Monoamine Oxidases and Their Selective Inhibition - 1st Edition - ISBN: 9780080263892, 9781483147864

Monoamine Oxidases and Their Selective Inhibition

1st Edition

Proceedings of the 3rd Congress of the Hungarian Pharmacological Society, Budapest, 1979

Editors: K. Magyar
eBook ISBN: 9781483147864
Imprint: Pergamon
Published Date: 1st January 1980
Page Count: 170
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Description

Monoamine Oxidases and Their Selective Inhibition, Volume IV, documents the proceedings of the 3rd Congress of the Hungarian Pharmacological Society held in Budapest, 1979. The discovery of the selective monoamine oxidase (MAO) inhibitors, such as clorgyline and deprenyl, has given a new impetus to MAO research as well as to the clinical applicability of these compounds. This volume contains 21 papers by researchers and clinicians from eight different countries. It begins with papers on the pharmacological effects and the biochemical mode of actions of deprenyl as well as some other new selective inhibitors. This is followed by communications concerning the biochemical methods applied in the study of the nature of MAO in the mitochondrial membrane. Finally, the neurologists provide an account of their experience with the clinical application of deprenyl, and other inhibitors in Parkinsonian patients. They also discuss the essential role of the dopaminergic mechanism with respect to the disease.

Table of Contents


Preface

List of Contributors

The Analysis of Amine Oxidases by the Use of Enzyme Inhibitors. Introductory Remarks

Recent Clinical Studies in Monoamine Oxidase Inhibition

Structure-Activity Relationship of Selective Inhibitors of MAO-B

Selective Inhibitors of MAO-B with Different Pharmacological Profiles

Is Methamphetamine a Therapeutically Important Metabolite of Deprenyl?

Monoamine Oxidase Inhibitors (MAOIs) and Food Intake

Deprenyl Inhibits Dopamine Uptake in the Rat Striatum In Vivo

Gel Chromatography of Phenylalkylamines

Human Platelet MAO-B - One Single Enzyme Form?

Suicide Inhibitors of Monoamine Oxidase

Purification and Properties of the Phenylhydrazine Adducts of Trimethylamine Dehydrogenase and of Monoamine Oxidase

Selective Inhibition of MAO Induced by New Antidepressant Derivatives of Pyrazine-Indole

Selective Inhibition of Monoamine Oxidase Type A by Some 4-Aminophenylisopropylamine Compounds

Thiol Compounds and Monoamine Oxidase in Rat Liver and Brain

Enzyme Stimulation and Inhibition as an Approach to Therapy for Parkinson's Disease

Pharmacotherapy of Parkinsonism

Clinical Experience in Extrapyramidal Disease with Selective MAOB Inhibitor, Deprenyl

(-)Deprenyl Has a Band of Selectivity for Therapeutic Action

The Action of L-Deprenyl in L-Dopa Treated Parkinsonian Patients, with Special Reference to the "on-off" Effect

Long-Term L-Deprenyl Treatment of on-off Phenomena in Parkinson's Disease

Late Kinetic Effects of L-Dopa and Combined Therapy in Parkinson's Disease

Subject Index

Details

No. of pages:
170
Language:
English
Copyright:
© Pergamon 1980
Published:
Imprint:
Pergamon
eBook ISBN:
9781483147864

About the Editor

K. Magyar