1st Edition - January 28, 1990

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  • Editor: Zen Itoh
  • eBook ISBN: 9780323157896

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Motilin focuses on the pharmacology and physiology of motilin, with emphasis on its relationship to interdigestive motor activities and species differences between these two parameters. Changes in plasma motilin in relation to some gastrointestinal diseases, including peptic ulcer, cholelithiasis, chronic idiopathic constipation, dumping syndrome, and irritable bowel syndrome, are discussed. This book is comprised of 17 chapters and begins with a historical background on motilin, including its discovery and isolation. The next chapter considers the structure of motilin in pigs and cats and presents evidence for the existence of motilin in other species. The chemical synthesis, radioimmunoassay, and immunoreactivity of motilin are also examined. Subsequent chapters explore the prohormone of human motilin; morphological identification of motilin in the gut; mechanisms of motilin excitation as determined by in situ and in vitro studies; and motilin receptors. This monograph should be of interest to scientists, physiologists, clinical specialists, morphologists, pharmacologists, and biochemists.

Table of Contents

  • Contributors


    1. Introduction



    2. The Discovery of Motilin



    3. Purification and Chemical Structure of Porcine and Canine Motilins and Evidence for the Existence of Motilin in Other Species

    I. Isolation of Porcine Motilin

    II. Amino Acid Composition and Sequence Analysis Porcine Motilin

    III. Isolation of Canine Motilin

    IV. Amino Acid Composition and Sequence Analysis of Canine Motilin

    V. Motilin in Other Species

    VI. Heterogeneity of Motilin

    VII. Structure-Activity Relationships


    4. Chemical Synthesis, Radioimmunoassay, and Distribution of Immunoreactivity of Motilin

    I. Introduction

    II. Chemical Synthesis

    III. Radioimmunoassay

    IV. Distribution of Immunoreactivity


    5. Prohormone of Human Motilin

    I. Heterogeneity of Human Motilin (Porcine Motilin)

    II. Isolation and Characterization of a Motilin cDNA Clone

    III. Primary Structure of Human Prepromotilin

    IV. Comparison of Motilin Sequence


    6. Morphological Identification of Motilin in the Gut

    I. Immunocytochemical Demonstration of Motilin-Containing Cells

    II. Immunocytochemical Controls

    III. Enterochromaffin Cells and Motilin

    IV. Structure and Ultrastructure of the Mo Cells

    V. Transportation Route of Motilin in the Lamina Propria Mucosae

    VI. Phylogeny, Ontogeny, and Kinetics

    VII. Mo Cells in the Segi's Cap


    7. Mechanisms of Motilin Excitation as Determined by in Situ and In Vitro Studies

    I. Introduction

    II. Sites and Mechanisms of Action

    III. Conclusion


    8. Motilin Receptors

    I. Introduction

    II. Search for Motilin Binding Sites

    III. Characterization of Motilin Binding

    IV. Localization of Motilin Receptors

    V. Regulation and Development

    VI. Motilin Agonists

    VII. Conclusions


    9. Biological Activity of Motilin in Gastric, Pancreatic, and Duodenal Secretion

    I. Introduction

    II. Distribution and Release of Motilin as Related to Gastrointestinal Motilin

    III. Mechanism of Action

    IV. Secretory Component of Migrating Motor Complex

    V. Motilin and Gastroduodenal Secretion

    VI. Motilin and Pancreatic and Biliary Secretion

    VII. Summary and Conclusion


    10. Biological Activity in Gastric Emptying

    I. Introduction

    II. Normal Regulation of Gastric Emptying

    III. Effect of Motilin on Gastric and Duodenal Smooth Muscle In Vitro

    IV. Effect of Motilin on Myoelectric and Contractile Activity In Vivo

    V. Effect of Motilin on Gastric Emptying in Animals

    VI. Effect of Motilin on Gastric Emptying in Humans


    11. Effect of Motilin on Gastrointestinal Motor Activity in the Dog

    I. Introduction

    II. Materials and Methods

    III. Results

    IV. Discussion and Conclusion


    12. Role of Motilin in Biliary Tract Physiology

    I. Introduction

    II. Physiological Background

    III. Effects of Exogenous Motilin Infusions on the Biliary Tract - In Vivo or In Vitro Experiments in Animals or Humans

    IV. Fasting Plasma Motilin Fluctuations in Relation to Inter-digestive Biliary Emptying—Studies in Humans

    V. Relationship between Inter-digestive Biliary Emptying - Motilin Release and Fasting Gastroduodenal Motility in Humans

    VI. General Summary


    13. Endogenous Motilin Release: Physiology and Pathophysiology

    I. Introduction

    II. Plasma Motilin Concentrations in Interdigestive States

    III. Motilin Release after Ingestion of a Meal or Fat

    IV. Effect of Duodenal pH Changes on Motilin Release

    V. Effects of Hormones, Peptides, and Others on Motilin Release

    VI. Plasma Motilin Levels in Relation to Inter-digestive Pancreatic Secretion

    VII. Motilin Release in Abnormal States


    14. Mechanism of Motilin Release by Luminal Stimuli and Vagal Nerve

    I. Introduction

    II. Localization of Motilin

    III. Neural Mechanisms for Motilin Release

    IV. Intraluminal Nutrients

    V. Intraluminal Acid and Alkali

    VI. Intraluminal Biliary and Pancreatic Secretions

    VII. Other Factors


    15. Clinical Significance of Motilin in Diseases of the Gastrointestinal Tract

    I. Normal Motilinemia

    II. Motilinemia and Gastrointestinal Dysfunction

    III. Therapeutic Applications

    IV. Summary and Conclusions


    16. Gastroduodenal Motor Dysfunction and Plasma Motilin Concentration in Patients with Duodenal Ulcers

    I. Interdigestive, Intragastric, and Duodenal pH and Motility in Normal Subjects

    II. IMC Appearance in 24-hr Monitoring of Intragastric and Duodenal pH and Motility of Normal Subjects

    III. Pattern of Interdigestive Gastroduodenal Motility and pH in Duodenal Ulcer Patients

    IV. IMC in 24-hr Monitoring of Gastroduodenal Motility and pH of Duodenal Ulcer Patients

    V. Comparison of Gastroduodenal Motility and pH in Duodenal Ulcer Patients and Normal Subjects

    VI. Plasma Motilin Concentrations and Inter-digestive Gastroduodenal Motility in Humans

    VII. Characteristics of Plasma Motilin Behavior and IMC Appearance in Duodenal Ulcer Patients

    VIII. Histamine H2 Receptor Antagonist Neutralizes Intraluminal pH of the Gastroduodenum, but GI-IMC Appears after an Increase in Plasma Motilin

    References 242

    17. Motilide, Motilin-like Macrolides

    I. Introduction

    II. Chemical Synthesis of Erythromycin Derivatives

    III. Biological Activity

    IV. Receptor Binding Study

    V. Discussion and Conclusion



Product details

  • No. of pages: 282
  • Language: English
  • Copyright: © Academic Press 1990
  • Published: January 28, 1990
  • Imprint: Academic Press
  • eBook ISBN: 9780323157896

About the Editor

Zen Itoh

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