Molecular Pharmacology V3 - 1st Edition - ISBN: 9780123956408, 9780323147149

Molecular Pharmacology V3

1st Edition

The Model of Action of Biology Active Compounds

Editors: E.J. Ariens
eBook ISBN: 9780323147149
Imprint: Academic Press
Published Date: 1st January 1964
Page Count: 526
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Molecular Pharmacology: The Model of Action of Biologically Active Compounds, Volume 1 discusses the mode of action of bioactive compounds on a molecular level. This book reviews the processes that control the uptake of drugs, their diffusion through tissues, as well as their metabolism and excretion. Comprised of three sections, this volume starts with an overview of the different aspects of drug distribution and metabolism. This text then examines the totality of intermolecular processes or reactions between drug and receptor molecules, which is known as drug-receptor interaction. Other chapters explore the actions of various pharmacodynamic agents, including hormones and substances with selective toxicity, auxins, and odorants. This book discusses as well the ways in which the actions of drugs combine with the tissues and act upon themselves. The final chapter deals with the complicated types of relations between stimulus and effect. Pharmacologists and researchers will find this book useful.

Table of Contents

List of Contributors Preface Foreword Some Introductory Remarks on the Conception of Receptors Contents of Volume II Part I A Molecular Approach to General Pharmacology General Introduction Section I.A Drug Transference: Distribution of Drugs in the Organism Introduction I.A.1. Passive Processes I.A.2. Active Transport Concluding Remarks References Section I.B Drug Transference: Drug Metabolism Introduction I.B.1. Dissimilation of Drug I.B.2. Factors Influencing Drug Metabolism I.B.3. General Aspects of Drug Metabolism I.B.4. Inhibitors of Drug Metabolism I.B.5. Assimilation of Drugs I.B.6. Drugs Acting Indirectly Concluding Remarks References Section II.A Drug-Receptor Interaction: Interaction of One or More Drugs with One Receptor System Introduction II.A.1. Structure and Action II.A.2. Dose-Response Curves II.A.3. Competitive Interaction II.A.4. Affinity and Intrinsic Activity II.A.5. Affinity and Intrinsic Activity in Relation to Chemical Structure II.A.6. Stereoisomers II.A.7. The Receptors Concluding Remarks References Section II.B Drug-Receptor Interaction: Interaction of One or More Drugs with Different Receptor Systems Introduction II.B.l. Noncompetitive Interaction II.B.2. Uncompetitive Interaction II.B.3. Chemical Antagonism II.B.4. Functional Interaction II.B.5. Compounds with Multiple Actions II.B.6. Specific and Nonspecific Drug Action II.B.7. Chemical and Physical Properties of Drugs with Local Anesthetic Action II.B.8. The pH and Drug Action Concluding Remarks References Section III The Relation between Stimulus and Effect


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© Academic Press 1964
Academic Press
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E.J. Ariens

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