Molecular Pharmacology V3

Molecular Pharmacology V3

The Model of Action of Biology Active Compounds

1st Edition - January 1, 1964

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  • Editor: E.J. Ariens
  • eBook ISBN: 9780323147149

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Molecular Pharmacology: The Model of Action of Biologically Active Compounds, Volume 1 discusses the mode of action of bioactive compounds on a molecular level. This book reviews the processes that control the uptake of drugs, their diffusion through tissues, as well as their metabolism and excretion. Comprised of three sections, this volume starts with an overview of the different aspects of drug distribution and metabolism. This text then examines the totality of intermolecular processes or reactions between drug and receptor molecules, which is known as drug-receptor interaction. Other chapters explore the actions of various pharmacodynamic agents, including hormones and substances with selective toxicity, auxins, and odorants. This book discusses as well the ways in which the actions of drugs combine with the tissues and act upon themselves. The final chapter deals with the complicated types of relations between stimulus and effect. Pharmacologists and researchers will find this book useful.

Table of Contents

  • List of Contributors



    Some Introductory Remarks on the Conception of Receptors

    Contents of Volume II

    Part I A Molecular Approach to General Pharmacology

    General Introduction

    Section I.A Drug Transference: Distribution of Drugs in the Organism


    I.A.1. Passive Processes

    I.A.2. Active Transport

    Concluding Remarks


    Section I.B Drug Transference: Drug Metabolism


    I.B.1. Dissimilation of Drug

    I.B.2. Factors Influencing Drug Metabolism

    I.B.3. General Aspects of Drug Metabolism

    I.B.4. Inhibitors of Drug Metabolism

    I.B.5. Assimilation of Drugs

    I.B.6. Drugs Acting Indirectly

    Concluding Remarks


    Section II.A Drug-Receptor Interaction: Interaction of One or More Drugs with One Receptor System


    II.A.1. Structure and Action

    II.A.2. Dose-Response Curves

    II.A.3. Competitive Interaction

    II.A.4. Affinity and Intrinsic Activity

    II.A.5. Affinity and Intrinsic Activity in Relation to Chemical Structure

    II.A.6. Stereoisomers

    II.A.7. The Receptors

    Concluding Remarks


    Section II.B Drug-Receptor Interaction: Interaction of One or More Drugs with Different Receptor Systems


    II.B.l. Noncompetitive Interaction

    II.B.2. Uncompetitive Interaction

    II.B.3. Chemical Antagonism

    II.B.4. Functional Interaction

    II.B.5. Compounds with Multiple Actions

    II.B.6. Specific and Nonspecific Drug Action

    II.B.7. Chemical and Physical Properties of Drugs with Local Anesthetic Action

    II.B.8. The pH and Drug Action

    Concluding Remarks


    Section III The Relation between Stimulus and Effect


    III.1. The All-or-None Response

    III.2. Threshold Phenomena

    III.3. Receptor Reserve

    III.4. Mechanical Factors and Reserve in Receptors

    III.5. The Sequence of Events after Interaction of a Drug with Its Specific Receptors

    III.6. Integral Dose-Response Relations

    Concluding Remarks


    Author Index

    Subject Index

Product details

  • No. of pages: 526
  • Language: English
  • Copyright: © Academic Press 1964
  • Published: January 1, 1964
  • Imprint: Academic Press
  • eBook ISBN: 9780323147149

About the Editor

E.J. Ariens

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