COVID-19 Update: We are currently shipping orders daily. However, due to transit disruptions in some geographies, deliveries may be delayed. To provide all customers with timely access to content, we are offering 50% off Science and Technology Print & eBook bundle options. Terms & conditions.
Mouse Models of the Nuclear Envelopathies and Related Diseases - 1st Edition - ISBN: 9780123979209, 9780123984647

Mouse Models of the Nuclear Envelopathies and Related Diseases, Volume 109

1st Edition

Serial Volume Editor: Colin Stewart
eBook ISBN: 9780123984647
Hardcover ISBN: 9780123979209
Imprint: Academic Press
Published Date: 2nd June 2014
Page Count: 352
Sales tax will be calculated at check-out Price includes VAT/GST
Price includes VAT/GST

Institutional Subscription

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Table of Contents

  • Preface
  • Chapter One: Functional Architecture of the Cell's Nucleus in Development, Aging, and Disease
    • Abstract
    • 1 Introduction
    • 2 The Laminopathies
    • 3 Mouse Models for the A-Type Laminopathies
    • 4 Laminopathies Associated with Mutations in the B-Type Lamins
    • 5 Diseases Resulting from NE Protein Mutations
    • Acknowledgments
  • Chapter Two: Mouse Models of Lipodystrophy and Their Significance in Understanding Fat Regulation
    • Abstract
    • 1 Introduction
    • 2 Lipodystrophy Syndromes
    • 3 Genes Mutated in Congenital Generalized Lipodystrophy
    • 4 Genes Disrupted in Familial Partial Lipodystrophies
    • 5 Limitations of the Current Models and Perspectives for the Future
    • 6 Conclusions
  • Chapter Three: Mouse Models of Neurodevelopmental Disease of the Basal Ganglia and Associated Circuits
    • Abstract
    • 1 Introduction
    • 2 Diseases and Links to Striatal Dysfunction
    • 3 Striatal Organization and Function
    • 4 Disease Mechanisms and Mouse Models
    • 5 OCD-Spectrum Disorders and Rodent Models
    • 6 Rett Syndrome and Mouse Models
    • 7 Primary Dystonia
    • 8 Concluding Remarks
  • Chapter Four: Mouse Models of Heart Failure: Cell Signaling and Cell Survival
    • Abstract
    • 1 Heart Failure: The Unmet Need
    • 2 Pathobiological Features
    • 3 Cardiac Muscle Cell Apoptosis in Heart Failure: Death Kills
    • 4 Pathways Executing Cardiac Muscle Cell Death
    • 5 Recapitulating Specific Mutations Associated with Heart Failure in Mice
    • 6 Mitogen-Activated Protein Kinases in Heart Failure
    • 7 Neurohormonal Responses: G proteins and G protein-Coupled Receptors
    • 8 Neurohumoral Responses: TNF-α
    • 9 Discussion: Protecting the Myocardium
  • Chapter Five: Mouse Models and Aging: Longevity and Progeria
    • Abstract
    • 1 Introduction
    • 2 Mouse Models Analyzing the GH/IGF-1 Axis
    • 3 Mouse Models Analyzing Target of Rapamycin Signaling
    • 4 Mouse Models Analyzing Sirtuin Function
    • 5 Mouse Models of Inflammation
    • 6 Mouse Models of DR or Calorie Restriction
    • 7 Mouse Models of Progeria
    • 8 Mouse Models Analyzing DNA Repair and Genomic Stability
    • 9 Mouse Models Resulting in Tumorigenesis
    • 10 Mouse Models Analyzing Oxidative Stress
    • 11 Summary
    • Acknowledgments
  • Chapter Six: LINC Complex Proteins in Development and Disease
    • Abstract
    • 1 Introduction to the LINC Complex
    • 2 The LINC Complex in Plants
    • 3 LINC Complex in Yeast
    • 4 The LINC Complex in Caenorhabditis elegans
    • 5 The LINC Complex in Drosophila melanogaster
    • 6 LINC Complex Proteins in Mammals
    • 7 Mouse Models of LINC Complex Proteins
    • 8 Diseases of the LINC Complex
    • 9 Conclusions
    • Acknowledgments
  • Index


Volume 109 of Current Topics in Developmental Biology covers mouse models of the nuclear envelopathies and related diseases, with contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as mouse models neurodegenerative diseases including Parkinson’s and dystonia, muscle ageing and sarcopenia, cardiac failure and repair, ageing and prospects lifespan extension, lipodystrophy and the significance in fat regulation, also identifying developmental mutations in mammals and nuclear envelope and LINC complex in disease.

Key Features

  • Covers the area of mouse models of developmental genetic disease
  • International board of authors
  • Provides a comprehensive set of reviews covering such topics as mouse models neurodegenerative diseases including Parkinson’s, muscle aging, lipodystrophy, and more


Researchers in cell, developmental, and molecular biology; genetics.


No. of pages:
© Academic Press 2014
2nd June 2014
Academic Press
eBook ISBN:
Hardcover ISBN:

Ratings and Reviews

About the Serial Volume Editor

Colin Stewart

Affiliations and Expertise

Senior Principal Investigator and Assistant Director, Institute of Medical Biology, Singapore