Molecular Nutrition - 1st Edition - ISBN: 9780128138625

Molecular Nutrition

1st Edition

Mother and Infant

Editors: Manlio Vinciguerra Paul Sanchez
Paperback ISBN: 9780128138625
Imprint: Academic Press
Published Date: 1st October 2018
Page Count: 768
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Molecular Nutrition: Mother and Infant presents the impact of diet in early life stages from pre-conception, throughout pregnancy and to the infant.

Separated into three parts, general and introductory aspects, molecular biology of the cell, and genetic machinery and its function, the first part of the book provides general coverage in relation to diet and nutrition, pregnancy, placenta, weight gain, breast milk, feeding practices, gestational disease, glucose metabolism, immunity, vitamins and minerals.

Part two addresses fetal programming, bioactive compounds, amino acids, intrauterine growth, one carbon metabolism, overnutrition, mitochondrial function, signalling, high fat diets, vascular function, and caffeine.

Finally, part three presents genetic risk factors, polymorphisms, folic acid genes, DNA methylation, genes involved in lipid metabolism, microRNAs, epigenetics, transcriptomics and micro RNA.

This book is sure to be a welcomed reference for research scientists and practitioners, including nutritionists and dieticians.

Key Features

  • Addresses mother an infant nutrition which is important for the wellbeing of humankind
  • Contains coverage from pre-conception to the young offspring
  • Includes pedagogical features (e.g. a list of key facts, mini-dictionaries of terms and definitions, and summary points) to assist in its use as a reference text
  • Contains coverage of emerging fields of molecular biology and important discoveries related to diet and nutritional health


Health scientists, clinicians, healthcare professionals, nutritionists, dieticians, teachers, lecturers and advanced students in nutritional sciences, policy makers pediatricians, and obstetricians

Table of Contents

Part 1: General and Introductory Aspects
1. Diet and maternal nutrition: an overview
2. Placenta metabolism
3. Pregnancy and weight gain
4. Breast milk feeding and impact on the infant: an overview
5. Feeding practices of infants
6. Nutritionally-driven gestational diseases and impact on health on the mother and infant
7. Glucose metabolism and pregnancy
8. Immune aspects of pregnancy and role of nutrition
9. Vitamin status in pregnancy and newborns
10. Fatty acid intake during perinatal periods
11. Mineral in pregnancy and newborns Prof
12. Perinatal interventions; current and future perspectives
13. Perinatal nutrition and obesity

Part 2: Molecular Biology of the Cell
14. Molecular aspects of fetal programming
15. Molecular aspects of dietary bioactive compounds in pregnancy
16. Amino acid transporters and protein metabolism in intrauterine growth (can focus on a single or groups of amino acids such as tryptophan)
17. Maternal micronutrients and one carbon metabolism
18. Overnutrition and mitochondrial function
19. mTOR, insulin/IGF-I signalling in relation to nutrients in pregnancy
20. Maternal high fat diet and molecular aspects of vascular function
21. Caffeine exposure and CNS developmental processes

Part 3: Genetic Machinery and Its Function
22. Genetic risk factors in nutrient metabolism and fetal development
23. Pregnancy loss and polymorphisms in folic acid genes
24. Maternal vitamins and DNA methylation and implications for offspring (may want to focus on B vitamins)
25. Maternal obesity, and genes involved in lipid metabolism
26. Diet in lactation periods and impact on cancer: genetic aspects of mammary tissue
27. Maternal diet consumption and microRNAs
28. Vitamins (example of vitamin D) in pregnancy and gene expression
29. Epigenetic changes associated to different fat consumption
30. Epigenetic genes and maternal obesity
31. Transcriptomics of cord blood and implications for nutrition and diet
32. Maternal undernutrition and organ microRNAs
33. Genomic imprinting and fetal development (to link with nutrition and growth)
34. Nutritional influence on miRNA epigenetic regulation


No. of pages:
© Academic Press 2019
Academic Press
Paperback ISBN:

About the Editor

Manlio Vinciguerra

Manlio Vinciguerra, BSc, MSc, PhD is a Principal Research Associate at the Institute for Liver and Digestive Health, University College London (UCL), UK. He holds research appointments at the International Clinical Research Center (ICRC), St. Anne's University Hospital, Brno, Czech Republic, and at the Italian Liver Foundation, University of Trieste, Italy. He obtained his BSc with Honours from the University of Catania, Italy, in 1999, with an experimental thesis performed at St. Radboud University Hospital, Nijmegen, Netherlands, on mitochondrial porins. In 2001, he joined the Department of Internal Medicine, Faculty of Medicine, University of Geneva (Switzerland), as a PhD student. In 2005 he joined as a post-doc the Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva (Switzerland). In 2008, supported by an interdisciplinary fellowship (EIPOD) he undertook a second post-doctoral project at the European Molecular Biology Laboratory (EMBL), between Heidelberg (Germany) and Monterotondo (Italy), prior to joining UCL. Dr. Vinciguerra delivered seminars in more than 20 countries, and he authored over 110 papers research and review papers on epigenetics, liver diseases, metabolism and cancer.

Affiliations and Expertise

Institute for Liver and Digestive Health (ILDH), University College London (UCL), UK

Paul Sanchez

Paul Cordero Sanchez, Pharmacist, MSc, PhD is a researcher at the Institute for Liver and Digestive Health, at University College London (London, United Kingdom). Dr. Cordero was graduated in 2007 at University of Navarra (Pamplona, Spain) in Pharmacy. During his degree he worked on research at Microbiology Department and at the Department of Nutrition, Food Science and Physiology. Moreover, he obtained a fellowship to carry out a stay at Santo Antonio Hospital (Porto, Portugal). After his master degree on Metabolism and Nutrition he obtained a competitive fellowship to perform his PhD in Pharmacy, gained on October 2012, at the Department of Nutrition, Food Science and Physiology at University of Navarra. During his career he has also carried out stays at Catalan Institute of Oncology (Barcelona, Spain) and University of Cambridge (Cambridge, United Kingdom). His research has been focused in the molecular regulation of diet-induced obesity and its comorbidities. He has worked on human and animal trials focused both in adult life, as well as in maternal nutrition during perinatal stages and its consequences on the offspring risk of suffer metabolic diseases. He has lectured in national and international symposia, reviewed journal and grant agencies and coordinated and organized conferences. He is also currently a member of the European Nutrition Leadership Platform.

Affiliations and Expertise

Institute for Liver and Digestive Health (ILDH), University College London (UCL)

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