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Muscle Biology - 1st Edition - ISBN: 9780128202784

Muscle Biology

1st Edition

The Life History of a Muscle

Author: Bruce Carlson
Paperback ISBN: 9780128202784
Imprint: Academic Press
Published Date: 1st September 2021
Page Count: 300
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Muscle Biology: The Life History of a Muscle tells the story of a muscle, from its embryonic origins to its condition at the end of life. This book uses the leg muscle, a tightly knitted group, the quadriceps femoris, which consists of four individual muscles (rectus femoris, vastus lateralis, vastus medialis and vastus intermedius) to provide an in-depth look at skeletal muscle biology. It covers the development of the muscle, muscle pathology, changes in the muscle from training and muscle regeneration.

Muscle Biology: The Life History of a Muscle conveys basic specific information about the various aspects of a muscle’s existence and educates readers to the fact that muscle can be viewed as a continuum of developmental events so that readers get a broad review of the essential ways that muscles adapt to their environment over the course of a lifetime. The book discusses both normal and abnormal changes in the muscle, the mechanisms behind those changes and how to mitigate deleterious changes from disease, ‘normal” aging, and disuse/lack of physical activity. This is a must-have reference for students, researchers and practitioners in need of a comprehensive overview of muscle biology.

Key Features

  • Provides an overview of muscle biology over the course of one’s entire lifespan
  • Explains the important elements of each aspect of muscle biology without drowning the reader in excessive detail
  • Contains over 300 illustrations and includes chapter summaries


Upper undergraduate, graduates, postdocs, professors and researchers studying biology, anatomy, physiology, developmental biology, pathophysiology, aging/gerontology, kinesiology/movement science and those across the life sciences interested in muscles/muscle biology as well as practitioners in physical therapy and occupational therapy

Table of Contents

1.  Introduction

2.  Embryonic origins of muscles
 A. Origins and cellular migrations
 B. Initial morphogenesis
 C. Myogenesis
      1. Single muscle fibers
      2. Muscle tissue
      3. Whole muscle
 D. Cranial vs. trunk muscles

3.  Postnatal development and maturation of muscle
 A. Normal growth
 B. Structure of a mature muscle fiber – light microscopy to molecular organization
 C. Structure of a mature muscle – include architecture
      1. Vasculature
      2.  Innervation – both motor and sensory

4.  Muscle contraction
 A. Functional components
 B. Contractile physiology – single fiber
 C. Motor units
 D. Whole muscle contraction
 E. Whole limb movements

5. Muscle metabolism
 A. Storage
 B. In relation to contraction
      1. During contraction
      2. Fatigue and recovery

6. Muscle-nerve interrelationships
 A. Motor
 B. Sensory

7. Adaptation – mechanisms
 A. Hypertrophy
 B. Endurance
 C. Lengthening and shortening

8. Muscle damage and regeneration

9.  Muscle pathology – e.g. muscular dystrophy

10. Muscle atrophy
 A. Inactivity, bed rest, space
 B. Denervation atrophy (paralysis)
      1. Upper motor neuron lesions
      2.  Lower motor neuron lesions
 C. Recovery from atrophy
      1. Physical therapy
      2. Electrical stimulation

11. Muscle aging
 A. Normal aging
      1. Mass and structure
      2. Function
      3. Nerve relationships
      4. Balance and innervation?
 C. Training effects


No. of pages:
© Academic Press 2021
1st September 2021
Academic Press
Paperback ISBN:

About the Author

Bruce Carlson

Dr. Carlson serves as Professor Emeritus of Anatomy in the Department of Cell and Developmental Biology in the University of Michigan Medical School in Ann Arbor. Dr. Carlson is the author of more than fifteen book publications including several books published by Elsevier (Human Embryology and Developmental Biology 1-5/e, Principles of Regenerative Biology, repurposed embryology and physiology texts for Elsevier’s digital Reference Module in Biomedical Sciences in 2014). Dr. Carlson has served as president of the American Association of Anatomists, and president of the Association of Anatomy, Cell Biology, and Neurobiology Chairpersons. Additional honors include the AAAS Newcomb-Cleveland Prize, membership in the Russian Academy of Natural Sciences, and the Henry Gray Award of the American Association of Anatomists. An accomplished teacher, Dr. Carlson has received both the Elizabeth Crosby Teaching Award and the Kaiser-Permanente Teaching Award from the University of Michigan Medical School.

Affiliations and Expertise

Professor Emeritus of Anatomy, Department of Cell and Developmental Biology, University of Michigan Medical School, USA

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