An Historical Perspective of the Development of Molecular Imprinting (H.S. Andersson, I.A. Nicholls). Introduction. Polyakov invents molecular imprinting. The contributions of Pauling and Dickey. Theories of antibody formation. Bio-imprinting in the 1940s. Dickey invents molecular imprinting. Methods for preparing molecularly imprinted silicas. The mechanism(s) of selectivity. More studies on Dickey's system - molecular footprints? An association mechanism? Objections to the association mechanism. Applications of molecularly imprinted silicas. Separation. Column chromatography. Thin layer chromatography. Structure elucidation. Catalysis. Other applications. Making money using molecular imprinting? The decline of imprinted silica research. Molecular imprinting in organic polymers. Conclusions. References.
Fundamental Aspects on the Synthesis and Characterisation of Imprinted Network Polymers (B. Sellergren, A.J. Hall). Introduction. Free radical polymerisation. Initiation. Propagation. Termination. Steady state. Chain transfer. Inhibition. Copolymerisation. Tacticity. Copolymers of divinylmonomers and monovinyl monomers. Pregel regime and kinetics. The system EDMA-MMA. The EDMA-MAA MIP system: primary structure. The EDMA-MAA MIP system: secondary structure. Build-up of the porous structure - the tertiary structure. Site stability, integrity and accessibility. Polymer porosity and swelling. Thermochemically versus photochemically initiated polymerisations. The cross-linking monomer. Extraction of template. Functional group titrations. Binding site location. Characterisation techniques for cross-linked vinyl polymers and MIPs. Elemental analysis. Gravimetric analysis. Nuclear magnetic resonance spectroscopy. Infrared spectroscopy. Fluorescence probes of network solvation. Pore structure in the dry state. Gas sorption measurements. Mercury penetration. Surface areas. Por