A valuable study of the science behind the medicine, Muscle: Fundamental Biology and Mechanisms of Disease brings together key leaders in muscle biology. These experts provide state-of-the-art insights into the three forms of muscle--cardiac, skeletal, and smooth--from molecular anatomy, basic physiology, disease mechanisms, and targets of therapy. Commonalities and contrasts among these three tissue types are highlighted. This book focuses primarily on the biology of the myocyte.


Individuals active in muscle investigation--as well as those new to the field--will find this work useful, as will students of muscle biology. In the case of hte former, many wish to grasp issues at the margins of their own expertise (e.g. clinical matters at one end; molecular matters at the other), adn this book is designed to assist them. Students, postdoctoral fellows, course directors and other faculty will find this book of interest. Beyond this, many clinicians in training (e.g. cardiology fellows) will benefit.

Key Features

  • The only resource to focus on science before the clinical work and therapeutics
  • Tiered approach to subject: discussion first of normal muscle function through pathological/disease state changes, and ending each section with therapeutic interventions
  • Coverage of topics ranging from basic physiology to newly discovered molecular mechanisms of muscle diseases for all three muscle types: cardiac, skeletal, and smooth


The primary audience for this work is entry level and experienced researchers, practicing clinicians, postdocs, graduate students, and medical students across molecular and muscle medicine, developmental biology, molecular biology, cell biology, physiology, pathology, pharmacology, cardiology, translational medicine and biomedicine.

Table of Contents

Part 1: Introduction

1. An Introduction to Muscle

2. A History of Muscle


Part II: Cardiac Muscle

Section A: Basic Physiology

3. Cardiac Myocyte Specification and Differentiation

4. Transcriptional Control of Cardiogenesis

5. Cardiomyocyte Ultrastructure

6. Overview of CArdiac Muscle Physiology

7. Ionic Fluxes and Genesis of the Cardiac Action Potential

8. G-Protein-Coupled Receptors in the Heart

9. Receptor Tyrosine Kinases in Cardiac Muscle

10. Communication in the Heart: Cardiokines as Mediators of a Molecular Social Network

11. Calcium Fluxes and Homeostasis

12. Excitation-Contraction Coupling in the Heart

13. Role of Sarcomeres in Cellular Tension, Shortening, and Signaling in Cardiac Muscle

14. Cardiovascular Mechanotransduction

15. Cardiomyocyte Metabolism: All Is in Flux

16. Transcriptional Control of Striated Muscle Mitochondrial Biogenesis and Function

17. Mitochondrial Morphology and Function

18. Genetics and Genomics in Cardiovascular Gene Discovery

19. Cardiovascular Proteomics: Assessment of Protein Post-Translational Modifications

Section B: Adaptations and Response

20. Adaption and Responses: Myocardial Innervations adn Neural Control

21. Regulation of Cardiac Systolic Function and Contractility

22. Intracellular Signaling Pathways in Cardiac Remodeling

23. Oxidative Stress and Cardiac Muscle

24. Physiologic and Molecular Responses of the Heart to Chronic Exercise

25. Epigenetics in Cardiovascular Biology

26. Cardiac MicroRNAs

27. Protein Quality Control in Cardiomyocytes

28. Cardioprotection

29. Cardiac Fibrosis: Cellular and Molecular Determinants

30. Autophagy in Cardiac Physiology and Disease

31. Programmed Cardiomyocyte Death in Heart Disease

32. Wnt and


No. of pages:
© 2012
Academic Press
Not Applicable ISBN:
Electronic ISBN:

About the authors

Joseph Hill

Dr. Hill is a cardiologist-scientist whose research strives to decipher mechanisms of structural, functional, and electrical remodeling of the heart. He earned M.D. and Ph.D. degrees from Duke University, conducted postdoctoral scientific training with Jean-Pierre Changeux at the Institut Pasteur in Paris, and pursued clinical training in Internal Medicine and Cardiology at Brigham and Women's Hospital, Harvard Medical School. Dr. Hill served on faculty at the University of Iowa for 5 years before moving in 2002 to UT Southwestern as Chief of Cardiology and Director of the Harry S. Moss Heart Center. Dr. Hill's honors include election to the Association of University Cardiologists and the Association of American Physicians. Dr. Hill maintains an active clinical practice focusing on general cardiology, hypertension, and heart failure.

Affiliations and Expertise

Professor of Internal Medicine and Molecular Biology; James T. Willerson, M.D. Distinguished Chair in Cardiovascular Diseases; Frank M. Ryburn, Jr., Chair in Heart Research, University of Texas Southwestern Medical Center, Dallas, TX, USA

Eric Olson

Dr. Olson has dedicated his career to deciphering mechanisms that control muscle gene regulation and development. He received B.A. and Ph.D. degrees from Wake Forest University. After postdoctoral training with Luis Glaser at Washington University School of Medicine, he joined the Department of Biochemistry and Molecular Biology at the M. D. Anderson Cancer Center in 1984 and became Professor and Chairman in 1991. In 1995, he founded the Department of Molecular Biology at UT Southwestern. Dr. Olson has received numerous prestigious awards and honors. He is a member of the American Academy of Arts and Sciences, and its Institute of Medicine.

Affiliations and Expertise

Professor of Molecular Biology; Robert A. Welch Distinguished Chair; Annie and Willie Nelson Professor; Pogue Distinguished Chair in Research on Cardiac Birth Defects, University of Texas Southwestern Medical Center, Dallas, TX, USA


"This two-volume set is distinguished by its emphasis on normal muscle function as well as changes evident in pathology or disease. Therapeutic interventions end each section, but the science comes first. Organization of 108 chapters is in sections on cardiac muscle (basic physiology, adaptations and response, myocardial disease); skeletal muscle (basics and adaptations, disease, and therapeutics); and smooth muscle (physiology, heterogeneities, adaptations and response, and disease). Editors Hill and Olson (both: U. of Texas Southwestern Medical Center) have shepherded the work of contributors based mostly in the US, with a few from Europe."--Reference & Research Book News October 2012