Molecular Mechanisms In Cellular Growth and Differentiation

Molecular Mechanisms In Cellular Growth and Differentiation

1st Edition - February 28, 1991

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  • Editor: A.R. Bellve
  • eBook ISBN: 9780323152730

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Description

Molecular Mechanisms in Cellular Growth and Differentiation describes the cellular differentiation and development. It emphasizes the pattern formation, specifically the genesis of spatial relationships, among the parts of a vertebrate or invertebrate organism, embryonic or adult. Organized into five parts, this book deals with the major steps leading from growth factor-receptor interactions, through transduction and modulation mechanisms, to proliferative response. It also discusses the relation of growth factors and their receptors to oncogenes and to protooncogenes. It also elucidates the roles of growth factors and receptors in cell differentiation and development, particularly, in pattern formation. The homeotic systems regulated intracellularly and the two differentiation systems thought to involve sequence-specific DNA-binding proteins in conjunction with small molecules are also explored.

Table of Contents


  • Preface

    Part I Polypeptide Growth Factors and other Signals: Cell Membrane Receptors, Transduction Mechanisms and Proliferative Response

    1 A Dual Binding Site Hypothesis of the Type I Insulin-Like Growth Factor Receptor

    Introduction

    Which Receptor Mediates the Actions of IGF-II?

    References

    2 Insulin Action on Membrane Protein Recycling

    Introduction

    Membrane Protein Recycling

    Conclusions

    References

    3 Growth-Factor and Oncogene-Mediated S6 Phosphorylation during the Mitogenic Response: A Novel S6 Kinase

    Stimulation of S6 Phosphorylation

    Activation of S6 Kinase

    Phosphatases

    Characteristics of the S6 Kinase

    Pathways Involved in S6 Phosphorylation

    References

    4 Phosphorylation of pp60c-src

    Introduction

    Serine 12

    Serine 17

    Other Amino-Terminal Phosphorylations

    Tyrosine 416

    Tyrosine 527

    Platelet-Derived Growth Factor Treatment

    Neuronal pp60c-src

    pp60c-src and Polyomavirus Middle T Antigen

    Vanadate Treatment

    Elevation of pp60c-src Protein Kinase Activity in Transformed Cells

    Summary

    References

    5 G Proteins May Exist as Polymeric Proteins: A Basis for the Disaggregation Theory

    of Hormone Action

    Introduction

    Depolymerization Theory

    Current Thoughts on G Proteins

    Some Structural Aspects of G Proteins

    Pertussis Toxin Actions

    Effects of Detergents on G Proteins

    Signal Transduction and Cytoskeletal Elements

    Summary and Speculations

    References

    6 Pleiotropic Functions of the Insulin Receptor

    Introduction

    Purification and Biological Characterization of the Insulin-

    Sensitive Enzyme Modulators

    The Enzyme Modulators Are Inositol Phosphate Glycans

    The Inositol Phosphate Glycan Enzyme Modulators Are Produced by an Insulin-Sensitive Phosphatidylinositol Glycan-Specific Phospholipase C Activity

    Turnover of Glycosylphosphatidylinositol in Insulin Action

    References

    7 Cooperative Regulation of Gene Expression in Liver Cells by Hormones and Extracellular

    Matrix

    Introduction

    Cell Culture

    Gene Expression in Normal Liver

    Gene Expression Studies in Hepatoma Cells

    Hypotheses on the Mechanisms of Matrix and Hormonal Regulation of Gene Expression: Delivery of Protein Hormones to the Nucleus by

    Proteoglycan/Glycosaminoglycan Carriers

    Summary

    References

    8 Receptor-Ligand Interactions: Role in Cancer Invasion and Metastasis

    Introduction

    Basement Membrane and the Three-Step Hypothesis of Invasion

    Components of Basement Membrane

    Laminin Receptor

    Role of Laminin and Laminin Receptor in Tumor Cell Metastasis

    Monoclonal Antibodies to Human Laminin Receptor

    Isolation of Human Laminin Receptor cDNA

    Overlapping Domain of Laminin Receptor cDNA Inserts

    Nucleotide and Deduced Amino Acid Sequence of the 2H5 Epitope of Human Laminin Receptor

    Synthetic Peptides and the Putative Ligand Binding Domain of Laminin Receptor

    Expression of Laminin Receptor mRNA

    Conclusions

    References

    9 Control of Cell Proliferation by Transforming Growth Factors

    Introduction

    Transforming Growth Factor-?

    Transforming Growth Factor-ß

    Autocrine Regulation of Epithelial Cells by Transforming Growth Factors-? and -ß

    References

    Part II Polypeptide Growth Factors and their Cell Membrane Receptors: Relation to Oncogenes

    10 The EGF Receptor Protooneogene: Structure, Evolution of Properties of Receptor Mutants

    Introduction

    Structure of the EGF Receptor

    Properties of EGF Receptor Mutants

    References

    11 Biological Effects of the v-erbA Oncogene in Transformation of Avian Erythroid Cells

    Biological Effects of the v-erhA and v-erbB Oncogenes

    Comparison of the v-erbA and c-erbA

    Effects of Mutant v-erbA Genes on Erythroblasts

    How Does v-erbA Contribute to Transformation of Erythroblasts?

    Conclusions

    References

    12 ras Transformation of 3T3 Cells Induces Basic Fibroblast Growth Factor Synthesis in Vitro and in Vivo

    Introduction

    Results

    Discussion

    References

    13 Cellular Oncogenes Conferring Growth Factor Independence on NIH 3T3 Cells

    Introduction

    Results

    Discussion

    References

    14 Potential Function of the mos Protooncogene in Germ Cell Differentiation and Early Development

    Introduction

    Expression of mos in Male Germ Cells

    Expression of mos in Oocytes

    Posttranscriptional Processing of mos in Eggs

    References

    Part III Polypeptide Growth Factors and their Cell Membrane Receptors: Role in Differentiation and Development

    15 Pleiotypic Actions of the Seminiferous Growth Factor

    Introduction

    Expression of Mitogenic Activity

    Biochemical Characterization

    Two Testicular Cell Lines: TM3 Leydig and TM4 Sertoli Cells

    Proliferation of TM3 Leydig and TM4 Sertoli Cells

    Extracellular Accumulation of Sulfated Glycoprotein

    Synthesis of Specific Peptides

    Immunological Properties of Heparin-Binding Growth Factors

    Discussion

    References

    16 Regulation of Blood Vessel Growth and Differentiation

    Introduction

    Growth and Development

    Embryonic Stem Cells as an Experimental Model System for Early Vascular Development

    Endothelial Cell Differentiation

    Concluding Remarks

    References

    17 Vascular Endothelium: Role in Albumin Transport

    Multiplicity of Endothelial Functions

    General Organization

    Continuous Microvascular Endothelium

    Physiological Data

    Attempts at Structural-Functional Integration

    Perspectives

    References

    18 A Growth Factor Homologous Gene Controlling Pattern Formation in Drosophila

    Introduction

    Overview of the Organization of the decapentaplegic Gene

    Contribution of the Hin Region to dpp Function

    Nature of the dpp Polypeptide

    References

    Part IV Sequence-Specific DNA-Binding Proteins: Role in Differentiation and Development

    19 The Role of Master Regulatory Genes in Controlling Development

    Text

    References

    20 engrailed, A Gene for All Segments

    Introduction

    The engrailed Gene Promoter

    The engrailed Protein Is a Phosphoprotein

    References

    21 Sequence-Specific DNA-Binding Activities of Even-Skipped and Other Homeo Box Proteins in Drosophih

    Introduction

    Results

    Discussion

    Materials and Methods

    References

    22 Identification and Characterization of Two Mouse Genes, EN-1 and EN-2, with Sequence Homology to the engrailed and invected Genes of Drosophih

    Introduction

    Results

    Discussion

    References

    23 Structure and Developmental Expression of Murine Homeo Box Genes

    Introduction

    Results and Discussion

    References

    Part V Small Molecules in Differentiation and Development

    24 Molecular Dissection of Pattern Formation in Vertebrate Limbs: Concepts and Experimental Approaches

    Background

    Retinoic Acid Mimics ZPA Tissue and Induces Pattern

    Duplications in a Highly Specific Way

    Retinoic Acid Can Induce Digit Formation in the Absence of ZPA Tissue

    Limb Buds Contain Endogenous Retinoic Acid

    Future Problems

    References

    25 Differentiation of a Multipotent Human Intestinal Cell Line: Expression of Villin, a Structural Component of Brush Borders

    The Intestinal Epithelium: A Model System for Study of Cell Diffferentiation and the Development of a Polarized Cytoskeleton

    A Pluripotent Human Intestinal Cell Line That Can Be Induced to Differentiate in Culture

    Organization of Intestinal Brush Border Cytoskeleton

    Villin, a Calcium-Regulated Actin-Binding Protein

    Villin Is an Organ-Specific Marker in Adults and Embryos

    Villin Expression during Intestinal Differentiation

    Summary and Conclusions

    References

    Index


Product details

  • No. of pages: 388
  • Language: English
  • Copyright: © Academic Press 1991
  • Published: February 28, 1991
  • Imprint: Academic Press
  • eBook ISBN: 9780323152730

About the Editor

A.R. Bellve

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