Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research - 1st Edition - ISBN: 9780128040782

Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research

1st Edition

Editors: Robert T. Gerlai
Hardcover ISBN: 9780128040782
Imprint: Academic Press
Published Date: 1st June 2018
Page Count: 702
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Description

Molecular-Genetic Techniques for Behavioral and Neural Research provides an informative and up-to-date account of the most modern molecular and genetic techniques and their use in biomedical research, behavioral and neuroscience studies, and, finally, disease diagnosis and research at a molecular level. This new work is a reworking of Elsevier's original Handbook of Molecular-Genetic Techniques for Brain and Behavior Research (1999) serving as an all-encompassing, updated reference that expands on techniques first described there in the wake of multiple revolutions in DNA technology including the Human Genome Project. Beginning with an introduction to genomic research, this illustrated work extensively discusses relevant experimental techniques, both basic research and translationally relevant, and also examines several species as model systems including Mus musculus, Drosophila melanogaster, Caenorhabditis elegans, and Danio rerio. It is a critical resource for clinicians, researchers, graduate students, and advanced undergraduates, as well as professors teaching in relevant disciplines.

Key Features

• Introduces the relevant aspects of genomic research and neuroinformatics to neuroscience researchers
• Describes the principal methods used to study brain and behavior
• Considers bioinformatics, genomic research, and molecular biology strategies for phenotypic analysis
• Includes discussion on both forward and reverse genetic approaches and genetic animal models of human diseases, and a section on ethical concerns arising from these methods and their applications

Readership

Neuroscientists, biomedical researchers, grad students, postdocs

Table of Contents

Section I: Neuroinformatics, Computational Models and Data Analysis
1. Neurological Biomarkers and NeuroInformatics: The Role of The Virtual Brain
2. Informatics for Interoperability of Molecular-Genetic and Neurobehavioral Databases
3. The Allen Brain Atlas: Towards understanding brain behavior and function through data acquisition, visualization, analysis and integration
4. ExAtlas: On-line tool to integrate gene expression and gene set enrichment analyses
5. Computational Models: How do they help to understand neurological diseases?
6. The Use of Recombinant Inbred Strains in Systems Genetics and Functional Analyses in Behavioral Pharmacology
Section II. Searching for New Genes: Natural Genetic Variation
7. Spontaneous versus induced mutations: Conceptual and methodological considerations for the neurobehavioral geneticist
8. Reduced complexity cross design for behavioral genetics
9. Collaborative Cross as the next-generation mouse genetic reference population designed for dissecting complex traits
10. Discovery of novel genes and other lineage-specific features through comparative genomics
11. Using signatures of directional selection to guide discovery
Section III: Discovery of New Genes and New Functions of Genes Using Gene Expression Analyses
12. Using Transcriptomics to Study Behavior
13. Genes, Behavior and Next-Generation Sequencing – The First Ten Years
14. Abnormal social behaviors and dysfunction of autism-related genes associated with daily agonistic interactions in mice
15. Epigenetic mechanisms of learning and memory
Section IV: Discovery of Genes and Biological Mechanisms: Forward Genetics and Other Screening-Based Methods
16. Systematic screens in zebrafish shed light on cellular and molecular mechanisms of complex brain phenotypes
17. The transition of zebrafish functional genetics from random mutagenesis to targeted integration
Section V: Manipulating Known Genes to Understand Biological Function: Reverse Genetics
18. Molecular Techniques Used to Explore Glutamate Receptors in Synaptic Plasticity and Memory
19. Using Herpes Simplex Virus Type-1-Based Amplicon Vectors for Neuroscience Research and Gene Therapy of Neurological Diseases
20. Cre-lox neurogenetics: history, present and future
21. Functional Analysis of Proteins Involved in Neurodegeneration Using the Model Organism Dictyostelium: Alzheimer’s, Huntington’s and Batten Disease
22. The role of human endogenous retroviruses (HERVs) in the pathologies of nervous system
23. Optogenetics dissection of sleep circuits and functions
24. The use of DREADDs for dissecting the contribution of cellular and neural circuit mechanisms in models of neurodegenerative disease
Section VI: Ethical Considerations
25. Genes and human behavior: Ethical implications
26. Ethical Considerations for Animal use in Behavioral and Neural Research


 

Details

No. of pages:
702
Language:
English
Copyright:
© Academic Press 2018
Published:
Imprint:
Academic Press
Hardcover ISBN:
9780128040782

About the Editor

Robert T. Gerlai

Robert T. Gerlai

Dr. Gerlai received his Ph.D. from the Hungarian Academy of Sciences with the highest distinction in 1989. He has held numerous academic positions in Europe and North America (Eötvös University of Budapest, Mount Sinai Hospital Research Institute of Toronto, Indiana University Purdue University Indianapolis, University of Hawaii Honolulu), and he also held leadership positions in the US biotechnology and biopharmaceutical research industry working as a senior research scientist and Vice President (Genentech Inc. South San Francisco, Eli Lilly & Co. Indianapolis, Saegis Pharma Half Moon Bay) before joining the University of Toronto in 2004, where he is currently full professor at the Department of Psychology. Dr. Gerlai has published over 200 papers in peer reviewed scientific journals and books with a cumulative citation number over 12000 and an H index of 55. He is member of editorial boards of PLOS ONE, Learning and Behavior, Genes Brain and Behaviour, Neurotoxicology and Teratology. He is Associate Editor of Frontiers in Genetics of Complex Traits, Review Editor for Frontiers in Neuroscience and Section Editor for BioMedCentral Neuroscience. He has edited several special issues of scientific journals and served as co-editor of handbooks on molecular genetic approaches in behavioural neuroscience. He is founding member of the International Behavioral and Neural Genetics Society, IBANGS. He was the president of the International Behavioral Neuroscience Society (IBNS) in 2007 and 2008, and he has been elected Fellow of this Society since 2005. He received the Distinguished Scientist Award from IBANGS in 2013 and the John Wiley Distinguished Speaker Award from the International Society of Developmental Psychobiology in 2014. In 2015, he was awarded the University of Toronto Mississauga Excellence in Research Award. Dr. Gerlai’s research focusses on the biological and genetic mechanisms of behaviour. For the past fourteen years his research at University of Toronto has been using zebrafish employing behavioural phenotyping, psychopharmacological and genetic methods to study mechanisms of alcohol abuse, fetal alcohol spectrum disorders, and of learning and memory. His laboratory has been funded by NIH, NSERC and Brain Canada.

Affiliations and Expertise

Department of Psychology, University of Toronto Mississauga, Mississauga, Ontario, Canada

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