Molecular Nutrition: Fats - 1st Edition - ISBN: 9780128112977

Molecular Nutrition: Fats

1st Edition

An Analysis of Implications on Cells to Public Health

Editors: Vinood Patel
Paperback ISBN: 9780128112977
Imprint: Academic Press
Published Date: 1st August 2018
Page Count: 1072
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Description

Molecular Nutrition: Fats presents the nutritional and molecular aspects of fats by assessing their dietary components, their structural and metabolic effects on the cell, and their role in health and disease. Subject areas include molecular mechanisms, membranes, polymorphisms, SNPs, genomic wide analysis, genotypes, gene expression, genetic modifications and other aspects. The book is divided into three sections, providing information on the general and introductory aspects, the molecular biology of the cell, and the genetic machinery and its function. Topics discussed include lipid-related molecules, dietary lipids and lipid metabolism, high fat diets, choline, cholesterol, membranes, trans-and saturated fatty acids, and lipid rafts.

Other sections provide comprehensive discussions on G protein-coupled receptors, micro RNA, transcriptomics, transcriptional factors, cholesterol, triacylglycerols, beta-oxidation, cholesteryl ester transfer, beta-oxidation, lysosomes, lipid droplets, insulin mTOR signaling and ligands, and more.

Key Features

  • Summarizes molecular nutrition in health as related to fats
  • Discusses the impact of fats on cancer, heart disease, dementia, and respiratory and intestinal disease
  • Includes preclinical, clinical and population studies
  • Covers the genome, the whole body and whole communities
  • Includes key facts, a mini dictionary of terms and summary points

Readership

Researchers, professionals (including nutritionists, dieticians, health scientists, health care professionals, policy makers), educators, and students

Table of Contents

Part 1: General and Introductory Aspects
1. Nomenclature, classes and functions of lipids and lipid-related molecules
2. Dietary lipids and lipid metabolism: an overview
3. Essential fatty acid deficiency in humankind
4. High fat diets, choline and cholesterol metabolism
5. Lipid membranes
6. Trans and saturated fatty acid levels in the blood and impact of diet
7. Fat-soluble vitamins and importance in the diet
8. Lipid emulsions in artificial nutrition
9. Fatty acid intake and cancer risk
10. Monounsaturated fatty acids and cancer
11. Combining omega-3 fatty acids and long-chain monounsaturated fatty acids in diets and effects in health
12. Lipid peroxidation and impact of products on
13. Sterols, stanols and statins
14. Hepatic steatosis
15. Lipids in emulsions
16. Omega-3 supplements and cardiovascular disease
17. Trans-fatty acids and coronary heart disease
18. Lipds and dementia
19. Intestinal disease and bioactive lipids
20. Respiratory disease and dietary lipids
21. Long chain polyunsaturated fatty acids in pregnancy
22. Lipid-based nutrient supplements to children
23. Lactation and dietary lipids
24. Public health aspects of nutritional counseling and low-density lipoprotein cholesterol
25. Public health impact of fatty acid intake and depression
26. Lipids in the diet and capillary dysfunction: public health implications of Alzheimer’s disease
27. C-reactive protein and plasma fatty acids: public health concerns and implications

Part 2: Molecular Biology of the Cell
28. The mitochondria as a site of fatty acid beta-oxidation
29. Subcellular organelles: lysosomes in lipid accumulation
30. Subcellular organelles: lipid droplets
31. Lipid raft formation in macrophages
32. Lipid rafts in vascular endothelial cells
33. G protein-coupled receptor 120 (GPR120)
34. The Bile Sale Export Bump (BSEP) and lipid metabolism
35. Dietary fat and insulin: from cell exposure to transcriptional processes
36. Stearoyl-CoA desaturase indexes as biomarkers in cardiometabolic
37. Polyunsaturated fatty acids and mTOR signaling Prof. P.A. Marignani
38. N-6 polyunsaturated fatty acids and brain polyunsaturated fatty acids
39. Fatty acid amide ligands and G protein-coupled receptors
40. Dietary fatty acids and weight gain via receptor activation: a focus on the endocannabinoid system
41. Lipid composition and intracellular trafficking
42. The LXR/SREBP-1c signaling pathway, lipids and atherosclerosis
43. Heart tissue, lipids and PKC activation
44. Brain signaling and monounsaturated dietary lipids compared to polunsaturated

Part 3: Genetic Machinery and Its Function
45. Intracerebral hemorrhages and genetic loci for serum total, LDL, and HDL cholesterol, and triglycerides
46. DNA methylation patterns and n-3 fatty acid intake
47. Glucokinase gene variations and fish oil
48. Dietary free fatty acids and gene expression in adipocytes and other cell types
49. Alternative splicing and cholesterol
50. Polymorphisms in triacylglycerol metabolism
51. Fatty acids and desaturase gene polymorphism in elderly
52. Polymorphisms of the CETP gene and public health implications
53. Fatty acid binding protein 2 genes and public health implications for diabetes
54. Polymorphisms in fatty acid beta-oxidation
55. Cholesteryl ester transfer protein polymorphisms
56. Micro RNA (miRNA) and lipid metabolism
57. Transcriptomics and n-3 polyunsaturated fatty acids supplementation
58. Transcriptional factor modulation by lipid peroxidation-derived aldehydes

Details

No. of pages:
1072
Language:
English
Copyright:
© Academic Press 2018
Published:
Imprint:
Academic Press
Paperback ISBN:
9780128112977

About the Editor

Vinood Patel

Vinood B. Patel, BSc, PhD, FRSC, is currently a Reader in Clinical Biochemistry at the University of Westminster and honorary fellow at King’s College London (Diabetes and Nutritional Sciences Division and the Department of Nutrition and Dietetics). He presently directs studies on molecular and metabolic pathways involved in organ disease, particularly related to subcellular organelles and cell death. He directs research into the role of nutrients, antioxidants, phytochemicals, minerals, toxins and macronutrients. Other areas of interest are identifying new biomarkers that can be used for the diagnosis and prognosis of disease and understanding oxidative stress. Dr Patel graduated from the University of Portsmouth with a degree in Pharmacology and completed his PhD in protein metabolism from King’s College London in 1997. His postdoctoral work was carried out at Wake Forest University Baptist Medical School studying structural-functional alterations to mitochondrial ribosomes, where he developed novel techniques to characterize their biophysical properties. Dr Patel is a nationally and internationally recognized liver researcher and was involved in several NIH-funded biomedical grants. Dr Patel has edited more than 20 biomedical books in the area of nutrition, health and disease and has published over 150 articles In 2014, he was elected as a Fellow to the prestigious Royal Society of Chemistry for bridging the academic and intellectual gap between chemistry and biological function.

Affiliations and Expertise

Department of Biomedical Sciences, Faculty of Science and Technology University of Westminster, London, UK

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