MRNA-Based Therapeutics

MRNA-Based Therapeutics

1st Edition - September 1, 2022

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  • Editors: Fernando Aranda Vega, Pedro Berraondo, Lorenzo Galluzzi
  • Hardcover ISBN: 9780323994019

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MRNA-Based Therapeutics, Volume 372 in the International Review of Cell and Molecular Biology series, covers topics surrounding the effect of different metabolic situations, their contribution to metabolic modulation, and their impact on tumor growth. Specific chapters in this release include New era of nucleic acid therapies: Clinical applications and perspectives, Messenger RNA as personalized therapy: time of truth for rare metabolic disease, Applications of Self-Replicating RNA, mRNA therapy in PKU, Advances in gene-editing technologies, mRNA delivery technologies: towards clinical translation, Advances in mRNA vaccines, and more.

Key Features

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in International Review of Cell and Molecular Biology serials
  • Updated release includes the latest information on MRNA-Based Therapeutics


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Table of Contents

  • 1. New era of nucleic acid therapies: Clinical applications and perspectives
    Andoni Garitano
    2. Messenger RNA as personalized therapy: time of truth for rare metabolic disease
    Antonio fontanellas
    3. Applications of Self-Replicating RNA
    Kenneth Lundstrom
    4. mRNA therapy in PKU
    Ramon Diaz Trelles
    5. Advances in gene-editing technologies
    Robert MacLaren and Ruofan Connie Han
    6. mRNA delivery technologies: towards clinical translation
    Maria Angeles Solinis
    7. Advances in mRNA vaccines
    Xiaojun Xia

Product details

  • No. of pages: 278
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: September 1, 2022
  • Imprint: Academic Press
  • Hardcover ISBN: 9780323994019

About the Serial Volume Editors

Fernando Aranda Vega

Clément Thomas is holding a group leader position at the Department of Oncology of the Luxembourg Institute of Health (LIH; Luxembourg City, Luxembourg). He received his PhD in Molecular and Cellular Biology in 2003 from Strasbourg University (France) in 2003. Since that moment, he has been interested in cell plasticity with a particular focus on actin cytoskeleton remodeling mechanisms. After more than ten years working with plant models, he joined the department of Oncology of LIH and established a group focused on the functions of the actin cytoskeleton in two central and complementary processes underlying cancer progression: invasion and immune evasion. Clément Thomas and his colleagues characterized a family of small, evolutionary-conserved, LIM domain-containing proteins (cysteine and glycine-rich proteins) that crosslink actin filaments into stable actin bundles and established the role of these proteins in promoting the formation and activity of invadopodia in breast cancer cells. Lately, Clément Thomas’ group has initiated a pioneering study aimed at elucidating the role of the cancer cell’s actin cytoskeleton during immune evasion.

Affiliations and Expertise

CIMA Universidad de Navarra, Program of Immunology & Immunotherapy, SPAIN

Pedro Berraondo

Lorenzo Galluzzi

Lorenzo Galluzzi
Lorenzo Galluzzi is Assistant Professor of Cell Biology in Radiation Oncology at the Department of Radiation Oncology of the Weill Cornell Medical College, Honorary Assistant Professor Adjunct with the Department of Dermatology of the Yale School of Medicine, Honorary Associate Professor with the Faculty of Medicine of the University of Paris, and Faculty Member with the Graduate School of Biomedical Sciences and Biotechnology of the University of Ferrara, the Graduate School of Pharmacological Sciences of the University of Padova, and the Graduate School of Network Oncology and Precision Medicine of the University of Rome “La Sapienza”. Moreover, he is Associate Director of the European Academy for Tumor Immunology and Founding Member of the European Research Institute for Integrated Cellular Pathology. Galluzzi is best known for major experimental and conceptual contributions to the fields of cell death, autophagy, tumor metabolism and tumor immunology. He has published over 450 articles in international peer-reviewed journals and is the Editor-in-Chief of four journals: OncoImmunology (which he co-founded in 2011), International Review of Cell and Molecular Biology, Methods in Cell biology, and Molecular and Cellular Oncology (which he co-founded in 2013). Additionally, he serves as Founding Editor for Microbial Cell and Cell Stress, and Associate Editor for Cell Death and Disease, Pharmacological Research and iScience.

Affiliations and Expertise

Assistant Professor of Cell Biology in Radiation Oncology, Department of Radiation Oncology, Weill Cornell Medical College, NY, USA

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