Molecular Nutrition - 1st Edition - ISBN: 9780128119075

Molecular Nutrition

1st Edition

Vitamins

Editors: Vinood Patel
Paperback ISBN: 9780128119075
Imprint: Academic Press
Published Date: 1st September 2019
Page Count: 1088
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Description

Molecular Nutrition: Vitamins presents the nutritional and molecular aspects of vitamins with specific focus on vitamins A, B1 (thiamine), B2 (riboflavin), B# (niacin), B5 (pantothenic acid), B6, (pyridoxine), B7 (biotin), B9 (folate), B12 (colbamin), C, D, E, and K. A part of the Molecular Nutrition series, this book is divided into three sections: general and introductory aspects, molecular biology of the cell, and genetic machinery and its function.

The first section, general and introductory aspects, presents general coverage of vitamins in relation to nutrition. The second section, molecular biology of the cell, includes material on signaling, transporters, oxidative stress, receptors, uptake, immunity, proliferation, endoplasmic reticulum, differentiation, carcinogenesis, and apoptosis. The third section, genetic machinery and its function, addresses transcriptional processes, homeostasis genes, cancer, gene expression, mutations, the sodium-dependent multivitamin transporter, p53, p21, microRNAs, one carbon metabolism, nucleic acids, DNA methylation and polymorphisms. The book also addresses emerging fields of molecular biology and presents important discoveries related to diet and nutritional health.

Key Features

  • Summarizes molecular nutrition in health as related to vitamins
  • Includes material on signaling, transporters, oxidative stress, receptors, uptake, immunity, proliferation, endoplasmic reticulum, differentiation, carcinogenesis, and apoptosis
  • Presents transcriptional processes, homeostasis genes, cancer, gene expression, mutations, the sodium-dependent multivitamin transporter, p53, p21, microRNAs, one carbon metabolism, nucleic acids, DNA methylation and polymorphisms
  • Addresses emerging fields of molecular biology and presents important discoveries related to diet and nutritional health
  • Covers Vitamins A, B, C, D, E, and K
  • Discusses impact on health relating to cancer, diabetes, arthritis, and aging
  • Includes key facts, a mini dictionary of terms, and summary points

Readership

Researchers, professionals (including nutritionists, dieticians, health scientists, health care professionals, policy makers), educators, and students

Table of Contents

I General and Introductory Aspects

1. Vitamin E: An Overview

2. Requirements for Vitamins in Different Stages of the Life Cycle

3. Vitamin C: Metabolism, Epigenetic Roles, and Cancer

4. Riboflavin and Health: A Review 

5. A Review of Vitamin B12

II Molecular Biology of the Cell

6. Vitamin D Receptor in Arterial Ageing

7. Tocotrienol Regulation of AMPK in Cancer

8. Niacin and Hyperlipidemia

9. Folate Transporters in Placentas

10. Linking B-vitamins, Choline, and Stroke

11. Riboflavin (Vitamin B2) and Mitochondrial Energy

12. Pantothenic Acid (Vitamin B5) - Immunoreactive Neurons

13. Ascorbic Acid (Vitamin C) and Alzheimer's Disease

14. Vitamin B1 and the Pyruvate Dehydrogenase Complex

15. Vitamin D and Diabetes Mellitus: Vitamin D Metabolism, Alterations of Vitamin D Endo-paracrine System and their Relation to Oxidative/Nitrosative Stress, Inflammation, and Cell survival

16. Grape Seed Extract and Pyridoxine (Vitamin B6)

17. Cobalamin (Vitamin B12) Malabsorption

18. Pyridoxine (Vitamin B6) and Selenium Interactions: Implications for Human Health

19. Linking Vitamin E and Nitric Oxide in Liver Disease

20. Use of Methylcobalamin (Vitamin B12) in Pain

21. New Properties of Vitamin B6 or Pyridoxine in Experimental Oxidative Stress in the Brain

22. Thiamine (B1), Oxidative Stress, and Ethanol

23. Vitamin E: Novel Metabolites and Treatments

24. Vitamin E Structure and Forms/Analytical Methods

25. Pyruvate Carboxylase (PC) and the Biotin Carboxylase Domain

26. Application of Vitamins

27. Vitamins in Chronic Kidney Disease

28. Inflammatory Bowel Disorders and Fat-soluble Vitamins

29. Vitamin E and Reproductive Health

30. Vitamin B12 and Diabetes

31. Biotin Status Screening

32. Prostate Cancer and Applications of Vitamin K

33. Non-alcoholic Fatty Liver Disease and Use of Folate

34. Scenarios of Low Vitamin K Intakes

III Genetic Machinery and its Function

35. Transcriptional Control of Cells by Vitamin D

36. Transcriptome Analysis for Vitamin B3 (Niacin) and its Receptor GPR109A

37. Novel preventive mechanisms of vitamin B6 against inflammation, inflammasome, and chronic diseases

38. Vitamins and Epigenetics

Details

No. of pages:
1088
Language:
English
Copyright:
© Academic Press 2019
Published:
Imprint:
Academic Press
Paperback ISBN:
9780128119075

About the Editor

Vinood Patel

Vinood B. Patel, BSc, PhD, FRSC, is currently a Reader in Clinical Biochemistry at the University of Westminster and honorary fellow at King’s College London (Diabetes and Nutritional Sciences Division and the Department of Nutrition and Dietetics). He presently directs studies on molecular and metabolic pathways involved in organ disease, particularly related to subcellular organelles and cell death. He directs research into the role of nutrients, antioxidants, phytochemicals, minerals, toxins and macronutrients. Other areas of interest are identifying new biomarkers that can be used for the diagnosis and prognosis of disease and understanding oxidative stress. Dr Patel graduated from the University of Portsmouth with a degree in Pharmacology and completed his PhD in protein metabolism from King’s College London in 1997. His postdoctoral work was carried out at Wake Forest University Baptist Medical School studying structural-functional alterations to mitochondrial ribosomes, where he developed novel techniques to characterize their biophysical properties. Dr Patel is a nationally and internationally recognized liver researcher and was involved in several NIH-funded biomedical grants. Dr Patel has edited more than 20 biomedical books in the area of nutrition, health and disease and has published over 150 articles In 2014, he was elected as a Fellow to the prestigious Royal Society of Chemistry for bridging the academic and intellectual gap between chemistry and biological function.

Affiliations and Expertise

University of Westminster, UK

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