Multiscale Modeling of Developmental Systems

Multiscale Modeling of Developmental Systems

1st Edition - December 18, 2007

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  • Editor: Gerald Schatten
  • Hardcover ISBN: 9780123742537
  • eBook ISBN: 9780080556536

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Mathematical and computational biology is playing an increasingly important role in the biological sciences. This science brings forward unique challenges, many of which are, at the moment, beyond the theoretical techniques available. Developmental biology, due to its complexity, has lagged somewhat behind its sister disciplines (such as molecular biology and population biology) in making use of quantitative modeling to further biological understanding. This volume comprises work that is among the best developmental modeling available and we feel it will do much to remedy this situation.This book is aimed at all those with an interest in the interdisciplinary field of computer and mathematical modeling of multi-cellular and developmental systems. It is also a goal of the Editors to attract more developmental biologists to consider integrating modeling components into their research. Most importantly, this book is intended to serve as a portal into this research area for younger scientists – especially graduate students and post-docs, from both biological and quantitative backgrounds.

Key Features

* Articles written by leading exponents in the field
* Provides techniques to address multiscale modeling
* Coverage includes a wide spectrum of modeling approaches
* Includes descriptions of the most recent advances in the field


Graduate students and scientists in developmental biology, mathematical sciences, biomathematics, and general life sciences.

Table of Contents

  • Chapter 1
    Philip K. Maini, Stuart A. Newman, Timothy J. Newman and Santiago Schnell

    Chapter 2
    Models of biological pattern formation: from elementary steps to the organization of embryonic axes
    Hans Meinhardt

    Chapter 3
    Robustness of embryonic spatial patterning in Drosophila melanogaster
    David Umulis, Michael B. O’Connor and Hans G. Othmer

    Chapter 4
    Integrating morphogenesis with underlying mechanics and cell biology.
    Lance A. Davidson

    Chapter 5
    The mechanisms underlying primitive streak formation in the chick embryo
    Manli Chuai, Cornelis J Weijer

    Chapter 6
    Grid-free models of multicellular systems, with an application to large-scale vortices accompanying primitive streak formation
    T. J. Newman

    Chapter 7
    Mathematical models for somite formation
    Ruth E. Baker, Santiago Schnell and Philip K. Maini

    Chapter 8
    Coordinated Action of N-CAM, N-cadherin, EphA4 and ephrinB2 Translates Genetic Prepatterns into Structure during Somitogenesis in Chick
    James A. Glazier, Ying Zhang, Maciej Swat, Benjamin Zaitlen, Santiago Schnell

    Chapter 9
    Branched organs: Mechanics of morphogenesis by multiple mechanisms
    Sharon R Lubkin

    Chapter 10
    Multicellular sprouting during vasculogenesis
    Andras Czirok, Evan A. Zamir, Andras Szabo and Charles D. Little

    Chapter 11
    Modelling lung branching morphogenesis
    Takashi Miura

    Chapter 12
    Multiscale Models for Vertebrate Limb Development
    Stuart A. Newman, Scott Christley, Tilmann Glimm, H.G.E. Hentschel, Bogdan Kazmierczak, Yong-Tao Zhang, Jianfeng Zhu and Mark Alber

    Chapter 13
    Tooth morphogenesis in vivo, in vitro and in silico
    Isaac Salazar-Ciudad

    Chapter 14
    Cell mechanics with a 3D kinetic and dynamic weighted Delaunay-triangulation
    Michael Meyer-Hermann

    Chapter 15
    Cellular automata as microscopic models of cell migration in heterogeneous environments
    H. Hatzikirou and A. Deutsch

    Chapter 16
    Multiscale modeling of biological pattern formation
    Ramon Grima

    Chapter 17
    Relating Biophysical Properties Across Scales
    Elijah Flenner, Francoise Marga, Adrian Neagu, Ioan Kosztin, Gabor Forgacs

    Chapter 18
    Complex Multicellular Systems and Immune Competition: New Paradigms Looking for a
    Mathematical Theory
    N. Bellomo, G. Forni

Product details

  • No. of pages: 604
  • Language: English
  • Copyright: © Academic Press 2007
  • Published: December 18, 2007
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123742537
  • eBook ISBN: 9780080556536

About the Serial Editor

Gerald Schatten

Affiliations and Expertise

University of Pittsburgh School of Medicine, PA, U.S.A.

About the Serial Volume Editors

Santiago Schnell

Philip Maini

Stuart A. Newman

Timothy Newman

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