Mucosal Vaccines

Mucosal Vaccines

Innovation for Preventing Infectious Diseases

1st Edition - October 18, 2019

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  • Editor: David Pascual
  • eBook ISBN: 9780128119259
  • Paperback ISBN: 9780128119242

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Mucosal Vaccines: Innovation for Preventing Infectious Diseases discusses basic knowledge and discovery in the area of mucosal immunology and its related scientific fields. This completely updated, revised and authoritative treatise covers all aspects of mucosal vaccines, including their development, mechanisms of action, molecular/cellular aspects and practical applications. The book is organized in a unique format with basic, clinical and practical aspects described and discussed. The accumulated knowledge and new discoveries on the development of mucosal vaccines are logically introduced and discussed in an easy-to-understand format.

Key Features

  • Provides the latest views on mucosal vaccines
  • Applies basic and current principles in the field of mucosal immunology and related scientific fields (e.g., microbiology, infectious diseases, systems biology, medicine, dentistry, veterinary medicine and translational research) to the development of new vaccines
  • Links basic, clinical and practical aspects of mucosal vaccines to different infectious diseases
  • Presents user-friendly organization using attractive illustrations


Diverse groups of clinicians and investigators whose interests are based in the fields of immunology, basic biology of the mucosal immune system or vaccines

Table of Contents

  • Introduction
    1. Why the Mucosal Immune System should be Zconsidered for the Development of Mucosal Vaccine
    David W. Pascual and Hiroshi Kiyono
    2. Historical Peerspectives into Mucosal Vaccines
    Michael W. Russell and Pearay Ogra

    Principles of Mucosal Vaccine
    3. Anatomical Uniqueness of the Mucosal Immune System (DEVELOPMENTAL FOR STRUCTURES, E.G., Ibalt, GALT, NALT) for the Induction and Regulation of Mucosal Immunity & Tolerance
    Troy Randall
    4. Mucosal Antigen Sampling System (M Cells and Dendritic Cells)
    Brian Kelsall and Ifor R. Williams
    5. Essential Role of SIgA in Mucosal Immunity
    Jiri Mestecky
    6. Mucosal Lymphocyte Homing
    Motomu Shimaoka
    7. Innate Immunity at Mucosal Surfaces
    Satoshi Uematsu
    8. Induction and Regulation of Mucosal Memory B Cell Responses
    Nils Y. Lycke
    9. Induction and Regulation of Mucosal Memory T Cell Responses
    Toshinori Nakyama
    10. Influence of Commensal Miro-biota and –metabolite for mucosal immunity
    Christian Jobin

    Mucosal Modulations for Induction of Effective Immunity
    11. Innate Immunity based Mucosal Modulator and Adjuvant
    Herman Ford Staats
    12. Toxin-based Modulators for Regulation of Mucosal Immune Responses
    Prosper N. Boyaka
    13. Influence of Dietary (or Nutritional) Materials for the Control of Mucosal Immunity
    Jun Kunisawa
    14. Mast Cells for the Control of Mucosal Immunity
    Soman N. Abraham
    15. Innate Lymphoid Cells for the Control of Mucosal Immunity
    David Artis
    16. Mucosal Regulatory System for the Balanced Immunity in the Gut
    Kiyoshi Takeda and Hisako Kayama
    17. Mucosal Regulatory System for the Balanced Immunity in the Genito-urinary Tract
    Kenneth Beagley
    18. Mucosal Regulatory System for the Balanced Occular Immunity
    Dan J. Carr
    19. Mucosal Regulatory System for the Balanced Oral Immunity
    Kazuhiko Nakano
    20. Mucosal Regulatory System for the Balanced Immunity in the Middle Ear
    Hideyuki Kawauchi

    Current and New Approaches for Mucosal Vaccine Delivery
    21. Mucosal Vaccine Delivery Systems
    Joon Haeng Rhee
    22. Plant-based Mucosal Vaccine Delivery Systems
    Yoshikazu Yuki and Hiroshi Kiyono
    23. Plant-based Mucosal Immunotherapy
    Kenneth L. Bost and Ken Piller
    24. Attenuated Salmonella for Oral Immunization
    Kenneth Roland, Qingke Kong and Yanlong Jiang
    25. Recombinant BCG for Mucosal Immunity
    Steven Craig Derrick
    26. Recombinant Adenovirus for Mucosal Vaccine Delivery
    Hildegund christa Ertl
    27. Mucosal Approaches for Systemic Immunity to Anthrax, Brucellosis and Plague
    David W. Pascual
    28. Nano-Delivery Vehicles for Mucosal Vaccines
    Hiroshi Kiyono and Yoshikazu Yuki
    29. Effectiveness of Sub-lingual Immunization
    Mi-Na Kweon
    30. Antibody Approaches for Passive Mucosal Immune Protection
    31. M Cell-Targeted Vaccines
    Shintaro Sato

    Mucosal Vaccines for Bacterial Diseases
    32. Mucosal Vaccines for Salmonella typhi Infection
    Marcelo B. Sztein
    33. Oral Vaccine for Shigella
    Marcela F. Pasetti
    34. Oral Vaccines for Cholera
    Jan Holmgren and John Daivd Clemens
    35. Oral Vaccines for enterotoxinogenic E. coli (ETEC)
    Ann-Mari Svennerholm
    36. Mucosal Immunity to Helicobacter pylori
    Thomas F. Mayer
    37. Mucosal Vaccines for Streptococcus pneumoniae
    Larry S. McDaniel and Edwin Swiatlo
    38. Mucosal Vaccines for TB
    Yasuhiro Yasutomi
    39. Mucosal Vaccines for Bacterial Sexually Transmitted Diseases
    Toni Darville
    40. Mucosal Vaccines for Oral Diseases
    Tomoko Kurita-Ochiai

    Mucosal Vaccines for Viral Diseases
    41. Mucosal RSV Vaccines
    Barney S. Graham and Tracy Ruckwardt
    42. Nasal Influenza Vaccines
    Hideki Hasegawa
    43. Development of Oral Rotavirus & Norovirus Vaccines
    Stephanie Karst
    44. Rotavirus Vaccines--The Clinical Experience
    Harry B. Greenberg
    45. Mucosal Vaccines for HIV/SIV
    Robin J. Shattock and Tetsuro Matano
    46. Mucosal Vaccines for Herpes
    Akiko Iwasaki
    47. Maternal Antibodies for Protection Against Viral Pathogens
    Sallie R Permar

    New and Novel Approaches for Mucosal Vaccine Development
    48. Systems Biology for Mucosal Vaccine Development
    Bali Pulendran
    49. Natural & Chemical Library for New Mucosal Modulators and Adjuvants
    Mark Jutila
    50. Commensal Bacteria-based Mucosal Vaccine Development
    Philippe Langella
    51. New Approaches for Vaccinating the Elderly
    Kohtaro Fujihashi

    Can Mucosal Vaccines be applied for other Infectious and Non-infectious Diseases?
    52. Mucosal Vaccine Development for Veterinary and Aquatic Diseases
    Lorne Babiuk, Heather Wilson and Volker Gerdts
    53. Mucosal Vaccine for Malaria
    Cevayir Coban
    54. Mucosal Vaccine for Parasitic Infections
    Hirotomo Kato
    55. Mucosal Vaccine for Allergy & Tolerance
    Cathryn Nagler
    56. Mucosal Immunity for Inflammation
    Peter Ernst

Product details

  • No. of pages: 940
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: October 18, 2019
  • Imprint: Academic Press
  • eBook ISBN: 9780128119259
  • Paperback ISBN: 9780128119242

About the Editor

David Pascual

Affiliations and Expertise

Department of Infectious Diseases and Pathology, University of Florida, USA

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