Molecular Pathology - 1st Edition - ISBN: 9780123744197, 9780080922195

Molecular Pathology

1st Edition

The Molecular Basis of Human Disease

Editors: William Coleman Gregory Tsongalis
eBook ISBN: 9780080922195
Hardcover ISBN: 9780123744197
Imprint: Academic Press
Published Date: 10th February 2009
Page Count: 664
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Description

Molecular Pathology: The Molecular Basis of Human Disease provides a current and comprehensive view of the molecular basis and mechanisms of human disease. Combining accepted principles with broader theoretical concepts and with contributions from a group of experts, the book looks into disease processes in the context of traditional pathology and their implications for translational molecular medicine. It also discusses concepts in molecular biology and genetics, recent scientific and technological advances in modern pathology, the concept of ""molecular pathogenesis"" of disease, and how disease evolves from normal cells and tissues due to perturbations in molecular pathways.

The book describes the integration of molecular and cellular pathogenesis using a bioinformatics approach and a systems biology approach to disease pathogenesis. It also discusses current and future strategies in molecular diagnosis of human disease, and the impact of molecular diagnosis on treatment decisions and the practice of personalized medicine.

This book is a valuable resource for students, biomedical researchers, practicing physician-scientists who undertake disease-related basic science and translational research, and pathology residents and other postdoctoral fellows.

Key Features

  • Exam Master® web site will host "Self-assessment" questions that students can use to study for the molecular section of the board exam
  • Teaches from the perspective of “integrative systems biology,” which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease
  • Outlines the principles and practice of molecular pathology
  • Explains the practice of “molecular medicine” and the translational aspects of molecular pathology

Readership

Medical students, pathology graduate students, biomedical graduate students, and some allied health students.

Table of Contents


List of Contributors

Preface

Foreword

Acknowledgments

Part I Essential Pathology – Mechanisms of Disease

Chapter 1 Molecular Mechanisms of Cell Death

Introduction

Modes of Cell Death

Structural Features of Necrosis and Apoptosis

Cellular and Molecular Mechanisms Underlying Necrotic Cell Death

Pathways to Apoptosis

Mitochondria

Nucleus

Endoplasmic Reticulum

Lysosomes

Concluding Remark

Chapter 2 Acute and Chronic Inflammation Induces Disease Pathogenesis

Introduction

Leukocyte Adhesion, Migration, and Activation

Acute Inflammation and Disease Pathogenesis

Pattern Recognition Receptors and Inflammatory Responses

Chronic Inflammation and Acquired Immune Responses

Tissue Remodeling During Acute and Chronic Inflammatory Disease

Chapter 3 Infection and Host Response

Microbes and Hosts—Balance of Power?

The Structure of the Immune Response

Regulation of Immunity

Pathogen Strategies

The African Trypanosome and Antibody Diversity: Dueling Genomes

Staphylococcus Aureus: the Extracellular Battleground

Mycobacterium Tuberculosis and the Macrophage

Herpes Simplex Virus: Taking Over

HIV: The Immune Guerilla

Perspectives

Chapter 4 Neoplasia

Introduction

Cancer Statistics and Epidemiology

Classification of Neoplastic Diseases

Characteristics of Benign and Malignant Neoplasms

Clinical Aspects of Neoplasia

Part II Concepts in Molecular Biology and Genetics

Chapter 5 Basic Concepts in Human Molecular Genetics

Introduction

Molecular Structure of DNA, DNA Transcription, and Protein Translation

Molecular Pathology and DNA Repair Mechanisms

Modes of Inheritance

Central Dogma and Rationale for Genetic Testing

Allelic Heterogeneity and Choice of Analytical Methodology

Conclusion

Chapter 6 The Human Genome: Implications for the Understanding of Human Disease

Introduction

Structure and Organization of the Human Genome

Overview of the Human Genome Project

Impact of the Human Genome Project on the Identification of Disease-Related Genes

Sources of Variation in the Human Genome

Types of Genetic Diseases

Genetic Diseases and Cancer

Perspectives

Chapter 7 The Human Transcriptome: Implications for the Understanding of Human Disease

Introduction

Gene Expression Profiling: The Search for Candidate

Genes Involved in Pathogenesis

Transcriptome Analysis Based on Microarrays: Technical Prerequisites

Microarrays: Bioinformatic Analysis

Microarrays: Applications in Basic Research and Translational Medicine Perspectives

Chapter 8 The Human Epigenome: Implications for the Understanding of Human Disease

Introduction

Epigenetic Regulation of the Genome

Genomic Imprinting

Cancer Epigenetics

Human Disorders Associated with Epigenetics

Environment and the Epigenome

Chapter 9 Clinical Proteomics and Molecular Pathology

Understanding Cancer at the Molecular Level: An Evolving Frontier

Microdissection Technology Brings Molecular Analysis to the Tissue Level

Serum Proteomics: An Emerging Landscape for Early Stage Cancer Detection

Chapter 10 Integrative Systems Biology: Implications for the Understanding of Human Disease

Introduction

Data Generation

Data Integration

Modeling Systems

Implications for Understanding Disease

Discussion

Part III Principles and Practice of Molecular Pathology

Chapter 11 Pathology: The Clinical Description of Human Disease

Introduction

Terms, Definitions, and Concepts

A Brief History of Approaches to Disease

Current Practice of Pathology

The Future of Diagnostic Pathology

Conclusion

Chapter 12 Understanding Molecular Pathogenesis: The Biological Basis of Human Disease and Implications for Improved Treatment of Human Disease

Introduction

Hepatitis C Virus Infection

Acute Myeloid Leukemia

Cystic Fibrosis

Chapter 13 Integration of Molecular and Cellular Pathogenesis: A Bioinformatics

Approach

Introduction

Overview of Bioinformatics

Database Resources

Data Analysis

The Future of Bioinformatics

Chapter 14 Molecular Basis of Cardiovascular Disease

Introduction

General Molecular Principles of Cardiovascular

Diseases

The Cells of Cardiovascular Organs

Atherosclerosis

Ischemic Heart Disease

Aneurysms

Vasculitis

Valvular Heart Disease

Cardiomyopathies

Chapter 15 Molecular Basis of Hemostatic and Thrombotic Diseases

Introduction and Overview of Coagulation

Disorders of Soluble Clotting Factors

Disorders of Fibrinolysis

Disorders of Platelet Number or Function

Thrombophilia

Chapter 16 Molecular Basis of Lymphoid and Myeloid Diseases

Development of the Blood and Lymphoid Organs

Myeloid Disorders

Lymphocyte Disorders

Chapter 17 Molecular Basis of Diseases of Immunity

Introduction

Normal Immune System

Major Syndromes

Chapter 18 Molecular Basis of Pulmonary Disease

Introduction

Neoplastic Lung and Pleural Diseases

Non-neoplastic Lung Disease

Obstructive Lung Diseases

Interstitial Lung Diseases

Pulmonary Vascular Diseases

Pulmonary Infections

Pulmonary Histiocytic Diseases

Pulmonary Occupational Diseases

Developmental Abnormalities

Chapter 19 Molecular Basis of Diseases of the Gastrointestinal Tract

Introduction

Gastric Cancer

Colorectal Cancer

Chapter 20 Molecular Basis of Liver Disease

Introduction

Molecular Basis of Liver Development

Molecular Basis of Liver Regeneration

Adult Liver Stem Cells in Liver Health and Disease

Molecular Basis of Hepatocyte Death

Molecular Basis of Nonalcoholic Fatty Liver Disease

Molecular Basis of Alcoholic Liver Disease

Molecular Basis of Hepatic Fibrosis and Cirrhosis

Molecular Basis of Hepatic Tumors

Chapter 21 Molecular Basis of Diseases of the Exocrine Pancreas

Acute Pancreatitis

Chronic and Hereditary Pancreatitis

Summary

Chapter 22 Molecular Basis of Diseases of the Endocrine System

Introduction

The Pituitary Gland

The Thyroid Gland

The Parathyroid Gland

The Adrenal Gland

Puberty

Chapter 23 Molecular Basis of Gynecologic Diseases

Introduction

Benign and Malignant Tumors of the Female

Reproductive Tract

Disorders Related to Pregnancy

Chapter 24 Molecular Pathogenesis of Prostate Cancer: Somatic, Epigenetic, and Genetic Alterations

Introduction

Hereditary Component of Prostate Cancer Risk

Somatic Alterations in Gene Expression

Epigenetics

Advances in Mouse Models of Prostate Cancer

Conclusion

Acknowledgments

Chapter 25 Molecular Biology of Breast Cancer

Introduction

Traditional Breast Cancer Classification

Biomarkers

Gene Expression Profiling

Conclusion

Chapter 26 Molecular Basis of Skin Disease

Introduction

Skin Diseases and Their Impact

Molecular Basis of Healthy Skin

Skin Development and Maintenance Provide New Insight into the Molecular Mechanisms of Disease

Molecular Pathology of Mendelian Genetic Skin Disorders

Molecular Pathology of Common Inflammatory Skin Diseases

Skin Proteins as Targets for Inherited and Acquired Disorders

Molecular Pathology of Skin Cancer

Molecular Diagnosis of Skin Disease

New Molecular Mechanisms and Novel Therapies

Chapter 27 Molecular Pathology: Neuropathology

Anatomy of the Central Nervous System

Neurodevelopmental Disorders

Neurological Injury: Stroke, Neurodegeneration, and Toxicants

Neoplasia

Disorders of Myelin

Part V Practice of Molecular Medicine

Chapter 28 Molecular Diagnosis of Human Disease

Introduction

History of Molecular Diagnostics

Molecular Laboratory Subspecialties

Future Applications

Chapter 29 Molecular Assessment of Human Disease in the Clinical Laboratory

Introduction

The Current Molecular Infectious Disease Paradigm

A New Paradigm for Molecular Diagnostic Applications

BCR-ABL: A Model for the New Paradigm

Conclusion

Chapter 30 Pharmacogenomics and Personalized Medicine in the Treatment of Human

Diseases

Introduction

Conclusion

Index




Details

No. of pages:
664
Language:
English
Copyright:
© Academic Press 2009
Published:
Imprint:
Academic Press
eBook ISBN:
9780080922195
Hardcover ISBN:
9780123744197

About the Editor

William Coleman

William B. Coleman, PhD is Professor of Pathology and Laboratory Medicine at the University of North Carolina School of Medicine (Chapel Hill, NC), and Director of the UNC Program in Translational Medicine. In addition, he is affiliated with the Curriculum in Toxicology, the Cancer Biology Training Program, and is a member of the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is actively involved in teaching biomedical graduate students and is a four-time recipient of the Joe W. Grisham Award for Excellence in Graduate Student Teaching from the Molecular and Cellular Pathology graduate students at UNC-Chapel Hill. Dr. Coleman is active in the leadership of the American Society for Investigative Pathology, and is a member of the American Association for Cancer Research. He serves as an associate editor for The American Journal of Pathology, BMC Cancer, and PLoS One, and serves on the editorial boards of Clinica Chimica Acta, Experimental and Molecular Pathology, Archives of Pathology and Laboratory Medicine, Laboratory Investigation, and Current Pathobiology Reports, and has served as an ad hoc reviewer for 95 other journals. Dr. Coleman’s major research interests are in the molecular pathogenesis of human cancers, with a specific interest in breast cancer epigenetics, liver carcinogenesis, and lung cancer biology. His research has been funded by the NIH/NCI, The Susan G. Komen Breast Cancer Foundation, Friends for an Earlier Breast Cancer Test, and the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is the author of over 125 original research articles, reviews, and book chapters. In addition, Dr. Coleman has co-edited or co-authored eight books on topics related to molecular pathology, molecular diagnostics, and the molecular pathogenesis of human cancer. Affiliations and Expertise Professor, Department of Pathology and Laboratory Medicine, Curriculum in Toxicology, UNC Program in Translational Medicine, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA

Affiliations and Expertise

PhD, Professor, Department of Pathology and Laboratory Medicine, Curriculum in Toxicology, Program in Translational Medicine, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA

Gregory Tsongalis

Greg Tsongalis is the Director of the Laboratory for Clinical Genomics and Advanced Technology (CGAT) at the Dartmouth-Hitchcock Medical Center and Norris Cotton Cancer Center (NCCC) in Lebanon, NH and a Professor of Pathology and Laboratory Medicine at the Audrey and Theodor Geisel School of Medicine at Dartmouth in Hanover, NH. He is a member of the NCCC Molecular Therapeutics Program and the gastrointestinal and breast cancer clinical oncology groups. In 2016 he became a member of Dartmouth College’s Program in Experimental and Molecular Medicine (PEMM), and he has served on the advisory board of the Health Care Genetics Professional Science Master’s Degree Program at the University of Connecticut (Storrs, CT). His area of expertise is in the development and implementation of clinical molecular diagnostic technologies. His research interests are in the pathogenesis of human cancers, personalized medicine and disruptive technologies. He has authored/edited twelve textbooks in the field of molecular pathology, published more than 200 peer reviewed manuscripts, and has been an invited speaker at both national and international meetings. He has served on numerous committees of the AACC, ASIP, FASEB and AMP where he is a past President. He is active in the Alliance for Clinical Trials in Oncology, the Association for Molecular Pathology, the American Association for Clinical Chemistry, the American Association of Bioanalyts, and the American Society for Investigative Pathology. He serves on the editorial boards of 8 journals including Clinical Chemistry, Experimental and Molecular Pathology, and the Journal of Molecular Diagnostics. He also serves on numerous corporate scientific advisory boards.

Affiliations and Expertise

PhD, Professor of Pathology and Laboratory Medicine, Director of Laboratory for Clinical Genomics and Advanced Technology (CGAT), Audrey and Theodor Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center and Norris Cotton Cancer Center, Lebanon, NH, USA

Reviews

"The editors of Molecular Pathology have produced a comprehensive compendium of the state-of-the-art in molecular pathogenesis, an impressive accomplishment given the diverse cells and organ systems involved in human disease. An established cadre of experts has contributed to this first, well-designed edition. As a result, essential topics ranging from cell injury/death, the molecular basis of cardiovascular diseases and disorders of the nervous system, and modern molecular diagnostics are amply addressed. In a rapidly emerging discipline, it is challenging to capture the details that define the field. Molecular Pathology has accomplished this goal in an outstanding manner and will serve as an excellent resource for those already established in clinical care and biomedical research, for those who seek to maintain competency in molecular pathology, as well as for all students involved in interdisciplinary studies related to human disease or modern clinical investigations."

--Linda M. McManus, PhD, Professor, University of Texas Health Science Center at San Antonio

"The focus of Molecular Pathology is genetic and molecular but it has been written to enhance the work of an active pathologist, clearly describing the basics as well as providing ample sampling of the molecular complexities of disease. Gladly the editors did not assemble an exhaustive compendium of facts and details that would inevitably become obsolete in short order. Instead, the contributors concentrated on clarity of explanation supported by selected examples so that the reader may grasp the fundamentals better. In fact, this may be one medical textbook that can be read cover-to-cover without being lost in details. The figures are clear, helpful, and plentiful which is important when dealing with so many complex technologies and concepts. I highly recommend this book."

--Edison T. Liu, M.D, Executive Director, Genome Institute of Singapore