This book examines the role of neurons in multiple sclerosis (MS) and the changes that occur in neurons as a result of MS. It places MS in a new and important perspective that not only explains the basis for symptom production, remission, and progress in MS, but also promises to open up new therapeutic possibilities.

Key Features

* Brings together the latest information from clinical, pathological, imaging, molecular, and pharmacological realms to explore the neurobiology of Multiple Sclerosis * Places MS in a new and important perspective that promises to open up new therapeutic avenues * Superbly illustrated and referenced


Neurologists, neuroscientists, and clinical and basic researchers studying multiple sclerosis.

Table of Contents

Preface Contributors I Structure, Molecular Organization, and Function of Myelinated Axons 1. The Structure of Myelinated Axons in the CNS 2. Dialogues: Communication Between Axons and Myelinating Glia 3. Molecular Specializations at the Glia-Axon Interface 4. Potassium Channel Organization of Myelinated and Demyelinated Axons 5. The Roles of Potassium and Calcium Channels in Physiology and Pathophysiology of Axons II Neuronal Concomitants of Demyelination 6. The Conduction Properties of Demyelinated and Remyelinated Axons 7. Altered Distributions and Functions of Multiple Sodium Channel Subtypes in Multiple Sclerosis and Its Models 8. Na+ Channel Reorganization in Demyelinated Axons 9. Ion Currents and Axonal Oscillators: A Possible Biophysical Basis for Positive Signs and Symptoms in Multiple Sclerosis 10. Clinical Pharmacology of Abnormal Potassium Channel Organization in Demyelinated Axons III Multiple Sclerosis as a Neurodegenerative Disease 11. Pathology of Neurons in Multiple Sclerosis 12. Axonal Degeneration in Multiple Sclerosis: The Histopathological Evidence 13. Natural History of Multiple Sclerosis: When Do Axons Degenerate? IV Measurement of Neuronal Changes in the Clinical Domain 14. Brain Atrophy as a Measure of Neurodegeneration and Neuroprotection 15. MRI–Clinical Correlations in Multiple Sclerosis: Implications for Our Understanding of Neuronal Changes 16. Electrophysiological Correlates of Relapse, Remission, Persistent Sensorimotor Deficit, and Long-Term Recovery Processes in Multiple Sclerosis V Cellular and Molecular Mechanisms of Axonal Degeneration in Multiple Sclerosis 17. Inflammation and Axon Degeneration 18. Nitric Oxide and Axonal Pathophysiology 19. Molecular Mechanisms of Calcium Influx in Axonal Degeneration 20. Axonal Damage and Neuron Death in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis:


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© 2005
Academic Press
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About the author

Stephen Waxman

Affiliations and Expertise

Yale University School of Medicine, CT, USA


"The editor and many excellent contributors present abundant evidence for importance of the neuronal component of multiple sclerosis. ...There is no doubt that Steve Waxman's forceful book will substantially influence the field by providing a strong impetus to research on the neuronal question in multiple sclerosis." --NATURE NEUROSCIENCE (February 2006) "...this book offers an excellent overview of the biology of the axon, the clinical assessment of axonal damage, and the mechanisms contributing to axonal damage. ...The book should provide valuable reading for the student of neurology as well as for those less familiar with the subtleties of the axon. It will also be of value to those knowledgeable about multiple sclerosis who are beginning to move into clinical studies of neuroprotection and repair." --Henry McFarland in THE NEW ENGLAND JOURNAL OF MEDICINE (September 22, 2005) "'MS as a Neuronal Disease' by Waxman and coauthors is a textbook long overdue. ...This book makes essential reading for neuroscientists and neurologists" --Archives of Neurology (December 2005)