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Mosaic of Autoimmunity - 1st Edition - ISBN: 9780128143070, 9780128143087

Mosaic of Autoimmunity

1st Edition

The Novel Factors of Autoimmune Diseases

Editors: Carlo Perricone Yehuda Shoenfeld
eBook ISBN: 9780128143087
Paperback ISBN: 9780128143070
Imprint: Academic Press
Published Date: 8th February 2019
Page Count: 728
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The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases.

An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis.

Key Features

  • Highlights the concept of the mosaic of autoimmune manifestations
  • Includes new visions on unsuspected molecules
  • Provides updated knowledge to physicians helping patients with autoimmune diseases
  • Presents thorough, up-to-date information on specific diseases, along with clinical applications


Researchers and physicians in immunology, autoimmune diseases, genetics, virologists and molecular biologists. Researchers, clinicians, clinical investigators, pathologists, medical students, and graduate students in the biomedical sciences, as well as basic scientists in such fields as immunology, rheumatology, genetics, cell biology and molecular and microbiology

Table of Contents

1. The history of the mosaic of autoimmunity
2. The novel aspects on the mosaic of autoimmunity 

Cellular and molecular mechanisms
3. B cells
4. B-reg 
5. T cells
6. Th17 cells
7. NK cells
8. Dendritic cells
9. Complement
10. Autoantibodies
11. Anti-DSF70
12. Genetic
13. Epigenetic
14. Post-translational modifications
15. Cytokines and chemokines
16. Autophagy
17. Diagnostic: laboratory 
18. Diagnostic: imaging

The classical factors associated with autoimmunity
19. Hormones
20. Microbiota
21. Infections: Viruses and bacteria

The novel environmental factors associated with autoimmunity
22. Geo-epidemiology
23. Seasonality
24. UV
25. Vitamin D
26. Vitamin D pregnancy and autoimmunity
27. Smell
28. Breast feeding
29. Vaccines
30. Silicone
31. Diet: spicy food and fatty acids
32. Diet: gluten
33. Psychological stress
34. Coffee
35. Obesity
36. Physical activity
37. Smoke
38. Cannabis
39. Bisphenol
40. Prolactin

Peculiar aspects
41. Cancer
42. Paraneoplastic syndromes

Classical autoimmune diseases
43. SLE
44. APS
45. CAPS
46. RA and inflammatory arthritides
47. PsA and Spondyloarthropathies
48. MS, MG and other neurological disorders
49. Systemic slcerosis
50. Sjogren
51. ASIA syndrome
52. Reproductive failure
53. Accelerated atherosclerosis
54. New autoimmune diseases

Treatment of autoimmune diseases
55. Neuroimmunology
56. Vasculitis
57. Personalized Medicine
58. Biologics and Biosimilars
59. Small molecules
60. Helminthes
61. Novel therapies and IVIg
62. Autoimmune and allergic disease
63. EBV Molecular Diagnosis
64. Statin and myositis
65. Autoimmunity and primary immunodeficiency


No. of pages:
© Academic Press 2019
8th February 2019
Academic Press
eBook ISBN:
Paperback ISBN:

About the Editors

Carlo Perricone

Dr. Carlo Perricone, is a ECR in autoimmune diseases, Born in Rome on 19 April 1984. 'Surgeon Specialist in Rheumatology, has a Ph.D. in Immunological Sciences, hematology, and Rheumatics at Sapienza University of Rome. He received with honors the Master Degree in Medicine and Surgery in July 2007 at the University of Rome

Affiliations and Expertise

Sapienza University of Rome | La Sapienza, Department of Internal and Specialized Medicine, Rome, Italy

Yehuda Shoenfeld

Yehuda Shoenfeld

President of the Center for Autoimmune diseases (Present). Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases in Tel-Aviv University (since 2002 – Present). Emeritus Professor of the Sackler School of Medicine in Tel-Aviv University, and teaches medical studies and MSc, & PhD students (since 1985). Prof. Shoenfeld edited series of Textbooks entailing "The Mosaic of Autoimmunity", Textbook on "Autoantibodies", "Infection and autoimmunity", and "Diagnostic criteria of Autoimmune Diseases".(Elsevier Pub.) On 36 Editorial Boards, and the organizer of more than 25 international congresses on Autoimmunity. Author of > 2000 peer review papers reported in the field of autoimmunity and internal medicine. More than 65,000 citations.

Affiliations and Expertise

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Affiliate of Tel-Aviv University, Israel

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