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Nanocarriers for Organ-Specific and Localised Drug Delivery - 1st Edition - ISBN: 9780128210932

Nanocarriers for Organ-Specific and Localised Drug Delivery

1st Edition

Authors: Muhammad Shah Muhammad Imran Shafi Ullah
Paperback ISBN: 9780128210932
Imprint: Elsevier
Published Date: 1st September 2021
Page Count: 300
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Table of Contents

  1. Nanocarriers in drug delivery: Classification, properties and targeted drug delivery applications
    2. Nanocarriers systems for brain targeted drug delivery and diagnosis
    3. Designing of nanocarriers for liver targeted drug delivery and diagnosis
    4. Nanocarries based improved drug delivery for treatment and management of cardiovascular diseases
    5. Improved pulmonary drug delivery through nanocarriers
    6. Transdermal drug delivery nanocarriers for improved treatment of skin diseases
    7. Targeted nano drug delivery systems for renal disorders
    8. Designing of nanocarriers for enhancing drugs absorption through gastrointestinal tract
    9. Nanomaterials as promising therapeutic platform for bone tissues engineering
    10. Overcoming ocular barriers through nanocarrier-based drug delivery systems
    11. Organ-specific toxicities of nanocarriers

Description

Organ-specific drug delivery is aimed at achieving increased concentration of therapeutic molecules at target sites with minimum side effects on other healthy tissues. Similarly, drug-specific delivery to some vital organs, such as the brain, lungs, heart and kidneys remains a challenging task for the formulation scientists. Oral delivery of most of the commercially available life-saving drugs has also been impeded by various physio-chemical and biological barriers. These advancements in nanotechnology have led to the development of various pharmaceutical nanocarriers.

Nanocarriers for Organ-Specific and Localised Drug Delivery summarizes targeted drug delivery systems and approaches to the major organs of the body. The book shows how drugs can be specifically targeted to the pathological area within an organ in a viable way. Employing pharmaceutical nanocarriers for drug delivery targeted to specific organs of the body requires a comprehensive knowledge of the disease site’s pathophysiology as well as physical, chemical and pharmaceutical techniques for modification or functionalization of the nanocarriers.

Combining theoretical principles and practical applications of various nanocarriers for organ-specific drug delivery, this is an important reference source for all those seeking to increase their understanding of how pharmaceutical nanocarriers are being used to create more efficient drug delivery systems.

Key Features

  • Outlines the underlying principles for the design of advanced pharmaceutical nanocarriers for organ specific drug delivery
  • Includes guidance on how to exploit the pathophysiology and microenvironment of the diseased sites for targeted drug delivery
  • Assesses the major challenges for creating pharmaceutical nanocarriers on a mass scale

Readership

Materials scientists, engineers and pharmaceutical scientists


Details

No. of pages:
300
Language:
English
Copyright:
© Elsevier 2021
Published:
1st September 2021
Imprint:
Elsevier
Paperback ISBN:
9780128210932

Ratings and Reviews


About the Authors

Muhammad Shah

Muhammad Shah

Muhammad Raza Shah is Full Professor at the International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University of Karachi, Pakistan. He is also the Head of the Center for Bioequivalence Studies and Clinical Research (CBSCR) and the recipient of numerous awards, including the civil award Tamgha-i-Imtiaz from the President of Pakistan, Salam prize, Prof. Atta ur Rahman gold medal and the Dr. M. Raziuddin Siddiqi Prize (2015) for Scientists under 40 in the Field of Chemistry by the Pakistan Academy of Sciences. He was selected TWAS Young Affiliate in 2010 by Third World Academy of Sciences. He has authored three books (Elsevier) and also edited two books (Elsevier) in addition contributing over 350 peer-reviewed journal papers with impact factor more than 820. One of his authored books was declared best book of year 2017 by Government of Pakistan, Higher Education Commission. He is fellow International Union of Pure and Applied Chemistry and Fellow the Chemical Society of Pakistan. He is editor the Journal of the Chemical Society of Pakistan. He is mentor of Pakistani International Chemistry Olympiad team since 2009. He is also member of National Nanotechnology Foresight Committee constituted by PCST. He remained a member of COMSTECH consultative working group of scientists from OIC countries, to prepare agenda and action plan for the Ten-Year Plan of Action (TYPOA 2016-2025).

Affiliations and Expertise

Professor, International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University, Karachi, Pakistan

Muhammad Imran

Muhammad Imran

Dr Muhammad Imran Malik graduated from Karl-Franzens-Universitäte Graz, Austria in polymer chemistry under the supervision of Prof. Bernd Trathnigg in 2009. Later he worked in the research groups of Prof. Harald Pasch, University of Stellenbosch South Africa (2010-2011) and Prof. Taihyun Chang, POSTECH South Korea (2015) as a post-doctoral reserach scientist. The research focus of Dr Malik in all above-mentioned positions was analytical polymer science. In 2012, he joined the International Center of Chemical and Biological Sciences, University of Karachi as an Assistant Professor. The major research interest of Dr Malik is synthesis of novel polymeric architecture and development of comprehensive analytical methods for polymers. His research interests extend to polymer stabilized nanoparticles and their applications, such as sensors, drug delivery, molecularly imprinted polymers, and organic solar cells. Dr Malik has authored/co-authored more than 60 peer reviwed publications, three chapters in edited books and one book entitled ‘Advanced Separation Techniques for Polyolefins’. Currently, Dr Malik is Associate Porfessor at the International Center for Chemical and Biological Sciences, University of Karachi.

Affiliations and Expertise

Associate Professor, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan

Shafi Ullah

Shafi Ullah

Shafi Ullah is a graduate student and based at the International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University of Karachi, Pakistan.

Affiliations and Expertise

International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Pakistan