Issues for Informatics

    Chapter 3 Standards, Guidelines, Regulations (including MINchar, ISA-TAB-Nano, and protocols)

    Chapter 4 Life cycle of Development of for Nanoinformatics(including Best Practices from caBIG)

    PART II Fundamentals of Nanotechnology for Developing Informatics Systems

    Chapter 5 Essential Elements of How Nanoparticles are Made

    Chapter 6 How to Measure Physico-chemical Properties

    Chapter 7 How to Measure Nanoparticles in vitro

    Chapter 8 How to Measure Nanoparticles in vivo

    PART III Fundamentals of Informatics Systems Design and Operations

    Chapter 9 Informatics for Nanotechnologists

    Chapter 10 Domain Models

    Chapter 11 Taxonomy, Controlled Vocabularies and Ontologies

    PART IV Analytics and Methods for Scientific Exploration and Discovery

    Chapter 12 Unsupervised Data Analysis

    Chapter 13 Generating Statistical Models from Data

    Chapter 14 Generating Mechanistic Models from Data

    Chapter 15 Quantitative Structure Activity Modeling

    PART V Case Studies and Resources

    Appendix: Metathesaurus for Nanoinformatics (including multiplicity of definitions from NCI, ASTM, ISO, NPO, with pointers to chapters with terms).

    Appendix: Characteristics of Nanoparticles


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    © 2015
    William Andrew
    Print ISBN:
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