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Medicinal Chemistry, Volume 18: Myocardial Infarction and Cardiac Death focuses on the prevention and treatment of myocardial infarction. This book explores the synthesis and biological evaluations of hypolipidemic agents. Organized into seven chapters, this volume starts with an overview of the anatomical and functional characteristics of the blood vessels, which is important in understanding the effect on the microcirculation of alterations in blood flow as would occur in myocardial infarction. This text then explores the two serious consequences that result from occlusion of the coronary arteries and the resultant myocardial infarction, namely, the failure of the heart as pump and the development of life-threatening arrhythmias. Other chapters review the medical treatment for primary and secondary prevention of myocardial infarction and sudden death. The final chapter deals with the interventions in the prevention of myocardial infarction, including drug therapy, surgical procedures, and lifestyle modifications. This book is a valuable resource for cardiologists and other health professionals.
1. Role of the Microvasculature in Myocardial Infarction
I. The Microvasculature of the Myocardium
II. Microcirculation in Myocardial Infarction
2. Animal Studies in Artificially Induced Myocardial Infarction
II. Methods of Producing Coronary Artery Occlusion
III. Ventricular Arrhythmia Associated with Myocardial Infarction
IV. Ischemia and Infarction
3. Pharmacologic Approaches to the Prevention of Myocardial Infarction and Sudden Death
II. β-Adrenoceptor Blocking Drugs
III. Lipid-Lowering Agents
IV. Vitamin Ε
V. Anticoagulation Therapy (Heparin and Sodium Warfarin)
VI. Anticoagulation (Antiplatelet Agents)
VII. Coronary Artery Surgery
4. Pharmacology of Antiplatelet Agents and Their Role in Coronary Disease
I. Summary of Clinical Trials of Antiplatelet Agents
II. Thrombus Formation in Arteries
III. Thromboembolism and Clinical Complications of Coronary Disease
IV. Effects of Substances Produced by Injured Vessel Walls
V. The Role of Platelets in the Initiation of Coronary Artery Disease
VI. Tests of the Effects of Drugs on Platelet Reactions
VII. Drugs That Inhibit Platelet Reactions
5. Platelets, Thrombosis, Atherosclerosis in Myocardial Infarction: Interactions and Relationships
II. Platelets and Thrombosis in Atherogenesis
III. Thrombosis in Progression of Atherosclerosis
IV. Thrombotic Complications of Atherosclerosis
V. Coronary Occlusion, Thromboembolism, and Cardiac Death
6. Clinical Pathogenesis and Physiological Processes Involved in Myocardial Infarction and Sudden Cardiac Death
II. The Clinical Setting of Sudden Death
III. Pathology of Sudden Death
IV. The Clinical Precursors of Sudden Death
V. Mechanism of Sudden Death
VI. Metabolic and Electrophysiologic Mechanisms
VII. Central and Autonomic Nervous Systems and Sudden Death
7. Considerations in the Design, Execution, and Interpretation of Clinical Trials in Cardiac Mortality
II. Methodological Standards in Clinical Trials
III. Considerations for the Design of Future Studies
IV. Multiple Analysis
- No. of pages:
- © Academic Press 1983
- 1st January 1983
- Academic Press
- eBook ISBN:
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