Multiple Sclerosis and Related Disorders, Volume 122

1st Edition

Editors: Douglas Goodin
Hardcover ISBN: 9780444520012
eBook ISBN: 9780444633095
Imprint: Elsevier
Published Date: 20th March 2014
Page Count: 736
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Table of Contents

Section 1 Pathogenesis
1. Immune regulation of multiple sclerosis  
2. Neuropathology of MS 
3. The good and the bad of neuroinflammation in multiple sclerosis 
4. Demyelination in multiple sclerosis 
5. Axonal Loss in Multiple Sclerosis: Causes and Mechanisms  
6. Insights from magnetic resonance imaging 
7. Infections and multiple sclerosis 
8. The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment

Section 2 Epidemiology and genetics
9. Multiple sclerosis genetics 
10. Genetics of primary progressive multiple sclerosis 
11. The epidemiology of multiple sclerosis: insights to disease pathogenesis

Section 3 Diagnosis and disease course
12. Multiple Sclerosis: Diagnosis, Differential Diagnosis and Clinical Presentation 
13. MRI mimics of multiple sclerosis 
14. Diagnosis of multiple sclerosis 
15. Clinical course of multiple sclerosis 
16. Early prognosis of multiple sclerosis 
17. Clinical outcome measures in Multiple Sclerosis 
18. MRI outcomes in the diagnosis and disease course of multiple sclerosis  
19. Multiple sclerosis in children

Section 4 Treatment
20. Clinical trials in multiple sclerosis 
21. Glucocorticoid treatment of multiple sclerosis 
22. Disease Modifying Agents in Multiple Sclerosis 
23. Immunosuppressive treatments in multiple sclerosis 
24. Symptomatic treatment and management of multiple sclerosis 
25. Future Treatment Approaches to multiple sclerosis 

Section 5 Other demyelinating diseases
26. Neuromyelitis Optica (Devic's Syndrome) 
27. Acute disseminated encephalomyelitis and other inflammatory demyelinating variants 


Description

Multiple Sclerosis (MS) is generally understood to be an inflammatory autoimmune disease of the central nervous system.  While we still are not certain of the root cause of MS, research results suggest that unknown environmental factors and the presence of specific genes seem the most probable targets.  MS causes an inflammatory response in the central nervous system leading to neurodegeneration, oligodendrocyte death, axonal damage, and gliosis. Over the past five years ongoing research has greatly expanded our understanding of the pathogenesis of MS, detailed insight into the epidemiology and genetic factors related to MS, the introduction of new technologies and tests to better diagnose and predict the future course of the disease and the introduction of new treatments targeting MS.  This collection of review chapters provides a comprehensive reference into the science and clinical applications of the latest Multiple Sclerosis research and will be a valuable resource for the neuroscience research community and the clinical neurology community of researchers and practitioners.

Key Features

  • A comprehensive tutorial reference detailing our current foundational understanding of Multiple Sclerosis
  • Includes chapters on key topics including the genetics of MS, MRI imaging and MS, and the latest treatment options
  • Each chapter is translational and focuses on current research and impact on diagnosis and treatment options

Readership

Neurologists
Neuroscience research workers


Details

No. of pages:
736
Language:
English
Copyright:
© Elsevier 2014
Published:
Imprint:
Elsevier
eBook ISBN:
9780444633095
Hardcover ISBN:
9780444520012

About the Editors

Douglas Goodin Editor

Dr. Douglas Goodin, director of the Multiple Sclerosis Center at UCSF Medical Center, is a neurologist and an internationally renowned expert in the treatment and research of multiple sclerosis.. He earned a bachelor of sciences degree in genetics and biochemistry at the University of Washington in Seattle; a master of sciences degree in molecular biology at Purdue University in Indiana; and a medical degree from the University of California, Irvine. He completed a residency in neurology at UCSF where he joined the medical center staff in 1982. In addition to multiple sclerosis, Goodin's research interests include various forms of dementia. Goodin also is a professor of neurology at UCSF.

Affiliations and Expertise

MS Center at the University of California, San Francisco, San Francisco, CA, USA