Nanobiomaterials in Cancer Therapy - 1st Edition - ISBN: 9780323428637, 9780323428866

Nanobiomaterials in Cancer Therapy

1st Edition

Applications of Nanobiomaterials

Editors: Alexandru Grumezescu
eBook ISBN: 9780323428866
Hardcover ISBN: 9780323428637
Imprint: William Andrew
Published Date: 7th April 2016
Page Count: 588
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Description

Nanobiomaterials in Cancer Therapy presents the major applications of nanobiomaterials in oncology, offering an up-to-date overview of the latest research in this field. Utilizing nanobiomaterials, novel therapeutic approaches enable significant improvements in drug-loading capacity, formulation stability and drug efficiency.

In this book, leading researchers from around the world share their expertise and unique insights. The book covers the fabrication methods of platforms for multimodal and combinatorial therapeutic options, along with simultaneous and real-time cancer imaging, and innovative approaches for oncology by passive or active pathways of multifunctional nanocarriers. The work also classifies and discusses engineered nanobiosystems for cancer therapy, prevention, and low cancer recurrence or relapse.

This book will be of interest to postdoctoral researchers, professors and students engaged in the fields of materials science, biotechnology and applied chemistry. It will also be highly valuable to those working in industry, including pharmaceutics and biotechnology companies, medical researchers, biomedical engineers and advanced clinicians.

Key Features

  • A comprehensive resource for researchers, practitioners and students working in biomedical, biotechnological and engineering fields
  • A valuable guide to recent scientific progress and the latest application methods
  • Discusses novel opportunities and ideas for developing or improving technologies in nanomedicine and nanobiology

Readership

Academic: Materials science, biotechnology and applied chemistry professors, PhD, MsC, postdocs, upper level undergraduate students. Industry: Pharmaceutics and biotechnology companies, medical researchers, biomedical engineers, advanced clinicians

Table of Contents

  • List of contributors
  • Preface of the series
  • Preface
    • About the Series (Volumes I–XI)
    • About Volume VII
  • Chapter 1. Nanopreparations for skin cancer therapy
    • Abstract
    • 1.1 Introduction
    • 1.2 Skin Morphology
    • 1.3 Types of Cancer
    • 1.4 Non-Melanoma Skin Cancer
    • 1.5 Melanoma Skin Cancer
    • 1.6 Penetration Pathways of Skin
    • 1.7 Drug Delivery Systems Applied to Skin Cancer Treatment
    • 1.8 Liposomes
    • 1.9 Nanoemulsions and Nanosuspensions
    • 1.10 Polymeric Nanoparticles
    • 1.11 Lipid Nanoparticles
    • 1.12 Dendrimers
    • 1.13 Photodynamic Therapy
    • 1.14 Conclusions
    • References
  • Chapter 2. Silver nanoparticles in cancer therapy
    • Abstract
    • 2.1 Introduction
    • 2.2 Silver Nanoparticles
    • 2.3 Synthesis
    • 2.4 Shape
    • 2.5 Silver Nanoparticles—Cancer Diagnosis and Treatment Applications
    • 2.6 Conclusions
    • References
  • Chapter 3. Nanobiomaterials in cancer therapy
    • Abstract
    • 3.1 Introduction
    • 3.2 The Enhanced Permeability and Retention (EPR) Effect
    • 3.3 Nanomaterials in Cancer Therapy
    • 3.4 Chemotherapy-Based Nanoformulations
    • 3.5 Multifunctional NPs
    • 3.6 Cancer Therapy Using Natural Products: Nanochemoprevention
    • 3.7 Cancer Stem Cells: A Nanotechnology Perspective
    • 3.8 Conclusions
    • References
  • Chapter 4. Advances in nanobiomaterials for oncology nanomedicine
    • Abstract
    • 4.1 Introduction
    • 4.2 Organic Nanobiomaterials
    • 4.3 Inorganic Nanobiomaterials
    • 4.4 Combination of Nanotechnology with Photodynamic Therapy to Improve Cancer Treatment
    • 4.5 Toxicity and Risk Management
    • 4.6 Conclusions
    • Acknowledgments
    • References
  • Chapter 5. Nanobiomaterials: Emerging platform in cancer theranostics
    • Abstract
    • 5.1 Introduction
    • 5.2 Theranostics and Nanomedicine
    • 5.3 Antibody as Theranostics
    • 5.4 Challenges to Effective Cancer Theranostics
    • 5.5 Conclusions and Future Perspectives
    • References
  • Chapter 6. Nanotherapeutics promises for colorectal cancer and pancreatic ductal adenocarcinoma
    • Abstract
    • List of Abbreviations
    • 6.1 Introduction
    • 6.2 Biology of Colorectal and Pancreatic Cancer
    • 6.3 Current Clinical Treatment
    • 6.4 Nanotherapeutics for Drug/Gene Delivery
    • 6.5 New Nano-Based Strategies for Improved Delivery and Enhanced Bioavailability of Anticancer Drugs
    • 6.6 Conventional and Nano-Based Prodrugs
    • 6.7 Challenges and Perspectives
    • References
  • Chapter 7. Multifunctional drug nanocarriers facilitate more specific entry of therapeutic payload into tumors and control multiple drug resistance in cancer
    • Abstract
    • 7.1 Introduction
    • 7.2 Cancer and its Microenvironment
    • 7.3 Characteristic Features of Tumor
    • 7.4 Different Types of Nanocarriers
    • 7.5 Tumor Targeting Through Nanocarriers
    • 7.6 Types of Targeting Ligands
    • 7.7 Challenges Associated with Targeting
    • 7.8 Drug Resistance and How to Combat it with Different Nanocarriers
    • 7.9 Major Mechanisms of Drug Resistance
    • 7.10 Advantages of NP-Based Drug Delivery for Effective Cancer Therapy
    • 7.11 Conclusions
    • References
  • Chapter 8. Nanoparticles as drug delivery systems of combination therapy for cancer
    • Abstract
    • 8.1 Introduction
    • 8.2 Liposomes for Combination Therapy
    • 8.3 Polymeric DDS for Combination Therapy
    • 8.4 Other Types of Polymeric DDS for Combination Therapy
    • 8.5 Challenges for Clinical Trials
    • 8.6 Conclusions
    • Acknowledgments
    • References
  • Chapter 9. Chitosan nanoparticles for efficient and targeted delivery of anticancer drugs
    • Abstract
    • 9.1 Introduction
    • 9.2 Nanomedicine
    • 9.3 Future Perspectives
    • Acknowledgments
    • References
  • Chapter 10. Nanoformulations: A lucrative tool for protein delivery in cancer therapy
    • Abstract
    • 10.1 Introduction
    • 10.2 Challenges in Protein Delivery
    • 10.3 The Vast Potential for Using Proteins in Cancer Therapy
    • 10.4 The Enhanced Permeability and Retention (EPR) Effect
    • 10.5 Methods for Protein Delivery
    • 10.6 Commercial Aspects
    • 10.7 Conclusions
    • References
  • Chapter 11. Nanobiomaterial-based delivery of drugs in various cancer therapies: Classifying the mechanisms of action (using biochemical and molecular biomarkers)
    • Abstract
    • 11.1 Introduction
    • 11.2 Polysaccharide-Based Nanoparticles
    • 11.3 Chitosan–Drug Nanocarrier System in Cancer Therapy
    • 11.4 Alginate Nanoparticles in Cancer Therapy
    • 11.5 Pullulan Nanoparticles in Cancer Therapy
    • 11.6 Heparin-Based Nanoparticles in Cancer Therapy
    • 11.7 Starch Nanoparticles in Cancer Therapy
    • 11.8 Protein-Based Nanoparticles
    • 11.9 Silk Fibroin
    • 11.10 Collagen
    • 11.11 β-Casein Nanoparticles in Cancer Therapy
    • 11.12 Albumin Nanoparticles in Cancer Therapy
    • 11.13 Conclusions
    • References
  • Chapter 12. Dual-function nanocarriers with interfacial drug-interactive motifs for improved delivery of chemotherapeutic agents
    • Abstract
    • 12.1 Introduction
    • 12.2 Dual-Function Nanocarriers for Enhanced Cancer Therapy
    • 12.3 Dual-Function Nanocarriers with Drug-Interactive Motifs for Improved Drug Delivery
    • 12.4 Conclusions
    • References
  • Chapter 13. Nanotechnology for cancer therapy: Invading the mechanics of cancer
    • Abstract
    • 13.1 Introduction
    • 13.2 Nanomedicine: A Revolutionary Treatment Modality for Cancer
    • 13.3 Tumor-Targeting Strategies
    • 13.4 Personalized Nanomedicine
    • 13.5 Conclusions
    • References
  • Chapter 14. Hadrontherapy enhanced by combination with heavy atoms: Role of Auger effect in nanoparticles
    • Abstract
    • 14.1 Introduction
    • 14.2 Improvement of Radiation Therapy by Different Methods
    • 14.3 Auger Effects in Radiobiology: General Properties
    • 14.4 Hadrontherapy Enhanced by Combination with High-Z Atoms
    • 14.5 Hadrontherapy and Nanoparticles
    • 14.6 Conclusions
    • 14.7 Appendix
    • References
  • Chapter 15. Toxicity of silver nanoparticles obtained by bioreduction as studied on malignant cells: Is it possible to create a new generation of anticancer remedies?
    • Abstract
    • List of Abbreviations
    • 15.1 Introduction
    • 15.2 Studies of NE-AgNP Toxicity on Cultured Cells and Animals: General Description
    • 15.3 Toxic Effects of NE-AgNPs Studied on Cancer Cells
    • 15.4 The Mechanisms of Cytotoxicity of Biogenic AgNPs
    • 15.5 Conclusions
    • References
  • Index

Details

No. of pages:
588
Language:
English
Copyright:
© William Andrew 2016
Published:
Imprint:
William Andrew
eBook ISBN:
9780323428866
Hardcover ISBN:
9780323428637

About the Editor

Alexandru Grumezescu

Alexandru Grumezescu

Dr. Alexandru Mihai Grumezescu is Assistant Professor at the Department of Science and Engineering of Oxide Materials and Nanomaterials, in the Faculty of Applied Chemistry and Materials Science, with a second affiliation to the Faculty of Medical Engineering, at the Politehnica University of Bucharest in Romania. He is an experienced and oft-published researcher and editor in the field of nano and biostructures, and he is the Editor-in-Chief of three journals: Biointerface Research in Applied Chemistry, Letters and Applied NanoBioScience, Biomaterials and Tissue Engineering Bulletin, and Journal of Food Bioengineering and Nanoprocessing. He also serves as editor or guest editor for several notable journals. Dr. Grumezescu has published 150 peer-reviewed papers, 20 book chapters, 8 co-authored books and 21 edited books. He has developed two new research directions related to bio-applications of metal oxide nanoparticles: (i) functional metal oxide nanostructures to improve the delivery of antimicrobials in active form with a high efficiency against Gram-positive and Gram-negative bacteria; and (ii) smart metal oxide nanostructures, functionalized with different fatty acids, essential oils or in combination with organic polymers, to inhibit bacterial colonization of different medical or industrial surfaces. Dr Alexandru Mihai Grumezescu is also Assistant Professor at the Department of Science and Engineering of Oxide Materials and Nanomaterials, in the Faculty of Applied Chemistry and Materials Science at the Politehnica University of Bucharest in Romania. He is an experienced and oft-published researcher and editor in the field of nano- and biostructures, and he is the Editor-in-Chief of four journals: Biointerface Research in Applied Chemistry, Letters and Applied NanoBioScience, Biomaterials and Tissue Engineering Bulletin, and Journal of Food Bioengineering and Nanoprocessing. He also serves as editor or guest editor for several notable journals. Dr Grumezescu has published 160 peer-reviewed papers, 20 book chapters, 9 coauthored books, and 21 edited books. Other details are available at http://grumezescu.com/.

Affiliations and Expertise

Assistant Professor, Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science and Faculty of Medical Engineering, Politehnica University of Bucharest, Romania