Mosaic of Autoimmunity - 1st Edition - ISBN: 9780128143070

Mosaic of Autoimmunity

1st Edition

The Novel Factors of Autoimmune Diseases

Editors: Carlo Perricone Yehuda Shoenfeld
Paperback ISBN: 9780128143070
Imprint: Academic Press
Published Date: 22nd February 2019
Page Count: 1136
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The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases.

An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis.

Key Features

  • Highlights the concept of the mosaic of autoimmune manifestations
  • Includes new visions on unsuspected molecules
  • Provides updated knowledge to physicians helping patients with autoimmune diseases
  • Presents thorough, up-to-date information on specific diseases, along with clinical applications


Researchers and physicians in immunology, autoimmune diseases, genetics, virologists and molecular biologists. Researchers, clinicians, clinical investigators, pathologists, medical students, and graduate students in the biomedical sciences, as well as basic scientists in such fields as immunology, rheumatology, genetics, cell biology and molecular and microbiology

Table of Contents


1. The history of the mosaic of autoimmunity

2. The novel aspects on the mosaic of autoimmunity 

Cellular and molecular mechanisms

3. B cells

4. B-reg 

5. T cells

6. Th17 cells

7. NK cells

8. Dendritic cells

9. Complement

10. Autoantibodies

11. Anti-DSF70

12. Genetic

13. Epigenetic

14. Post-translational modifications

15. Cytokines and chemokines

16. Autophagy

17. Diagnostic: laboratory 

18. Diagnostic: imaging

The classical factors associated with autoimmunity

19. Hormones 

20. Microbiota 

21. Infections: Viruses and bacteria

The novel environmental factors associated with autoimmunity

22. Geo-epidemiology

23. Seasonality

24. UV

25. Vitamin D

26. Vitamin D pregnancy and autoimmunity

27. Smell

28. Breast feeding

29. Vaccines

30. Silicone

31. Diet: spicy food and fatty acids

32. Diet: gluten

33. Psychological stress

34. Coffee

35. Obesity

36. Physical activity

37. Smoke

38. Cannabis

39. Bisphenol

40. Prolactin

Peculiar aspects

41. Cancer 

42. Paraneoplastic syndromes

Classical autoimmune diseases

43. SLE

44. APS

45. CAPS

46. RA and inflammatory arthritides 

47. PsA and Spondyloarthropathies 

48. MS, MG and other neurological disorders

49. Systemic slcerosis

50. Sjogren

51. ASIA syndrome

52. Reproductive failure

53. Accelerated atherosclerosis

54. New autoimmune diseases

Treatment of autoimmune diseases

55. Neuroimmunology

56. Vasculitis

57. Personalized Medicine

58. Biologics and Biosimilars

59. Small molecules

60. Helminthes

61. Novel therapies and IVIg

62. Autoimmune and allergic disease

63. EBV Molecular Diagnosis

64. Statin and myositis

65. Autoimmunity and primary immunodeficiency


No. of pages:
© Academic Press 2019
Academic Press
Paperback ISBN:

About the Editor

Carlo Perricone

Dr. Carlo Perricone, is a ECR in autoimmune diseases, Born in Rome on 19 April 1984. 'Surgeon Specialist in Rheumatology, has a Ph.D. in Immunological Sciences, hematology, and Rheumatics at Sapienza University of Rome. He received with honors the Master Degree in Medicine and Surgery in July 2007 at the University of Rome

Affiliations and Expertise

Sapienza University of Rome | la sapienza, Department of Internal and Specialized Medicine, Rome, Italy

Yehuda Shoenfeld

Yehuda Shoenfeld

Prof. Yehuda Shoenfeld is the founder and head of the Zabludowicz Center for Autoimmune Diseases, at the Sheba Medical Center which is affiliated to the Sackler Faculty of Medicine in Tel-Aviv University, in Israel. Dr. Shoenfeld is the Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases at the Tel-Aviv University.

His clinical and scientific works focus on autoimmune and rheumatic diseases, and he has published more than 1750 papers in journals such as New Eng J Med, Nature, Lancet, Proc Nat Acad Scie, J Clin Invest, J Immunol, Blood, FASEB, J Exp Med, Circulation, Cancer and others. His articles have had over 35,000 citations. He has written more than three hundred and fifty chapters in books, and has authored and edited 25 books, some of which became cornerstones in science and clinical practice, such as "The Mosaic of Autoimmunity", "Infections and Autoimmunity" and the textbook "Autoantibodies" and "Diagnostic criteria of autoimmune diseases", all of which were published by Elsevier and sold by the thousands.

He is on the editorial board of 43 journals in the field of rheumatology and autoimmunity and is the founder and the editor of the IMAJ (Israel Medical Association Journal) the representative journal of science and medicine in the English language in Israel, and also is the founder and Editor of the "Autoimmunity Reviews" (Elsevier) (Impact factor 7.9) and Co-Editor of "Journal of Autoimmunity" (Impact factor 8.1). He has organized over 20 international congresses in autoimmunity.

Prof. Shoenfeld received the EULAR prize in 2005, in Vienna, Austria: "The infectious etiology of anti-phospholipid syndrome". He has received a gold medal from the Slovak Society of Physicians for his contribution to Israel – Slovakia collaboration (March 2006), and is honorary member of the Hungarian Association of Rheumatology. In UC Davis, USA, Dr. Shoenfeld received the Nelson's Prize for Humanity and Science for 2008. In 2009 he was honored as Doctoris Honoris Causa, from Debrecen University (Hungary), and from 2009 he is honorary member of the Slovenian National Academy of Sciences. He has recently been awarded a Life Contribution Prize in Internal Medicine in Israel, 2012 as well as the ACR Master Award in 2013.

Prof. Shoenfeld has educated a long list of students (>25) being heads of departments and institutes.

Affiliations and Expertise

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Affiliate of Tel-Aviv University, Israel

Ratings and Reviews