Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip

Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip: Principles and Applications provides chemists, biophysicists, engineers, life scientists, biotechnologists, and pharmaceutical scientists with the principles behind the design, manufacture, and testing of life sciences microfluidic systems. This book serves as a reference for technologies and applications in multidisciplinary areas, with an emphasis on quickly developing or new emerging areas, including digital microfluidics, nanofluidics, papers-based microfluidics, and cell biology. The book offers practical guidance on how to design, analyze, fabricate, and test microfluidic devices and systems for a wide variety of applications including separations, disease detection, cellular analysis, DNA analysis, proteomics, and drug delivery.

Calculations, solved problems, data tables, and design rules are provided to help researchers understand microfluidic basic theory and principles and apply this knowledge to their own unique designs. Recent advances in microfluidics and microsystems for life sciences are impacting chemistry, biophysics, molecular, cell biology, and medicine for applications that include DNA analysis, drug discovery, disease research, and biofluid and environmental monitoring.

• Provides calculations, solved problems, data tables and design rules to help understand microfluidic basic theory and principles
• Gives an applied understanding of the principles behind the design, manufacture, and testing of microfluidic systems
• Emphasizes on quickly developing and emerging areas, including digital microfluidics, nanofluidics, papers-based microfluidics, and cell biology

Researchers in analytical chemistry, biology and engineering, researchers enrolled in a lab-on-chip, microfluidics, or biomedical devices course or engaged in research related fields. Researchers in medical instrumentation, health sciences, biotechnology, pharmaceuticals, and engineering professionals and industries wishing an overview of the microfluidics and life sciences microsystems fields

Part I: Fundamentals of microfluidic/nanofluidic lab-on-a-chip
1. Micromachining Methods
2. Micromachining of silicon, glass devices
3. Micromachining of polymers
4. Fabrication of paper-based microfluidic devices
5. Biocompatibility and surface modifications
6. Systems interconnect and world-to-chip interface
7. Microfluidic Flow control

Part II: New Emerging Techniques
8. Droplet microfluidics
9. Closed-channel Droplet generation
10. Open-format Digital microfluidics
11. Nanofluidics
12. Nanofabrication
13. Characteristics of nanofluidics

Part III: Applications
14. Applications to Cell Biology
15. Manipulation of cells
16. Cellular measurements and analysis
17. Single-cell analysis
18. 3D cell culture
19. Organs-on-a-chip
20. Applications to Nuclei Aids Analysis
21. Nucleic acids extraction and purification
22. Nucleic acids amplification
23. Forensic DNA typing
24. Microarray DNA chips
25. Applications to proteins analysis
26. Immunoassay
27. Protein separation
28. Enzymatic analysis
29. Proteomics
30. Applications to global health
31. Low-cost Paper-based diagnosis devices
32. Field diagnosis
33. Other applications
43. Environmental analysis
44. Forensic analysis
45. Small ions and molecules analysis
46. Microreacter
47. Perspective
48. Instrument/device commercialization