Monoclonal Antibodies - 1st Edition - ISBN: 9780123348807, 9780323155434

Monoclonal Antibodies

1st Edition

Probes for The Study of Autoimmunity and Immunodeficiency

Editors: Barton Haynes
eBook ISBN: 9780323155434
Imprint: Academic Press
Published Date: 28th January 1983
Page Count: 336
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Monoclonal Antibodies: Probes for the Study of Autoimmunity and Immunodeficiency focuses on the research/studies using monoclonal antibodies in two major classes of diseases, which are autoimmunity and immunodeficiency. The book comprises of 14 chapters; each is written in detail and includes studies using monoclonal antibodies of the pathogenesis and treatment of various types of diseases of disordered immunity. The first chapter presents an overview of the use of monoclonal antibodies in the study of autoimmunity and immunodeficiency. The following chapters focus on other monoclonal reagents and their uses and applications to different diseases. The last four chapters discuss specific classic endocrine diseases in reference to discoveries regarding the beginning of autoimmune mechanisms and pathophysiology. Because the book is technically written, students with background in biology, microbiology, and biochemistry are most likely the target audience of this book. Other parties in the fields of immunology, clinical medicine, pathology, and physiology will also find this book a good reference material.

Table of Contents



1. Use of Monoclonal Antibodies in the Study of Autoimmunity and Immunodeficiency

I. Introduction

II. Differentiation of T Lymphocytes

III. Functions of Mature T Lymphocyte Subsets

IV. Clinical Disorders of T Lymphocytes

V. Conclusion


2. Monoclonal Antilymphocyte Antibodies: Probes for the Study of the Regulation of Hematopoiesis and Potential Clinical Applications

I. Introduction

II. Identification of Specific Lymphocyte Cell-Surface Molecules

III. Effect of T Cells on Hematopoiesis

IV. Clinical Applications

V. Summary


3. Use of Monoclonal Antibodies to Identify Cell-Surface Antigens of Human Neuroendocrine Thymic Epithelium

I. Introduction

II. Identification of Human and Rodent Endocrine Thymic Epithelium Using Tetanus Toxin and Monoclonal Antibody A2B5

III. A Human Thymic Epithelial Antigen Acquired during Ontogeny Recognized by a Monoclonal Antibody against Human T Cell Leukemia Virus p19

IV. Discussion

V. Summary


4. Role of Prethymic and Intrathymic Elements in the Induction of T Cell Tolerance to Allogeneic Determinants: The Thymus Is Not Sufficient to Prevent Autoreactivity

I. Introduction

II. General Experimental Approach

III. Intrathymic T Cells Are Specifically Tolerized to the Allogeneic MHC Encoded Determinants Expressed by Radioresistant Thymic Cells

IV. Peripheral T Cells Are Not Tolerant to Allogeneic Thymic Elements

V. Pre-T Cells Express Anti-MHC Receptors Prior to Their Entry into the Thymus, Permitting the Induction of Specific Tolerance in the Prethymic Compartment

VI. The Prethymic Compartment Tolerizes to MHC Alloantigens, but Not to Non-MHC Alloantigens: Evidence That Pre-T Cells Express Anti-MHC Receptors

VII. Discussion


5. Studies of Patients with Severe Cellular and Humoral Immunodeficiency Diseases Using Monoclonal Antibodies

I. Introduction

II. Lymphocyte Subpopulations in Normal Donors

III. Lymphocyte Subpopulation in Patients with Severe Cellular and/or Humoral Immunodeficiency

IV. Correlation between Phenotypes and Function

V. Lymphocyte Markers and Function after Bone Marrow Transplantation

VI. Discussion


6. The Use of Monoclonal Antibodies to Characterize Human Natural Killer Cell Ontogeny and Function

I. Introduction

II. Monoclonal Antibodies Reactive with Human Natural Killer Cells

III. Human Natural Killer Cell Ontogeny and Function Defined by Monoclonal Antibodies

IV. Conclusion


7. Utilization of Monoclonal Antibodies in the Study of Cell-Surface Antigens on Human B Lymphocytes

I. Introduction

II. Serologic Characterization of BA-1, BA-2, and BA-3

III. Immunochemical Characterization of the Cell-Surface Molecules Recognized by BA-1, BA-2, and BA-3

IV. Utilization of BA-1, BA-2, and BA-3 in the Study of Human Disease

V. Summary


8. The Establishment of Human-Human and Human-Mouse B Cell Hybrids and Their Use in the Study of B Cell Activation

I. Introduction

II. Historical Perspective

III. Production of Hybrid Cell Lines Secreting Human Monoclonal Antibodies

IV. Optimization of Conditions for the Production of Heterohybridomas Secreting Human Monoclonal Antibodies of Predefined Specificities

V. Production of Human-Mouse Heterohybridomas Secreting Human Monoclonal Antibodies of Predetermined Specificities

VI. Use of Human-Human and Human-Mouse B Cell Hybrids in the Study of Human B Cell Activation and Immunoregulation

VII. Conclusion


9. Murine Hybridomas Producing Autoantibodies from MRL Mice

I. Introduction

II. Autoantibody Production in Human and Murine Systemic Lupus Erythematosus

III. Monoclonal Autoantibodies from MRL Mice

IV. Summary


10. Dual Recognition by Coupled Receptors in a Model of T Lymphocyte Differentiation

I. Introduction

II. Studies in Animal Systems

III. Human T Cell Differentiation Antigens

IV. A Model of T Cell Antigen Receptors

V. Prethymic Differentiation

VI. Thymic Differentiation

VII. Postthymic Differentiation

VIII. Conclusion


11. Type I Diabetes: Autoimmunity and Immunodeficiency

I. Introduction

II. Islet Cell Antibodies

III. The BB Rat

IV. Cellular Abnormalities of Type I Diabetes in Man

V. Immunotherapy

VI. Summary


12. Autoimmune Thyroid Disease Studied with Monoclonal Antibodies to the Thyrotropin Receptor

I. The Thyrotropin Receptor and Autoimmune Disease

II. Thyrotropin Receptor Structure

III. Monoclonal Antibodies to the TSH Receptor

IV. Summary


13. Use of Monoclonal Antibodies in the Study of Myasthenia Gravis

I. Rationale for Use of Monoclonal Antibodies to Acetylcholine Receptors to Study Myasthenia Gravis

II. Antigenic Structure of Acetylcholine Receptor

III. Use of Monoclonal Antibodies to Determine Specificities of Autoantibodies to Acetylcholine Receptors in Sera of Myasthenia Gravis Patients

IV. Use of Monoclonal Antibodies as Model Autoantibodies to Determine Pathological Effects of Antibodies of Various Specificities

V. Use of Monoclonal Antibodies for Therapy of Myasthenia Gravis

VI. Concluding Remarks


14. Peripheral T Cell Circulatory Kinetics and Intrathymic T Cell Differentiation in Myasthenia Gravis

I. Introduction

II. Peripheral Blood Lymphocyte Subsets in Myasthenia Gravis

III. Intrathymic T Cell Maturation in MG Patients Compared with Normals

IV. Discussion




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© Academic Press 1983
Academic Press
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About the Editor

Barton Haynes

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