Monoamine Oxidases and their Inhibitors - 1st Edition - ISBN: 9780123864673, 9780123864680

Monoamine Oxidases and their Inhibitors, Volume 100

1st Edition

Serial Volume Editors: Moussa Youdim Peter Riederer
eBook ISBN: 9780123864680
Hardcover ISBN: 9780123864673
Imprint: Academic Press
Published Date: 10th October 2011
Page Count: 320
Tax/VAT will be calculated at check-out Price includes VAT (GST)
206.32
204.00
124.00
155.00
Unavailable
Price includes VAT (GST)
DRM-Free

Easy - Download and start reading immediately. There’s no activation process to access eBooks; all eBooks are fully searchable, and enabled for copying, pasting, and printing.

Flexible - Read on multiple operating systems and devices. Easily read eBooks on smart phones, computers, or any eBook readers, including Kindle.

Open - Buy once, receive and download all available eBook formats, including PDF, EPUB, and Mobi (for Kindle).

Institutional Access

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Table of Contents

CONTRIBUTORS

PREFACE

STRUCTURAL PROPERTIES OF HUMAN MONOAMINE OXIDASES A AND B

I. Introduction

II. Crystallization of Purified MAO-B and MAO-A

III. Structure of Human MAO-B

IV. Structure of Human MAO-A and Comparison with Rat MAO-A

V. Insights into Membrane Binding of MAO-A and MAO-B

VI. Structural Basis for Inhibitor-Binding Specificities of MAO-A and MAO-B

VII. Conclusions and Future Prospects

BEHAVIORAL OUTCOMES OF MONOAMINE OXIDASE DEFICIENCY: PRECLINICAL AND CLINICAL EVIDENCE

I. General Characteristics of Monoamine Oxidase

II. Phenotypical Outcomes of MAO-A Deficit

III. Phenotypical Outcomes of MAO-B Deficit

IV. Phenotypical Outcomes of Combined MAO-A and MAO-B Deficit

V. Conclusions

KINETIC BEHAVIOR AND REVERSIBLE INHIBITION OF MONOAMINE OXIDASES—ENZYMES THAT MANY WANT DEAD

I. Introduction

II. Some Basics of Enzyme Inhibition

III. Systems Behavior of Reversible Inhibitors

IV. How Can Kinetic Studies of MAO Help?

V. Tight-Binding Inhibitors

VI. Recovery from Inhibition

VII. Conclusions

THE PHARMACOLOGY OF SELEGILINE

I. Historical Aspects of Selegiline

II. The Multiplicity of Monoamine Oxidase

III. The Pharmacology of MAO-B Inhibition

IV. Structure–Activity Relationship Studies

V. Effects of Selegiline Not Relating to MAO-B Inhibition

VI. Antiapoptotic Effect of Selegiline

VII. Pharmacokinetics of Selegiline

VIII. Metabolism of Selegiline

IX. The Role of Birkmayer and His Group in the Introduction of Selegiline in the Therapy of Parkinson’s Disease

X. Future Perspectives

XI. Overall Conclusions

TYPE A MONOAMINE OXIDASE REGULATES LIFE AND DEATH OF NEURONS IN NEURODEGENERATION AND NEUROPROTECTION

I. Introduction

II. Type A and B MAO in Cell Death of Neurons

III. MAO-A in Neuroprotection by MAO-Is

IV. MAO-A in Induction of Neurotrophic Factors by MAO-Is

V. Is MAO-A the Binding Site of MAO-Is for Induction of Neuroprotective Genes?

VI. Signal Pathway for Induction of Prosurvival Genes by MAO-Is

VII. Discussion

MULTIMODAL DRUGS AND THEIR FUTURE FOR ALZHEIMER’S AND PARKINSON’S DISEASE

I. Introduction

II. Concepts in Multimodal Drug Design

III. Monoamine Oxidase as a Common Target in AD and PD

IV. Multimodal Drugs That Target MAO (1)

V. Multimodal Drugs That Target MAO (2)

VI. Multimodal Drugs That Target MAO (3)

VII. Multimodal Drugs That Target Memory and Neurogenesis

VIII. Conclusion

NEUROPROTECTIVE PROFILE OF THE MULTITARGET DRUG RASAGILINE IN PARKINSON’S DISEASE

I. Introduction

II. Multiple Activities of Rasagiline

III. The Major Metabolite of Rasagiline, 1-(R)-Aminoindan

IV. Summary and Conclusions

RASAGILINE IN PARKINSON’S DISEASE

I. Introduction

II. In Vivo and In Vitro Neuroprotective Effects of Rasagiline

III. Pharmacokinetics and Pharmacodynamics

IV. Evidence for the Symptomatic Benefits of Rasagiline in PD

V. Evidence for Disease Modification with Rasagiline in PD

VI. Adverse Effects

VII. Conclusion

SELECTIVE INHIBITORS OF MONOAMINE OXIDASE TYPE B AND THE “CHEESE EFFECT”

I. Introduction

II. Pharmacology of Tyramine

III. Mechanism of “Cheese Effect”

IV. Cardiovascular Actions of Tyramine

V. Selegiline

VI. Clinical Use of Selegiline and Cheese Effect

VII. Clinical Use of Rasagiline and Cheese Effect

VIII. Reversible Inhibitors of MAO-B

IX. Modification of L-Dopa Cardiovascular Response by Selective Inhibitors of MAO-B

X. Tyramine Content in Foods

XI. Treatment of Cheese Reaction

XII. Specific Foods

XIII. Fish Sauces

XIV. Meat

XV. Beer and Wine

XVI. Conclusions

A NOVEL ANTI-ALZHEIMER’S DISEASE DRUG, LADOSTIGIL

I. Introduction

II. The Underlying Strategy in the Design of Ladostigil

III. MAO Inhibition and Antidepressant Activity of Ladostigil

IV. ChE Inhibitory Activity of Ladostigil

V. Neuroprotective Activities of Ladostigil in Preclinical Models of Neurodegeneration

VI. Mechanism of Action of Ladostigil

VII. Summary and Future Perspectives

NOVEL MAO-B INHIBITORS

I. Introduction

II. MAO-B Inhibitors

III. Apoptosis in PD

IV. Clinical Potential of PF9601N

V. Concluding Remarks

Subject Index

Contents of recent volumes


Description

Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. In this volume, invited experts provide authoritative reviews on various aspects of Monoamine Oxidase and its Inhibitors.

Key Features

  • Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research
  • Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered
  • All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Readership

Neuroscientists, Neurologists, Neurobiologists


Details

No. of pages:
320
Language:
English
Copyright:
© Academic Press 2011
Published:
Imprint:
Academic Press
eBook ISBN:
9780123864680
Hardcover ISBN:
9780123864673

Reviews

"Invaluable reading." - NATURE
"A valuable addition to any library as current reference material for advanced undergraduates, graduate students, and professional scientists."
- CHOICE


About the Serial Volume Editors

Moussa Youdim Serial Volume Editor

Affiliations and Expertise

Eve Topf Centre of Excellence for Neurodegenerative Diseases, Hafia, Israel

Peter Riederer Serial Volume Editor

Affiliations and Expertise

University of Wurzburg, Germany