Description

Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. In this volume, invited experts provide authoritative reviews on various aspects of Monoamine Oxidase and its Inhibitors.

Key Features

  • Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research
  • Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered
  • All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Readership

Neuroscientists, Neurologists, Neurobiologists

Table of Contents

CONTRIBUTORS

PREFACE

STRUCTURAL PROPERTIES OF HUMAN MONOAMINE OXIDASES A AND B

I. Introduction

II. Crystallization of Purified MAO-B and MAO-A

III. Structure of Human MAO-B

IV. Structure of Human MAO-A and Comparison with Rat MAO-A

V. Insights into Membrane Binding of MAO-A and MAO-B

VI. Structural Basis for Inhibitor-Binding Specificities of MAO-A and MAO-B

VII. Conclusions and Future Prospects

BEHAVIORAL OUTCOMES OF MONOAMINE OXIDASE DEFICIENCY: PRECLINICAL AND CLINICAL EVIDENCE

I. General Characteristics of Monoamine Oxidase

II. Phenotypical Outcomes of MAO-A Deficit

III. Phenotypical Outcomes of MAO-B Deficit

IV. Phenotypical Outcomes of Combined MAO-A and MAO-B Deficit

V. Conclusions

KINETIC BEHAVIOR AND REVERSIBLE INHIBITION OF MONOAMINE OXIDASES—ENZYMES THAT MANY WANT DEAD

I. Introduction

II. Some Basics of Enzyme Inhibition

III. Systems Behavior of Reversible Inhibitors

IV. How Can Kinetic Studies of MAO Help?

V. Tight-Binding Inhibitors

VI. Recovery from Inhibition

VII. Conclusions

THE PHARMACOLOGY OF SELEGILINE

I. Historical Aspects of Selegiline

II. The Multiplicity of Monoamine Oxidase

III. The Pharmacology of MAO-B Inhibition

IV. Structure–Activity Relationship Studies

V. Effects of Selegiline Not Relating to MAO-B Inhibition

VI. Antiapoptotic Effect of Selegiline

VII. Pharmacokinetics of Selegiline

VIII. Metabolism of Selegiline

IX. The Role of Birkmayer and His Group in the Introduction of Selegiline in the Therapy of Parkinson’s Disease

X. Future Perspectives

XI. Overall Conclusions

TYPE A MONOAMINE OXIDASE REGULATES LIFE AND DEATH OF NEURONS IN NEURODEGENERATION AND NEUROPROTECTION

I. Introduction

II. Type A and B MAO in Cell Death of Neurons

Details

No. of pages:
320
Language:
English
Copyright:
© 2011
Published:
Imprint:
Academic Press
Electronic ISBN:
9780123864680
Print ISBN:
9780123864673
Print ISBN:
9780323163811

About the serial-volume-editors

Reviews

"Invaluable reading." - NATURE
"A valuable addition to any library as current reference material for advanced undergraduates, graduate students, and professional scientists."
- CHOICE