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Molecular Imaging - 2nd Edition - ISBN: 9780128163863

Molecular Imaging

2nd Edition

Principles and Practice

Editors: Brian Ross Sanjiv Gambhir
Hardcover ISBN: 9780128163863
Imprint: Academic Press
Published Date: 9th August 2021
Page Count: 1868
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The detection and measurement of the dynamic regulation and interactions of cells and proteins within the living cell are critical to the understanding of cellular biology and pathophysiology. The multidisciplinary field of molecular imaging of living subjects continues to expand with dramatic advances in chemistry, molecular biology, therapeutics, engineering, medical physics and biomedical applications. Molecular Imaging: Principles and Practice, Volumes 1 and 2, Second Edition provides the first point of entry for physicians, scientists, and practitioners. This authoritative reference book provides a comprehensible overview along with in-depth presentation of molecular imaging concepts, technologies and applications making it the foremost source for both established and new investigators, collaborators, students and anyone interested in this exciting and important field.

Key Features

The most authoritative and comprehensive resource available in the molecular-imaging field, written by over 170 of the leading scientists from around the world who have evaluated and summarized the most important methods, principles, technologies and data
Concepts illustrated with over 600 color figures and molecular-imaging examples
Chapters/topics include, artificial intelligence and machine learning, use of online social media, virtual and augmented reality, optogenetics, FDA regulatory process of imaging agents and devices, emerging instrumentation, MR elastography, MR fingerprinting, operational radiation safety, multiscale imaging and uses in drug development
This edition is packed with innovative science, including theranostics, light sheet fluorescence microscopy, (LSFM), mass spectrometry imaging, combining in vitro and in vivo diagnostics, Raman imaging, along with molecular and functional imaging applications
Valuable applications of molecular imaging in pediatrics, oncology, autoimmune, cardiovascular and CNS diseases are also presented
This resource helps integrate diverse multidisciplinary concepts associated with molecular imaging to provide readers with an improved understanding of current and future applications


Molecular imaging basic scientists, molecular biologists, oncologists, functional and nuclear medicine imaging, radiologists with molecular imaging background/interest

Table of Contents

1. General Principles of Molecular Imaging

2. Imaging of Structure and Function with PET/CT
5. Principles of Micro X-ray Computed Tomography
6. Small Animal SPECT, SPECT/CT, and SPECT/MRI
7. Instrumentation and Methods to Combine Small Animal PET with Other Imaging Modalities
8. Functional Imaging Using Bioluminescent Markers
9. Optical Multimodality Technologies
10. Fiber Optic Fluorescence Imaging
11. Fluorescence Tomography
12. Endomicroscopy
13. lntravital Microscopy
14. Diffuse Optical Tomography and Spectroscopy
15. Ultrasound
16. Molecular Photoacoustic Tomography
17. Optical Projection Tomography
18. Potential Roles for Retrospective Registration in Molecular Imaging

19. Chemistry of Molecular Imaging: An Overview
20. Radiochemistry of PET
21. Radiochemistry of SPECT: Examples of 99mTc and 1111n Complexes
22. Nanochemistry for Molecular
23. Newer Bioconjugation Methods
24. Targeted Antibodies and Peptides
25. Hyperpolarized 13C Magnetic Resonance Imaging-Principles and Applications
26. Magnetic Resonance Imaging Agents
27. Optical Imaging Agents
28. Ultrasound Contrast Agents
29. Multimodality Agents
30. "Click Chemistry": Applications to Molecular Imaging
31. The "One-Bead-One-Compound" Combinatorial Approach to Identifying Molecular Imaging Probes
32. Chemical Biology Approaches to Molecular Imaging
33. Theranostics: Agents for Diagnosis and Therapy
34. Magnetic Nanoparticles
35. Fluorocarbon Agents for Quantitative Multimodal Molecular Imaging and Targeted Therapeutics
36. Aptamers for Molecular Imaging
37. Nonclinical Product Developmental Strategies, Safety Considerations, and Toxicity Profiles of Medical Imaging and Radiopharmaceuticals Products

38. Overview of Molecular and Cell Biology
39. Systems Biology
40. Protein Engineering for Molecular Imaging
41. Phage Display for Imaging Agent Development
42. Molecular Imaging of Gene Therapy
43. Developing Diagnostic and Therapeutic Viral Vectors
44. Cell Voyeurism Using Magnetic Resonance Imaging
45. Tumor Vasculature
46. Imaging Hypoxia
47. Molecular Imaging of Protein-Protein Interactions
48. Fluorescence Readouts of Biochemistry in Live Cells and Organisms
49. Imaging of Signaling Pathways

50. Molecular and Functional Imaging of the Tumor Microenvironment
51. Novel MR and PET Imaging in the RT Planning and Assessment of Response of Malignant Gliomas
52. PET Diagnosis and Response Monitoring in Oncology
53. Magnetic Resonance Spectroscopy Treatment Response and Detection
54. Diffusion MRI: A Biomarker for Early Cancer Treatment Response Assessment
55. Myocardial Metabolism
56. Congestive Heart Failure
57. Molecular Imaging of Atherosclerosis
58. Thrombosis and Embolism
59. Molecular Imaging of Stem Cells in Myocardial Infarction
60. Central Nervous System Molecular Imaging
61. Neuroreceptor Imaging: Applications, Advances, and Limitations
62. PET and SPECT Imaging of Neurodegelierative Diseases
63. Molecular Imaging of Autoimmune Diseases
64. Rheumatoid Arthritis
65. Autoimmune Diabetes
66. Imaging in Asthma

67. Molecular and Functional Imaging in Drug Development
68. PET Imaging in Cancer Clinical Trials
69. Magnetic Resonance Imaging in Clinical Trials
70. Imaging of Gene Therapy: Basis and Clinical Trials

71. Visualization
72. Quantification of Radiotracer Uptake into Tissue
73. Mining Genomic Data for Molecular Imaging Targets
74. Pharmacokinetic Modeling
75. Cost-Effectiveness Analysis/Economics of Probe Development
76. The Regulatory and Reimbursement Process for Imaging Agents and Devices


No. of pages:
© Academic Press 2021
9th August 2021
Academic Press
Hardcover ISBN:

About the Editors

Brian Ross

Dr. Ross is the Director of the Center for Molecular Imaging at the University of Michigan, which provides state-of-the-art imaging services for the research community and offering a broad range of imaging systems (two IVIS bioluminescent/fluorescent imaging systems, an Agilent 7 Tesla horizontal bore MRI system, a Siemens PET/CT, a Trifoil Imaging SPECT/CT, and a Bruker CT system). As part of CMI, his research helps to develop applications for imaging to allow for investigations of cancer growth and response to therapy including noninvasive detection of molecular signaling events in living tissue.

Affiliations and Expertise

Roger A. Berg Research Professor of Radiology; Director, Center for Molecular Imaging; Associate Chair for Basic Science Research; Professor of Biological Chemistry; University of Michigan School of Medicine, Ann Arbor, Michigan, USA

Sanjiv Gambhir

Dr. Gambhir served as the Director of the Molecular Imaging Program at Stanford (MIPS) and Canary Center at Stanford for Cancer Early Detection. He has authored over 600 publications, has over 40 patents pending or granted, has been featured on the cover of over 25 journals including the Nature Series, Science, and Science Translational Medicine. He was on the editorial board of several journals including Nano Letters, Nature Clinical Practice Oncology, and Science Translational Medicine. He mentored post-doctoral fellows and graduate students from diverse disciplines. His research focused on the development of imaging assays to monitor fundamental cellular/molecular events in living subjects with an emphasis on the detection and management of cancer. A particular interest of his research and lab was early cancer detection including combining in vivo and in vitro diagnostics.

Affiliations and Expertise

Virginia & D.K. Ludwig Professor of Radiology and Bioengineering; Director, Molecular Imaging Program at Stanford (MIPS); Director, Canary Center for Cancer Early Detection at Stanford; Chief, Division of Nuclear Medicine; Stanford University School of Medicine, Stanford, California, USA

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