COVID-19 Update: We are currently shipping orders daily. However, due to transit disruptions in some geographies, deliveries may be delayed. To provide all customers with timely access to content, we are offering 50% off Science and Technology Print & eBook bundle options. Terms & conditions.
Molecular Pathology - 1st Edition - ISBN: 9780123744197, 9780080922195

Molecular Pathology

1st Edition

The Molecular Basis of Human Disease

Editors: William Coleman Gregory Tsongalis
eBook ISBN: 9780080922195
Hardcover ISBN: 9780123744197
Imprint: Academic Press
Published Date: 10th February 2009
Page Count: 664
Sales tax will be calculated at check-out Price includes VAT/GST
Price includes VAT/GST

Institutional Subscription

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.


Molecular Pathology: The Molecular Basis of Human Disease provides a current and comprehensive view of the molecular basis and mechanisms of human disease. Combining accepted principles with broader theoretical concepts and with contributions from a group of experts, the book looks into disease processes in the context of traditional pathology and their implications for translational molecular medicine. It also discusses concepts in molecular biology and genetics, recent scientific and technological advances in modern pathology, the concept of ""molecular pathogenesis"" of disease, and how disease evolves from normal cells and tissues due to perturbations in molecular pathways.

The book describes the integration of molecular and cellular pathogenesis using a bioinformatics approach and a systems biology approach to disease pathogenesis. It also discusses current and future strategies in molecular diagnosis of human disease, and the impact of molecular diagnosis on treatment decisions and the practice of personalized medicine.

This book is a valuable resource for students, biomedical researchers, practicing physician-scientists who undertake disease-related basic science and translational research, and pathology residents and other postdoctoral fellows.

Key Features

  • Exam Master® web site will host "Self-assessment" questions that students can use to study for the molecular section of the board exam
  • Teaches from the perspective of “integrative systems biology,” which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease
  • Outlines the principles and practice of molecular pathology
  • Explains the practice of “molecular medicine” and the translational aspects of molecular pathology


Medical students, pathology graduate students, biomedical graduate students, and some allied health students.

Table of Contents

List of Contributors




Part I Essential Pathology – Mechanisms of Disease

Chapter 1 Molecular Mechanisms of Cell Death


Modes of Cell Death

Structural Features of Necrosis and Apoptosis

Cellular and Molecular Mechanisms Underlying Necrotic Cell Death

Pathways to Apoptosis



Endoplasmic Reticulum


Concluding Remark

Chapter 2 Acute and Chronic Inflammation Induces Disease Pathogenesis


Leukocyte Adhesion, Migration, and Activation

Acute Inflammation and Disease Pathogenesis

Pattern Recognition Receptors and Inflammatory Responses

Chronic Inflammation and Acquired Immune Responses

Tissue Remodeling During Acute and Chronic Inflammatory Disease

Chapter 3 Infection and Host Response

Microbes and Hosts—Balance of Power?

The Structure of the Immune Response

Regulation of Immunity

Pathogen Strategies

The African Trypanosome and Antibody Diversity: Dueling Genomes

Staphylococcus Aureus: the Extracellular Battleground

Mycobacterium Tuberculosis and the Macrophage

Herpes Simplex Virus: Taking Over

HIV: The Immune Guerilla


Chapter 4 Neoplasia


Cancer Statistics and Epidemiology

Classification of Neoplastic Diseases

Characteristics of Benign and Malignant Neoplasms

Clinical Aspects of Neoplasia

Part II Concepts in Molecular Biology and Genetics

Chapter 5 Basic Concepts in Human Molecular Genetics


Molecular Structure of DNA, DNA Transcription, and Protein Translation

Molecular Pathology and DNA Repair Mechanisms

Modes of Inheritance

Central Dogma and Rationale for Genetic Testing

Allelic Heterogeneity and Choice of Analytical Methodology


Chapter 6 The Human Genome: Implications for the Understanding of Human Disease


Structure and Organization of the Human Genome

Overview of the Human Genome Project

Impact of the Human Genome Project on the Identification of Disease-Related Genes

Sources of Variation in the Human Genome

Types of Genetic Diseases

Genetic Diseases and Cancer


Chapter 7 The Human Transcriptome: Implications for the Understanding of Human Disease


Gene Expression Profiling: The Search for Candidate

Genes Involved in Pathogenesis

Transcriptome Analysis Based on Microarrays: Technical Prerequisites

Microarrays: Bioinformatic Analysis

Microarrays: Applications in Basic Research and Translational Medicine Perspectives

Chapter 8 The Human Epigenome: Implications for the Understanding of Human Disease


Epigenetic Regulation of the Genome

Genomic Imprinting

Cancer Epigenetics

Human Disorders Associated with Epigenetics

Environment and the Epigenome

Chapter 9 Clinical Proteomics and Molecular Pathology

Understanding Cancer at the Molecular Level: An Evolving Frontier

Microdissection Technology Brings Molecular Analysis to the Tissue Level

Serum Proteomics: An Emerging Landscape for Early Stage Cancer Detection

Chapter 10 Integrative Systems Biology: Implications for the Understanding of Human Disease


Data Generation

Data Integration

Modeling Systems

Implications for Understanding Disease


Part III Principles and Practice of Molecular Pathology

Chapter 11 Pathology: The Clinical Description of Human Disease


Terms, Definitions, and Concepts

A Brief History of Approaches to Disease

Current Practice of Pathology

The Future of Diagnostic Pathology


Chapter 12 Understanding Molecular Pathogenesis: The Biological Basis of Human Disease and Implications for Improved Treatment of Human Disease


Hepatitis C Virus Infection

Acute Myeloid Leukemia

Cystic Fibrosis

Chapter 13 Integration of Molecular and Cellular Pathogenesis: A Bioinformatics



Overview of Bioinformatics

Database Resources

Data Analysis

The Future of Bioinformatics

Chapter 14 Molecular Basis of Cardiovascular Disease


General Molecular Principles of Cardiovascular


The Cells of Cardiovascular Organs


Ischemic Heart Disease



Valvular Heart Disease


Chapter 15 Molecular Basis of Hemostatic and Thrombotic Diseases

Introduction and Overview of Coagulation

Disorders of Soluble Clotting Factors

Disorders of Fibrinolysis

Disorders of Platelet Number or Function


Chapter 16 Molecular Basis of Lymphoid and Myeloid Diseases

Development of the Blood and Lymphoid Organs

Myeloid Disorders

Lymphocyte Disorders

Chapter 17 Molecular Basis of Diseases of Immunity


Normal Immune System

Major Syndromes

Chapter 18 Molecular Basis of Pulmonary Disease


Neoplastic Lung and Pleural Diseases

Non-neoplastic Lung Disease

Obstructive Lung Diseases

Interstitial Lung Diseases

Pulmonary Vascular Diseases

Pulmonary Infections

Pulmonary Histiocytic Diseases

Pulmonary Occupational Diseases

Developmental Abnormalities

Chapter 19 Molecular Basis of Diseases of the Gastrointestinal Tract


Gastric Cancer

Colorectal Cancer

Chapter 20 Molecular Basis of Liver Disease


Molecular Basis of Liver Development

Molecular Basis of Liver Regeneration

Adult Liver Stem Cells in Liver Health and Disease

Molecular Basis of Hepatocyte Death

Molecular Basis of Nonalcoholic Fatty Liver Disease

Molecular Basis of Alcoholic Liver Disease

Molecular Basis of Hepatic Fibrosis and Cirrhosis

Molecular Basis of Hepatic Tumors

Chapter 21 Molecular Basis of Diseases of the Exocrine Pancreas

Acute Pancreatitis

Chronic and Hereditary Pancreatitis


Chapter 22 Molecular Basis of Diseases of the Endocrine System


The Pituitary Gland

The Thyroid Gland

The Parathyroid Gland

The Adrenal Gland


Chapter 23 Molecular Basis of Gynecologic Diseases


Benign and Malignant Tumors of the Female

Reproductive Tract

Disorders Related to Pregnancy

Chapter 24 Molecular Pathogenesis of Prostate Cancer: Somatic, Epigenetic, and Genetic Alterations


Hereditary Component of Prostate Cancer Risk

Somatic Alterations in Gene Expression


Advances in Mouse Models of Prostate Cancer



Chapter 25 Molecular Biology of Breast Cancer


Traditional Breast Cancer Classification


Gene Expression Profiling


Chapter 26 Molecular Basis of Skin Disease


Skin Diseases and Their Impact

Molecular Basis of Healthy Skin

Skin Development and Maintenance Provide New Insight into the Molecular Mechanisms of Disease

Molecular Pathology of Mendelian Genetic Skin Disorders

Molecular Pathology of Common Inflammatory Skin Diseases

Skin Proteins as Targets for Inherited and Acquired Disorders

Molecular Pathology of Skin Cancer

Molecular Diagnosis of Skin Disease

New Molecular Mechanisms and Novel Therapies

Chapter 27 Molecular Pathology: Neuropathology

Anatomy of the Central Nervous System

Neurodevelopmental Disorders

Neurological Injury: Stroke, Neurodegeneration, and Toxicants


Disorders of Myelin

Part V Practice of Molecular Medicine

Chapter 28 Molecular Diagnosis of Human Disease


History of Molecular Diagnostics

Molecular Laboratory Subspecialties

Future Applications

Chapter 29 Molecular Assessment of Human Disease in the Clinical Laboratory


The Current Molecular Infectious Disease Paradigm

A New Paradigm for Molecular Diagnostic Applications

BCR-ABL: A Model for the New Paradigm


Chapter 30 Pharmacogenomics and Personalized Medicine in the Treatment of Human






No. of pages:
© Academic Press 2009
10th February 2009
Academic Press
eBook ISBN:
Hardcover ISBN:

About the Editors

William Coleman

William B. Coleman, PhD is the Executive Officer for the American Society for Investigative Pathology (Rockville, MD). Prior to taking this position with the American Society for Investigative Pathology, Dr. Coleman spent 28 years at the University of North Carolina School of Medicine (Chapel Hill, NC), first as a postdoctoral fellow (1990-1995) and then as a faculty member (1995-2018) in the Department of Pathology and Laboratory Medicine. During his time at the UNC School of Medicine, Dr. Coleman served as Director of Graduate Studies for the Molecular and Cellular Pathology Ph.D. Program (2006-2012; now the Pathobiology and Translational Medicine Ph.D. Program), was a co-founder of the UNC Program in Translational Medicine and served as its Co-Director (2006-2015) and then its Director (2015-2018), was affiliated with the Curriculum in Toxicology, the Cancer Biology Training Program, and was a member of the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman was active in teaching biomedical graduate students and is a four-time recipient of the Joe W. Grisham Award for Excellence in Graduate Student Teaching from the Molecular and Cellular Pathology graduate students at the UNC School of Medicine. Prior to becoming an employee, Dr. Coleman was active in the leadership of the American Society for Investigative Pathology, serving in various roles including President (2015-2016). Dr. Coleman was honored with the ASIP Outstanding Investigator Award in 2013 from the American Society for Investigative Pathology. He is also a long-time member of the American Association for Cancer Research. He serves as Senior Associate Editor for The American Journal of Pathology, and is an Associate Editor for BMC Cancer, and PLoS One, and serves on the editorial boards of Clinica Chimica Acta, Experimental and Molecular Pathology, Archives of Pathology and Laboratory Medicine, Laboratory Investigation, and Current Pathobiology Reports, and has served as an ad hoc reviewer for 99 other journals. Dr. Coleman’s major research interests are in the molecular pathogenesis of human cancers, with a specific interest in breast cancer epigenetics, liver carcinogenesis, and lung cancer biology. His research was funded by the NIH/NCI, The Susan G. Komen Breast Cancer Foundation, Friends for an Earlier Breast Cancer Test, and the UNC Lineberger Comprehensive Cancer Center. Dr. Coleman is the author of over 140 original research articles, reviews, and book chapters. In addition, Dr. Coleman has co-edited or co-authored ten books on topics related to molecular pathology, molecular diagnostics, and the molecular pathogenesis of human cancer.

Affiliations and Expertise

Executive Officer, American Society for Investigative Pathology, Rockville, MD, USA

Gregory Tsongalis

Gregory Tsongalis, Ph.D., H.C.L.D., is the Vice Chair for Research and the Director of the Laboratory for Clinical Genomics and Advanced Technology (CGAT) in the Department of Pathology and Laboratory Medicine at the Dartmouth-Hitchcock Medical Center and Norris Cotton Cancer Center (NCCC) in Lebanon, NH. He is a Professor of Pathology and Laboratory Medicine at the Audrey and Theodor Geisel School of Medicine at Dartmouth in Hanover, NH and a member of the NCCC Molecular Therapeutics Program and the gastrointestinal and breast cancer clinical oncology groups. In 2016 he became a member of Dartmouth College’s Program in Experimental and Molecular Medicine (PEMM), and he has served on the advisory board of the Health Care Genetics Professional Science Master’s Degree Program and Diagnostic Genetic Sciences Program at the University of Connecticut (Storrs, CT). His area of expertise is in the development and implementation of clinical molecular diagnostic technologies. His research interests are in the pathogenesis of human cancers, personalized medicine and disruptive technologies. He has authored/edited twelve textbooks in the field of molecular pathology, published more than 230 peer reviewed manuscripts, and has been an invited speaker at both national and international meetings. He has served on numerous committees of the American Association for Clinical Chemistry, the American Society for Investigative Pathology, the Federation for American Societies for Experimental Biology, and the Association for Molecular Pathology (where he is a past President). He is active in the Alliance for Clinical Trials in Oncology, the Association for Molecular Pathology, the American Association for Clinical Chemistry, the American Association of Bioanalysts, and the American Society for Investigative Pathology. He serves on the editorial boards of 8 journals including Clinical Chemistry, Experimental and Molecular Pathology, and the Journal of Molecular Diagnostics. In 2016, Dr. Tsongalis received the Norris Cotton Cancer Center Award for Excellence, in 2017 the Association for Molecular Pathology (AMP) Jeffrey A. Kant Leadership Award, and in 2019 the American Society for Investigative Pathology Robbins Distinguished Educator Award. He also serves on numerous corporate scientific advisory boards.

Affiliations and Expertise

Professor, Vice Chair for Research, and Director of the Laboratory for Clinical Genomics and Advanced Technologies, Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Health System and the Audrey and Theodor Geisel School of Medicine, Lebanon, NH, USA”


"The editors of Molecular Pathology have produced a comprehensive compendium of the state-of-the-art in molecular pathogenesis, an impressive accomplishment given the diverse cells and organ systems involved in human disease. An established cadre of experts has contributed to this first, well-designed edition. As a result, essential topics ranging from cell injury/death, the molecular basis of cardiovascular diseases and disorders of the nervous system, and modern molecular diagnostics are amply addressed. In a rapidly emerging discipline, it is challenging to capture the details that define the field. Molecular Pathology has accomplished this goal in an outstanding manner and will serve as an excellent resource for those already established in clinical care and biomedical research, for those who seek to maintain competency in molecular pathology, as well as for all students involved in interdisciplinary studies related to human disease or modern clinical investigations."

--Linda M. McManus, PhD, Professor, University of Texas Health Science Center at San Antonio

"The focus of Molecular Pathology is genetic and molecular but it has been written to enhance the work of an active pathologist, clearly describing the basics as well as providing ample sampling of the molecular complexities of disease. Gladly the editors did not assemble an exhaustive compendium of facts and details that would inevitably become obsolete in short order. Instead, the contributors concentrated on clarity of explanation supported by selected examples so that the reader may grasp the fundamentals better. In fact, this may be one medical textbook that can be read cover-to-cover without being lost in details. The figures are clear, helpful, and plentiful which is important when dealing with so many complex technologies and concepts. I highly recommend this book."

--Edison T. Liu, M.D, Executive Director, Genome Institute of Singapore

Ratings and Reviews