The Handbook of Clinical Neurology Vol 101: Muscular Dystrophies discusses the pathogenesis and treatment prospects for muscular dystrophies. It summarizes the advances in molecular and cell biology, biochemistry, and other biological sciences, with an emphasis on their application to this group of muscle disorders and to their clinical implications. Starting with an overview of muscular dystrophies, the book’s 16 chapters discuss dystrophinopathies; sarcoglycanopathies; congenital muscular dystrophies; collagen VI-related myopathies; limb-girdle muscular dystrophy 2A; dysferlinopathies; limb-girdle muscular dystrophy 2H and the role of TRIM32; and caveolinopathies. The book also covers myofibrillar myopathies; Emery–Dreifuss muscular dystrophy; facioscapulohumeral dystrophy and scapuloperoneal syndromes; oculopharyngeal muscular dystrophy; myotonic dystrophy types 1 and 2; and distal muscular dystrophies. This book is useful to basic investigators, as it offers an increased understanding of muscular dystrophies; and to clinicians, with its emphasis on issues that are relevant to the care, diagnosis, and management of patients with these disorders.

Key Features

* Valuable insights into the muscular dystrophies, including treatment, diagnosis, and care and patient management
* A comprehensive compilation of the combined wisdom of the most highly regarded physicians, experts, and scientists studying the muscular dystrophies
* An evaluation of the way advances in molecular and cell biology, biochemistry, and other biological sciences continue to advance the study of these disorders

Table of Contents

Foreword Preface List of Contributors 1. Overview of the muscular dystrophies 2. Dystrophinopathies 3. Sarcoglycanopathies 4. Congenital muscular dystrophies 5. The collagen VI-related myopathies: Ullrich congenital muscular dystrophy and Bethlem myopathy 6. Limb-girdle muscular dystrophy 2A 7. Dysferlinopathies 8. Other limb-girdle muscular dystrophies 9. Limb-girdle muscular dystrophy 2H and the role of TRIM32 10. Caveolinopathies: translational implications of caveolin-3 in skeletal and cardiac muscle disorders 11. Myofibrillar myopathies 12. Emery–Dreifuss muscular dystrophy 13. Facioscapulohumeral dystrophy and scapuloperoneal syndromes 14. Oculopharyngeal muscular dystrophy 15. Myotonic dystrophy types 1 and 2 16. Distal muscular dystrophies Index


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© 2011
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About the editors

Robert Griggs

Affiliations and Expertise

Professor of Neurology, Pediatrics, Pathology and Laboratory Medicine; Center for Human Experimental Therapeutics; University of Rochester School of Medicine and Dentistry; Rochester, New York

Anthony Amato

Affiliations and Expertise

Associate Professor, Department of Neurology, Harvard Medical School; Chief, Neuromuscular Division, Director, Clinical Neurophysiology, Laboratory, Vice-Chairman, Department of Neurology, Brigham and Women's Hospital, Associate Neurologist and Neuromuscular Consultant, Massachusetts General Hospital, Boston, MA