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Molecular Imaging - 2nd Edition - ISBN: 9780128163863

Molecular Imaging

2nd Edition

Principles and Practice

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Editors: Brian Ross Sanjiv Gambhir
Book ISBN: 9780128163863
Imprint: Academic Press
Published Date: 1st March 2021
Page Count: 1500
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Description

The detection and measurement of the dynamic interactions of proteins within the living cell are critical to the understanding of cell physiology and pathophysiology. The field of molecular imaging of living subjects continues to expand and has seen dramatic advances in chemistry, engineering and biomedical applications. Molecular Imaging, Second Edition provides the first point of entry to the research for all scientists interested in this multi-disciplinary field. Molecular imaging is very diverse: new investigators, collaborators, and students entering this field need an authoritative reference to bring this field together. Editors Brian Ross and Sam Gambhir designed this revision precisely to fill this need.

Key Features

  • The most authoritative and effective resource available in the field, written by over 170 of the leading scientists from around the world who have evaluated and summarized the most important methods, principles, technologies and data within the field
  • Concepts illustrated with over 600 color figures and molecular-imaging examples
  • This edition packed with innovative science, including: Light sheet fluorescence microscopy (LSFM); Mass Spectrometry Imaging; Combining In vitro and in vivo diagnostics; Raman Imaging; Optogenetics; FDA approval of current imaging agents

Readership

Molecular imaging basic scientists, molecular biologists, oncologists, functional and nuclear medicine imaging, radiologists with molecular imaging background/interest

Table of Contents

1. General Principles of Molecular Imaging

PART I: MOLECULAR IMAGING TECHNOLOGI ES
2. Imaging of Structure and Function with PET/CT
3. PET/MRI
4. SPECT and SPECT/CT
5. Principles of Micro X-ray Computed Tomography
6. Small Animal SPECT, SPECT/CT, and SPECT/MRI
7. Instrumentation and Methods to Combine Small Animal PET with Other Imaging Modalities
8. Functional Imaging Using Bioluminescent Markers
9. Optical Multimodality Technologies
10. Fiber Optic Fluorescence Imaging
11. Fluorescence Tomography
12. Endomicroscopy
13. lntravital Microscopy
14. Diffuse Optical Tomography and Spectroscopy
15. Ultrasound
16. Molecular Photoacoustic Tomography
17. Optical Projection Tomography
18. Potential Roles for Retrospective Registration in Molecular Imaging

PART II: CHEMISTRY OF MOLECULAR IMAGING
19. Chemistry of Molecular Imaging: An Overview
20. Radiochemistry of PET
21. Radiochemistry of SPECT: Examples of 99mTc and 1111n Complexes
22. Nanochemistry for Molecular
23. Newer Bioconjugation Methods
24. Targeted Antibodies and Peptides
25. Hyperpolarized 13C Magnetic Resonance Imaging-Principles and Applications
26. Magnetic Resonance Imaging Agents
27. Optical Imaging Agents
28. Ultrasound Contrast Agents
29. Multimodality Agents
30. "Click Chemistry": Applications to Molecular Imaging
31. The "One-Bead-One-Compound" Combinatorial Approach to Identifying Molecular Imaging Probes
32. Chemical Biology Approaches to Molecular Imaging
33. Theranostics: Agents for Diagnosis and Therapy
34. Magnetic Nanoparticles
35. Fluorocarbon Agents for Quantitative Multimodal Molecular Imaging and Targeted Therapeutics
36. Aptamers for Molecular Imaging
37. Nonclinical Product Developmental Strategies, Safety Considerations, and Toxicity Profiles of Medical Imaging and Radiopharmaceuticals Products

PART III: MOLECULAR IMAGING IN CELL AND MOLECULAR BIOLOGY
38. Overview of Molecular and Cell Biology
39. Systems Biology
40. Protein Engineering for Molecular Imaging
41. Phage Display for Imaging Agent Development
42. Molecular Imaging of Gene Therapy
43. Developing Diagnostic and Therapeutic Viral Vectors
44. Cell Voyeurism Using Magnetic Resonance Imaging
45. Tumor Vasculature
46. Imaging Hypoxia
47. Molecular Imaging of Protein-Protein Interactions
48. Fluorescence Readouts of Biochemistry in Live Cells and Organisms
49. Imaging of Signaling Pathways

PART IV: APPLICATIONS OF MOLECULAR IMAGING
50. Molecular and Functional Imaging of the Tumor Microenvironment
51. Novel MR and PET Imaging in the RT Planning and Assessment of Response of Malignant Gliomas
52. PET Diagnosis and Response Monitoring in Oncology
53. Magnetic Resonance Spectroscopy Treatment Response and Detection
54. Diffusion MRI: A Biomarker for Early Cancer Treatment Response Assessment
55. Myocardial Metabolism
56. Congestive Heart Failure
57. Molecular Imaging of Atherosclerosis
58. Thrombosis and Embolism
59. Molecular Imaging of Stem Cells in Myocardial Infarction
60. Central Nervous System Molecular Imaging
61. Neuroreceptor Imaging: Applications, Advances, and Limitations
62. PET and SPECT Imaging of Neurodegelierative Diseases
63. Molecular Imaging of Autoimmune Diseases
64. Rheumatoid Arthritis
65. Autoimmune Diabetes
66. Imaging in Asthma

PART V: MOLECULAR IMAGING IN DRUG EVALUATION
67. Molecular and Functional Imaging in Drug Development
68. PET Imaging in Cancer Clinical Trials
69. Magnetic Resonance Imaging in Clinical Trials
70. Imaging of Gene Therapy: Basis and Clinical Trials

PART VI: OTHER
71. Visualization
72. Quantification of Radiotracer Uptake into Tissue
73. Mining Genomic Data for Molecular Imaging Targets
74. Pharmacokinetic Modeling
75. Cost-Effectiveness Analysis/Economics of Probe Development
76. The Regulatory and Reimbursement Process for Imaging Agents and Devices

Details

No. of pages:
1500
Language:
English
Copyright:
© Academic Press 2021
Published:
1st March 2021
Imprint:
Academic Press
Book ISBN:
9780128163863

About the Editors

Brian Ross

Dr. Ross is the Director of the Center for Molecular Imaging at the University of Michigan, which provides state-of-the-art imaging services for the research community and offering a broad range of imaging systems (two IVIS bioluminescent/fluorescent imaging systems, an Agilent 7 Tesla horizontal bore MRI system, a Siemens PET/CT, a Trifoil Imaging SPECT/CT, and a Bruker CT system). As part of CMI, his research helps to develop applications for imaging to allow for investigations of cancer growth and response to therapy including noninvasive detection of molecular signaling events in living tissue.

Affiliations and Expertise

University of Michigan School of Medicine, Professor, Biological Chemistry; Roger A. Berg Research Professor of Radiology; Departments of Radiology and Biological Chemistry; Director - Center for Molecular Imaging, Associate Chair for Basic Science Research, Ann Arbor, MI, USA

Sanjiv Gambhir

Dr. Gambhir serves as the Director of the Molecular Imaging Program at Stanford (MIPS) and Canary Center at Stanford for Cancer Early Detection. He has authored over 600 publications, has over 40 patents pending or granted, has been featured on the cover of over 25 journals including the Nature Series, Science, and Science Translational Medicine. He is on the editorial board of several journals including Nano Letters, Nature Clinical Practice Oncology, and Science Translational Medicine. He has mentored post-doctoral fellows and graduate students from diverse disciplines. His research focuses on the development of imaging assays to monitor fundamental cellular/molecular events in living subjects with an emphasis on the detection and management of cancer. A particular interest of his research and lab is early cancer detection including combining in vivo and in vitro diagnostics.

Affiliations and Expertise

Virginia and D.K. Ludwig Professor of Radiology and Bioengineering; Director, Molecular Imaging Program at Stanford (MIPS); Director, Canary Center for Cancer Early Detection at Stanford; Chief, Division of Nuclear Medicine; Stanford University School of Medicine, Stanford, California, USA

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