Monoclonal Antibodies

Monoclonal Antibodies

Probes for The Study of Autoimmunity and Immunodeficiency

1st Edition - January 28, 1983

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  • Editor: Barton Haynes
  • eBook ISBN: 9780323155434

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Description

Monoclonal Antibodies: Probes for the Study of Autoimmunity and Immunodeficiency focuses on the research/studies using monoclonal antibodies in two major classes of diseases, which are autoimmunity and immunodeficiency. The book comprises of 14 chapters; each is written in detail and includes studies using monoclonal antibodies of the pathogenesis and treatment of various types of diseases of disordered immunity. The first chapter presents an overview of the use of monoclonal antibodies in the study of autoimmunity and immunodeficiency. The following chapters focus on other monoclonal reagents and their uses and applications to different diseases. The last four chapters discuss specific classic endocrine diseases in reference to discoveries regarding the beginning of autoimmune mechanisms and pathophysiology. Because the book is technically written, students with background in biology, microbiology, and biochemistry are most likely the target audience of this book. Other parties in the fields of immunology, clinical medicine, pathology, and physiology will also find this book a good reference material.

Table of Contents


  • Contributors

    Preface

    1. Use of Monoclonal Antibodies in the Study of Autoimmunity and Immunodeficiency

    I. Introduction

    II. Differentiation of T Lymphocytes

    III. Functions of Mature T Lymphocyte Subsets

    IV. Clinical Disorders of T Lymphocytes

    V. Conclusion

    References

    2. Monoclonal Antilymphocyte Antibodies: Probes for the Study of the Regulation of Hematopoiesis and Potential Clinical Applications

    I. Introduction

    II. Identification of Specific Lymphocyte Cell-Surface Molecules

    III. Effect of T Cells on Hematopoiesis

    IV. Clinical Applications

    V. Summary

    References

    3. Use of Monoclonal Antibodies to Identify Cell-Surface Antigens of Human Neuroendocrine Thymic Epithelium

    I. Introduction

    II. Identification of Human and Rodent Endocrine Thymic Epithelium Using Tetanus Toxin and Monoclonal Antibody A2B5

    III. A Human Thymic Epithelial Antigen Acquired during Ontogeny Recognized by a Monoclonal Antibody against Human T Cell Leukemia Virus p19

    IV. Discussion

    V. Summary

    References

    4. Role of Prethymic and Intrathymic Elements in the Induction of T Cell Tolerance to Allogeneic Determinants: The Thymus Is Not Sufficient to Prevent Autoreactivity

    I. Introduction

    II. General Experimental Approach

    III. Intrathymic T Cells Are Specifically Tolerized to the Allogeneic MHC Encoded Determinants Expressed by Radioresistant Thymic Cells

    IV. Peripheral T Cells Are Not Tolerant to Allogeneic Thymic Elements

    V. Pre-T Cells Express Anti-MHC Receptors Prior to Their Entry into the Thymus, Permitting the Induction of Specific Tolerance in the Prethymic Compartment

    VI. The Prethymic Compartment Tolerizes to MHC Alloantigens, but Not to Non-MHC Alloantigens: Evidence That Pre-T Cells Express Anti-MHC Receptors

    VII. Discussion

    References

    5. Studies of Patients with Severe Cellular and Humoral Immunodeficiency Diseases Using Monoclonal Antibodies

    I. Introduction

    II. Lymphocyte Subpopulations in Normal Donors

    III. Lymphocyte Subpopulation in Patients with Severe Cellular and/or Humoral Immunodeficiency

    IV. Correlation between Phenotypes and Function

    V. Lymphocyte Markers and Function after Bone Marrow Transplantation

    VI. Discussion

    References

    6. The Use of Monoclonal Antibodies to Characterize Human Natural Killer Cell Ontogeny and Function

    I. Introduction

    II. Monoclonal Antibodies Reactive with Human Natural Killer Cells

    III. Human Natural Killer Cell Ontogeny and Function Defined by Monoclonal Antibodies

    IV. Conclusion

    References

    7. Utilization of Monoclonal Antibodies in the Study of Cell-Surface Antigens on Human B Lymphocytes

    I. Introduction

    II. Serologic Characterization of BA-1, BA-2, and BA-3

    III. Immunochemical Characterization of the Cell-Surface Molecules Recognized by BA-1, BA-2, and BA-3

    IV. Utilization of BA-1, BA-2, and BA-3 in the Study of Human Disease

    V. Summary

    References

    8. The Establishment of Human-Human and Human-Mouse B Cell Hybrids and Their Use in the Study of B Cell Activation

    I. Introduction

    II. Historical Perspective

    III. Production of Hybrid Cell Lines Secreting Human Monoclonal Antibodies

    IV. Optimization of Conditions for the Production of Heterohybridomas Secreting Human Monoclonal Antibodies of Predefined Specificities

    V. Production of Human-Mouse Heterohybridomas Secreting Human Monoclonal Antibodies of Predetermined Specificities

    VI. Use of Human-Human and Human-Mouse B Cell Hybrids in the Study of Human B Cell Activation and Immunoregulation

    VII. Conclusion

    References

    9. Murine Hybridomas Producing Autoantibodies from MRL Mice

    I. Introduction

    II. Autoantibody Production in Human and Murine Systemic Lupus Erythematosus

    III. Monoclonal Autoantibodies from MRL Mice

    IV. Summary

    References

    10. Dual Recognition by Coupled Receptors in a Model of T Lymphocyte Differentiation

    I. Introduction

    II. Studies in Animal Systems

    III. Human T Cell Differentiation Antigens

    IV. A Model of T Cell Antigen Receptors

    V. Prethymic Differentiation

    VI. Thymic Differentiation

    VII. Postthymic Differentiation

    VIII. Conclusion

    References

    11. Type I Diabetes: Autoimmunity and Immunodeficiency

    I. Introduction

    II. Islet Cell Antibodies

    III. The BB Rat

    IV. Cellular Abnormalities of Type I Diabetes in Man

    V. Immunotherapy

    VI. Summary

    References

    12. Autoimmune Thyroid Disease Studied with Monoclonal Antibodies to the Thyrotropin Receptor

    I. The Thyrotropin Receptor and Autoimmune Disease

    II. Thyrotropin Receptor Structure

    III. Monoclonal Antibodies to the TSH Receptor

    IV. Summary

    References

    13. Use of Monoclonal Antibodies in the Study of Myasthenia Gravis

    I. Rationale for Use of Monoclonal Antibodies to Acetylcholine Receptors to Study Myasthenia Gravis

    II. Antigenic Structure of Acetylcholine Receptor

    III. Use of Monoclonal Antibodies to Determine Specificities of Autoantibodies to Acetylcholine Receptors in Sera of Myasthenia Gravis Patients

    IV. Use of Monoclonal Antibodies as Model Autoantibodies to Determine Pathological Effects of Antibodies of Various Specificities

    V. Use of Monoclonal Antibodies for Therapy of Myasthenia Gravis

    VI. Concluding Remarks

    References

    14. Peripheral T Cell Circulatory Kinetics and Intrathymic T Cell Differentiation in Myasthenia Gravis

    I. Introduction

    II. Peripheral Blood Lymphocyte Subsets in Myasthenia Gravis

    III. Intrathymic T Cell Maturation in MG Patients Compared with Normals

    IV. Discussion

    References

    Index


Product details

  • No. of pages: 336
  • Language: English
  • Copyright: © Academic Press 1983
  • Published: January 28, 1983
  • Imprint: Academic Press
  • eBook ISBN: 9780323155434

About the Editor

Barton Haynes

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