Molecular Pathology, An Issue of Surgical Pathology Clinics

1st Edition, Volume 14-3 - August 11, 2021
Editor: Lauren Ritterhouse
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 7 9 4 6 6 - 4
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 7 9 4 6 7 - 1

In this issue of Surgical Pathology Clinics, guest editor Lauren L. Ritterhouse brings her considerable expertise to the topic of molecular pathology.… Read more

Molecular Pathology, An Issue of Surgical Pathology Clinics

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In this issue of Surgical Pathology Clinics, guest editor Lauren L. Ritterhouse brings her considerable expertise to the topic of molecular pathology.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Molecular Methods: Clinical Utilization and Designing a Test Menu
Building your molecular toolbox
Pre-analytical considerations
Molecular methods
Considerations in designing a molecular test menu
Clinics care points
Molecular Pathology of Lung Cancer
Overview
Specimens for testing
Testing methodology
Biomarkers for testing
Programmed death–ligand 1
Emerging targets
Summary
Clinics care points
Molecular Pathology of Gliomas
Overview
Differential diagnosis
Molecular pathology features
Pediatric low-grade gliomas
Summary
Clinics care points
Molecular Pathology of Prostate Cancer
Overview
Prostate cancer etiology and germline alterations
Precursors lesions
The multifocal and multiclonal nature of prostate cancer
Clinically relevant molecular alterations
Assessing metastatic prostate cancer
Summary
Molecular Pathology of Urothelial Carcinoma
Overview
Molecular characterization of invasive urothelial carcinoma
Molecular taxonomy of urothelial carcinoma
Molecular updates on histologic variants of urothelial carcinoma
Summary and future directions
Molecular Pathology of Ovarian Epithelial Neoplasms: Predictive, Prognostic, and Emerging Biomarkers
Overview
Histologic subtypes of epithelial tumors
Clinics care points
Molecular Approach to Colorectal Carcinoma: Current Evidence and Clinical Application
Overview
Mismatch repair deficiency and microsatellite instability
Sporadic mismatch repair deficiency
Lynch syndrome
Mismatch repair and microsatellite instability testing
Prognostic features of microsatellite instability-high cancer
Therapeutic implications of microsatellite instability-high tumors
Neurotrophic tyrosine receptor kinase
Epidermal growth factor receptor and downstream signaling pathways
Summary
Clinics care points
Disclosure
Molecular Pathology of Gastroesophageal Cancer
Overview
Esophageal squamous cell carcinoma
Esophageal adenocarcinoma
Gastric adenocarcinoma
Intratumoral genomic heterogeneity in esophageal and gastric adenocarcinoma
Precision medicine in upper gastrointestinal cancers
Clinics care points
Disclosure
Molecular Pathology of Breast Tumors: Diagnostic and Actionable Genetic Alterations
Overview
Molecular classification of breast cancer
Key diagnostic somatic alterations in breast tumors
Key actionable somatic alterations in breast cancer
Resistance alterations in breast cancer
Emerging molecular markers and future trends
Clinics care points
Disclosure
Molecular Alterations in Pediatric Solid Tumors
Overview
Categorization of pediatric extracranial solid tumors
Molecular alterations in pediatric bone and soft tissue tumors
Molecular alterations in organ-based solid tumors
Differences from adult solid tumors
Tumor predisposition syndromes in pediatric solid tumors
Molecular techniques
Conventional molecular techniques
Use of next-generation sequencing–based molecular assays in pediatric solid tumors
Clinics care points
Emerging concepts
Summary
Funding
Molecular Pathology of Thyroid Tumors: Old Problems and New Concepts
Overview
The RAS mutant thyroid nodule
Hürthel cell neoplasms
Molecular alteration in unusual thyroid tumors
Determining actionable molecular alterations by immunohistochemistry
Clinics care points
Disclosure
Pan-Cancer Molecular Biomarkers: A Paradigm Shift in Diagnostic Pathology
Overview
The emergence of pan-cancer molecular biomarkers has been enabled by technological advances in clinical cancer sequencing
Many targetable mutations are shared across tumors of various primary sites
Molecular biomarkers beyond single mutations: mutational signatures and tumor mutational burden
New clinical trial design strategies in the validation of pan-cancer biomarkers
Summary
Clinics care points
Molecular Pathology of Myeloid Neoplasms: Molecular Pattern Recognition
Overview
Patterns are essential
The “old” stem cell and clonal hematopoiesis
Disclosure
Molecular Pathology of Mature Lymphoid Malignancies
Overview
Mature B-cell neoplasms
Mature T-cell and natural killer cell neoplasms
Summary and future directions
Clinics care points