Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip

Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip

Principles and Applications

1st Edition - September 19, 2021

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  • Editors: Xiujun (James) Li, Chaoyong Yang, Paul C. H. Li
  • Hardcover ISBN: 9780444594327
  • eBook ISBN: 9780444594617

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Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip: Principles and Applications provides chemists, biophysicists, engineers, life scientists, biotechnologists, and pharmaceutical scientists with the principles behind the design, manufacture, and testing of life sciences microfluidic systems. This book serves as a reference for technologies and applications in multidisciplinary areas, with an emphasis on quickly developing or new emerging areas, including digital microfluidics, nanofluidics, papers-based microfluidics, and cell biology. The book offers practical guidance on how to design, analyze, fabricate, and test microfluidic devices and systems for a wide variety of applications including separations, disease detection, cellular analysis, DNA analysis, proteomics, and drug delivery. Calculations, solved problems, data tables, and design rules are provided to help researchers understand microfluidic basic theory and principles and apply this knowledge to their own unique designs. Recent advances in microfluidics and microsystems for life sciences are impacting chemistry, biophysics, molecular, cell biology, and medicine for applications that include DNA analysis, drug discovery, disease research, and biofluid and environmental monitoring.

Key Features

  • Provides calculations, solved problems, data tables and design rules to help understand microfluidic basic theory and principles
  • Gives an applied understanding of the principles behind the design, manufacture, and testing of microfluidic systems
  • Emphasizes on quickly developing and emerging areas, including digital microfluidics, nanofluidics, papers-based microfluidics, and cell biology


Researchers in analytical chemistry, biology and engineering, researchers enrolled in a lab-on-chip, microfluidics, or biomedical devices course or engaged in research related fields. Researchers in medical instrumentation, health sciences, biotechnology, pharmaceuticals, and engineering professionals and industries wishing an overview of the microfluidics and life sciences microsystems fields

Table of Contents

  • Part I: Fundamentals of microfluidic/nanofluidic lab-on-a-chip
    1. Micromachining Methods
    2. Micromachining of silicon, glass devices
    3. Micromachining of polymers
    4. Fabrication of paper-based microfluidic devices
    5. Biocompatibility and surface modifications
    6. Systems interconnect and world-to-chip interface
    7. Microfluidic Flow control

    Part II: New Emerging Techniques
    8. Droplet microfluidics
    9. Closed-channel Droplet generation
    10. Open-format Digital microfluidics
    11. Nanofluidics
    12. Nanofabrication
    13. Characteristics of nanofluidics

    Part III: Applications
    14. Applications to Cell Biology
    15. Manipulation of cells
    16. Cellular measurements and analysis
    17. Single-cell analysis
    18. 3D cell culture
    19. Organs-on-a-chip
    20. Applications to Nuclei Aids Analysis
    21. Nucleic acids extraction and purification
    22. Nucleic acids amplification
    23. Forensic DNA typing
    24. Microarray DNA chips
    25. Applications to proteins analysis
    26. Immunoassay
    27. Protein separation
    28. Enzymatic analysis
    29. Proteomics
    30. Applications to global health
    31. Low-cost Paper-based diagnosis devices
    32. Field diagnosis
    33. Other applications
    43. Environmental analysis
    44. Forensic analysis
    45. Small ions and molecules analysis
    46. Microreacter
    47. Perspective
    48. Instrument/device commercialization

Product details

  • No. of pages: 484
  • Language: English
  • Copyright: © Elsevier 2021
  • Published: September 19, 2021
  • Imprint: Elsevier
  • Hardcover ISBN: 9780444594327
  • eBook ISBN: 9780444594617

About the Editors

Xiujun (James) Li

XiuJun (James) Li, Ph.D., is an Associate Professor with early tenure in the Department of Chemistry and Biochemistry, Biomedical Engineering, and Border Biomedical Research Center at the University of Texas at El Paso (UTEP), USA. After he obtained his Ph.D. degree in microfluidic lab-on-a-chip bioanalysis from Simon Fraser University (SFU) in Canada in 2008, he pursued his postdoctoral research with Prof. Richard Mathies at University of California Berkeley and Prof. George Whitesides at Harvard University, while holding a Postdoctoral Fellowship from Natural Sciences and Engineering Research Council (NSERC) of Canada. He has gained extensive experience in bioanalysis using microfluidic systems, such as single-cell analysis, genetic analysis, low-cost diagnosis, pathogen detection, 3D cell culture, and so on. Dr. Li’s current research interest is centered on the development of innovative microfluidic lab-on-a-chip and nanotechnology for bioanalysis, biomaterial, biomedical engineering, and environmental applications, including but not limited to low-cost diagnosis, nano-biosensing, tissue engineering, and single-cell analysis. He has coauthored about 100 publications in high-impact journals (such as Adv. Drug Deliv. Rev, Appl. Catal. B-Environ, Anal. Chem., Lab Chip, Biosens. Bioelectron.) and 22 patents, including two books from Elsevier on microfluidic devices for biomedical applications. He is an Advisory Board member of Lab on a Chip and Analyst, the Founder of microBioChip Diagnostics LLC, and an editor of 6 journals including Scientific Reports from the Nature publishing group, Micromachines, etc. He is the recipient of the “Bioanalysis New Investigator Award” in 2014, UT STARS Award in 2012, NSERC Postdoctoral Fellow Award in 2009, and so on. For more information, please visit

Affiliations and Expertise

Department of Chemistry and Biochemistry, Biomedical Engineering, Environmental Science and Engineering, Border Biomedical Research Center, University of Texas at El Paso

Chaoyong Yang

Dr. Chaoyong Yang received his PhD from University of Florida in 2006 under the guidance of Professor Weihong Tan. He joined Professor Richard Mathies’ group at the University of California, Berkeley as a postdoc. In 2008, he joined Xiamen University where he is now a Distinguished Professor in the Department of Chemical Biology. Professor Yang has published over 200 articles in international journals which have received over 11 000 citations, and is named inventor on over 40 patents. He serves as associate editor for ACS Applied Bio Materials. He is a Fellow of the Royal Society of Chemistry. He is the recipient of CAPA Distinguished Faculty Award in 2012, National Outstanding Young Investigator Award in 2013, Chinese Young Analyst Award in 2015, Chinese Chemical Society-Royal Society of Chemistry Young Chemist Award in 2016, and 2021 ACS Advances in Measurement Science Lectureship Award. His current research is particularly focused on bio-sensing, high throughput evolution, single cell analysis and microfluidics.

Affiliations and Expertise

Professor, Department of Chemical Biology, Xiamen University, China

Paul C. H. Li

Paul C. H. Li
Dr. Paul Li obtained his Ph.D. in analytical chemistry at the University of Toronto, and conducted postdoctoral work at the University of Alberta. Then, he developed the microfluidic lab-on-a-chip at Simon Fraser University, where he was promoted to full professor. Dr. Li is interested in integrating chip microfluidics for chemical sensing, single-cell analysis, and nucleic acid bioassay. He has been visiting professors at Johannes Gutenberg Universitat-Mainz (Germany), Griffith University (Australia) and City University of Hong Kong. Dr. Li has published several books, e.g. Fundamentals of lab on a chip for biological analysis and discovery, and Microarray Technology: Methods and Applications. He is associate editor of Canadian Journal of Pure and Applied Sciences, and sits on the editorial board of Hong Kong Pharmaceutical Journal. Dr. Li is the inventor of six patented technologies and 5 pending patents, and he is the founder of ZellChip Technologies Inc. specializing in microfluidics-based instruments and solutions.

Affiliations and Expertise

Professor of Bioanalytical Chemistry, Department of Chemistry, Simon Fraser University, Canada

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