Molecular Pathology
1st Edition
The Molecular Basis of Human Disease
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Description
Molecular Pathology: The Molecular Basis of Human Disease provides a current and comprehensive view of the molecular basis and mechanisms of human disease. Combining accepted principles with broader theoretical concepts and with contributions from a group of experts, the book looks into disease processes in the context of traditional pathology and their implications for translational molecular medicine. It also discusses concepts in molecular biology and genetics, recent scientific and technological advances in modern pathology, the concept of ""molecular pathogenesis"" of disease, and how disease evolves from normal cells and tissues due to perturbations in molecular pathways.
The book describes the integration of molecular and cellular pathogenesis using a bioinformatics approach and a systems biology approach to disease pathogenesis. It also discusses current and future strategies in molecular diagnosis of human disease, and the impact of molecular diagnosis on treatment decisions and the practice of personalized medicine.
This book is a valuable resource for students, biomedical researchers, practicing physician-scientists who undertake disease-related basic science and translational research, and pathology residents and other postdoctoral fellows.
Key Features
- Exam Master® web site will host "Self-assessment" questions that students can use to study for the molecular section of the board exam
- Teaches from the perspective of “integrative systems biology,” which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease
- Outlines the principles and practice of molecular pathology
- Explains the practice of “molecular medicine” and the translational aspects of molecular pathology
Readership
Medical students, pathology graduate students, biomedical graduate students, and some allied health students.
Table of Contents
List of Contributors
Preface
Foreword
Acknowledgments
Part I Essential Pathology – Mechanisms of Disease
Chapter 1 Molecular Mechanisms of Cell Death
Introduction
Modes of Cell Death
Structural Features of Necrosis and Apoptosis
Cellular and Molecular Mechanisms Underlying Necrotic Cell Death
Pathways to Apoptosis
Mitochondria
Nucleus
Endoplasmic Reticulum
Lysosomes
Concluding Remark
Chapter 2 Acute and Chronic Inflammation Induces Disease Pathogenesis
Introduction
Leukocyte Adhesion, Migration, and Activation
Acute Inflammation and Disease Pathogenesis
Pattern Recognition Receptors and Inflammatory Responses
Chronic Inflammation and Acquired Immune Responses
Tissue Remodeling During Acute and Chronic Inflammatory Disease
Chapter 3 Infection and Host Response
Microbes and Hosts—Balance of Power?
The Structure of the Immune Response
Regulation of Immunity
Pathogen Strategies
The African Trypanosome and Antibody Diversity: Dueling Genomes
Staphylococcus Aureus: the Extracellular Battleground
Mycobacterium Tuberculosis and the Macrophage
Herpes Simplex Virus: Taking Over
HIV: The Immune Guerilla
Perspectives
Chapter 4 Neoplasia
Introduction
Cancer Statistics and Epidemiology
Classification of Neoplastic Diseases
Characteristics of Benign and Malignant Neoplasms
Clinical Aspects of Neoplasia
Part II Concepts in Molecular Biology and Genetics
Chapter 5 Basic Concepts in Human Molecular Genetics
Introduction
Molecular Structure of DNA, DNA Transcription, and Protein Translation
Molecular Pathology and DNA Repair Mechanisms
Modes of Inheritance
Central Dogma and Rationale for Genetic Testing
Allelic Heterogeneity and Choice of Analytical Methodology
Conclusion
Chapter 6 The Human Genome: Implications for the Understanding of Human Disease
Introduction
Structure and Organization of the Human Genome
Overview of the Human Genome Project
Impact of the Human Genome Project on the Identification of Disease-Related Genes
Sources of Variation in the Human Genome
Types of Genetic Diseases
Genetic Diseases and Cancer
Perspectives
Chapter 7 The Human Transcriptome: Implications for the Understanding of Human Disease
Introduction
Gene Expression Profiling: The Search for Candidate
Genes Involved in Pathogenesis
Transcriptome Analysis Based on Microarrays: Technical Prerequisites
Microarrays: Bioinformatic Analysis
Microarrays: Applications in Basic Research and Translational Medicine Perspectives
Chapter 8 The Human Epigenome: Implications for the Understanding of Human Disease
Introduction
Epigenetic Regulation of the Genome
Genomic Imprinting
Cancer Epigenetics
Human Disorders Associated with Epigenetics
Environment and the Epigenome
Chapter 9 Clinical Proteomics and Molecular Pathology
Understanding Cancer at the Molecular Level: An Evolving Frontier
Microdissection Technology Brings Molecular Analysis to the Tissue Level
Serum Proteomics: An Emerging Landscape for Early Stage Cancer Detection
Chapter 10 Integrative Systems Biology: Implications for the Understanding of Human Disease
Introduction
Data Generation
Data Integration
Modeling Systems
Implications for Understanding Disease
Discussion
Part III Principles and Practice of Molecular Pathology
Chapter 11 Pathology: The Clinical Description of Human Disease
Introduction
Terms, Definitions, and Concepts
A Brief History of Approaches to Disease
Current Practice of Pathology
The Future of Diagnostic Pathology
Conclusion
Chapter 12 Understanding Molecular Pathogenesis: The Biological Basis of Human Disease and Implications for Improved Treatment of Human Disease
Introduction
Hepatitis C Virus Infection
Acute Myeloid Leukemia
Cystic Fibrosis
Chapter 13 Integration of Molecular and Cellular Pathogenesis: A Bioinformatics
Approach
Introduction
Overview of Bioinformatics
Database Resources
Data Analysis
The Future of Bioinformatics
Chapter 14 Molecular Basis of Cardiovascular Disease
Introduction
General Molecular Principles of Cardiovascular
Diseases
The Cells of Cardiovascular Organs
Atherosclerosis
Ischemic Heart Disease
Aneurysms
Vasculitis
Valvular Heart Disease
Cardiomyopathies
Chapter 15 Molecular Basis of Hemostatic and Thrombotic Diseases
Introduction and Overview of Coagulation
Disorders of Soluble Clotting Factors
Disorders of Fibrinolysis
Disorders of Platelet Number or Function
Thrombophilia
Chapter 16 Molecular Basis of Lymphoid and Myeloid Diseases
Development of the Blood and Lymphoid Organs
Myeloid Disorders
Lymphocyte Disorders
Chapter 17 Molecular Basis of Diseases of Immunity
Introduction
Normal Immune System
Major Syndromes
Chapter 18 Molecular Basis of Pulmonary Disease
Introduction
Neoplastic Lung and Pleural Diseases
Non-neoplastic Lung Disease
Obstructive Lung Diseases
Interstitial Lung Diseases
Pulmonary Vascular Diseases
Pulmonary Infections
Pulmonary Histiocytic Diseases
Pulmonary Occupational Diseases
Developmental Abnormalities
Chapter 19 Molecular Basis of Diseases of the Gastrointestinal Tract
Introduction
Gastric Cancer
Colorectal Cancer
Chapter 20 Molecular Basis of Liver Disease
Introduction
Molecular Basis of Liver Development
Molecular Basis of Liver Regeneration
Adult Liver Stem Cells in Liver Health and Disease
Molecular Basis of Hepatocyte Death
Molecular Basis of Nonalcoholic Fatty Liver Disease
Molecular Basis of Alcoholic Liver Disease
Molecular Basis of Hepatic Fibrosis and Cirrhosis
Molecular Basis of Hepatic Tumors
Chapter 21 Molecular Basis of Diseases of the Exocrine Pancreas
Acute Pancreatitis
Chronic and Hereditary Pancreatitis
Summary
Chapter 22 Molecular Basis of Diseases of the Endocrine System
Introduction
The Pituitary Gland
The Thyroid Gland
The Parathyroid Gland
The Adrenal Gland
Puberty
Chapter 23 Molecular Basis of Gynecologic Diseases
Introduction
Benign and Malignant Tumors of the Female
Reproductive Tract
Disorders Related to Pregnancy
Chapter 24 Molecular Pathogenesis of Prostate Cancer: Somatic, Epigenetic, and Genetic Alterations
Introduction
Hereditary Component of Prostate Cancer Risk
Somatic Alterations in Gene Expression
Epigenetics
Advances in Mouse Models of Prostate Cancer
Conclusion
Acknowledgments
Chapter 25 Molecular Biology of Breast Cancer
Introduction
Traditional Breast Cancer Classification
Biomarkers
Gene Expression Profiling
Conclusion
Chapter 26 Molecular Basis of Skin Disease
Introduction
Skin Diseases and Their Impact
Molecular Basis of Healthy Skin
Skin Development and Maintenance Provide New Insight into the Molecular Mechanisms of Disease
Molecular Pathology of Mendelian Genetic Skin Disorders
Molecular Pathology of Common Inflammatory Skin Diseases
Skin Proteins as Targets for Inherited and Acquired Disorders
Molecular Pathology of Skin Cancer
Molecular Diagnosis of Skin Disease
New Molecular Mechanisms and Novel Therapies
Chapter 27 Molecular Pathology: Neuropathology
Anatomy of the Central Nervous System
Neurodevelopmental Disorders
Neurological Injury: Stroke, Neurodegeneration, and Toxicants
Neoplasia
Disorders of Myelin
Part V Practice of Molecular Medicine
Chapter 28 Molecular Diagnosis of Human Disease
Introduction
History of Molecular Diagnostics
Molecular Laboratory Subspecialties
Future Applications
Chapter 29 Molecular Assessment of Human Disease in the Clinical Laboratory
Introduction
The Current Molecular Infectious Disease Paradigm
A New Paradigm for Molecular Diagnostic Applications
BCR-ABL: A Model for the New Paradigm
Conclusion
Chapter 30 Pharmacogenomics and Personalized Medicine in the Treatment of Human
Diseases
Introduction
Conclusion
Index
Details
- No. of pages:
- 664
- Language:
- English
- Copyright:
- © Academic Press 2009
- Published:
- 10th February 2009
- Imprint:
- Academic Press
- eBook ISBN:
- 9780080922195
- Hardcover ISBN:
- 9780123744197
About the Editors
William Coleman
William B. Coleman, PhD is the Executive Officer for the American Society for Investigative Pathology (Rockville, MD). Prior to taking this position with the American Society for Investigative Pathology, Dr. Coleman spent 28 years at the University of North Carolina School of Medicine (Chapel Hill, NC), first as a postdoctoral fellow (1990-1995) and then as a faculty member (1995-2018) in the Department of Pathology and Laboratory Medicine. During his time at the UNC School of Medicine, Dr. Coleman served as Director of Graduate Studies for the Molecular and Cellular Pathology Ph.D. Program (2006-2012; now the Pathobiology and Translational Medicine Ph.D. Program), was a co-founder of the UNC Program in Translational Medicine and served as its Co-Director (2006-2015) and then its Director (2015-2018), was affiliated with the Curriculum in Toxicology, the Cancer Biology Training Program, and was a member of the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman was active in teaching biomedical graduate students and is a four-time recipient of the Joe W. Grisham Award for Excellence in Graduate Student Teaching from the Molecular and Cellular Pathology graduate students at the UNC School of Medicine. Prior to becoming an employee, Dr. Coleman was active in the leadership of the American Society for Investigative Pathology, serving in various roles including President (2015-2016). Dr. Coleman was honored with the ASIP Outstanding Investigator Award in 2013 from the American Society for Investigative Pathology. He is also a long-time member of the American Association for Cancer Research. He serves as Senior Associate Editor for The American Journal of Pathology, and is an Associate Editor for BMC Cancer, and PLoS One, and serves on the editorial boards of Clinica Chimica Acta, Experimental and Molecular Pathology, Archives of Pathology and Laboratory Medicine, Laboratory Investigation, and Current Pathobiology Reports, and has served as an ad hoc reviewer for 99 other journals. Dr. Coleman’s major research interests are in the molecular pathogenesis of human cancers, with a specific interest in breast cancer epigenetics, liver carcinogenesis, and lung cancer biology. His research was funded by the NIH/NCI, The Susan G. Komen Breast Cancer Foundation, Friends for an Earlier Breast Cancer Test, and the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is the author of over 140 original research articles, reviews, and book chapters. In addition, Dr. Coleman has co-edited or co-authored ten books on topics related to molecular pathology, molecular diagnostics, and the molecular pathogenesis of human cancer.
Affiliations and Expertise
Executive Officer, American Society for Investigative Pathology, Rockville, MD, USA
Gregory Tsongalis
Gregory Tsongalis, Ph.D., H.C.L.D., is the Vice Chair for Research and the Director of the Laboratory for Clinical Genomics and Advanced Technology (CGAT) in the Department of Pathology and Laboratory Medicine at the Dartmouth-Hitchcock Medical Center and Norris Cotton Cancer Center (NCCC) in Lebanon, NH. He is a Professor of Pathology and Laboratory Medicine at the Audrey and Theodor Geisel School of Medicine at Dartmouth in Hanover, NH and a member of the NCCC Molecular Therapeutics Program and the gastrointestinal and breast cancer clinical oncology groups. In 2016 he became a member of Dartmouth College’s Program in Experimental and Molecular Medicine (PEMM), and he has served on the advisory board of the Health Care Genetics Professional Science Master’s Degree Program and Diagnostic Genetic Sciences Program at the University of Connecticut (Storrs, CT). His area of expertise is in the development and implementation of clinical molecular diagnostic technologies. His research interests are in the pathogenesis of human cancers, personalized medicine and disruptive technologies. He has authored/edited twelve textbooks in the field of molecular pathology, published more than 230 peer reviewed manuscripts, and has been an invited speaker at both national and international meetings. He has served on numerous committees of the American Association for Clinical Chemistry, the American Society for Investigative Pathology, the Federation for American Societies for Experimental Biology, and the Association for Molecular Pathology (where he is a past President). He is active in the Alliance for Clinical Trials in Oncology, the Association for Molecular Pathology, the American Association for Clinical Chemistry, the American Association of Bioanalysts, and the American Society for Investigative Pathology. He serves on the editorial boards of 8 journals including Clinical Chemistry, Experimental and Molecular Pathology, and the Journal of Molecular Diagnostics. In 2016, Dr. Tsongalis received the Norris Cotton Cancer Center Award for Excellence, in 2017 the Association for Molecular Pathology (AMP) Jeffrey A. Kant Leadership Award, and in 2019 the American Society for Investigative Pathology Robbins Distinguished Educator Award. He also serves on numerous corporate scientific advisory boards.
Affiliations and Expertise
Professor, Vice Chair for Research, and Director of the Laboratory for Clinical Genomics and Advanced Technologies, Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Health System and the Audrey and Theodor Geisel School of Medicine, Lebanon, NH, USA”
Reviews
"The editors of Molecular Pathology have produced a comprehensive compendium of the state-of-the-art in molecular pathogenesis, an impressive accomplishment given the diverse cells and organ systems involved in human disease. An established cadre of experts has contributed to this first, well-designed edition. As a result, essential topics ranging from cell injury/death, the molecular basis of cardiovascular diseases and disorders of the nervous system, and modern molecular diagnostics are amply addressed. In a rapidly emerging discipline, it is challenging to capture the details that define the field. Molecular Pathology has accomplished this goal in an outstanding manner and will serve as an excellent resource for those already established in clinical care and biomedical research, for those who seek to maintain competency in molecular pathology, as well as for all students involved in interdisciplinary studies related to human disease or modern clinical investigations."
--Linda M. McManus, PhD, Professor, University of Texas Health Science Center at San Antonio
"The focus of Molecular Pathology is genetic and molecular but it has been written to enhance the work of an active pathologist, clearly describing the basics as well as providing ample sampling of the molecular complexities of disease. Gladly the editors did not assemble an exhaustive compendium of facts and details that would inevitably become obsolete in short order. Instead, the contributors concentrated on clarity of explanation supported by selected examples so that the reader may grasp the fundamentals better. In fact, this may be one medical textbook that can be read cover-to-cover without being lost in details. The figures are clear, helpful, and plentiful which is important when dealing with so many complex technologies and concepts. I highly recommend this book."
--Edison T. Liu, M.D, Executive Director, Genome Institute of Singapore
Ratings and Reviews
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