The Handbook of Stress and the Brain focuses on the impact of stressful events on the functioning of the central nervous system; how stress affects molecular and cellular processes in the brain, and in turn, how these brain processes determine our perception of and reactivity to, stressful challenges - acutely and in the long-run. Written for a broad scientific audience, the Handbook comprehensively reviews key principles and facts to provide a clear overview of the interdisciplinary field of stress. The work aims to bring together the disciplines of neurobiology, physiology, immunology, psychology and psychiatry, to provide a reference source for both the non-clinical and clinical expert, as well as serving as an introductory text for novices in this field of scientific inquiry.

Part 1 addresses basic aspects of the neurobiology of the stress response including the involvement of neuropeptide, neuroendocrine and neurotransmitter systems and its corollaries regarding gene expression and behavioural processes such as cognition, motivation and emotionality.

Key Features

* Provides an overview of recent advances made in stress research * Includes timely discussion of stress and its effect on the immune system * Presents novel treatment strategies targeting brain processes involved in stress processing and coping mechanisms


Researchers and clinicians in the fields of neuroscience, neurobiology, physiology, immunology, psychology, and psychiatry.

Table of Contents

List of contributors. Preface. A Memorial for David de Wied. 1. Concepts of Stress. 1.1 Stress: An historical perspective S. Levine. 1.2 The Neuropsychology of stress T. Steckler. 1.3 An introduction to the HPA axis A.J. Fulford and M.S. Harbuz 1.4 Hormones of the pituitary M. Páez-Pereda and Günter K. Stalla. 1.5 Molecular biology of the HPA axis K.-B. Abel and J.A. Majzoub. 1.6 The hypothalamic-pituitary-adrenal axis as a dynamically organized system: lessons from exercising mice J.M.H.M. Reul and S.K. Droste. 2. Hypothalamic Hormones Involved in Stress Responsivitity. 2.1 Novel CRH family peptides and their receptors: an evolutionary analysis S.Y.T. Hsu. 2.2 Regulation of CRF activity on the molecular level P.H. Roseboom, N.H. Kalin, T. Steckler and F.M. Dautzenberg. 2.3 Behavioral consequences of altered corticotropin-releasing factor activation in brain: a functionalist view of affective neuroscience S.C. Heinrichs. 2.4 The roles of urocortins 1, 2 and 3 in the brain E.P. Zorrilla and G.F. Koob. 2.5 Vasopressin and oxytocin A.J. Douglas. 2.6 The role of vasopressin in behaviours associated with aversive stimuli K.C. Chambers and U.L. Hayes. 3. Stress and the HPA Axis. 3.1 Corticosteroid receptors and HPA axis regulation E.R. De Kloet, M. Schmidt and O.C. Meijer. 3.2 Glucocorticoid effects on gene expression T. Kino and G.P. Chrousos. 3.3 The role of 11ß-hydroxysteroid dehydrogenases in the regulation of corticosteroid activity in the brain J.R. Seckl, J.L.W. Yau and M.C. Holmes. 3.4 Cortico


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© 2005
Elsevier Science
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