Description

A valuable study of the science behind the medicine, Muscle: Fundamental Biology and Mechanisms of Disease brings together key leaders in muscle biology. These experts provide state-of-the-art insights into the three forms of muscle--cardiac, skeletal, and smooth--from molecular anatomy, basic physiology, disease mechanisms, and targets of therapy. Commonalities and contrasts among these three tissue types are highlighted. This book focuses primarily on the biology of the myocyte.

 

Individuals active in muscle investigation--as well as those new to the field--will find this work useful, as will students of muscle biology. In the case of hte former, many wish to grasp issues at the margins of their own expertise (e.g. clinical matters at one end; molecular matters at the other), adn this book is designed to assist them. Students, postdoctoral fellows, course directors and other faculty will find this book of interest. Beyond this, many clinicians in training (e.g. cardiology fellows) will benefit.

Key Features

  • The only resource to focus on science before the clinical work and therapeutics
  • Tiered approach to subject: discussion first of normal muscle function through pathological/disease state changes, and ending each section with therapeutic interventions
  • Coverage of topics ranging from basic physiology to newly discovered molecular mechanisms of muscle diseases for all three muscle types: cardiac, skeletal, and smooth

Readership

The primary audience for this work is entry level and experienced researchers, practicing clinicians, postdocs, graduate students, and medical students across molecular and muscle medicine, developmental biology, molecular biology, cell biology, physiology, pathology, pharmacology, cardiology, translational medicine and biomedicine.

Table of Contents

List of Contributors

Acknowledgments

VOLUME 1

Part I: Introduction

Chapter 1. An Introduction to Muscle

Cardiac Muscle

Skeletal Muscle

Smooth Muscle

Common Molecular Mechanisms

Summary

Chapter 2. A History of Muscle

Introduction

Early Observations

Animal Spirits and the Vital Force

Electrical Activation

Energy Utilization: Work and Heat

Energy Production: Metabolism

Contractile Proteins

The Sliding-Filament Hypothesis

Calcium, Excitation–Contraction Coupling, Relaxation

Skeletal, Cardiac, and Smooth Muscle

Conclusion

REFERENCES

Part II: Cardiac Muscle

Section A: Basic Physiology

Chapter 3. Cardiac Myocyte Specification and Differentiation

Early Fate Decisions in Commitment of Mesoderm to the Cardiac Muscle Lineage

Cardiac Progenitors Arise from Two Molecularly Distinct “Heart Fields”

Differentiation of Cardiac Progenitors into Functional Myocytes

Conclusions

REFERENCES

Chapter 4. Transcriptional Control of Cardiogenesis

Overview of Transcription Factors Necessary for Heart Development

Transcriptional Regulation of Cardiac Morphogenesis

Transcriptional Regulation of Cardiac Conduction System Development

Transcriptional Regulation of Cardiomyocyte Proliferation

Summary and Perspectives

Acknowledgments

REFERENCES

Chapter 5. Cardiomyocyte Ultrastructure

Introduction

Myocyte Architecture

Non-Myocyte Tissue Compartment

Regional Variation in Structure

REFERENCES

Chapter 6. Overview of Cardiac Muscle Physiology

Introduction

The Cardiac Pump

Regulation of the Cardiac Pump

Basis for the Cardiac Output Changes During Exercise

Bibliography

Chapter 7. Ioni

Details

No. of pages:
1528
Language:
English
Copyright:
© 2012
Published:
Imprint:
Academic Press
Print ISBN:
9780123815101
Electronic ISBN:
9780123815118

About the authors

Joseph Hill

Dr. Hill is a cardiologist-scientist whose research strives to decipher mechanisms of structural, functional, and electrical remodeling of the heart. He earned M.D. and Ph.D. degrees from Duke University, conducted postdoctoral scientific training with Jean-Pierre Changeux at the Institut Pasteur in Paris, and pursued clinical training in Internal Medicine and Cardiology at Brigham and Women's Hospital, Harvard Medical School. Dr. Hill served on faculty at the University of Iowa for 5 years before moving in 2002 to UT Southwestern as Chief of Cardiology and Director of the Harry S. Moss Heart Center. Dr. Hill's honors include election to the Association of University Cardiologists and the Association of American Physicians. Dr. Hill maintains an active clinical practice focusing on general cardiology, hypertension, and heart failure.

Eric Olson

Dr. Olson has dedicated his career to deciphering mechanisms that control muscle gene regulation and development. He received B.A. and Ph.D. degrees from Wake Forest University. After postdoctoral training with Luis Glaser at Washington University School of Medicine, he joined the Department of Biochemistry and Molecular Biology at the M. D. Anderson Cancer Center in 1984 and became Professor and Chairman in 1991. In 1995, he founded the Department of Molecular Biology at UT Southwestern. Dr. Olson has received numerous prestigious awards and honors. He is a member of the American Academy of Arts and Sciences, and its Institute of Medicine.

Reviews

"This two-volume set is distinguished by its emphasis on normal muscle function as well as changes evident in pathology or disease. Therapeutic interventions end each section, but the science comes first. Organization of 108 chapters is in sections on cardiac muscle (basic physiology, adaptations and response, myocardial disease); skeletal muscle (basics and adaptations, disease, and therapeutics); and smooth muscle (physiology, heterogeneities, adaptations and response, and disease). Editors Hill and Olson (both: U. of Texas Southwestern Medical Center) have shepherded the work of contributors based mostly in the US, with a few from Europe."--Reference & Research Book News October 2012