COVID-19 Update: We are currently shipping orders daily. However, due to transit disruptions in some geographies, deliveries may be delayed. To provide all customers with timely access to content, we are offering 50% off Science and Technology Print & eBook bundle options. Terms & conditions.
Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip - 1st Edition - ISBN: 9780444594327

Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip

1st Edition

Principles and Applications

Editors: Xiujun Li Chaoyong Yang Paul Li
Hardcover ISBN: 9780444594327
Imprint: Elsevier
Published Date: 1st June 2021
Page Count: 350
Sales tax will be calculated at check-out Price includes VAT/GST

Institutional Subscription

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.


Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip: Principles and Applications provides chemists, biophysicists, engineers, life scientists, biotechnologists, and pharmaceutical scientists with the principles behind the design, manufacture, and testing of life sciences microfluidic systems. This book serves as a reference for technologies and applications in multidisciplinary areas, with an emphasis on quickly developing or new emerging areas, including digital microfluidics, nanofluidics, papers-based microfluidics, and cell biology. The book offers practical guidance on how to design, analyze, fabricate, and test microfluidic devices and systems for a wide variety of applications including separations, disease detection, cellular analysis, DNA analysis, proteomics, and drug delivery.

Calculations, solved problems, data tables, and design rules are provided to help researchers understand microfluidic basic theory and principles and apply this knowledge to their own unique designs. Recent advances in microfluidics and microsystems for life sciences are impacting chemistry, biophysics, molecular, cell biology, and medicine for applications that include DNA analysis, drug discovery, disease research, and biofluid and environmental monitoring.

Key Features

  • Provides calculations, solved problems, data tables and design rules to help understand microfluidic basic theory and principles
  • Gives an applied understanding of the principles behind the design, manufacture, and testing of microfluidic systems
  • Emphasizes on quickly developing and emerging areas, including digital microfluidics, nanofluidics, papers-based microfluidics, and cell biology


Researchers in analytical chemistry, biology and engineering, researchers enrolled in a lab-on-chip, microfluidics, or biomedical devices course or engaged in research related fields. Researchers in medical instrumentation, health sciences, biotechnology, pharmaceuticals, and engineering professionals and industries wishing an overview of the microfluidics and life sciences microsystems fields

Table of Contents

Part I: Fundamentals of microfluidic/nanofluidic lab-on-a-chip
1. Micromachining Methods
2. Micromachining of silicon, glass devices
3. Micromachining of polymers
4. Fabrication of paper-based microfluidic devices
5. Biocompatibility and surface modifications
6. Systems interconnect and world-to-chip interface
7. Microfluidic Flow control

Part II: New Emerging Techniques
8. Droplet microfluidics
9. Closed-channel Droplet generation
10. Open-format Digital microfluidics
11. Nanofluidics
12. Nanofabrication
13. Characteristics of nanofluidics

Part III: Applications
14. Applications to Cell Biology
15. Manipulation of cells
16. Cellular measurements and analysis
17. Single-cell analysis
18. 3D cell culture
19. Organs-on-a-chip
20. Applications to Nuclei Aids Analysis
21. Nucleic acids extraction and purification
22. Nucleic acids amplification
23. Forensic DNA typing
24. Microarray DNA chips
25. Applications to proteins analysis
26. Immunoassay
27. Protein separation
28. Enzymatic analysis
29. Proteomics
30. Applications to global health
31. Low-cost Paper-based diagnosis devices
32. Field diagnosis
33. Other applications
43. Environmental analysis
44. Forensic analysis
45. Small ions and molecules analysis
46. Microreacter
47. Perspective
48. Instrument/device commercialization


No. of pages:
© Elsevier 2021
1st June 2021
Hardcover ISBN:

About the Editors

Xiujun Li

XiuJun (James) Li, Ph.D., is an Associate Professor with early tenure in the Department of Chemistry and Biochemistry, Biomedical Engineering, and Border Biomedical Research Center at University of Texas at El Paso (UTEP), USA. After he obtained his Ph.D. degree in microfluidic lab-on-a-chip bioanalysis from Simon Fraser University (SFU) in Canada in 2008, he pursued his postdoctoral research with Prof. Richard Mathies at University of California Berkeley and Prof. George Whitesides at Harvard University. Dr. Li’s current research interest is centered on the development of innovative microfluidic lab-on-a-chip and nanotechnology for bioanalysis, environmental, biomaterial, and biomedical engineering applications, including but not limited to low-cost diagnosis, nano-biosensing, tissue engineering, and single-cell analysis. He has coauthored about 90 publications in high-impact journals (such as Adv. Drug Deliv. Rev, Appl. Catal. B-Environ, Anal. Chem., Lab Chip, Biosens. Bioelectron.) and 18 patents. He published a book of “Microfluidic Devices for Biomedical Applications” from Elsevier in 2013. He is an Advisory Board member of Lab on a Chip and Analyst, and an editor of 6 journals including Scientific Reports from the Nature publishing group, Micromachines, etc. He is the recipient of the “Bioanalysis Young Investigator Award” in 2014, UT STARS Award in 2012, NSERC Postdoctoral Fellow Award (2009), and so on. For more information, please visit

Affiliations and Expertise

Department of Chemistry and Biochemistry, Biomedical Engineering, Environmental Science and Engineering, Border Biomedical Research Center, University of Texas at El Paso

Chaoyong Yang

Prof. Chaoyong Yang has been a professor at Xiamen University, China, since 2007. He received his PhD from the University of Florida, United States, in 2006 and conducted his postdoctoral research at the University of California Berkeley, United States, from 2006 to 2007. He received the CAPA Distinguished Faculty Award in 2012, National Outstanding Young Investigator Award in 2013, Chinese Young Analyst Award in 2015, and Chinese Chemical Society-Royal Society of Chemistry Young Chemist Award in 2016. He has published more than 190 articles with total citation of more 10,000 times. His current research is particularly focused on molecular engineering, molecular recognition, high throughput evolution, single cell analysis, and microfluidics.

Affiliations and Expertise

Professor, Department of Chemical Biology, Xiamen University, China

Paul Li

Paul Li

Paul C.H. Li, Ph.D. is a professor at the Department of Chemistry, Simon Fraser University, British Columbia, Canada. Dr. Li's group focuses on carrying out various chemical and biochemical analysis, which are enhanced by the use of microfluidic devices.

Affiliations and Expertise

Professor, Department of Chemistry, Simon Fraser University, British Columbia, Canada

Ratings and Reviews