Nanocarriers for Drug-Targeting Brain Tumors

Nanocarriers for Drug-Targeting Brain Tumors

1st Edition - June 17, 2022

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  • Editors: Lalit Kumar, Yashwant Pathak
  • Paperback ISBN: 9780323907736

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Description

Nanocarriers for Drug-Targeting Brain Tumors covers different types of nanocarriers and  their design and development for targeting drugs to the brain. The book also presents case studies and the mechanism of action of nanocarriers in drug targeting to a specific site. This helps researchers and clinicians understand the design, development and mechanism of action of nanocarriers. As brain tumors continue to be a significant health problem globally, and very complex for targeting drugs, conventional dosage forms are not very effective and side-effects are a major concern. Functionalized nanocarriers can address these problems. Furthermore, the targeting of nanocarriers is preferred for reducing toxicity and improving the effectiveness of the drugs. However, there is a need for understanding the design and development of formulation with the mechanism of action of nanocarriers for brain targeting.

Key Features

  • Provides information on the design and development of nanocarriers for targeting brain tumors
  • Outlines the working principles of different nanocarriers for targeting brain tumors
  • Includes case studies of different nanocarriers for targeting brain tumors

Readership

Materials scientists and engineers

Table of Contents

  • Part A. Anatomy and Physiology of the Brain
    1. An overview of the anatomy and physiology of brain
    2. Pharmacological and clinical problems with special focus on brain tumors

    Part B. Pharmacological and Clinical Problems
    3. Challenges in targeting to the brain and brain tumors
    4. Potential targeting sites in the brain and brain tumors
    5. Drug resistance problems during chemotherapy

    Part C. Introduction, Brain Tumor Targeting Strategies and Biomedical Applications of Nanocarriers
    6. An overview on nanocarriers
    7. An overview on brain tumor targeting strategies of nanocarriers
    8. Biomedical applications of nanocarriers in brain tumor targeting

    Part D. Lipophilic Nanocarriers
    9. Solid lipid nanoparticle-based drug delivery for targeting brain tumors
    10. Nanostructured lipid carriers as an alternative carrier with high drug loading for targeting brain tumors
    11. Design, development and mechanism of liposomes in drug targeting brain tumors
    12. Niosome-based drug delivery in targeting brain tumors
    13. Nanoemulsions as effective carriers for targeting brain tumors

    Part E. Polymeric Nanocarriers
    14. Mechanism of polymeric micelles for drug targeting brain tumors
    15. Dendrimers as carriers for active targeting of brain tumors
    16. Multifunctional polymeric nanocarriers for the treatment of brain tumors
    17. Polymersomes for targeting brain tumors

    Part F. Metallic Nanocarriers Systems
    18. Development, mechanism and applications of gold nanoparticles for drug targeting brain tumors
    19. Gold nanoparticles in cancer theranostics
    20. Targeting of silver nanoparticles to brain tumors

    Part G. Hybrid Nanocarriers
    21. Hybrid nanoparticles to cross the blood-brain barrier
    22. Targeting of lipid/polymeric (hybrid) nanoparticles to brain tumors
    23. Multifunctional liposome-quantum dot hybrid nanocarriers for drug targeting brain tumors
    24. Tunable lipidoid-telodendrimer hybrid nanocarriers for the treatment of brain tumors

    Part H. Immunotherapy of Brain Tumors
    25. Nano immune-conjugates in drug targeting glioblastoma
    26. Nanocarriers-enabled immunotherapy for brain tumors

    Part I. Pharmacokinetics and Tissue Distribution Studies of Nanocarriers
    27. An overview on pharmacokinetics of nanocarriers in the brain and brain tumors
    28. Tracking and neuroimaging for tissue distribution studies of brain tumor targeted nanocarriers

    Part J. Future Directions and Toxic Concerns
    29. Expert opinion on current challenges and future directions
    30. Neurotoxicity issues related to nanocarriers in the treatment of brain tumors

Product details

  • No. of pages: 850
  • Language: English
  • Copyright: © Elsevier 2022
  • Published: June 17, 2022
  • Imprint: Elsevier
  • Paperback ISBN: 9780323907736

About the Editors

Lalit Kumar

Lalit Kumar, is Assistant Professor in the Department of Pharmaceutics, at Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India. His area of research includes the development of nanocarriers for drug-targeting tumor cells in the colon, brain, breast, and lung.

Affiliations and Expertise

Assistant Professor, Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India

Yashwant Pathak

Yashwant Pathak, is Professor and Associate Dean for the Faculty Affairs at the College of Pharmacy, at the University of South Florida. Tampa, USA. His area of research is in health care education, nanotechnology, drug delivery systems and nutraceuticals.

Affiliations and Expertise

Professor and Associate Dean, Faculty Affairs, College of Pharmacy, University of South Florida, Tampa, USA

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