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Molecular Genetics Pt 2 - 1st Edition - ISBN: 9780126844023, 9780323146845

Molecular Genetics Pt 2

1st Edition

Editor: Herbert Taylor
eBook ISBN: 9780323146845
Imprint: Academic Press
Published Date: 1st January 1967
Page Count: 534
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Molecular Genetics, Part II covers the significant developments in various areas of molecular genetics. This book is composed of 10 chapters that also consider the gene expression and regulation of some enzymes. The opening chapters deal with the mechanisms of nucleic acid replication and repair, as well as the structural aspects of the genetic apparatus of viruses and cells. The next chapters explore the patterns and mechanisms of genetic recombination, the in vitro and in vivo experiments to delineate the genetic code, and the initiation of peptide chains in Escherichia coli. These topics are followed by discussions of the mechanism of DNA-dependent RNA synthesis, the regulation of enzyme synthesis in microorganisms, and the regulation of viral replication. The final chapters consider the theoretical and practical aspects of the metabolic regulation in metazoan system and the procedures for the study of DNA-DNA and DNA-RNA interactions. This book will be of great value to molecular geneticists, biochemists, and researchers.

Table of Contents

Contributors To Part II


Contents Of Part I

Chapter I Mechanisms of Replication and Repair of Nucleic Acid

I. Introduction

II. Replication of DNA in Vitro

III. Replication of DNA in Vivo

IV. Damage and Repair of DNA

V. Effects of the Thymineless State

VI. Relation of DNA Replication to Protein Synthesis

VII. Single-Stranded DNA and RNA Phages

VIII. Conclusions


Chapter II Structural Aspects of the Genetic Apparatus of Viruses and Cells

I. Introduction

II. Nucleic Acids as Linear Macromolecules

III. Natural Nucleic Acids

IV. Circularity and Discontinuity in DNA

V. Replication of Nucleic Acids

VI. Structural Aspects of Organized Chromosomes

VII. Cytoplasmic Genetic Material

VIII. Models

IX. Conclusions


Chapter III Patterns and Mechanisms of Genetic Recombination

I. Introduction

II. Recombination in Bacteriophages

III. Genetic Transfer in Bacteria

IV. Recombination in Meiotic Divisions

V. Mechanisms of Genetic Recombination in Meiosis

VI. A Modified Chromosome Model with Some Implications for Recombination

VII. Addendum


Chapter IV The Genetic Code

I. Introduction

II. Deciphering the Code


Chapter V On Peptide Chain Initiation

I. Initiation of Peptide Chains in E. coli

II. On the Involvement of N-Formylmethionyl-tRNAF in Regulation

III. On Peptide Chain Initiation in Organisms Other Than E. coli

IV. Further Problems

V. Summary


Chapter VI RNA Synthesis—Mechanism of Genetic Transcription

I. Introduction

II. Mechanism of DNA-Dependent RNA Synthesis

III. The Product of in Vivo and in Vitro Transcription

IV. Regulation of RNA Synthesis


Chapter VII Regulation of Enzyme Synthesis in Microorganisms

I. Historical

II. Physiological Aspects of Regulation

III. Mechanisms


Chapter VIII Regulation in Viruses

I. General Considerations

II. Regulation of Gene Action

III. Regulation of Replication

IV. Conclusions and Perspectives


Chapter IX Metabolic Regulation in Metazoan System

I. Introduction

II. Some Theoretical and Practical Considerations in Metabolic Regulation

III. Control of Enzyme Synthesis in Metazoa

IV. Selected Physiological and Pathological Control Mechanisms in Metazoa

V. Conclusions—Contrast of Controls in Unicellular and Multicellular Organisms

VI. Addendum


Chapter X Studies of Nucleic Acid Interactions Using DNA-Agar

I. Introduction

II. Procedures for the Study of Nucleic Acid Interactions

III. DNA-DNA Interactions

IV. DNA-RNA Interactions

V. Renaturation of the DNA of Higher Organisms

VI. Implications for Evolution

VII. Conclusions

VIII. Addendum


Author Index

Subject Index


No. of pages:
© Academic Press 1967
1st January 1967
Academic Press
eBook ISBN:

About the Editor

Herbert Taylor

Affiliations and Expertise

National Institutes of Health, Bethesda, Maryland, U.S.A.

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