Myelin Biology and Disorders, Two-Volume Set - 1st Edition - ISBN: 9780124395107, 9780080537207

Myelin Biology and Disorders, Two-Volume Set

1st Edition

Editor-in-Chiefs: Robert Lazzarini
Hardcover ISBN: 9780124395107
eBook ISBN: 9780080537207
Imprint: Academic Press
Published Date: 19th December 2003
Page Count: 1600

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Description

Section I: Diseases of Myelin Leukodystrophies: Overview and Classification Multiple Sclerosis: Classification and Overview Genetic Susceptibility and Epidemiology Cellular Damage and Repair in MS MRI Visualization of MS Multiple Sclerosis (General Clinical and Trials) Adrenoleukodystrophies Krabbe's Disease Alexander's Disease Pelizeaus-Merzbacher Disease Guillain Barre Syndrome Charcot-Marie-Tooth Disease Infectious Demyelinating Diseases Ischemic White Matter Damage Protein Misfolding as a Disease Determinant

Section II: Animals Models of Human Disease Experimental Allergic Encephalomyelitis Experimental Models of Virus Induced Demyelination Model's of Krabbe's Disease Model's of Alexander's Disease Model's of Pelizeaus Merzbacher Disease Models of Charcot-Marie-Tooth Disease

Section III: The Myelin Genes and Products Myelin Basic Protein Gene Proteolipid Protein Gene Myelin Associated Glycoprotein Gene Myelin Oligodendrocyte Glycoprotein Gene Cyclic Nucleotide Phosophohydrolase Gene P0 Protein Gene PMP 22 Gene The Claudin 11 Gene The Neurexin Gene The Connexin 32 Gene The Integrin Genes The Periaxin Gene The QK1 Gene

Section IV: Glial Cell Development Invertebrate Glia Neural Cell Specification During Development Progenitor Cells of the Adult Human White Matter Oligodendrocyte Lineage Astrocyte Lineage Schwann Cell Development Olfactory Ensheathing Cells

Section V: Glial Cell and Myelin Functional Biology Structure of the Myelinated Axon Cell Biology of Myelin Assembly The Transport and Assembly of Myelin Lipids Functional Organization of the Nodes of Ranvier Electrophysiologic Consequences of Myelination Remyelination Through Engraftment Remyelination by Endogenous Glia

Key Features

  • Critically reviews and evaluates all the important genetic and molecular and cellular biological data on the individual myelin genes/proteins
  • Details the structural and functional biology of myelin, including a look at the relationship between neuronal damage and myelin damage as seen in multiple sclerosis
  • Includes forward-looking section on potential therapeutic interventions in myelin diseases

Readership

Neurologists, neurobiologists, and cell biologists.

Table of Contents

Section I: Diseases of Myelin Leukodystrophies: Overview and Classification Multiple Sclerosis: Classification and Overview Genetic Susceptibility and Epidemiology Cellular Damage and Repair in MS MRI Visualization of MS Multiple Sclerosis (General Clinical and Trials) Adrenoleukodystrophies Krabbe's Disease Alexander's Disease Pelizeaus-Merzbacher Disease Guillain Barre Syndrome Charcot-Marie-Tooth Disease Infectious Demyelinating Diseases Ischemic White Matter Damage Protein Misfolding as a Disease Determinant

Section II: Animals Models of Human Disease Experimental Allergic Encephalomyelitis Experimental Models of Virus Induced Demyelination Model's of Krabbe's Disease Model's of Alexander's Disease Model's of Pelizeaus Merzbacher Disease Models of Charcot-Marie-Tooth Disease

Section III: The Myelin Genes and Products Myelin Basic Protein Gene Proteolipid Protein Gene Myelin Associated Glycoprotein Gene Myelin Oligodendrocyte Glycoprotein Gene Cyclic Nucleotide Phosophohydrolase Gene P0 Protein Gene PMP 22 Gene The Claudin 11 Gene The Neurexin Gene The Connexin 32 Gene The Integrin Genes The Periaxin Gene The QK1 Gene

Section IV: Glial Cell Development Invertebrate Glia Neural Cell Specification During Development Progenitor Cells of the Adult Human White Matter Oligodendrocyte Lineage Astrocyte Lineage Schwann Cell Development Olfactory Ensheathing Cells

Section V: Glial Cell and Myelin Functional Biology Structure of the Myelinated Axon Cell Biology of Myelin Assembly The Transport and Assembly of Myelin Lipids Functional Organization of the Nodes of Ranvier Electrophysiologic Consequences of Myelination Remyelination Through Engraftment Remyelination by Endogenous Glia

Details

No. of pages:
1600
Language:
English
Copyright:
© Academic Press 2004
Published:
Imprint:
Academic Press
Hardcover ISBN:
9780124395107
eBook ISBN:
9780080537207

About the Editor-in-Chief

Robert Lazzarini

Affiliations and Expertise

The Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, NY, U.S.A.

Reviews

"Myelin Biology and Disorders, an extraordinary compilation of knowledge about myelin and myelin diseases, benefits from the intrinsic interest and importance of the topic no less than from the hard work of its contributing authors. ...Myelin Biology and Disorders represents a bravura achievement for all concerned and, now, a standard for the field." --THE NEW ENGLAND JOURNAL OF MEDICINE(October 21, 2004) "...a splendid book, an important addition to any serious clinical neuroscience bookshelf, and of lasting value: it is an outstanding achievement on the part of the Editor and the publisher." --BRAIN, 2005 "...no medical library or institution with a neuroscience research program can afford to be without a copy of this treatise. Lazzarini and his five section editors are to be applauded for overseeing the production of such a well-illustrated and thorough work on this set of major debilitating diseases. There is also an excellent historical preface that recounts the work of the remarkable set of early researchers whose splendid work in the late 19th and early 20th centuries founded this important field of research." --Lloyd Davidson, Life Sciences Librarian, Head, Access Services and Kaplan Humanities Fellow, Northwestern University Seeley G. Mudd Library for Science and Engineering, E-STREAMS Vol 7 No 11, November 2004) "Under the baton of Robert Lazzarini, five distinguished editors have assembled a comprehensive treatise covering the origin and neurobiology of myelin-forming cells, the assembly of the myelin sheath and its often unforgiving diseases." --Monique Dubois-Dalcq, MD, Department of Neuroscience, The Pasteur Institute, Paris, France "This book comprises comprehensive, thoughtfully edited, uniformly first-rate chapters on myelination. It is the definitive work in the field." --David R. Colman. Ph.D., Director, The Montreal Neurological Institute "The two volumes on Glial Cell and Myelin Functional Biology serve as an impressive platform to showcase the rich literature on oligodendrocytes and Schwann cells in development and disease...The current and comprehensive style will make this book a standard for the field." --Moses V. Chao, Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York City, U.S.A.