The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases Revisited, Second Edition describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of the many factors that are involved in auto-immunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this communication, only the environmental factors are reviewed such as: infectious agents (represented by Epstein-Barr virus and cytomegalovirus), vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases. Some aspects of stress as implicated in causing autoimmunity and the processes leading to autoimmunity are reviewed as well.
It has been now 30 years ago that the concept of the ‘mosaic of autoimmunity’ was introduced to the scientific community, and since then this concept has continuously evolved, with new pebbles being added regularly. We are now looking at an era in which the players of autoimmunity have changed names and roles. Indeed, we are at the forefront of autoimmunity science. Within the environmental factors generating autoimmunity are now included unsuspected molecules such as vitamin D, salt and dietary factors, cannabis. Some adjuvants such as aluminum are recognized as causal factors in the development of the autoimmune response. An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), has been recently described together with other diseases that are now recognized as having an autoimmune etiopathogenesis. This is the new wind blowing within the branches of autoimmunity, adding knowledge to physicians for helping patients with autoimmu
- Provides an overview in a quickly evolving topic. This will benefit the reader who wishes to rapidly become informed and become up to date with these new developments
- Highlights the concept of the mosaic of autoimmune manifestations
- Includes new visions on unsuspected molecules
- Provides updated knowledge to physicians helping patients with autoimmune diseases
- Thorough, up-to-date information on specific diseases, along with clinical applications, provide an easily found reference for clinicians and researchers interested in certain diseases
Researchers and physicians in immunology, autoimmune diseases, genetics, virologists and molecular biologists. Researchers, clinicians, clinical investigators, pathologists, medical students, and graduate students in the biomedical sciences, as well as basic scientists in such fields as immunology, rheumatology, genetics, cell biology and molecular and microbiology
1. The history of the mosaic of autoimmunity
2. The novel aspects on the mosaic of autoimmunity
Cellular and molecular mechanisms
3. B cells
5. T cells
6. Th17 cells
7. NK cells
8. Dendritic cells
13. Post-translational modifications
14. Cytokines and chemokines
16. Diagnostic: laboratory
17. Diagnostic: imaging
The classical factors associated with autoimmunity
20. Infections: Viruses and bacteria
The novel environmental factors associated with autoimmunity
24. Vitamin D
25. Vitamin D pregnancy and autoimmunity
27. Breast feeding
30. Diet: spicy food and fatty acids
31. Diet: gluten
32. Beverages/psychological stress
35. Physical activity
42. Paraneoplastic syndromes
Classical autoimmune diseases
46. RA and inflammatory arthritides
47. PsA and Spondyloarthropathies
48. MS, MG and other ne
- No. of pages:
- © Academic Press 2019
- 1st October 2018
- Academic Press
- Paperback ISBN:
Dr. Carlo Perricone, is a ECR in autoimmune diseases, Born in Rome on 19 April 1984. 'Surgeon Specialist in Rheumatology, has a Ph.D. in Immunological Sciences, hematology, and Rheumatics at Sapienza University of Rome. He received with honors the Master Degree in Medicine and Surgery in July 2007 at the University of Rome
Sapienza University of Rome | la sapienza, Department of Internal and Specialized Medicine, Rome, Italy
Prof. Yehuda Shoenfeld is the founder and head of the Zabludowicz Center for Autoimmune Diseases, at the Sheba Medical Center which is affiliated to the Sackler Faculty of Medicine in Tel-Aviv University, in Israel. Dr. Shoenfeld is the Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases at the Tel-Aviv University.
His clinical and scientific works focus on autoimmune and rheumatic diseases, and he has published more than 1750 papers in journals such as New Eng J Med, Nature, Lancet, Proc Nat Acad Scie, J Clin Invest, J Immunol, Blood, FASEB, J Exp Med, Circulation, Cancer and others. His articles have had over 35,000 citations. He has written more than three hundred and fifty chapters in books, and has authored and edited 25 books, some of which became cornerstones in science and clinical practice, such as "The Mosaic of Autoimmunity", "Infections and Autoimmunity" and the textbook "Autoantibodies" and "Diagnostic criteria of autoimmune diseases", all of which were published by Elsevier and sold by the thousands.
He is on the editorial board of 43 journals in the field of rheumatology and autoimmunity and is the founder and the editor of the IMAJ (Israel Medical Association Journal) the representative journal of science and medicine in the English language in Israel, and also is the founder and Editor of the "Autoimmunity Reviews" (Elsevier) (Impact factor 7.9) and Co-Editor of "Journal of Autoimmunity" (Impact factor 8.1). He has organized over 20 international congresses in autoimmunity.
Prof. Shoenfeld received the EULAR prize in 2005, in Vienna, Austria: "The infectious etiology of anti-phospholipid syndrome". He has received a gold medal from the Slovak Society of Physicians for his contribution to Israel – Slovakia collaboration (March 2006), and is honorary member of the Hungarian Association of Rheumatology. In UC Davis, USA, Dr. Shoenfeld received the Nelson's Prize for Humanity and Science for 2008. In 2009 he was honored as Doctoris Honoris Causa, from Debrecen University (Hungary), and from 2009 he is honorary member of the Slovenian National Academy of Sciences. He has recently been awarded a Life Contribution Prize in Internal Medicine in Israel, 2012 as well as the ACR Master Award in 2013.
Prof. Shoenfeld has educated a long list of students (>25) being heads of departments and institutes.
Head, Zabludowicz Center for Autoimmune Diseases,Sheba Medical Center, Affiliate of Tel-Aviv University, Israel