Multiple sclerosis has rapidly changed over the last decade into a condition necessitating a multi-disciplinary approach to both its management and understanding. This book reflects all these advances including contributions from genetics, immunology and molecular biology. The many new drugs, both approved or in advanced stages of clinical trials, which give cause for optimism for the treatment of the disease, are described. This new comprehensive work has both editors and contributors that bring together basic science researchers and clinicians from Europe and the USA.
- A comprehensive reference on multiple sclerosis covering diagnosis, treatment and scientific background.
- Coverage of emergent drugs which are not in other books, eg Antegrin, as well as current frontline drugs.
- International group of contributors which includes leading researchers in the field from USA, Switzerland, France, UK and Germany.
- Based on cutting edge research but stresses the practical issues of diagnosis and treatment needed by neurologists.
- Comprehensive coverage of primary treatment of the disease process itself and symptomatic therapies, sexual and bladder dysfunction and rehabilitation.
Section I: Multiple sclerosis: history and clinical manifestations:
History of multiple sclerosis. Clinical features of multiple sclerosis. Unusual presentations and variants of ideopathic central nervous system demyelinating diseases. Paediatric multiple sclerosis. Diagnosis of multiple sclerosis. Neuroimaging in multiple sclerosis. Cerebrospinal fluid analysis in multiple sclerosis. Natural history of multiple sclerosis. Epidemiology of multiple sclerosis. Clinical neurophysiology of multiple sclerosis.
Section II: Multiple sclerosis: pathophysiology and biology:
Neuropathology of multiple sclerosis. Neurophysiology of demyelination. Immunology of multiple sclerosis. Genetics of multiple sclerosis. Infectious agents and multiple sclerosis. Models of chronic relapsing experimental autoimmune encaphalomyelitis. Genetic manipulatuions of experimental autoimmune encephalomyelitis in the mouse. Biology of myelin. New tools for investigating the immunopathogenesis of multiple sclerosis.
Section III: Multiple sclerosis: tretment and prospects:
Immunomodulatory therapy: critical appraisal of trial results and marketing claims. Treatment of multiple sclerosis with disease-modifying therapies. Escape therapies and management of multiple sclerosis. Novel and promising therapeutic stratgies for multiple sclerosis. Moving towards remyelinating and neuroprotective therapies in multiple sclerosis. Symptomatic therpaies for multiple sclerosis. Bladder and sexual dysfunction in multiple sclerosis. Neuropsychological aspects of multiple sclerosis. Rehabilitations of multiple sclerosis. Design and analysis of clinical trials in multiple sclerosis. Role of data monitoring committees in multiple sclerosis clinical trials. Outcome measures in multiple sclerosis.
- No. of pages:
- © Saunders Ltd. 2008
- 8th July 2008
- Saunders Ltd.
- eBook ISBN:
Professor, Departments of Pathology (Neuropathology), Neurology and Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA Professor of Pathology (Neuropathology), Neurology and Neuroscience
Chief, Neuroimmunology Branch and Clinical Director, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
Professor and Director of the Institue for Clinical Neuroimmunology, Ludwig-Maximilians University, Klinikum Grosshadern, Munich, Germany