Myocardial Preservation and Cellular Adaptation - 1st Edition - ISBN: 9780762303915, 9780080877235

Myocardial Preservation and Cellular Adaptation, Volume 6

1st Edition

Editors: D.K. Das
eBook ISBN: 9780080877235
Hardcover ISBN: 9780762303915
Imprint: Elsevier Science
Published Date: 18th December 1998
Page Count: 274
Tax/VAT will be calculated at check-out Price includes VAT (GST)
25% off
25% off
25% off
25% off
25% off
20% off
20% off
30% off
30% off
30% off
30% off
30% off
20% off
20% off
30% off
30% off
30% off
30% off
30% off
20% off
20% off
30% off
30% off
30% off
30% off
30% off
20% off
20% off
30% off
30% off
30% off
30% off
30% off
20% off
20% off
13900.00
10425.00
10425.00
10425.00
10425.00
10425.00
11120.00
11120.00
123.00
86.10
86.10
86.10
86.10
86.10
98.40
98.40
78.00
54.60
54.60
54.60
54.60
54.60
62.40
62.40
128.00
89.60
89.60
89.60
89.60
89.60
102.40
102.40
96.95
67.86
67.86
67.86
67.86
67.86
77.56
77.56
Unavailable
Price includes VAT (GST)
× DRM-Free

Easy - Download and start reading immediately. There’s no activation process to access eBooks; all eBooks are fully searchable, and enabled for copying, pasting, and printing.

Flexible - Read on multiple operating systems and devices. Easily read eBooks on smart phones, computers, or any eBook readers, including Kindle.

Open - Buy once, receive and download all available eBook formats, including PDF, EPUB, and Mobi (for Kindle).

Institutional Access

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Table of Contents

Preface (D.K. Das). Preconditioning Induces both Immediate and Delayed Protection against Arrhythmias Resulting from Ischemia and Reperfusion (J.R. Parratt and A. Vegh). Myocardial Protection by Brief Ischemic and Nonischemic Stress (P.D. Verdouw, B.C.G. Gho, and M.A. van den Doel). Cardiac Adaptation to Chronic Hypoxia (B. Ostadal, I. Ostadalova, F. Kolar, V. Pelouch, and N.S. Dhalla). Analysis of Altered Gene Expression during Ischemic Preconditioning (N. Maulik). Myocardial Preconditioning Via ATP-Sensitive Potassium Channels Interactions with Adenosine (G.J. Gross, T. Mizumura, K. Nithipatikom, and D.A. Mei). Ischemic Preconditioning: Role of Multiple Kinases in Signal Amplification and Modulation (D.K. Das). Early and Lat Preconditioning against Myocardial Stunning: Pathogenesis and Pathophysiology (J.A. Auchampach, X. Tang, Y. Qiu, P. Ping, and R. Bolli). Changes in Cardiac Energetics during Preconditioning and Adaptation (N. Takeda). Molecular Adaptation of Transcriptional Apparatus in Cardiac Hypertrophy and Embryonic Development (S. Ghatpande, M. Wagner, and M.A.Q. Siddiqui). Signal Divergence and Convergence in Cardiac Adaptation (A. Banerjee, A.H. Harken, E.E. Moore, K. Joo, B.C. Cain, D.R. Meldrum, F.G. Robertson, C.B. Caims, and X. Meng). The Role of ATP-Sensitive Potassium Channels in Myocardial Ischemic Stress (A. Tosaki and D.K. Das). Delayed Preconditioning: Mechanisms of Endogenous and Pharmacologic Induction of this Adaptive Response to Ischemia (G.T. Elliot and P.A. Weber). Adaptation of Cellular Thermogenic Reactions (T. Ramasarma). From Raynaud's Phenomenon to Systemic Sclerosis Scleroderma: Lack or Exhaustion of Adaptation? (M.M. Cerinic, S. Generini, A. Pignone, and M. Cagnoni). Molecular Adaptation to Toxic Chemicals and Drugs (P.K. Ray and T. Das).


Description

Living organisms exhibit specific responses when confronted with sudden changes in their environmental conditions. The ability of the cells to acclimate to their new environment is the integral driving force for adaptive modification of the cells. Such adaptation involves a number of cellular and biochemical alteration including metabolic homeostasis and reprogramming of gene expression. Changes in metabolic pathways are generally short-lived and reversible, while the consequences of gene expression are a long-term process and may lead to permanent alternation in the pattern of adaptive responses.

The heart possesses remarkable ability to adapt itself against any stressful situation by increasing resistance to the adverse consequences. Stress composes the foundation of many degenerative heart diseases including atherosclerosis, spasm, thrombosis, cardiomyopathy, and congestive heart failure. Based on the concept that excessive stress may play a crucial role in the pathogenesis of ischemic heart disease, attempts were made to design methods for preventing of myocardial injury. Creation of stress reactions by repeated ischemia and reperfusion or subjecting the hearts to heat or oxidative stress enables them to meet the future stress challenge. Repeated stress exposures adapt the heart to withstand more severe stress reactions probably by upregulating the cellular defense and direct accumulation of intracellular mediators, which presumably constitute the material basis of increased adaptation to stress. Thus, the powerful cardioprotective effect of adaptation is likely to originate at the cellular and molecular levels that compose fundamental processes in the prophylaxis of such diseases.

Volume six of the Advances in Organ Biology series contains state-of-the-art reviews on myocardial preservation and cellular adaptation from the leading authorities in this subject.


Details

No. of pages:
274
Language:
English
Copyright:
© Elsevier Science 1998
Published:
Imprint:
Elsevier Science
eBook ISBN:
9780080877235
Hardcover ISBN:
9780762303915

About the Editors

D.K. Das Editor

Affiliations and Expertise

Department of Surgery, University of Connecticut Health Center, Farmington, CT, USA