Molecular Genetics of Sex Determination

Molecular Genetics of Sex Determination

1st Edition - November 18, 1993

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  • Editor: Stephen Wachtel
  • eBook ISBN: 9781483295589

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In this era of accelerated discovery and prolific output, Molecular Genetics of Sex Determination keeps readers abreast of this fields fast-moving biology. Its chapters were completed by experts in eacharea only months before publication. The text is organized into two parts. First, it reviews the basic biology of sex determination and summarizes ground-breaking work in mouse, marsupial, and Drosophila systems. Second, it covers current human genetics, clinical studies, and the syndromes of abnormal sex differentiation. With chapters by preeminent reproductive biologists, this is a capital work. Ohno's law is described by Ohno; the Lyon hypothesis, by Lyon; Sinclair tells how he cloned the testis-determining gene; and so on. Molecular Genetics of Sex Determination is authoritative, comprehensive, and current. It is prime reading for geneticists, developmental biologists, graduate students in these and related fields, clinical researchers, physicians, and medical students.

Key Features

  • Reviews the genetics of sex determination in 19 up-to-date chapters
  • Features research on sex chromosomes and sex-determining genes
  • Includes abnormalities of sex determination and clinical genetics
  • Written by scientists who pioneered work in this field


Researchers and graduate students in genetics, molecular biology, developmental biology, neurobiology, endocrinology, reproductive biology, clinical medicine, obstetrics, gynecology, pediatrics, and medical genetics

Table of Contents

  • Part I:
    S.S. Wachtel and T.R. Tiersch, The Search for the Male Determining Gene.
    A. Sinclair, The Cloning of SRY.
    J. Gubbay and R. Lovell-Badge, The Mouse Y Chromosome.
    A. McLaren, XX Sex Reversal in the Mouse.
    C.M. Nagamine, XY Sex Reversal in the Mouse.
    S. Ohno, Conservation of the X-Linkage Group in Toto by all Eutherian Mammals.
    M.F. Lyon, X-Chromosome Inactivation.
    G.K. Hampikian, D.W. Cooper, J.A. Marshall Graves, Sex Determination in Marsupials and Monotremes.
    C. Cronmiller and H.K. Salz, The Feminine Mystique: The Initiation of Sex Determination in Drosophila.
    Part II:
    U. Muller, The Human Y Chromosome.
    N.A. Affara and M.A. Ferguson-Smith, DNA Sequence Homology between the Human Sex Chromosomes.
    S.S. Wachtel, XX Sex Reversal in the Human.
    S.S. Wachtel and J.L. Simpson, XY Sex Reversal in the Human.
    K.Neeley and R.G. Rosenfeld, Phenotypic Correlations of X Chromosome Loss.
    L. Pinsky, M. Trifiro, L.K. Beitel, and M. Kaufman, Molecular Genetics of Androgen Insensitivity Syndromes in Man.
    M. Zachmann, Male Pseudohermaphroditism.
    M.I. New and C. Crawford, Molecular Genetics of Steroid 21-Hydroxylase Deficiency.
    N. Josso, S. Imbeaud, J.-Y. Picard, and R.L. Cate, The Gene for Anti-Mullerian Hormone.
    M.L. Gustafson and P.K. Donahoe, Mullerian Inhibiting Substance: Critical Roles in Sexual Differentiation.

Product details

  • No. of pages: 518
  • Language: English
  • Copyright: © Academic Press 1993
  • Published: November 18, 1993
  • Imprint: Academic Press
  • eBook ISBN: 9781483295589

About the Editor

Stephen Wachtel

Affiliations and Expertise

University of Tennessee, Memphis, U.S.A.

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