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Molecular Genetics, Part II covers the significant developments in various areas of molecular genetics. This book is composed of 10 chapters that also consider the gene expression and regulation of some enzymes. The opening chapters deal with the mechanisms of nucleic acid replication and repair, as well as the structural aspects of the genetic apparatus of viruses and cells. The next chapters explore the patterns and mechanisms of genetic recombination, the in vitro and in vivo experiments to delineate the genetic code, and the initiation of peptide chains in Escherichia coli. These topics are followed by discussions of the mechanism of DNA-dependent RNA synthesis, the regulation of enzyme synthesis in microorganisms, and the regulation of viral replication. The final chapters consider the theoretical and practical aspects of the metabolic regulation in metazoan system and the procedures for the study of DNA-DNA and DNA-RNA interactions. This book will be of great value to molecular geneticists, biochemists, and researchers.
Contributors To Part II
Contents Of Part I
Chapter I Mechanisms of Replication and Repair of Nucleic Acid
II. Replication of DNA in Vitro
III. Replication of DNA in Vivo
IV. Damage and Repair of DNA
V. Effects of the Thymineless State
VI. Relation of DNA Replication to Protein Synthesis
VII. Single-Stranded DNA and RNA Phages
Chapter II Structural Aspects of the Genetic Apparatus of Viruses and Cells
II. Nucleic Acids as Linear Macromolecules
III. Natural Nucleic Acids
IV. Circularity and Discontinuity in DNA
V. Replication of Nucleic Acids
VI. Structural Aspects of Organized Chromosomes
VII. Cytoplasmic Genetic Material
Chapter III Patterns and Mechanisms of Genetic Recombination
II. Recombination in Bacteriophages
III. Genetic Transfer in Bacteria
IV. Recombination in Meiotic Divisions
V. Mechanisms of Genetic Recombination in Meiosis
VI. A Modified Chromosome Model with Some Implications for Recombination
Chapter IV The Genetic Code
II. Deciphering the Code
Chapter V On Peptide Chain Initiation
I. Initiation of Peptide Chains in E. coli
II. On the Involvement of N-Formylmethionyl-tRNAF in Regulation
III. On Peptide Chain Initiation in Organisms Other Than E. coli
IV. Further Problems
Chapter VI RNA Synthesis—Mechanism of Genetic Transcription
II. Mechanism of DNA-Dependent RNA Synthesis
III. The Product of in Vivo and in Vitro Transcription
IV. Regulation of RNA Synthesis
Chapter VII Regulation of Enzyme Synthesis in Microorganisms
II. Physiological Aspects of Regulation
Chapter VIII Regulation in Viruses
I. General Considerations
II. Regulation of Gene Action
III. Regulation of Replication
IV. Conclusions and Perspectives
Chapter IX Metabolic Regulation in Metazoan System
II. Some Theoretical and Practical Considerations in Metabolic Regulation
III. Control of Enzyme Synthesis in Metazoa
IV. Selected Physiological and Pathological Control Mechanisms in Metazoa
V. Conclusions—Contrast of Controls in Unicellular and Multicellular Organisms
Chapter X Studies of Nucleic Acid Interactions Using DNA-Agar
II. Procedures for the Study of Nucleic Acid Interactions
III. DNA-DNA Interactions
IV. DNA-RNA Interactions
V. Renaturation of the DNA of Higher Organisms
VI. Implications for Evolution
- No. of pages:
- © Academic Press 1967
- 1st January 1967
- Academic Press
- eBook ISBN:
National Institutes of Health, Bethesda, Maryland, U.S.A.
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