Myocardial Infarction And Cardiac Death

1st Edition - January 1, 1983
Editor: Erwin Margulies
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 5 9 6 0 - 9

Medicinal Chemistry, Volume 18: Myocardial Infarction and Cardiac Death focuses on the prevention and treatment of myocardial infarction. This book explores the synthesis and… Read more

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Medicinal Chemistry, Volume 18: Myocardial Infarction and Cardiac Death focuses on the prevention and treatment of myocardial infarction. This book explores the synthesis and biological evaluations of hypolipidemic agents. Organized into seven chapters, this volume starts with an overview of the anatomical and functional characteristics of the blood vessels, which is important in understanding the effect on the microcirculation of alterations in blood flow as would occur in myocardial infarction. This text then explores the two serious consequences that result from occlusion of the coronary arteries and the resultant myocardial infarction, namely, the failure of the heart as pump and the development of life-threatening arrhythmias. Other chapters review the medical treatment for primary and secondary prevention of myocardial infarction and sudden death. The final chapter deals with the interventions in the prevention of myocardial infarction, including drug therapy, surgical procedures, and lifestyle modifications. This book is a valuable resource for cardiologists and other health professionals.

In Memoriam

Contributors

Preface

1. Role of the Microvasculature in Myocardial Infarction

I. The Microvasculature of the Myocardium

II. Microcirculation in Myocardial Infarction

References

2. Animal Studies in Artificially Induced Myocardial Infarction

I. Introduction

II. Methods of Producing Coronary Artery Occlusion

III. Ventricular Arrhythmia Associated with Myocardial Infarction

IV. Ischemia and Infarction

V. Summary

References

3. Pharmacologic Approaches to the Prevention of Myocardial Infarction and Sudden Death

I. Introduction

II. β-Adrenoceptor Blocking Drugs

III. Lipid-Lowering Agents

IV. Vitamin Ε

V. Anticoagulation Therapy (Heparin and Sodium Warfarin)

VI. Anticoagulation (Antiplatelet Agents)

VII. Coronary Artery Surgery

VIII. Summary

References

4. Pharmacology of Antiplatelet Agents and Their Role in Coronary Disease

I. Summary of Clinical Trials of Antiplatelet Agents

II. Thrombus Formation in Arteries

III. Thromboembolism and Clinical Complications of Coronary Disease

IV. Effects of Substances Produced by Injured Vessel Walls

V. The Role of Platelets in the Initiation of Coronary Artery Disease

VI. Tests of the Effects of Drugs on Platelet Reactions

VII. Drugs That Inhibit Platelet Reactions

References

5. Platelets, Thrombosis, Atherosclerosis in Myocardial Infarction: Interactions and Relationships

I. Introduction

II. Platelets and Thrombosis in Atherogenesis

III. Thrombosis in Progression of Atherosclerosis

IV. Thrombotic Complications of Atherosclerosis

V. Coronary Occlusion, Thromboembolism, and Cardiac Death

VI. Summary

References

6. Clinical Pathogenesis and Physiological Processes Involved in Myocardial Infarction and Sudden Cardiac Death

I. Introduction

II. The Clinical Setting of Sudden Death

III. Pathology of Sudden Death

IV. The Clinical Precursors of Sudden Death

V. Mechanism of Sudden Death

VI. Metabolic and Electrophysiologic Mechanisms

VII. Central and Autonomic Nervous Systems and Sudden Death

References

7. Considerations in the Design, Execution, and Interpretation of Clinical Trials in Cardiac Mortality

I. Introduction

II. Methodological Standards in Clinical Trials

III. Considerations for the Design of Future Studies

IV. Multiple Analysis

V. Summary

References

Index