Myocardial Infarction And Cardiac Death

Myocardial Infarction And Cardiac Death

1st Edition - January 1, 1983

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  • Editor: Erwin Margulies
  • eBook ISBN: 9780323159609

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Description

Medicinal Chemistry, Volume 18: Myocardial Infarction and Cardiac Death focuses on the prevention and treatment of myocardial infarction. This book explores the synthesis and biological evaluations of hypolipidemic agents. Organized into seven chapters, this volume starts with an overview of the anatomical and functional characteristics of the blood vessels, which is important in understanding the effect on the microcirculation of alterations in blood flow as would occur in myocardial infarction. This text then explores the two serious consequences that result from occlusion of the coronary arteries and the resultant myocardial infarction, namely, the failure of the heart as pump and the development of life-threatening arrhythmias. Other chapters review the medical treatment for primary and secondary prevention of myocardial infarction and sudden death. The final chapter deals with the interventions in the prevention of myocardial infarction, including drug therapy, surgical procedures, and lifestyle modifications. This book is a valuable resource for cardiologists and other health professionals.

Table of Contents


  • In Memoriam

    Contributors

    Preface

    1. Role of the Microvasculature in Myocardial Infarction

    I. The Microvasculature of the Myocardium

    II. Microcirculation in Myocardial Infarction

    References

    2. Animal Studies in Artificially Induced Myocardial Infarction

    I. Introduction

    II. Methods of Producing Coronary Artery Occlusion

    III. Ventricular Arrhythmia Associated with Myocardial Infarction

    IV. Ischemia and Infarction

    V. Summary

    References

    3. Pharmacologic Approaches to the Prevention of Myocardial Infarction and Sudden Death

    I. Introduction

    II. β-Adrenoceptor Blocking Drugs

    III. Lipid-Lowering Agents

    IV. Vitamin Ε

    V. Anticoagulation Therapy (Heparin and Sodium Warfarin)

    VI. Anticoagulation (Antiplatelet Agents)

    VII. Coronary Artery Surgery

    VIII. Summary

    References

    4. Pharmacology of Antiplatelet Agents and Their Role in Coronary Disease

    I. Summary of Clinical Trials of Antiplatelet Agents

    II. Thrombus Formation in Arteries

    III. Thromboembolism and Clinical Complications of Coronary Disease

    IV. Effects of Substances Produced by Injured Vessel Walls

    V. The Role of Platelets in the Initiation of Coronary Artery Disease

    VI. Tests of the Effects of Drugs on Platelet Reactions

    VII. Drugs That Inhibit Platelet Reactions

    References

    5. Platelets, Thrombosis, Atherosclerosis in Myocardial Infarction: Interactions and Relationships

    I. Introduction

    II. Platelets and Thrombosis in Atherogenesis

    III. Thrombosis in Progression of Atherosclerosis

    IV. Thrombotic Complications of Atherosclerosis

    V. Coronary Occlusion, Thromboembolism, and Cardiac Death

    VI. Summary

    References

    6. Clinical Pathogenesis and Physiological Processes Involved in Myocardial Infarction and Sudden Cardiac Death

    I. Introduction

    II. The Clinical Setting of Sudden Death

    III. Pathology of Sudden Death

    IV. The Clinical Precursors of Sudden Death

    V. Mechanism of Sudden Death

    VI. Metabolic and Electrophysiologic Mechanisms

    VII. Central and Autonomic Nervous Systems and Sudden Death

    References

    7. Considerations in the Design, Execution, and Interpretation of Clinical Trials in Cardiac Mortality

    I. Introduction

    II. Methodological Standards in Clinical Trials

    III. Considerations for the Design of Future Studies

    IV. Multiple Analysis

    V. Summary

    References

    Index

Product details

  • No. of pages: 234
  • Language: English
  • Copyright: © Academic Press 1983
  • Published: January 1, 1983
  • Imprint: Academic Press
  • eBook ISBN: 9780323159609

About the Editor

Erwin Margulies

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