Mosaic of Autoimmunity

Mosaic of Autoimmunity

The Novel Factors of Autoimmune Diseases

1st Edition - February 8, 2019

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  • Editors: Carlo Perricone, Yehuda Shoenfeld
  • eBook ISBN: 9780128143087
  • Paperback ISBN: 9780128143070

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The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases. An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis.

Key Features

  • Highlights the concept of the mosaic of autoimmune manifestations
  • Includes new visions on unsuspected molecules
  • Provides updated knowledge to physicians helping patients with autoimmune diseases
  • Presents thorough, up-to-date information on specific diseases, along with clinical applications


Researchers and physicians in immunology, autoimmune diseases, genetics, virologists and molecular biologists. Researchers, clinicians, clinical investigators, pathologists, medical students, and graduate students in the biomedical sciences, as well as basic scientists in such fields as immunology, rheumatology, genetics, cell biology and molecular and microbiology

Table of Contents

  • Introduction
    1. The history of the mosaic of autoimmunity
    2. The novel aspects on the mosaic of autoimmunity 

    Cellular and molecular mechanisms
    3. B cells
    4. B-reg 
    5. T cells
    6. Th17 cells
    7. NK cells
    8. Dendritic cells
    9. Complement
    10. Autoantibodies
    11. Anti-DSF70
    12. Genetic
    13. Epigenetic
    14. Post-translational modifications
    15. Cytokines and chemokines
    16. Autophagy
    17. Diagnostic: laboratory 
    18. Diagnostic: imaging

    The classical factors associated with autoimmunity
    19. Hormones
    20. Microbiota
    21. Infections: Viruses and bacteria

    The novel environmental factors associated with autoimmunity
    22. Geo-epidemiology
    23. Seasonality
    24. UV
    25. Vitamin D
    26. Vitamin D pregnancy and autoimmunity
    27. Smell
    28. Breast feeding
    29. Vaccines
    30. Silicone
    31. Diet: spicy food and fatty acids
    32. Diet: gluten
    33. Psychological stress
    34. Coffee
    35. Obesity
    36. Physical activity
    37. Smoke
    38. Cannabis
    39. Bisphenol
    40. Prolactin

    Peculiar aspects
    41. Cancer
    42. Paraneoplastic syndromes

    Classical autoimmune diseases
    43. SLE
    44. APS
    45. CAPS
    46. RA and inflammatory arthritides
    47. PsA and Spondyloarthropathies
    48. MS, MG and other neurological disorders
    49. Systemic slcerosis
    50. Sjogren
    51. ASIA syndrome
    52. Reproductive failure
    53. Accelerated atherosclerosis
    54. New autoimmune diseases

    Treatment of autoimmune diseases
    55. Neuroimmunology
    56. Vasculitis
    57. Personalized Medicine
    58. Biologics and Biosimilars
    59. Small molecules
    60. Helminthes
    61. Novel therapies and IVIg
    62. Autoimmune and allergic disease
    63. EBV Molecular Diagnosis
    64. Statin and myositis
    65. Autoimmunity and primary immunodeficiency

Product details

  • No. of pages: 728
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: February 8, 2019
  • Imprint: Academic Press
  • eBook ISBN: 9780128143087
  • Paperback ISBN: 9780128143070

About the Editors

Carlo Perricone

Dr. Carlo Perricone, is a ECR in autoimmune diseases, Born in Rome on 19 April 1984. 'Surgeon Specialist in Rheumatology, has a Ph.D. in Immunological Sciences, hematology, and Rheumatics at Sapienza University of Rome. He received with honors the Master Degree in Medicine and Surgery in July 2007 at the University of Rome

Affiliations and Expertise

Sapienza University of Rome | La Sapienza, Department of Internal and Specialized Medicine, Rome, Italy

Yehuda Shoenfeld

Yehuda Shoenfeld
Professor Yehuda Shoenfeld is the President of the Center for Autoimmune Diseases (present), incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases in Tel Aviv University (since 2002–Present), Emeritus Professor of the Sackler School of Medicine in Tel Aviv University and teaches medical studies and MSc and PhD students (since 1985). Prof. Shoenfeld has edited a series of textbooks entailing "The Mosaic of Autoimmunity," "Autoantibodies," "Infection and Autoimmunity," and "Diagnostic Criteria of Autoimmune Diseases" (Elsevier Pub.). He has served on 36 editorial boards and is the organizer of more than 25 international congresses on autoimmunity. He is the author of > 2000 peer-reviewed papers reported in the field of autoimmunity and internal medicine. More than 65,000 citations.

Affiliations and Expertise

President of the Center for Autoimmune diseases (Present). Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases in Tel-Aviv University, Israel

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