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Molecular Genetics Medicine - 1st Edition - ISBN: 9780124620049, 9781483295572

Molecular Genetics Medicine, Volume 4

1st Edition

Editor: Theodore Friedmann
eBook ISBN: 9781483295572
Imprint: Academic Press
Published Date: 12th August 1994
Page Count: 188
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Table of Contents

G.C.M. Black and I.W. Craig, The Molecular Genetics of Blindness. D.J. Driscoll, Genomic Imprinting in Humans. D. Patterson, H.R. Warner, L.M. Fox, and Z. Rahmani, Superoxide Dismutase, Oxygen Radical Metabolism, and Amyotrophic Lateral Sclerosis. E.A.C. Wiemer and S. Subramani, Protein Import Deficiencies in Human Peroxisomal Disorders. K.R. Thomas, The Impact of Gene Targeting on Medicine. Subject Index.


Continuing to keep pace with progress in human molecular genetics, Volume 4 of Molecular Genetic Medicine reviews five new areas of critical importance. Chapter 1 reviews the molecular mechanisms that have beenunraveled in the pathogenesis of eye diseases. The second chapter explains the remarkable new principle if genomic imprinting, or epigenetic modification imposed by parental history. Chapter 3 describes the etiology of amyotrophic lateral sclerosis, or Lou Gehrig's Disease, as effected by superdioxide dismutase function and neuron degeneration. The fourth chapter covers the normal and aberrant functions of peroxisomes, now implicated in many diseases, most notably adrenoleukodystrophy, publicized widelyby the"cure"called Lorenzo's oil. The final chapter summarizes recombination techniques that permit functional new genetic material to be introduced into, and subsequently transmitted through, the germ line of mammalian cells. These amazing methods arehaving profound impacts on medicine and on concepts of the study of normal human development and disease.

Key Features

Presents technical and historical overviews of molecular biology applied to disease detection, diagnosis, and treatment Chronicles the continuing explosion of knowledge in molecular genetic medicine giving current approaches to understanding human illness Documents the revolution in human and molecular genetics leading to a new field of medicine


Researchers and students of all aspects of human genetics, molecular biology, and medicine. Academic, medical, industrial, and library markets.


No. of pages:
© Academic Press 1994
12th August 1994
Academic Press
eBook ISBN:

Ratings and Reviews

About the Editor

Theodore Friedmann

School of Medicine, University of California at San Diego, USA

Affiliations and Expertise

School of Medicine, University of California at San Diego, USA