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The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases.
An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis.
- Highlights the concept of the mosaic of autoimmune manifestations
- Includes new visions on unsuspected molecules
- Provides updated knowledge to physicians helping patients with autoimmune diseases
- Presents thorough, up-to-date information on specific diseases, along with clinical applications
Researchers and physicians in immunology, autoimmune diseases, genetics, virologists and molecular biologists. Researchers, clinicians, clinical investigators, pathologists, medical students, and graduate students in the biomedical sciences, as well as basic scientists in such fields as immunology, rheumatology, genetics, cell biology and molecular and microbiology
1. The history of the mosaic of autoimmunity
2. The novel aspects on the mosaic of autoimmunity
Cellular and molecular mechanisms
3. B cells
5. T cells
6. Th17 cells
7. NK cells
8. Dendritic cells
14. Post-translational modifications
15. Cytokines and chemokines
17. Diagnostic: laboratory
18. Diagnostic: imaging
The classical factors associated with autoimmunity
21. Infections: Viruses and bacteria
The novel environmental factors associated with autoimmunity
25. Vitamin D
26. Vitamin D pregnancy and autoimmunity
28. Breast feeding
31. Diet: spicy food and fatty acids
32. Diet: gluten
33. Psychological stress
36. Physical activity
42. Paraneoplastic syndromes
Classical autoimmune diseases
46. RA and inflammatory arthritides
47. PsA and Spondyloarthropathies
48. MS, MG and other neurological disorders
49. Systemic slcerosis
51. ASIA syndrome
52. Reproductive failure
53. Accelerated atherosclerosis
54. New autoimmune diseases
Treatment of autoimmune diseases
57. Personalized Medicine
58. Biologics and Biosimilars
59. Small molecules
61. Novel therapies and IVIg
62. Autoimmune and allergic disease
63. EBV Molecular Diagnosis
64. Statin and myositis
65. Autoimmunity and primary immunodeficiency
- No. of pages:
- © Academic Press 2019
- 8th February 2019
- Academic Press
- eBook ISBN:
- Paperback ISBN:
Dr. Carlo Perricone, is a ECR in autoimmune diseases, Born in Rome on 19 April 1984. 'Surgeon Specialist in Rheumatology, has a Ph.D. in Immunological Sciences, hematology, and Rheumatics at Sapienza University of Rome. He received with honors the Master Degree in Medicine and Surgery in July 2007 at the University of Rome
Sapienza University of Rome | La Sapienza, Department of Internal and Specialized Medicine, Rome, Italy
President of the Center for Autoimmune diseases (Present). Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases in Tel-Aviv University (since 2002 – Present). Emeritus Professor of the Sackler School of Medicine in Tel-Aviv University, and teaches medical studies and MSc, & PhD students (since 1985). Prof. Shoenfeld edited series of Textbooks entailing "The Mosaic of Autoimmunity", Textbook on "Autoantibodies", "Infection and autoimmunity", and "Diagnostic criteria of Autoimmune Diseases".(Elsevier Pub.) On 36 Editorial Boards, and the organizer of more than 25 international congresses on Autoimmunity. Author of > 2000 peer review papers reported in the field of autoimmunity and internal medicine. More than 65,000 citations.
Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Affiliate of Tel-Aviv University, Israel
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