Molecular Genetics Pt 2

Molecular Genetics Pt 2

1st Edition - January 1, 1967

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  • Editor: Herbert Taylor
  • eBook ISBN: 9780323146845

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Molecular Genetics, Part II covers the significant developments in various areas of molecular genetics. This book is composed of 10 chapters that also consider the gene expression and regulation of some enzymes. The opening chapters deal with the mechanisms of nucleic acid replication and repair, as well as the structural aspects of the genetic apparatus of viruses and cells. The next chapters explore the patterns and mechanisms of genetic recombination, the in vitro and in vivo experiments to delineate the genetic code, and the initiation of peptide chains in Escherichia coli. These topics are followed by discussions of the mechanism of DNA-dependent RNA synthesis, the regulation of enzyme synthesis in microorganisms, and the regulation of viral replication. The final chapters consider the theoretical and practical aspects of the metabolic regulation in metazoan system and the procedures for the study of DNA-DNA and DNA-RNA interactions. This book will be of great value to molecular geneticists, biochemists, and researchers.

Table of Contents

  • Contributors To Part II


    Contents Of Part I

    Chapter I Mechanisms of Replication and Repair of Nucleic Acid

    I. Introduction

    II. Replication of DNA in Vitro

    III. Replication of DNA in Vivo

    IV. Damage and Repair of DNA

    V. Effects of the Thymineless State

    VI. Relation of DNA Replication to Protein Synthesis

    VII. Single-Stranded DNA and RNA Phages

    VIII. Conclusions


    Chapter II Structural Aspects of the Genetic Apparatus of Viruses and Cells

    I. Introduction

    II. Nucleic Acids as Linear Macromolecules

    III. Natural Nucleic Acids

    IV. Circularity and Discontinuity in DNA

    V. Replication of Nucleic Acids

    VI. Structural Aspects of Organized Chromosomes

    VII. Cytoplasmic Genetic Material

    VIII. Models

    IX. Conclusions


    Chapter III Patterns and Mechanisms of Genetic Recombination

    I. Introduction

    II. Recombination in Bacteriophages

    III. Genetic Transfer in Bacteria

    IV. Recombination in Meiotic Divisions

    V. Mechanisms of Genetic Recombination in Meiosis

    VI. A Modified Chromosome Model with Some Implications for Recombination

    VII. Addendum


    Chapter IV The Genetic Code

    I. Introduction

    II. Deciphering the Code


    Chapter V On Peptide Chain Initiation

    I. Initiation of Peptide Chains in E. coli

    II. On the Involvement of N-Formylmethionyl-tRNAF in Regulation

    III. On Peptide Chain Initiation in Organisms Other Than E. coli

    IV. Further Problems

    V. Summary


    Chapter VI RNA Synthesis—Mechanism of Genetic Transcription

    I. Introduction

    II. Mechanism of DNA-Dependent RNA Synthesis

    III. The Product of in Vivo and in Vitro Transcription

    IV. Regulation of RNA Synthesis


    Chapter VII Regulation of Enzyme Synthesis in Microorganisms

    I. Historical

    II. Physiological Aspects of Regulation

    III. Mechanisms


    Chapter VIII Regulation in Viruses

    I. General Considerations

    II. Regulation of Gene Action

    III. Regulation of Replication

    IV. Conclusions and Perspectives


    Chapter IX Metabolic Regulation in Metazoan System

    I. Introduction

    II. Some Theoretical and Practical Considerations in Metabolic Regulation

    III. Control of Enzyme Synthesis in Metazoa

    IV. Selected Physiological and Pathological Control Mechanisms in Metazoa

    V. Conclusions—Contrast of Controls in Unicellular and Multicellular Organisms

    VI. Addendum


    Chapter X Studies of Nucleic Acid Interactions Using DNA-Agar

    I. Introduction

    II. Procedures for the Study of Nucleic Acid Interactions

    III. DNA-DNA Interactions

    IV. DNA-RNA Interactions

    V. Renaturation of the DNA of Higher Organisms

    VI. Implications for Evolution

    VII. Conclusions

    VIII. Addendum


    Author Index

    Subject Index

Product details

  • No. of pages: 534
  • Language: English
  • Copyright: © Academic Press 1967
  • Published: January 1, 1967
  • Imprint: Academic Press
  • eBook ISBN: 9780323146845

About the Editor

Herbert Taylor

Affiliations and Expertise

National Institutes of Health, Bethesda, Maryland, U.S.A.

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