Multiple Aspects of DNA and RNA: from Biophysics to Bioinformatics, Volume 82

1st Edition

Lecture Notes of the Les Houches Summer School 2004

Series Volume Editors: Didier Chatenay Simona Cocco Remi Monasson Denis Thieffry Jean Dalibard
Hardcover ISBN: 9780444520814
eBook ISBN: 9780080461540
Imprint: Elsevier Science
Published Date: 2nd December 2005
Page Count: 378
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Table of Contents

In August 2004, the Ecole de Physique des Houches hosted a Summer School dedicated to biological, physical and computational aspects of nucleic acids. Central to vital processes, these biological molecules have been experimentally studied by molecular biologists for five decades since the discovery of the structure of DNA by J. Watson and F. Crick in 1953. Recent progresses, such as the development of DNA arrays, manipulations at the single molecule level, the availability of huge genomic databases, have foster the need for theoretical modeling. In particular, a global understanding of the structure and function of DNA and RNA require the concerted development and application of proper experimental and theoretical approaches, involving methods and tools from different disciplines, including physics. The aim of this Summer School was precisely to provide a comprehensive overview of these issues at the interface between physics, biology and information science. The Summer School encompassed three main sections: 1) Biochemistry and Biology of DNA/RNA; 2) Biophysics: from Experiments to modeling and theory; 3) Bioinformatics. The present book follows the same organization, and is mainly intended to advances graduate students or young researchers willing to acquire a broad inter-disciplinary understanding of the multiple aspects of DNA and RNA. The first section comprises an introduction to biochemistry and biology of nucleic acids. The structure and function of DNA are reviewed in R. Lavery's chapter. The next contribution, by V. Fritsch and E. Westhof, concentrates on the folding properties of RNA molecules. The cellular processes involving these molecules are reviewed by J. Kadonaga, with special emphasis on the regulation of transcription of DNA. These chapters do not require any preliminary knowledge in the field, except that of elementary

Description

This book is dedicated to the multiple aspects, that is, biological, physical and computational of DNA and RNA molecules. These molecules, central to vital processes, have been experimentally studied by molecular biologists for five decades since the discovery of the structure of DNA by Watson and Crick in 1953. Recent progresses (e.g. use of DNA chips, manipulations at the single molecule level, availability of huge genomic databases...) have revealed an imperious need for theoretical modelling. Further progresses will clearly not be possible without an integrated understanding of all DNA and RNA aspects and studies.

The book is intended to be a desktop reference for advanced graduate students or young researchers willing to acquire a broad interdisciplinary understanding of the multiple aspects of DNA and RNA. It is divided in three main sections:

The first section comprises an introduction to biochemistry and biology of nucleic acids. The structure and function of DNA are reviewed in R. Lavery's chapter. The next contribution, by V. Fritsch and E. Westhof, concentrates on the folding properties of RNA molecules. The cellular processes involving these molecules are reviewed by J. Kadonaga, with special emphasis on the regulation of transcription. These chapters does not require any preliminary knowledge in the field (except that of elementary biology and chemistry).

The second section covers the biophysics of DNA and RNA, starting with basics in polymer physics in the contribution by R. Khokhlov. A large space is then devoted to the presentation of recent experimental and theoretical progresses in the field of single molecule studies. T. Strick's contribution presents a detailed description of the various micro-manipulation techniques, and reviews recent experiments on the interactions between DNA and proteins (helicases, topoisomerases, ...). The theoretical modeling of single molecules is presented b

Key Features

. Provides a comprehensive overview of the structure and function of DNA and RNA at the interface between physics, biology and information science.

Readership

Advanced graduate students and young researchers willing to acquire a broad inter-disciplinary understanding of the multiple aspects of DNA and RNA.


Details

No. of pages:
378
Language:
English
Copyright:
© Elsevier Science 2005
Published:
Imprint:
Elsevier Science
eBook ISBN:
9780080461540
Hardcover ISBN:
9780444520814

About the Series Volume Editors

Didier Chatenay Series Volume Editor

Didier Chatenay activities since 1995 is devoted to experimental research at the frontiers between physics and biology. His first contributions were in the field of single molecule experiments and particulary in the micromanipulation of single nucleic acid molecules (DNA, RNA). In particular he evidenced new structural transitions of a single DNA molecule submitted to an external force.

Affiliations and Expertise

Laboratoire de Physique Statistique de l'ENS, Paris, France.

Simona Cocco Series Volume Editor

Simona Cocco's research activity since 2001 is devoted to the applications of statistical physics to biophysics. Her main contributions on the latter issue, in collaboration with Remi Monasson, are related to the modeling of single molecule experiments, in particular the structural transtitions of the DNA and RNA molecules under mechanical stress.

Affiliations and Expertise

Laboratoire de Physique Statistique de l'ENS, Paris, France.

Remi Monasson Series Volume Editor

Remi Monasson's research activity since 1995 is devoted to the applications of statistical physics to interdisciplinary fields as computer science and biophysics. His main contributions on the latter issue, in collaboration with Simona Cocco, are related to the modeling of single molecule experiments, in particular the structural transitions of the DNA and RNA molecules under mechanical stress.

Affiliations and Expertise

Laboratoire de Physique Theorique de l'ENS, Paris, France.

Denis Thieffry Series Volume Editor

The research of Denis Thieffry focuses on the development of qualitative tools for the integration, the modeling and the dynamical analysis of biological regulatory networks. These tools are currently applied to the dynamical modeling of gene networks involved in development, cell cycle and cancer.

Affiliations and Expertise

Laboratoire de Genetique et Physiologie du Developpement, Marseille, France.

Jean Dalibard Series Volume Editor

Jean Dalibard works in the field of atomic physics and quantum optics. His recent activities is centered on the physics of cold quantum gases, in particular Bose-Einstein condensation.

Affiliations and Expertise

Laboratoire Kastler Brossel, ENS, Paris, France