Mouse Development

1st Edition

Patterning, Morphogenesis, and Organogenesis

Authors: Janet Rossant Patrick Tam
Print ISBN: 9780123911254
eBook ISBN: 9780080537030
Imprint: Academic Press
Published Date: 1st March 2002
Page Count: 712
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This book represents a classic compilation of current knowledge about mouse development and its correlates to research in cell biology, molecular biology, genetics, and neuroscience. Emphasis is placed on the research strategy, experimental design, and critical analysis of the data, disguishing this from other books that only focus on protocols for mouse developmental research. Selected chapters are indexed to electronic databases such as GeneBank, GenBank, Electronic Mouse Atlas, and Transgenic/Knockout, further increasing the utility of this book as a reference.

Key Features

Broad-based overview of mouse development from fundamental to specialist levels Extensive coverage of a wide range of developmental mutations of the mouse Excellent benchmark illustrations of brain, craniofacial, gut and heart development In-depth experiment-based assessment of concepts in mammalian development Focus on models of specific relevance to human development Comprehensive reference to key literature and electronic databases related to mouse development *High-quality full-color production


Developmental biologists, cell biologists, and molecular biologists.

Table of Contents

Establishment of Body Pattern

Fertilization and Activation of the Embryonic Genome
Asymmetry and Pre-Pattern in Mammalian Development
Anterior Posterior Patterning of the Mouse Body Axis at Gastrulation
Left-Right Asymmetry
Patterning, Regionalization and Cell Differentiation in the Forebrain Establishment of Anterior-Posterior and Dorsal-Ventral Pattern in the Early Central Nervous System
Somitogenesis: Segmentation of the Paraxial Mesoderm and the Delineation of Tissue Compartments

II. Lineage Specification and Differentiation

Extraembryonic tissues Germ Cells
Development of the Vertebrate Hematopoetic System
Vasculogenesis and Angiogenesis
Stem Cells of the Nervous System
Cellular and Molecular Mechanisms Regulating Skeletal Muscle Development Chondrogenesis and Skeletogenesis

III. Organogenesis

Development of the Endoderm and its Tissue Derivatives
Heart Development: Induction, Myogenesis and Patterning Sex Determination and Differentiation
The Development of the Excretory System
Craniofacial Development
Pituitary Gland Development
Sensory Organs: Eye
Development of the Mouse Inner Ear
Integumentary Structures


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© Academic Press 2002
Academic Press
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About the Author

Janet Rossant

Affiliations and Expertise

Samuel Lunenfeld Research Institute, Toronto, Canada

Patrick Tam


@qu:"...two of the most respected mouse developmental biologists have produced an exceptional book. Right from the outset, it highlights the incredible explosion in our knowledge and understanding of mammalian development over the past decade...will sit very comfortably upon any bookshelf." @source:—Paul Trainor, Stowers Institute for Medical Research for NATURE CELL BIOLOGY (September 2002) @qu:" excellent resource for scientists interested in any of the selected topics covered by one of the authors." @source:—DOODY'S NOTES (2002)