Molecular Nutrition and Mitochondria

Molecular Nutrition and Mitochondria

Metabolic Deficits, Whole-Diet Interventions, and Targeted Nutraceuticals

1st Edition - September 1, 2022

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  • Editor: Sergej Ostojic
  • Paperback ISBN: 9780323902564

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Molecular Nutrition and Mitochondria: Metabolic Deficits, Whole-Diet Interventions, and Targeted Nutraceuticals provides a comprehensive examination of molecular aspects of mitochondrial nutrition and how dietary compounds might impact the treatment of mitochondrial dysfunction. Beginning with an overview of the fundamentals of mitochondria physiology and the methods used to evaluate mitochondrial imbalance in clinical practice, the book goes on to outline nutritional shortfalls in mitochondrial dysfunction and highlights the complex intra-organelle milieu affecting interactions between food compounds and mitochondrial co-factors, metabolites, and signaling molecules. Further sections explore the impact of essential nutrients, such as vitamin E, fatty acids, and complex lipids, on mitochondrial biogenesis, as well as non-essential bioactive compounds originating from food that can be evaluated for their mitochondria-modulating potential, such as mitochondria-targeted small molecule antioxidants, plant-based pigments and organic compounds, nucleotides, non-proteogenic amino acids and derivatives, and mitochondria-specific enzyme mimetics from food. Molecular Nutrition and Mitochondria covers the key impacts of nutrition on mitochondria, and is the ideal reference for researchers, students and clinicians looking to develop an in-depth understanding of how dietary compounds can prevent and treat disorders associated with mitochondrial dysfunction.

Key Features

  • Describes the fundamentals of mitochondria physiology and considers the methods used to evaluate mitochondrial imbalance in clinical practice
  • Provides broad biochemical and metabolic background on nutritional deficits found in mitochondrial dysfunction
  • Explores the prevention and treatment of various inherited and acquired disorders associated with mitochondrial dysfunction
  • Discusses the link between the dosage for each nutrient (nutritional vs. pharmacological) and the clinical effect
  • Features a dedicated section on whole-diet interventions and mitochondrial function


Researchers in molecular biology, biochemistry, molecular nutrition, cell biology, pharmacy and pharmacology. Graduate students (PhD) and clinicians in molecular biology, biochemistry, nutrition, metabolism, pharmacology and pharmacy; physicians and health practitioners

Table of Contents

    1. Nutritional Support in Mitochondrial Diseases: The State of the Art
    2. Targeting Mitochondrial Dysfunction: Challenges and Opportunities
    3. Impact of Mitointeractions On Health-Disease Responses to Diet
    4. Mitochondrion at the Crossroads Between Nutrients and Epigenome
    5. Inadequate Nutritional Intake in Mitochondrial Diseases
    6. Nutritional Deficits Involved in Mitocondrial Damage in Critical Illness

    7. Mitochondrial Response to Controlled Nutrition in Health and Disease
    8. Diet Restriction-Induced Mitochondrial Signalling and Healthy Aging
    9. Ketogenic Diets, Mitochondria, and Neurological diseases
    10. Ferility Diet and Mitochondrial Function
    11. Maternal Nutrient Modulation and Fetal Mitochondrial Gene Expression
    12. Dietary Modulation and Mitochondrial DNA Damage

    13. Vitamin E, Mitochondrial Dysfunction and Aging
    14. The Role of B Vitamins in Protecting Mitochondrial Function
    15. Triggering Mitochondrion-Dependent Necrosis by Fatty Acids
    16. Dietary Lipids and Mitochondrial Gene Expression
    17. Dietary EPA and DHA for Mitochondrial Biosynthesis and Dynamics
    18. Supplemental Vitamin C for Mitochondrial Biogenesis in Health and Exercise

    19. Mitochondria-Targeted Antioxidants: Coezyme Q10, MitoQ and beyond
    20. Flavonoids, Mitochondrial Enzymes and Heart Protection
    21. Tea Polyphenols Stimulate Mt Bioenergetics in Cardiometabolic Diseases
    22. Quercetin and Mitochondria: from Nutrition to Nanomedicine
    23. N-acetylcysteine and Up-Regulation of Mitochondrial Biogenesis
    24. Dietary Carnitine, Mitochondrial Function and Therapy
    25. Creatine Monohydrate for Mitochondrial Nutrition
    26. Benefits of Supplemental Arginine and Citrullne in MELAS syndrome
    27. Nutraceuticals for Targeting NAD+ to Restore Mitochondrial Function
    28. Curcumin for Protecting Mitochondria and Down Regulating Inflammation
    29. Dietary Molecular Hydrogen for Mitochondrial Viability
    30. Fucoxantin and Mitochondrial Uncoupling Protein-1 in Obesity
    31. Rice Bran Extract for the Prevention of Mitochondrial Dysfunction
    32. Dietary Modulators of Nuclear Factor Erythroid-2-Related Factor 2
    33. Plant Silymarin Affects Mitochondrial Integrity in Stress Conditions
    34. Alternative Respiratory Chain Enzymes: Therapeutic Potential and Possible Pitfalls
    35. New Mitochondria Permeability Transition Pore Inhibitor Based on Dietary Gallic Acid
    36. Plant-Derived Compounds, Vitagens, and Mitochondrial Function
    37. Buckwheat Trypsin Inhibitor (rBTI): A Novel Nutrceutical for Mitochondrial Homeostasis in Age-Related Conditions
    38. Nutraceutical Effects of Indian Gooseberry on Mitochondria-Mediated Cellular Damage
    39. 5-Heptadecylresorcinol from Whol Grain Rye for Mitochondrial Bioactivities
    40. Combined Nutraceutical Therapy for Mitochondrial Cytopathies

Product details

  • No. of pages: 650
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: September 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323902564

About the Editor

Sergej Ostojic

Dr. Sergej M. Ostojic is a Full Professor in the Biomedical Sciences Department of the University of Novi Sad, Belgrade, Serbia. His current research is focused on evaluating effectiveness and safety of novel mitochondria-targeted nutraceuticals (including molecular hydrogen, creatine salts and guanidinoacetic acid) tackling impaired bioenergetics in health and disease. To date, he has authored and co-authored over 160 peer-reviewed research and review articles in high-impact journals, such as The Lancet, Trends in Endocrinology and Metabolism, Theranostics, Sports Medicine, Mayo Clinic Proceedings, Clinical Science, Pharmacological Research, International Journal of Cardiology, and the European Journal of Nutrition. He is a member of the American Society for Nutrition, the American Physiological Society, the American College of Sports Medicine, and the Nutrition Society, and has been the recipient of internationally research grants such as the World Anti-Doping Agency and NSCA International Award. Dr. Ostojic holds 4 patents in the US, UK, EU, and Japan.

Affiliations and Expertise

Sergej M. Ostojic, Department of Nutrition and Public Health, University of Agder, Kristiansand, Norway

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