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Monoamine Oxidases and Their Selective Inhibition, Volume IV, documents the proceedings of the 3rd Congress of the Hungarian Pharmacological Society held in Budapest, 1979. The discovery of the selective monoamine oxidase (MAO) inhibitors, such as clorgyline and deprenyl, has given a new impetus to MAO research as well as to the clinical applicability of these compounds. This volume contains 21 papers by researchers and clinicians from eight different countries. It begins with papers on the pharmacological effects and the biochemical mode of actions of deprenyl as well as some other new selective inhibitors. This is followed by communications concerning the biochemical methods applied in the study of the nature of MAO in the mitochondrial membrane. Finally, the neurologists provide an account of their experience with the clinical application of deprenyl, and other inhibitors in Parkinsonian patients. They also discuss the essential role of the dopaminergic mechanism with respect to the disease.
List of Contributors
The Analysis of Amine Oxidases by the Use of Enzyme Inhibitors. Introductory Remarks
Recent Clinical Studies in Monoamine Oxidase Inhibition
Structure-Activity Relationship of Selective Inhibitors of MAO-B
Selective Inhibitors of MAO-B with Different Pharmacological Profiles
Is Methamphetamine a Therapeutically Important Metabolite of Deprenyl?
Monoamine Oxidase Inhibitors (MAOIs) and Food Intake
Deprenyl Inhibits Dopamine Uptake in the Rat Striatum In Vivo
Gel Chromatography of Phenylalkylamines
Human Platelet MAO-B - One Single Enzyme Form?
Suicide Inhibitors of Monoamine Oxidase
Purification and Properties of the Phenylhydrazine Adducts of Trimethylamine Dehydrogenase and of Monoamine Oxidase
Selective Inhibition of MAO Induced by New Antidepressant Derivatives of Pyrazine-Indole
Selective Inhibition of Monoamine Oxidase Type A by Some 4-Aminophenylisopropylamine Compounds
Thiol Compounds and Monoamine Oxidase in Rat Liver and Brain
Enzyme Stimulation and Inhibition as an Approach to Therapy for Parkinson's Disease
Pharmacotherapy of Parkinsonism
Clinical Experience in Extrapyramidal Disease with Selective MAOB Inhibitor, Deprenyl
(-)Deprenyl Has a Band of Selectivity for Therapeutic Action
The Action of L-Deprenyl in L-Dopa Treated Parkinsonian Patients, with Special Reference to the "on-off" Effect
Long-Term L-Deprenyl Treatment of on-off Phenomena in Parkinson's Disease
Late Kinetic Effects of L-Dopa and Combined Therapy in Parkinson's Disease
- No. of pages:
- © Pergamon 1980
- 1st January 1980
- eBook ISBN: