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Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip: Principles and Applications provides chemists, biophysicists, engineers, life scientists, biotechnologists, and pharmaceutical scientists with the principles behind the design, manufacture, and testing of life sciences microfluidic systems. This book serves as a reference for technologies and applications in multidisciplinary areas, with an emphasis on quickly developing or new emerging areas, including digital microfluidics, nanofluidics, papers-based microfluidics, and cell biology. The book offers practical guidance on how to design, analyze, fabricate, and test microfluidic devices and systems for a wide variety of applications including separations, disease detection, cellular analysis, DNA analysis, proteomics, and drug delivery.
Calculations, solved problems, data tables, and design rules are provided to help researchers understand microfluidic basic theory and principles and apply this knowledge to their own unique designs. Recent advances in microfluidics and microsystems for life sciences are impacting chemistry, biophysics, molecular, cell biology, and medicine for applications that include DNA analysis, drug discovery, disease research, and biofluid and environmental monitoring.
- Provides calculations, solved problems, data tables and design rules to help understand microfluidic basic theory and principles
- Gives an applied understanding of the principles behind the design, manufacture, and testing of microfluidic systems
- Emphasizes on quickly developing and emerging areas, including digital microfluidics, nanofluidics, papers-based microfluidics, and cell biology
Researchers in analytical chemistry, biology and engineering, researchers enrolled in a lab-on-chip, microfluidics, or biomedical devices course or engaged in research related fields. Researchers in medical instrumentation, health sciences, biotechnology, pharmaceuticals, and engineering professionals and industries wishing an overview of the microfluidics and life sciences microsystems fields
Part I: Fundamentals of microfluidic/nanofluidic lab-on-a-chip
1. Micromachining Methods
2. Micromachining of silicon, glass devices
3. Micromachining of polymers
4. Fabrication of paper-based microfluidic devices
5. Biocompatibility and surface modifications
6. Systems interconnect and world-to-chip interface
7. Microfluidic Flow control
Part II: New Emerging Techniques
8. Droplet microfluidics
9. Closed-channel Droplet generation
10. Open-format Digital microfluidics
13. Characteristics of nanofluidics
Part III: Applications
14. Applications to Cell Biology
15. Manipulation of cells
16. Cellular measurements and analysis
17. Single-cell analysis
18. 3D cell culture
20. Applications to Nuclei Aids Analysis
21. Nucleic acids extraction and purification
22. Nucleic acids amplification
23. Forensic DNA typing
24. Microarray DNA chips
25. Applications to proteins analysis
27. Protein separation
28. Enzymatic analysis
30. Applications to global health
31. Low-cost Paper-based diagnosis devices
32. Field diagnosis
33. Other applications
43. Environmental analysis
44. Forensic analysis
45. Small ions and molecules analysis
48. Instrument/device commercialization
- No. of pages:
- © Elsevier 2021
- 1st June 2021
- Hardcover ISBN:
XiuJun (James) Li, Ph.D., is an Associate Professor with early tenure in the Department of Chemistry and Biochemistry, Biomedical Engineering, and Border Biomedical Research Center at University of Texas at El Paso (UTEP), USA. After he obtained his Ph.D. degree in microfluidic lab-on-a-chip bioanalysis from Simon Fraser University (SFU) in Canada in 2008, he pursued his postdoctoral research with Prof. Richard Mathies at University of California Berkeley and Prof. George Whitesides at Harvard University. Dr. Li’s current research interest is centered on the development of innovative microfluidic lab-on-a-chip and nanotechnology for bioanalysis, environmental, biomaterial, and biomedical engineering applications, including but not limited to low-cost diagnosis, nano-biosensing, tissue engineering, and single-cell analysis. He has coauthored about 90 publications in high-impact journals (such as Adv. Drug Deliv. Rev, Appl. Catal. B-Environ, Anal. Chem., Lab Chip, Biosens. Bioelectron.) and 18 patents. He published a book of “Microfluidic Devices for Biomedical Applications” from Elsevier in 2013. He is an Advisory Board member of Lab on a Chip and Analyst, and an editor of 6 journals including Scientific Reports from the Nature publishing group, Micromachines, etc. He is the recipient of the “Bioanalysis Young Investigator Award” in 2014, UT STARS Award in 2012, NSERC Postdoctoral Fellow Award (2009), and so on. For more information, please visit http://li.utep.edu.
Department of Chemistry and Biochemistry, Biomedical Engineering, Environmental Science and Engineering, Border Biomedical Research Center, University of Texas at El Paso
Prof. Chaoyong Yang has been a professor at Xiamen University, China, since 2007. He received his PhD from the University of Florida, United States, in 2006 and conducted his postdoctoral research at the University of California Berkeley, United States, from 2006 to 2007. He received the CAPA Distinguished Faculty Award in 2012, National Outstanding Young Investigator Award in 2013, Chinese Young Analyst Award in 2015, and Chinese Chemical Society-Royal Society of Chemistry Young Chemist Award in 2016. He has published more than 190 articles with total citation of more 10,000 times. His current research is particularly focused on molecular engineering, molecular recognition, high throughput evolution, single cell analysis, and microfluidics.
Professor, Department of Chemical Biology, Xiamen University, China
Paul C.H. Li, Ph.D. is a professor at the Department of Chemistry, Simon Fraser University, British Columbia, Canada. Dr. Li's group focuses on carrying out various chemical and biochemical analysis, which are enhanced by the use of microfluidic devices.
Professor, Department of Chemistry, Simon Fraser University, British Columbia, Canada
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