Molecular Mechanisms In Cellular Growth and Differentiation - 1st Edition - ISBN: 9780120853601, 9780323152730

Molecular Mechanisms In Cellular Growth and Differentiation

1st Edition

Editors: A.R. Bellve
eBook ISBN: 9780323152730
Imprint: Academic Press
Published Date: 28th February 1991
Page Count: 388
Tax/VAT will be calculated at check-out Price includes VAT (GST)
30% off
30% off
30% off
30% off
30% off
20% off
20% off
30% off
30% off
30% off
30% off
30% off
20% off
20% off
30% off
30% off
30% off
30% off
30% off
20% off
20% off
72.95
51.06
51.06
51.06
51.06
51.06
58.36
58.36
54.95
38.47
38.47
38.47
38.47
38.47
43.96
43.96
43.99
30.79
30.79
30.79
30.79
30.79
35.19
35.19
Unavailable
Price includes VAT (GST)
× DRM-Free

Easy - Download and start reading immediately. There’s no activation process to access eBooks; all eBooks are fully searchable, and enabled for copying, pasting, and printing.

Flexible - Read on multiple operating systems and devices. Easily read eBooks on smart phones, computers, or any eBook readers, including Kindle.

Open - Buy once, receive and download all available eBook formats, including PDF, EPUB, and Mobi (for Kindle).

Institutional Access

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Description

Molecular Mechanisms in Cellular Growth and Differentiation describes the cellular differentiation and development. It emphasizes the pattern formation, specifically the genesis of spatial relationships, among the parts of a vertebrate or invertebrate organism, embryonic or adult. Organized into five parts, this book deals with the major steps leading from growth factor-receptor interactions, through transduction and modulation mechanisms, to proliferative response. It also discusses the relation of growth factors and their receptors to oncogenes and to protooncogenes. It also elucidates the roles of growth factors and receptors in cell differentiation and development, particularly, in pattern formation. The homeotic systems regulated intracellularly and the two differentiation systems thought to involve sequence-specific DNA-binding proteins in conjunction with small molecules are also explored.

Table of Contents


Preface

Part I Polypeptide Growth Factors and other Signals: Cell Membrane Receptors, Transduction Mechanisms and Proliferative Response

1 A Dual Binding Site Hypothesis of the Type I Insulin-Like Growth Factor Receptor

Introduction

Which Receptor Mediates the Actions of IGF-II?

References

2 Insulin Action on Membrane Protein Recycling

Introduction

Membrane Protein Recycling

Conclusions

References

3 Growth-Factor and Oncogene-Mediated S6 Phosphorylation during the Mitogenic Response: A Novel S6 Kinase

Stimulation of S6 Phosphorylation

Activation of S6 Kinase

Phosphatases

Characteristics of the S6 Kinase

Pathways Involved in S6 Phosphorylation

References

4 Phosphorylation of pp60c-src

Introduction

Serine 12

Serine 17

Other Amino-Terminal Phosphorylations

Tyrosine 416

Tyrosine 527

Platelet-Derived Growth Factor Treatment

Neuronal pp60c-src

pp60c-src and Polyomavirus Middle T Antigen

Vanadate Treatment

Elevation of pp60c-src Protein Kinase Activity in Transformed Cells

Summary

References

5 G Proteins May Exist as Polymeric Proteins: A Basis for the Disaggregation Theory

of Hormone Action

Introduction

Depolymerization Theory

Current Thoughts on G Proteins

Some Structural Aspects of G Proteins

Pertussis Toxin Actions

Effects of Detergents on G Proteins

Signal Transduction and Cytoskeletal Elements

Summary and Speculations

References

6 Pleiotropic Functions of the Insulin Receptor

Introduction

Purification and Biological Characterization of the Insulin-

Sensitive Enzyme Modulators

The Enzyme Modulators Are Inositol Phosphate Glycans

The Inositol Phosphate Glycan Enzyme Modulators Are Produced by an Insulin-Sensitive Phosphatidylinositol Glycan-Specific Phospholipase C Activity

Turnover of Glycosylphosphatidylinositol in Insulin Action

References

7 Cooperative Regulation of Gene Expression in Liver Cells by Hormones and Extracellular

Matrix

Introduction

Cell Culture

Gene Expression in Normal Liver

Gene Expression Studies in Hepatoma Cells

Hypotheses on the Mechanisms of Matrix and Hormonal Regulation of Gene Expression: Delivery of Protein Hormones to the Nucleus by

Proteoglycan/Glycosaminoglycan Carriers

Summary

References

8 Receptor-Ligand Interactions: Role in Cancer Invasion and Metastasis

Introduction

Basement Membrane and the Three-Step Hypothesis of Invasion

Components of Basement Membrane

Laminin Receptor

Role of Laminin and Laminin Receptor in Tumor Cell Metastasis

Monoclonal Antibodies to Human Laminin Receptor

Isolation of Human Laminin Receptor cDNA

Overlapping Domain of Laminin Receptor cDNA Inserts

Nucleotide and Deduced Amino Acid Sequence of the 2H5 Epitope of Human Laminin Receptor

Synthetic Peptides and the Putative Ligand Binding Domain of Laminin Receptor

Expression of Laminin Receptor mRNA

Conclusions

References

9 Control of Cell Proliferation by Transforming Growth Factors

Introduction

Transforming Growth Factor-?

Transforming Growth Factor-ß

Autocrine Regulation of Epithelial Cells by Transforming Growth Factors-? and -ß

References

Part II Polypeptide Growth Factors and their Cell Membrane Receptors: Relation to Oncogenes

10 The EGF Receptor Protooneogene: Structure, Evolution of Properties of Receptor Mutants

Introduction

Structure of the EGF Receptor

Properties of EGF Receptor Mutants

References

11 Biological Effects of the v-erbA Oncogene in Transformation of Avian Erythroid Cells

Biological Effects of the v-erhA and v-erbB Oncogenes

Comparison of the v-erbA and c-erbA

Effects of Mutant v-erbA Genes on Erythroblasts

How Does v-erbA Contribute to Transformation of Erythroblasts?

Conclusions

References

12 ras Transformation of 3T3 Cells Induces Basic Fibroblast Growth Factor Synthesis in Vitro and in Vivo

Introduction

Results

Discussion

References

13 Cellular Oncogenes Conferring Growth Factor Independence on NIH 3T3 Cells

Introduction

Results

Discussion

References

14 Potential Function of the mos Protooncogene in Germ Cell Differentiation and Early Development

Introduction

Expression of mos in Male Germ Cells

Expression of mos in Oocytes

Posttranscriptional Processing of mos in Eggs

References

Part III Polypeptide Growth Factors and their Cell Membrane Receptors: Role in Differentiation and Development

15 Pleiotypic Actions of the Seminiferous Growth Factor

Introduction

Expression of Mitogenic Activity

Biochemical Characterization

Two Testicular Cell Lines: TM3 Leydig and TM4 Sertoli Cells

Proliferation of TM3 Leydig and TM4 Sertoli Cells

Extracellular Accumulation of Sulfated Glycoprotein

Synthesis of Specific Peptides

Immunological Properties of Heparin-Binding Growth Factors

Discussion

References

16 Regulation of Blood Vessel Growth and Differentiation

Introduction

Growth and Development

Embryonic Stem Cells as an Experimental Model System for Early Vascular Development

Endothelial Cell Differentiation

Concluding Remarks

References

17 Vascular Endothelium: Role in Albumin Transport

Multiplicity of Endothelial Functions

General Organization

Continuous Microvascular Endothelium

Physiological Data

Attempts at Structural-Functional Integration

Perspectives

References

18 A Growth Factor Homologous Gene Controlling Pattern Formation in Drosophila

Introduction

Overview of the Organization of the decapentaplegic Gene

Contribution of the Hin Region to dpp Function

Nature of the dpp Polypeptide

References

Part IV Sequence-Specific DNA-Binding Proteins: Role in Differentiation and Development

19 The Role of Master Regulatory Genes in Controlling Development

Text

References

20 engrailed, A Gene for All Segments

Introduction

The engrailed Gene Promoter

The engrailed Protein Is a Phosphoprotein

References

21 Sequence-Specific DNA-Binding Activities of Even-Skipped and Other Homeo Box Proteins in Drosophih

Introduction

Results

Discussion

Materials and Methods

References

22 Identification and Characterization of Two Mouse Genes, EN-1 and EN-2, with Sequence Homology to the engrailed and invected Genes of Drosophih

Introduction

Results

Discussion

References

23 Structure and Developmental Expression of Murine Homeo Box Genes

Introduction

Results and Discussion

References

Part V Small Molecules in Differentiation and Development

24 Molecular Dissection of Pattern Formation in Vertebrate Limbs: Concepts and Experimental Approaches

Background

Retinoic Acid Mimics ZPA Tissue and Induces Pattern

Duplications in a Highly Specific Way

Retinoic Acid Can Induce Digit Formation in the Absence of ZPA Tissue

Limb Buds Contain Endogenous Retinoic Acid

Future Problems

References

25 Differentiation of a Multipotent Human Intestinal Cell Line: Expression of Villin, a Structural Component of Brush Borders

The Intestinal Epithelium: A Model System for Study of Cell Diffferentiation and the Development of a Polarized Cytoskeleton

A Pluripotent Human Intestinal Cell Line That Can Be Induced to Differentiate in Culture

Organization of Intestinal Brush Border Cytoskeleton

Villin, a Calcium-Regulated Actin-Binding Protein

Villin Is an Organ-Specific Marker in Adults and Embryos

Villin Expression during Intestinal Differentiation

Summary and Conclusions

References

Index


Details

No. of pages:
388
Language:
English
Copyright:
© Academic Press 1991
Published:
Imprint:
Academic Press
eBook ISBN:
9780323152730

About the Editor

A.R. Bellve