Mouse Development

Mouse Development

Patterning, Morphogenesis, and Organogenesis

1st Edition - March 1, 2001

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  • Authors: Janet Rossant, Patrick Tam
  • eBook ISBN: 9780080537030
  • Hardcover ISBN: 9780125979511

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This book represents a classic compilation of current knowledge about mouse development and its correlates to research in cell biology, molecular biology, genetics, and neuroscience. Emphasis is placed on the research strategy, experimental design, and critical analysis of the data, disguishing this from other books that only focus on protocols for mouse developmental research. Selected chapters are indexed to electronic databases such as GeneBank, GenBank, Electronic Mouse Atlas, and Transgenic/Knockout, further increasing the utility of this book as a reference.

Key Features

*Broad-based overview of mouse development from fundamental to specialist levels
*Extensive coverage of a wide range of developmental mutations of the mouse
*Excellent benchmark illustrations of brain, craniofacial, gut and heart development
*In-depth experiment-based assessment of concepts in mammalian development
*Focus on models of specific relevance to human development
*Comprehensive reference to key literature and electronic databases related to mouse development
*High-quality full-color production


Developmental biologists, cell biologists, and molecular biologists.

Table of Contents

  • Establishment of Body Pattern

    Fertilization and Activation of the Embryonic Genome
    Asymmetry and Pre-Pattern in Mammalian Development
    Anterior Posterior Patterning of the Mouse Body Axis at Gastrulation
    Left-Right Asymmetry
    Patterning, Regionalization and Cell Differentiation in the Forebrain
    Establishment of Anterior-Posterior and Dorsal-Ventral Pattern in the Early Central Nervous System
    Somitogenesis: Segmentation of the Paraxial Mesoderm and the Delineation of Tissue Compartments

    II. Lineage Specification and Differentiation

    Extraembryonic tissues
    Germ Cells
    Development of the Vertebrate Hematopoetic System
    Vasculogenesis and Angiogenesis
    Stem Cells of the Nervous System
    Cellular and Molecular Mechanisms Regulating Skeletal Muscle Development
    Chondrogenesis and Skeletogenesis

    III. Organogenesis

    Development of the Endoderm and its Tissue Derivatives
    Heart Development: Induction, Myogenesis and Patterning
    Sex Determination and Differentiation
    The Development of the Excretory System
    Craniofacial Development
    Pituitary Gland Development
    Sensory Organs: Eye
    Development of the Mouse Inner Ear
    Integumentary Structures

Product details

  • No. of pages: 736
  • Language: English
  • Copyright: © Academic Press 2002
  • Published: March 1, 2001
  • Imprint: Academic Press
  • eBook ISBN: 9780080537030
  • Hardcover ISBN: 9780125979511

About the Authors

Janet Rossant

Affiliations and Expertise

Samuel Lunenfeld Research Institute, Toronto, Canada

Patrick Tam

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