Molecular Pathology: The Molecular Basis of Human Disease provides a current and comprehensive view of the molecular basis and mechanisms of human disease. Combining accepted principles with broader theoretical concepts and with contributions from a group of experts, the book looks into disease processes in the context of traditional pathology and their implications for translational molecular medicine. It also discusses concepts in molecular biology and genetics, recent scientific and technological advances in modern pathology, the concept of ""molecular pathogenesis"" of disease, and how disease evolves from normal cells and tissues due to perturbations in molecular pathways. The book describes the integration of molecular and cellular pathogenesis using a bioinformatics approach and a systems biology approach to disease pathogenesis. It also discusses current and future strategies in molecular diagnosis of human disease, and the impact of molecular diagnosis on treatment decisions and the practice of personalized medicine. This book is a valuable resource for students, biomedical researchers, practicing physician-scientists who undertake disease-related basic science and translational research, and pathology residents and other postdoctoral fellows.

Key Features

* Exam Master® web site will host "Self-assessment" questions that students can use to study for the molecular section of the board exam * Companion Web Site – will host a complete set of PowerPoint slides: to include images from the book and additional images for teaching; course materials; lecture materials * Teaches from the perspective of “integrative systems biology,” which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease * Outlines the principles and practice of molecular pathology * Explains the practice of “molecular medicine” and the translational aspects of molecular pathology


Medical students, pathology graduate students, biomedical graduate students, and some allied health students.

Table of Contents

List of Contributors Preface Foreword Acknowledgments Part I Essential Pathology – Mechanisms of Disease     Chapter 1 Molecular Mechanisms of Cell Death          Introduction          Modes of Cell Death          Structural Features of Necrosis and Apoptosis          Cellular and Molecular Mechanisms Underlying Necrotic Cell Death          Pathways to Apoptosis          Mitochondria          Nucleus          Endoplasmic Reticulum          Lysosomes          Concluding Remark     Chapter 2 Acute and Chronic Inflammation Induces Disease Pathogenesis          Introduction          Leukocyte Adhesion, Migration, and Activation          Acute Inflammation and Disease Pathogenesis          Pattern Recognition Receptors and Inflammatory Responses          Chronic Inflammation and Acquired Immune Responses          Tissue Remodeling During Acute and Chronic Inflammatory Disease     Chapter 3 Infection and Host Response          Microbes and Hosts—Balance of Power?          The Structure of the Immune Response          Regulation of Immunity          Pathogen Strategies          The African Trypanosome and Antibody Diversity: Dueling Genomes          Staphylococcus Aureus: the Extracellular Battleground          Mycobacterium Tuberculosis and the Macrophage          Herpes Simplex Virus: Taking Over          HIV: The Immune Guerilla          Perspectives     Chapter 4 Neoplasia          Introduction          Cancer Statistics and Epidemiology          Classification of Neoplastic Diseases          Characteristics of Benign and Malignant Neoplasms          Clinical Aspects of Neoplasia Part II Concepts in Molecular Biology and Genetics     Chapter 5 Basic Concepts in Human Molecular Genetics          Introduction          Molecular Structure of DNA, DNA Transcription, and Protein Translation          Molecular Pathology and DNA Repair Mechanisms          Modes of Inheritance          Central Dogma and Rati


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Academic Press
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About the editors

William Coleman

William B. Coleman, PhD is Professor of Pathology and Laboratory Medicine and Director of Graduate Studies for the Molecular and Cellular Pathology Graduate Program at the University of North Carolina School of Medicine (Chapel Hill, NC). Dr. Coleman is co-director of the UNC Program in Translational Medicine, and co-director of the Environmental Pathology Predoctoral and Postdoctoral Training Program. In addition, he is affiliated with the Curriculum in Toxicology and is a member of the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is actively involved in teaching biomedical graduate students and is a three-time recipient of the Joe W. Grisham Award for Excellence in Graduate Student Teaching from the Molecular and Cellular Pathology graduate students at UNC-Chapel Hill. Dr. Coleman is active in the leadership of the American Society for Investigative Pathology, and is a member of the American Association for Cancer Research. He serves on the editorial boards of Clinica Chimica Acta, The American Journal of Pathology, Experimental and Molecular Pathology, Archives of Pathology and Laboratory Medicine, and Laboratory Investigation, and has served as an ad hoc reviewer for 48 other journals. Dr. Coleman’s major research interests are in the molecular pathogenesis of human cancers, with a specific interest in breast cancer epigenetics, liver carcinogenesis, and lung cancer biology. His research has been funded by the NIH/NCI, The Susan G. Komen Breast Cancer Foundation, Friends for an Earlier Breast Cancer Test, and the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is the author of over 100 original research articles, reviews, and book chapters. In addition, Dr. Coleman has co-edited or co-authored six books on topics related to molecular pathology, molecular diagnostics, and the molecular pathogenesis of human cancer.

Affiliations and Expertise

Professor, Department of Pathology and Laboratory Medicine, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA

Gregory Tsongalis

Gregory J. Tsongalis, Ph.D., H.C.L.D., C.C. is Professor of Pathology, Director, Molecular Pathology, and Co-Director Translational Research Program, Department of Pathology, Dartmouth Hitchcock Medical Center and The Audrey and Theodor Geisel School of Medicine at Dartmouth, Lebanon, NH, USA

Affiliations and Expertise

Professor of Pathology, Director, Molecular Pathology, and Co-Director Translational Research Program, Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA


"The editors of Molecular Pathology have produced a comprehensive compendium of the state-of-the-art in molecular pathogenesis, an impressive accomplishment given the diverse cells and organ systems involved in human disease. An established cadre of experts has contributed to this first, well-designed edition. As a result, essential topics ranging from cell injury/death, the molecular basis of cardiovascular diseases and disorders of the nervous system, and modern molecular diagnostics are amply addressed. In a rapidly emerging discipline, it is challenging to capture the details that define the field. Molecular Pathology has accomplished this goal in an outstanding manner and will serve as an excellent resource for those already established in clinical care and biomedical research, for those who seek to maintain competency in molecular pathology, as well as for all students involved in interdisciplinary studies related to human disease or modern clinical investigations."

--Linda M. McManus, PhD, Professor, University of Texas Health Science Center at San Antonio

"The focus of Molecular Pathology is genetic and molecular but it has been written to enhance the work of an active pathologist, clearly describing the basics as well as providing ample sampling of the molecular complexities of disease. Gladly the editors did not assemble an exhaustive compendium of facts and details that would inevitably become obsolete in short order. Instead, the contributors concentrated on clarity of explanation supported by selected examples so that the reader may grasp the fundamentals better. In fact, this may be one medical textbook that can be read cover-to-cover without being lost in details. The figures are clear, helpful, and plentiful which is important when dealing with so many complex technologies and concepts. I highly recommend this book."

--Edison T. Liu, M.D, Executive Director, Genome Institute of S