With the completion of the "Human Genome Project" and the cloning and complete molecular description of the known myelin genes, the stage has been set for a detailed understanding of the biology of myelin, the disease processes affecting myelin and the potential for myelin repair and regeneration. Myelin Biology and Disorders brings together in one place, the recent advances in molecular and cellular biology along with visual data from MRI, confocal microscopy and high voltage EM techniques to provide new insights into disease mechanisms. This book represents a unique research reference on myelin biology and will serve as the definitive resource for both the professional clinical and basic scientist.
- Critically reviews and evaluates all the important genetic and molecular and cellular biological data on the individual myelin genes/proteins
- Details the structural and functional biology of myelin, including a look at the relationship between neuronal damage and myelin damage as seen in multiple sclerosis
- Includes forward-looking section on potential therapeutic interventions in myelin diseases
Neurologists, neurobiologists, and cell biologists.
Section I: Diseases of Myelin Leukodystrophies: Overview and Classification Multiple Sclerosis: Classification and Overview Genetic Susceptibility and Epidemiology Cellular Damage and Repair in MS MRI Visualization of MS Multiple Sclerosis (General Clinical and Trials) Adrenoleukodystrophies Krabbe's Disease Alexander's Disease Pelizeaus-Merzbacher Disease Guillain Barre Syndrome Charcot-Marie-Tooth Disease Infectious Demyelinating Diseases Ischemic White Matter Damage Protein Misfolding as a Disease Determinant
Section II: Animals Models of Human Disease Experimental Allergic Encephalomyelitis Experimental Models of Virus Induced Demyelination Model's of Krabbe's Disease Model's of Alexander's Disease Model's of Pelizeaus Merzbacher Disease Models of Charcot-Marie-Tooth Disease
Section III: The Myelin Genes and Products Myelin Basic Protein Gene Proteolipid Protein Gene Myelin Associated Glycoprotein Gene Myelin Oligodendrocyte Glycoprotein Gene Cyclic Nucleotide Phosophohydrolase Gene P0 Protein Gene PMP 22 Gene The Claudin 11 Gene The Neurexin Gene The Connexin 32 Gene The Integrin Genes The Periaxin Gene The QK1 Gene
Section IV: Glial Cell Development Invertebrate Glia Neural Cell Specification During Development Progenitor Cells of the Adult Human White Matter Oligodendrocyte Lineage Astrocyte Lineage Schwann Cell Development Olfactory Ensheathing Cells
Section V: Glial Cell and Myelin Functional Biology Structure of the Myelinated Axon Cell Biology of Myelin Assembly The Transport and Assembly of Myelin Lipids Functional Organization of the Nodes of Ranvier Electrophysiologic Consequences of Myelination Remyelination Through Engraftment Remyelination by Endogenous Glia
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- © Academic Press 2004
- 19th December 2003
- Academic Press
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The Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, NY, U.S.A.
"Myelin Biology and Disorders, an extraordinary compilation of knowledge about myelin and myelin diseases, benefits from the intrinsic interest and importance of the topic no less than from the hard work of its contributing authors. ...Myelin Biology and Disorders represents a bravura achievement for all concerned and, now, a standard for the field." --THE NEW ENGLAND JOURNAL OF MEDICINE(October 21, 2004) "...a splendid book, an important addition to any serious clinical neuroscience bookshelf, and of lasting value: it is an outstanding achievement on the part of the Editor and the publisher." --BRAIN, 2005 "...no medical library or institution with a neuroscience research program can afford to be without a copy of this treatise. Lazzarini and his five section editors are to be applauded for overseeing the production of such a well-illustrated and thorough work on this set of major debilitating diseases. There is also an excellent historical preface that recounts the work of the remarkable set of early researchers whose splendid work in the late 19th and early 20th centuries founded this important field of research." --Lloyd Davidson, Life Sciences Librarian, Head, Access Services and Kaplan Humanities Fellow, Northwestern University Seeley G. Mudd Library for Science and Engineering, E-STREAMS Vol 7 No 11, November 2004) "Under the baton of Robert Lazzarini, five distinguished editors have assembled a comprehensive treatise covering the origin and neurobiology of myelin-forming cells, the assembly of the myelin sheath and its often unforgiving diseases." --Monique Dubois-Dalcq, MD, Department of Neuroscience, The Pasteur Institute, Paris, France "This book comprises comprehensive, thoughtfully edited, uniformly first-rate chapters on myelination. It is the definitive work in the field." --David R. Colman. Ph.D., Director, The Montreal Neurological Institute "The two volumes on Glial Cell and Myelin Functional Biology serve as an impressive platform to showcase the rich literature on oligodendrocytes and Schwann cells in development and disease...The current and comprehensive style will make this book a standard for the field." --Moses V. Chao, Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York City, U.S.A.