Molecular Pharmacology V2 - 1st Edition - ISBN: 9780123956415, 9780323157391

Molecular Pharmacology V2

1st Edition

The Model of Action of Biology Active Compounds

Editors: E.J. Ariens
eBook ISBN: 9780323157391
Imprint: Academic Press
Published Date: 1st January 1964
Page Count: 292
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Molecular Pharmacology: The Mode of Action of Biologically Active Compound, Volume II presents the mode of action of bioactive compounds on a molecular level, which concerns a wide variety of pharmacodynamic agents. This book discusses in detail the actions of odorants, the chemotherapeutics used in the fight against cancer, as well as the interactions of substrates and enzymes. Comprised of three parts, this volume starts with an overview of the mode of action of odorants and explores the anatomical and histochemical location of the receptors. This text then explains the molecular processes that are involved olfaction. Other chapters consider the different types of chemotherapeutics used against cancer, such as the antimetabolites and radiomimetics. The final chapter deals with the structure of chemical groups that constitute the receptors and the active sites on the enzymes. This book is a valuable resource for pharmacologists and clinical researchers interested in the study of bioactive compounds.

Table of Contents

List of Contributors Preface Contents of Volume I Part II A Molecular Approach to Olfaction I. Introduction II. The Carrier III. Material Contact or Radiation? IV. The Structure of the Receptor Organ V. Concentration of the Stimulant VI. Electrophysiological Methods VII. The Molecular Structure of the Stimulant VIII. Other Approaches IX. Related Subjects X. Conclusions References Part III The Molecular Basis of Cancer Chemotherapy I. Introduction II. How is Cytotoxicity Brought About? III. Chemotherapeutic Targets IV. Selective Toxicity V. Biological Alkylating Agents; Attempts at Improvement of Selective Toxicity VI. Drug Resistance References Part IV Receptor Theory in Enzymology Introduction I. Mechanism of Enzyme Action II. Substrate Inhibition III. Noncompetitive Interaction IV. Competitive Interaction V. The Receptors Conclusion References Author Index Subject Index


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© Academic Press 1964
Academic Press
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E.J. Ariens

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