Comprehensive Biotechnology

2nd Edition

Editor-in-Chiefs: Murray Moo-Young
Hardcover ISBN: 9780444533524
eBook ISBN: 9780080885049
Imprint: Pergamon
Published Date: 20th July 2011
Page Count: 5320
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The second edition of Comprehensive Biotechnology continues the tradition of the first inclusive work on this dynamic field with up-to-date and essential entries on the principles and practice of biotechnology. The integration of the latest relevant science and industry practice with fundamental biotechnology concepts is presented with entries from internationally recognized world leaders in their given fields. With two volumes covering basic fundamentals, and four volumes of applications, from environmental biotechnology and safety to medical biotechnology and healthcare, this work serves the needs of newcomers as well as established experts combining the latest relevant science and industry practice in a manageable format. It is a multi-authored work, written by experts and vetted by a prestigious advisory board and group of volume editors who are biotechnology innovators and educators with international influence.

Key Features

  • All six volumes are published at the same time, not as a series; this is not a conventional encyclopedia but a symbiotic integration of brief articles on established topics and longer chapters on new emerging areas.
  • Hyperlinks provide sources of extensive additional related information; material authored and edited by world-renown experts in all aspects of the broad multidisciplinary field of biotechnology
  • Scope and nature of the work are vetted by a prestigious International Advisory Board including three Nobel laureates
  • Each article carries a glossary and a professional summary of the authors indicating their appropriate credentials
  • An extensive index for the entire publication gives a complete list of the many topics treated in the increasingly expanding field


Researchers, administrators, instructors and students(especially graduates and upper undergraduates) involved in biotechnology-related activities (academia, government, industry, medicine, agriculture, environment concerns, regulatory issues); university departments with programs/courses in the Life Sciences (especially microbiology, molecular biology, biochemistry, biophysics, genetics) and in bio-engineering (especially biochemical engineering, biological engineering, biomedical engineering, environmental engineering, food engineering, pharmaceutical engineering, agricultural engineering); useful for both neophytes and veterans of the field of biotechnology.

Table of Contents


Volume Editors

Section Editors

General Preface

Nomenclature Guidelines

Permission Acknowledgments

1.01. Introduction

1.02. Amino Acid Metabolism


1.02.1. Introduction

1.02.2. General Properties, Classification, and Structure of Amino Acids

1.02.3. Biosynthesis of Amino Acids

1.02.4. Catabolism of Amino Acids

1.02.5. Important Biomolecules Synthesized from Amino Acids

1.03. Enzyme Biocatalysis


1.03.1. Introduction to Enzymes

1.03.2. Enzyme Kinetics

1.03.3. Enzyme Engineering

1.03.4. Enzyme Production

1.03.5. Immobilized Enzymes

1.03.6. Enzyme Applications

1.03.7. Conclusions

1.04. Immobilized Biocatalysts

1.04.1. Introduction: Definitions and Scope

1.04.2. Applications of Immobilized Enzymes

1.04.3. Methods of Enzyme Immobilization

1.04.4. Properties of Immobilized Enzymes

1.04.5. Evaluation of Enzyme Immobilization

1.04.6. Heterogeneous Biocatalysis

1.04.7. Future Prospects for Immobilized Biocatalysts

1.05. Lipids, Fatty Acids


1.05.1. Introduction

1.05.2. Structure of Fatty Acids

1.05.3. Nomenclature

1.05.4. Form in the Cell

1.05.5. What Do Lipids Do?

1.05.6. Biosynthesis of Fatty Acids and Lipids

1.05.7. Biochemistry of Lipid Accumulation

1.06. DNA Cloning in Plasmid Vectors


1.06.1. Introduction

1.06.2. Cloning Vectors: Replication Origins and Partition Regions

1.06.3. Cloning Vectors: Selection Markers

1.06.4. Preparing DNA Fragments for Ligation

1.06.5. Ligation Systems

1.06.6. Methods of Bacterial and Yeast Transformation

1.06.7. Exploitation of Bacteriophage Packaging


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About the Editor-in-Chief

Murray Moo-Young

Murray Moo-Young is a distinguished professor emeritus at the University of Waterloo, Canada. Before academia, he worked in England for the British Ministry of Industry. A Jamaican-Chinese Canadian, Murray received his degrees from the University of London (BSc Chemistry, PhD Biochemical Engineering) and University of Toronto (MASc Chemical Engineering) followed by a postdoctoral fellowship at the University of Edinburgh. He has been a visiting professor at top universities worldwide including MIT, UC Berkeley, University of Oxford, Federal Polytechnic Institute Lausanne, University of Karlsruhe, Dalian University of Science and Technology and Osaka University. To date, his research has produced 13 books, nine patents and over 355 papers. He is an international consultant to industry and government and the executive editor of the journal Biotechnology Advances (Impact Factor 8.250). Dr. Moo-Young's honors include the top awards of the Canadian Society for Chemical Engineering and the American Chemical Society, Biochemical Technology Division. As an elected fellow of the American Institute for Medical and Biological Engineering (FAIMBE) and the Royal Society of Canada (FRSC), "the highest accolade for an academic in Canada", Dr. Moo-Young has come to be known as a leader in the field of biotechnology.

Affiliations and Expertise

University of Waterloo, Canada


"It would be very difficult to thoroughly cover the scope of biotechnology in one book. But this new edition of Comprehensive Biotechnology (1st ed., 1989) accomplishes what the title claims; the six-volume set provides detailed synopses of the applications, instruments, methodologies, and principles of modern biotechnology. Volume 1 provides the science background needed to understand biotechnology; it covers the essential biochemistry, biology, biophysics, chemistry, and computer science used in biotechnology applications and research. An explanation of engineering principles relevant to biotechnology follows in volume 2. The authors focus on engineering concepts appropriate to biotechnology product manufacturing. The third volume builds on the first two volumes in its coverage of biotechnology applications in industry and commodity products, including coverage of food ingredients, clinical products, and specialty chemicals.  Summing Up: Highly recommended. Lower-division undergraduates through professionals."--CHOICE

Review of the 1st Edition:

"Murray Moo-Young and his colleagues have brought off a notable success in producing this work... Comprehensive Biotechnology will be an essential purchase for all departments and institutions, academic or industrial, that claim an interest in any aspect of the ill-defined field popularly known as biotechnology..." --Nature, Volume 321 (1986)